Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini.

abstract：:The occurrence of genome segment reassortment between two antigenically related orbiviruses was demonstrated in cattle. Individual virus clones were isolated by cell culture plaque assays directly from the blood of a calf infected with two serotypes of bluetongue virus. The majority (89%) of progeny viruses isolated f...

journal_title：Journal of virology

authors： Stott JL,Oberst RD,Channell MB,Osburn BI

更新日期：1987-09-01 00:00:00

abstract：:We have previously identified 11 epitopes located in two topologically nonoverlapping antigenic sites (A and B) and a third bridging site (C) on the human type 3 parainfluenza virus (PIV3) hemagglutinin-neuraminidase (HN) glycoprotein by using monoclonal antibodies (MAbs) which inhibit hemagglutination and virus infec...

journal_title：Journal of virology

authors： Coelingh KJ,Winter CC,Murphy BR,Rice JM,Kimball PC,Olmsted RA,Collins PL

更新日期：1986-10-01 00:00:00

abstract：:We have recently reported the isolation and molecular cloning of a human immunodeficiency virus type 1 isolate (HIV-1 DH125) that exhibits rapid replication kinetics and marked cytopathicity in both human and chimpanzee peripheral blood mononuclear cells (PBMC). To identify the viral determinants responsible for infec...

journal_title：Journal of virology

authors： Cho MW,Shibata R,Martin MA

更新日期：1996-10-01 00:00:00

abstract：:We have demonstrated that a liposomal array of well-ordered trimers enhances B cell activation, germinal center formation, and the elicitation of tier-2 autologous neutralizing antibodies. Previously, we coupled well-ordered cleavage-independent NFL trimers via their C-terminal polyhistidine tails to nickel lipids int...

journal_title：Journal of virology

authors： Bale S,Goebrecht G,Stano A,Wilson R,Ota T,Tran K,Ingale J,Zwick MB,Wyatt RT

更新日期：2017-07-27 00:00:00

abstract：:Recombination is one of the driving forces of viral evolution. RNA recombination events among similar RNA viruses are frequent, although RNA recombination could also take place among unrelated viruses. In this paper, we have established efficient interviral recombination systems based on yeast and plants. We show that...

journal_title：Journal of virology

authors： Kovalev N,Pogany J,Nagy PD

更新日期：2019-12-12 00:00:00

abstract：:Cauliflower mosaic virus (CaMV) forms two types of inclusion bodies within infected plant cells: numerous virus factories, which are the sites for viral replication and virion assembly, and a single transmission body (TB), which is specialized for virus transmission by aphid vectors. The TB reacts within seconds to ap...

journal_title：Journal of virology

authors： Bak A,Gargani D,Macia JL,Malouvet E,Vernerey MS,Blanc S,Drucker M

更新日期：2013-11-01 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent involved in the disease HTLV-1-associated myelopathy, or tropical spastic paraparesis (HAM/TSP). The pathogenesis of HAM/TSP is poorly understood, but it is probable that viral infection has an indirect, deleterious effect on neural function. In ...

journal_title：Journal of virology

authors： Akaoka H,Hardin-Pouzet H,Bernard A,Verrier B,Belin MF,Giraudon P

更新日期：1996-12-01 00:00:00

abstract：:The membrane glycoproteins G1 and G2 of Uukuniemi virus, a member of the Bunyaviridae family, are cotranslationally cleaved from a common precursor in the endoplasmic reticulum (ER). Here, we show that newly made G1 and G2 associate transiently with calnexin and calreticulin, two lectins involved in glycoprotein foldi...

journal_title：Journal of virology

authors： Veijola J,Pettersson RF

更新日期：1999-07-01 00:00:00

abstract：:Inhibitors of hemagglutination by type A2 influenza virus and a recently isolated strain of type B influenza virus were separated by sucrose density gradient centrifugation and agarose gel filtration from horse serum. Using selected reagents, it was demonstrated that the active substituent on the horse serum inhibitor...

journal_title：Journal of virology

authors： Levinson B,Pepper D,Belyavin G

更新日期：1969-05-01 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) viral interleukin-6 (vIL-6) is a cytokine that is poorly secreted and localized largely to the endoplasmic reticulum (ER). It has been implicated, along with other HHV-8 proinflammatory and/or angiogenic viral proteins, in HHV-8-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), ...

journal_title：Journal of virology

authors： Li Q,Xiang Q,Chen D,Nicholas J

更新日期：2020-09-15 00:00:00

abstract：:In some type C retroviruses, translation of the pol gene appears to require translational suppression of the proximal gag amber codon. To identify the region of the viral nucleic acid responsible for synthesis of the pol gene products, a 300-base-pair DNA fragment containing the stop codon from a type C murine virus (...

journal_title：Journal of virology

authors： Panganiban AT

更新日期：1988-10-01 00:00:00

abstract：:Norovirus immunity is poorly understood as the limited data available on protection after infection are often contradictory. In contrast to the more prominent GII noroviruses, GI norovirus infections are less frequent in outbreaks. The GI noroviruses display very complex patterns of heterotypic immune responses follow...

journal_title：Journal of virology

authors： Lindesmith LC,Donaldson E,Leon J,Moe CL,Frelinger JA,Johnston RE,Weber DJ,Baric RS

更新日期：2010-02-01 00:00:00

abstract：:Zika virus (ZIKV) has emerged as a cause of congenital brain anomalies and a range of placenta-related abnormalities, highlighting the need to unveil the modes of maternal-fetal transmission. The most likely route of vertical ZIKV transmission is via the placenta. The earliest events of ZIKV transmission in the matern...

journal_title：Journal of virology

authors： Weisblum Y,Oiknine-Djian E,Vorontsov OM,Haimov-Kochman R,Zakay-Rones Z,Meir K,Shveiky D,Elgavish S,Nevo Y,Roseman M,Bronstein M,Stockheim D,From I,Eisenberg I,Lewkowicz AA,Yagel S,Panet A,Wolf DG

更新日期：2017-01-31 00:00:00

abstract：:While a diversity of immunogens that elicit qualitatively different cellular immune responses are being assessed in clinical human immunodeficiency virus vaccine trials, the consequences of those varied responses for viral control remain poorly understood. In the present study, we evaluated the induction of virus-spec...

journal_title：Journal of virology

authors： Sun Y,Santra S,Schmitz JE,Roederer M,Letvin NL

更新日期：2008-09-01 00:00:00

abstract：:Three polyadenylated RNAs, 9, 7.3, and 3.5 kilobases long, of a human endogenous retrovirus, ERV3, are abundant in human placental chorion, representing about 0.03 to 0.05% of the total mRNA. We characterized the structure of these mRNAs by Northern blot and S1 nuclease mapping analyses. We found that all three RNAs w...

journal_title：Journal of virology

authors： Kato N,Pfeifer-Ohlsson S,Kato M,Larsson E,Rydnert J,Ohlsson R,Cohen M

更新日期：1987-07-01 00:00:00

abstract：:The inhibition of multilineage hematopoiesis which occurs in the severe combined immunodeficiency mouse with transplanted human fetal thymus and liver tissues (SCID-hu Thy/Liv) due to human immunodeficiency virus type 1 (HIV-1) infection is also accompanied by a severe loss of c-Mpl expression on these progenitor cell...

journal_title：Journal of virology

authors： Koka PS,Kitchen CM,Reddy ST

更新日期：2004-10-01 00:00:00

abstract：:Among the members of the paramyxovirus family, the transcription process and the components involved have been studied under in vitro conditions thus far. Here, we reexamined the function of the viral RNA-dependent RNA polymerase through infection studies with Sendai virus (SeV) N and P deletion (Delta) mutants. To el...

journal_title：Journal of virology

authors： Wiegand MA,Bossow S,Schlecht S,Neubert WJ

更新日期：2007-12-01 00:00:00

abstract：UNLABELLED:Crimean-Congo hemorrhagic fever virus (CCHFV; genus Nairovirus) is an extremely pathogenic member of the Bunyaviridae family. Since handling of the virus requires a biosafety level 4 (BSL-4) facility, little is known about pathomechanisms and host interactions. Here, we describe the establishment of a transc...

journal_title：Journal of virology

authors： Devignot S,Bergeron E,Nichol S,Mirazimi A,Weber F

更新日期：2015-06-01 00:00:00

abstract：:The proteins of purified avian oncoviruses were analyzed by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis and isoelectric focusing. Certain members of the avian leukosis-sarcoma viruses (ALSV) had group-specific antigens with altered electrophoretic properties. (i) The p27 protein of Rous-associated ...

journal_title：Journal of virology

authors： Rettenmier CW,Hanafusa H

更新日期：1977-12-01 00:00:00

abstract：:When human adenovirus type 2 or 12 infects cells, either productively or non-productively, three classes of viral deoxyribonucleic acid (DNA) are found within the cells: (i) viral DNA which cosediments with DNA extracted from infectious adenovirions at 31.3S for adenovirus type 2 and at 29.0S for adenovirus type 12, (...

journal_title：Journal of virology

authors： Burlingham BT,Doerfler W

更新日期：1971-06-01 00:00:00

abstract：:Transfection has been found and characterized in pneumococcus. For replicating omega3 phage DNA extracted from infected cells, transfection was relatively efficient and rose linearly with DNA concentration and quadratically with time, according to T(T - 3.5) min(2). For mature DNA extracted from phage particles, trans...

journal_title：Journal of virology

authors： Porter RD,Guild WR

更新日期：1978-01-01 00:00:00

abstract：:The recent advent of genome sequences as the only source available to classify many newly discovered viruses challenges the development of virus taxonomy by expert virologists who traditionally rely on extensive virus characterization. In this proof-of-principle study, we address this issue by presenting a computation...

journal_title：Journal of virology

authors： Lauber C,Gorbalenya AE

更新日期：2012-04-01 00:00:00

abstract：:9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) is more potent and has a more prolonged inhibitory effect against Epstein-Barr virus (EBV) in vitro than does acyclovir (ACV). To assess the mechanism of this difference, we first compared the extent of phosphorylation of the two drugs in superinfected Ra...

journal_title：Journal of virology

authors： Lin JC,Nelson DJ,Lambe CU,Choi EI

更新日期：1986-11-01 00:00:00

abstract：:Oligomer formation of the gB glycoprotein of herpes simplex virus type 1 was studied by sedimentation analysis of radioactively labeled infected cell and virion lysates. Fractions from sucrose gradients were precipitated with a pool of gB-specific monoclonal antibodies and analyzed by sodium dodecyl sulfate-polyacryla...

journal_title：Journal of virology

authors： Highlander SL,Goins WF,Person S,Holland TC,Levine M,Glorioso JC

更新日期：1991-08-01 00:00:00

abstract：:Glycoprotein B (gB) is the most highly conserved of the envelope glycoproteins of human herpesviruses. The gB protein of human cytomegalovirus (CMV) serves multiple roles in the life cycle of the virus. To investigate structural properties of gB that give rise to its function, we sought to determine the disulfide bond...

journal_title：Journal of virology

authors： Lopper M,Compton T

更新日期：2002-06-01 00:00:00

abstract：UNLABELLED:Virus entry into cells is a multistep process that often requires the subversion of subcellular machineries. A more complete understanding of these steps is necessary to develop new antiviral strategies. While studying the potential role of the actin network and one of its master regulators, the small GTPase...

journal_title：Journal of virology

authors： Chou YY,Cuevas C,Carocci M,Stubbs SH,Ma M,Cureton DK,Chao L,Evesson F,He K,Yang PL,Whelan SP,Ross SR,Kirchhausen T,Gaudin R

更新日期：2016-04-14 00:00:00

abstract：:A number of retrovirus-like sequences have been cloned from chimpanzee DNA which constitute the chimpanzee homologs of the endogenous colobus type C virus CPC-1. One of the clones contains a nearly complete viral genome, but others have sustained deletions of 1 to 2 kilobases in the polymerase gene. The pattern of rel...

journal_title：Journal of virology

authors： Bonner TI,Birkenmeier EH,Gonda MA,Mark GE,Searfoss GH,Todaro GJ

更新日期：1982-09-01 00:00:00

abstract：:Acute measles in children can be prevented by immunization with the live attenuated measles vaccine virus. Although immunization is able to induce CD4 and CD8 T cells as well as neutralizing antibodies, only the latter have been correlated with protective immunity. CD8 T cells, however, have been documented to be impo...

journal_title：Journal of virology

authors： Pueschel K,Tietz A,Carsillo M,Steward M,Niewiesk S

更新日期：2007-08-01 00:00:00

abstract：:Glycoprotein gIII of pseudorabies virus is a major antigen found in the envelopes of virus particles as well as in and on the surfaces of infected cells. It is not an essential gene product for virus growth in tissue culture. In this report, we provide evidence that, although it is not essential, the gIII protein is r...

journal_title：Journal of virology

authors： Whealy ME,Robbins AK,Enquist LW

更新日期：1988-07-01 00:00:00

abstract：:Purified avian myeloblastosis virus was iodinated by the lactoperoxidase method. Disruption of the labeled virions and chromatography of the viral proteins showed that radioiodine was associated only with the glycoproteins of the viral envelope. Reaction of the radiolabeled virus with antiviral antibody followed by mi...

journal_title：Journal of virology

authors： Fritz RB

更新日期：1974-01-01 00:00:00