Abstract:
:Inhibitors of hemagglutination by type A2 influenza virus and a recently isolated strain of type B influenza virus were separated by sucrose density gradient centrifugation and agarose gel filtration from horse serum. Using selected reagents, it was demonstrated that the active substituent on the horse serum inhibitor of A2 influenza virus was 4-O-acetyl-N-acetylneuraminic acid; however, the active substituent on the inhibitor of the influenza B virus was shown to be N-acetylneuraminic acid (NANA). Sodium metaperiodate treatment of a component of horse serum resulted in a 10 to 15-fold enhancement of inhibitory activity against the type B virus, whereas the A2 inhibitor was completely destroyed. Since this enhancement did not occur with influenza B viruses isolated prior to 1965, it was considered that this sensitivity to an oxidized NANA glycoside may have been a reflection of an antigenic change which occurred at that time. The use of different virus strains and selected chemical reagents to define the important sialic acid prosthetic groups active in inhibition was described.
journal_name
J Viroljournal_title
Journal of virologyauthors
Levinson B,Pepper D,Belyavin Gdoi
10.1128/JVI.3.5.477-483.1969subject
Has Abstractpub_date
1969-05-01 00:00:00pages
477-83issue
5eissn
0022-538Xissn
1098-5514journal_volume
3pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.5.2764-2773.1996
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doi:10.1128/JVI.00795-06
更新日期:2006-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.8.2642-2647.1987
更新日期:1987-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章,评审
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.11.6496-6501.1992
更新日期:1992-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01398-19
更新日期:2019-12-12 00:00:00