A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting.

abstract：:A lysate from hypotonically swollen polyoma-infected BALB/3T3 cells incorporated labeled deoxynucleotide triphosphates into both viral and cellular DNAs. The incorporation was stimulated by the presence of ATP, deoxynucleotide triphosphates, thiols, and magnesium ions. Strong inhibition of incorporation was observed w...

journal_title：Journal of virology

authors： Hunter T,Francke B

更新日期：1974-01-01 00:00:00

abstract：:Homozygous human immunodeficiency virus type 1 (HIV-1)-transgenic mice (Tg26) appear normal at birth but die within 3 to 4 weeks. The skin of these animals shows diffuse scaling and high-level expression of both HIV-1 mRNA and gp120. Previous experiments showed that treatment with human chorionic gonadatropin (hCG) pr...

journal_title：Journal of virology

authors： De SK,Devadas K,Notkins AL

更新日期：2002-11-01 00:00:00

abstract：:Infection of primary or secondary cultures of Chinese hamster embryo cells with simian virus 40 at a multiplicity of 20 to 50 induced synthesis of the virus-specific intranuclear T antigen in 80 to 90% of the cells within 48 to 72 hr. In the infected cultures, 30 to 50% more cells were recruited into deoxyribonucleic ...

journal_title：Journal of virology

authors： Lehman JM,Defendi V

更新日期：1970-12-01 00:00:00

abstract：:The E8 open reading frame of bovine papillomavirus type 4 encodes a small hydrophobic polypeptide which contributes to cell transformation by conferring anchorage-independent growth. Using an in vitro translation system, we show that the E8 polypeptide binds to ductin, the 16-kDa proteolipid that forms transmembrane c...

journal_title：Journal of virology

authors： Faccini AM,Cairney M,Ashrafi GH,Finbow ME,Campo MS,Pitts JD

更新日期：1996-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) SM protein is an essential nuclear shuttling protein expressed by EBV early during the lytic phase of replication. SM acts to increase EBV lytic gene expression by binding EBV mRNAs and enhancing accumulation of the majority of EBV lytic cycle mRNAs. SM increases target mRNA stability and nucl...

journal_title：Journal of virology

authors： Han Z,Verma D,Hilscher C,Dittmer DP,Swaminathan S

更新日期：2009-11-01 00:00:00

abstract：:TT virus (TTV) is a recently identified widespread DNA virus of humans that produces persistent viremia in the absence of overt clinical manifestations. In an attempt to shed light on the dynamics of chronic infection, we measured the levels of TTV in the plasma of 25 persistently infected patients during the first 3 ...

journal_title：Journal of virology

authors： Maggi F,Pistello M,Vatteroni M,Presciuttini S,Marchi S,Isola P,Fornai C,Fagnani S,Andreoli E,Antonelli G,Bendinelli M

更新日期：2001-12-01 00:00:00

abstract：:A novel swine-origin H1N1 influenza virus [A(H1N1)pdm09 virus] caused the 2009 influenza pandemic. Most patients exhibited mild symptoms similar to seasonal influenza, but some experienced severe clinical signs and, in the worst cases, died. Such differences in symptoms are generally associated with preexisting medica...

journal_title：Journal of virology

authors： Uraki R,Kiso M,Shinya K,Goto H,Takano R,Iwatsuki-Horimoto K,Takahashi K,Daniels RS,Hungnes O,Watanabe T,Kawaoka Y

更新日期：2013-02-01 00:00:00

abstract：:Fusion of the membrane of the Moloney murine leukemia virus (Mo-MLV) Env protein is facilitated by cleavage of the R peptide from the cytoplasmic tail of its TM subunit, but the mechanism for this effect has remained obscure. The fusion is also controlled by the isomerization of the intersubunit disulfide of the Env S...

journal_title：Journal of virology

authors： Löving R,Li K,Wallin M,Sjöberg M,Garoff H

更新日期：2008-03-01 00:00:00

abstract：:Translation of poliovirus RNA occurs by the binding of ribosomes to an internal segment of RNA sequence within the 5' untranslated region of the viral RNA. This region is predicted to consist of six domains (I to VI) that possess complex secondary and tertiary structures. Domain IV is a large region in which alteratio...

journal_title：Journal of virology

authors： Blyn LB,Chen R,Semler BL,Ehrenfeld E

更新日期：1995-07-01 00:00:00

abstract：:We previously reported the establishment of several lymphoid cell lines from X-ray-induced thymomas of C57BL/Ka mice, and all, except one, produce retroviruses (P. Sankar-Mistry and P. Jolicoeur, J. Virol.35:270-275, 1980). Biological characterization of five of these new primary radiation leukemia viruses (RadLVs) in...

journal_title：Journal of virology

authors： Rassart E,Sankar-Mistry P,Lemay G,DesGroseillers L,Jolicoeur P

更新日期：1983-02-01 00:00:00

abstract：:The potential use of the modified vaccinia virus Ankara (MVA) strain as a live recombinant vector to deliver antigens and elicit protective immune responses against infectious diseases demands a comprehensive understanding of the effect of MVA infection on human host gene expression. We used microarrays containing mor...

journal_title：Journal of virology

authors： Guerra S,López-Fernández LA,Conde R,Pascual-Montano A,Harshman K,Esteban M

更新日期：2004-06-01 00:00:00

abstract：:Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is amplified to high copy number and infectious virus is produced. Viral production has not yet been observed in vitro due to the inability of st...

journal_title：Journal of virology

authors： Bedell MA,Hudson JB,Golub TR,Turyk ME,Hosken M,Wilbanks GD,Laimins LA

更新日期：1991-05-01 00:00:00

abstract：:Although the envelope gene of human immunodeficiency virus type 1 shows considerable strain variability, cysteine residues of the envelope protein are strongly conserved, suggesting that they are important to the envelope structure. We constructed and analyzed mutants of a biologically active molecular clone of human ...

journal_title：Journal of virology

authors： Tschachler E,Buchow H,Gallo RC,Reitz MS Jr

更新日期：1990-05-01 00:00:00

abstract：:An mRNA-ribonucleoprotein particle (mRNP) was found in vesicular stomatitis virus (VSV)-infected Chinese hamster ovary cells. The particle was present 3 and 4.5 h after infection but was barely discernible at 2 h. The mRNP (buoyant density, 1.56 g/cm3), which cosedimented with viral nucleocapsid in a sucrose density g...

journal_title：Journal of virology

authors： Rosen CA,Ennis HL,Cohen PS

更新日期：1982-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a global challenge to public health. Several factors have been proven to be critical for HCV entry, including the newly identified claudin-1 (CLDN1). However, the mechanism of HCV entry is still obscure. Presently, among the 20 members of the claudin family identified in humans so far, CLDN1...

journal_title：Journal of virology

authors： Zheng A,Yuan F,Li Y,Zhu F,Hou P,Li J,Song X,Ding M,Deng H

更新日期：2007-11-01 00:00:00

abstract：:We are using site-directed mutagenesis of single viral genes to identify and analyze the genetic determinants of human and simian immunodeficiency virus pathogenicity. In a first approach, we have constructed a series of simian immunodeficiency virus SIVmac nef mutants by partial deletion and insertions in the nef gen...

journal_title：Journal of virology

authors： Binninger D,Ennen J,Bonn D,Norley SG,Kurth R

更新日期：1991-10-01 00:00:00

abstract：:The influenza A virus nucleoprotein (NP) is a multifunctional polypeptide which plays a pivotal role in virus replication. To get information on the domains and specific residues involved in the different NP activities, we describe here the preparation and characterization of 20 influenza A virus mutant NPs. The mutat...

journal_title：Journal of virology

authors： Mena I,Jambrina E,Albo C,Perales B,Ortín J,Arrese M,Vallejo D,Portela A

更新日期：1999-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) is frequently attenuated after long-term culture in vitro. The attenuation process probably involves mutations of functions required for replication and pathogenicity in vivo. Analysis of attenuated HIV-1 for replication and pathogenicity in vivo will help to define these fu...

journal_title：Journal of virology

authors： Duus KM,Miller ED,Smith JA,Kovalev GI,Su L

更新日期：2001-04-01 00:00:00

abstract：:Tryptic digests of four polypeptides found in Kunjin virus-infected Vero cells, NV5, NV4, V3, and NV3, were compared by peptide mapping. The polypeptides to be analyzed were labeled with radioactive methionine and separated by electrophoresis through polyacrylamide gels containing sodium dodecyl sulfate. Because infec...

journal_title：Journal of virology

authors： Wright PJ,Bowden DS,Westaway EG

更新日期：1977-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) establishes a persistent latent infection in B lymphocytes and is associated with the development of numerous human tumors. Epstein-Barr nuclear antigen 3C (EBNA 3C) is essential for B-cell immortalization, has potent cell cycle deregulation capabilities, and functions as a regulator of both v...

journal_title：Journal of virology

authors： McClellan MJ,Khasnis S,Wood CD,Palermo RD,Schlick SN,Kanhere AS,Jenner RG,West MJ

更新日期：2012-05-01 00:00:00

abstract：:The capsid mRNA transcripts of human bocavirus 1 (HBoV1) can be generated by alternative splicing from the mRNA precursor transcribed from the P5 promoter. However, the alternative translation regulation mechanism of capsid mRNA transcripts is largely unknown. Here we report that the polycistronic capsid mRNA transcri...

journal_title：Journal of virology

authors： Liu X,Hao S,Chen Z,Xu H,Wang H,Huang M,Guan W

更新日期：2018-10-12 00:00:00

abstract：:The UL11 tegument protein of herpes simplex virus plays a critical role in the secondary envelopment; however, the mechanistic details remain elusive. Here, we report a new function of UL11 in the budding process in which it directs efficient acquisition of glycoprotein E (gE) via a direct interaction. In vitro bindin...

journal_title：Journal of virology

authors： Han J,Chadha P,Meckes DG Jr,Baird NL,Wills JW

更新日期：2011-09-01 00:00:00

abstract：:Interaction between viral proteins is necessary for viral replication and viral particle assembly. We used the yeast two-hybrid assay to identify interactions among all the mature proteins of the hepatitis C virus. The interaction between NS3 and NS3 was one of the strongest viral protein-protein interactions detected...

journal_title：Journal of virology

authors： Khu YL,Koh E,Lim SP,Tan YH,Brenner S,Lim SG,Hong WJ,Goh PY

更新日期：2001-01-01 00:00:00

abstract：:The expression and predicted products of rat c-ros-1 gene, the proto-oncogene of v-ros in UR2 sarcoma virus, were characterized. The c-ros-1 gene was found to be expressed in a tissue-specific manner, and the sizes of its transcripts were heterogeneous: 8.2 kilobases (kb) long in lung and kidney tissues, 6.9 kb in hea...

journal_title：Journal of virology

authors： Matsushime H,Shibuya M

更新日期：1990-05-01 00:00:00

abstract：:This study reports the identification and initial characterization of the precursors, modified forms, and oligomers of bovine herpesvirus 1 (BHV-1) gI and gE proteins with polyvalent rabbit serum specific for gI or gE. Our experiments used the Colorado strain of BHV-1 and mutant viruses with insertions of the Escheric...

journal_title：Journal of virology

authors： Whitbeck JC,Knapp AC,Enquist LW,Lawrence WC,Bello LJ

更新日期：1996-11-01 00:00:00

abstract：:The genome of the Snyder-Theilen strain of feline sarcoma virus (ST-FeSV) is a 4.3-kilobase-pair (kbp) RNA molecule that contains a 1.5-kbp cellular insertion (fes gene) flanked by feline leukemia virus sequences at its 5' end (1.6 kbp) and 3' end (1.2 kbp) (Sherr et al., J. Virol. 34:200-212, 1980). DNA transfection ...

journal_title：Journal of virology

authors： Barbacid M

更新日期：1981-01-01 00:00:00

abstract：UNLABELLED:Capsid-associated tegument proteins have been identified in alpha- and betaherpesviruses to play an essential role in viral DNA packaging. Whether and how such tegument proteins exist in gammaherpesviruses have been mysteries. Here, we report a 6-Å-resolution cryo-electron microscopy (cryo-EM) structure of K...

journal_title：Journal of virology

authors： Dai X,Gong D,Wu TT,Sun R,Zhou ZH

更新日期：2014-11-01 00:00:00

abstract：:Protective immunity to rotavirus (RV) is primarily mediated by antibodies produced by RV-specific memory B cells (RV-mBc). Of note, most of these cells express IgM, but the function of this subset is poorly understood. Here, using limiting dilution assays of highly sort-purified human IgM(+) mBc, we found that 62% and...

journal_title：Journal of virology

authors： Narváez CF,Feng N,Vásquez C,Sen A,Angel J,Greenberg HB,Franco MA

更新日期：2012-10-01 00:00:00

abstract：:Utilization of internal ribosome entry segment (IRES) structures in the 5' noncoding region (5'NCR) of picornavirus RNAs for initiation of translation requires a number of host cell factors whose distribution may vary in different cells and whose requirement may vary for different picornaviruses. We have examined the ...

journal_title：Journal of virology

authors： Graff J,Cha J,Blyn LB,Ehrenfeld E

更新日期：1998-12-01 00:00:00

abstract：:A chimeric poliovirus type 1 (PV1) genome was constructed in which the 3D RNA polymerase (3D(pol)) coding sequences were replaced with those from coxsackievirus B3 (CVB3). No infectious virus was produced from HeLa cells transfected with the chimeric RNA. Processing of the PV1 capsid protein precursor was incomplete, ...

journal_title：Journal of virology

authors： Bell YC,Semler BL,Ehrenfeld E

更新日期：1999-11-01 00:00:00