Cell surface expression of major histocompatibility complex class I molecules is reduced in hepatitis C virus subgenomic replicon-expressing cells.

abstract：:The envelope of human parainfluenza virus type 3 (HPF3) contains two viral glycoproteins, the hemagglutinin-neuraminidase (HN) and the fusion protein (F). HN, which is responsible for receptor attachment and for promoting F-mediated fusion, also possesses neuraminidase (receptor-destroying) activity. We reported previ...

journal_title：Journal of virology

authors： Porotto M,Greengard O,Poltoratskaia N,Horga MA,Moscona A

更新日期：2001-08-01 00:00:00

abstract：UNLABELLED:Cavally virus (CavV) and related viruses in the family Mesoniviridae diverged profoundly from other nidovirus lineages but largely retained the characteristic set of replicative enzymes conserved in the Coronaviridae and Roniviridae. The expression of these enzymes in virus-infected cells requires the extens...

journal_title：Journal of virology

authors： Blanck S,Stinn A,Tsiklauri L,Zirkel F,Junglen S,Ziebuhr J

更新日期：2014-12-01 00:00:00

abstract：:Influenza A H9N2 viruses are common poultry pathogens that occasionally infect swine and humans. It has been shown previously with H9N2 viruses that reassortment can generate novel viruses with increased transmissibility. Here, we demonstrate the modeling power of a novel transfection-based inoculation system to selec...

journal_title：Journal of virology

authors： Kimble JB,Angel M,Wan H,Sutton TC,Finch C,Perez DR

更新日期：2014-01-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) UL138 protein downregulates the cell surface expression of the multidrug resistance-associated protein 1 (MRP1) transporter. We examined the genetic requirements within UL138 for MRP1 downregulation. We determined that the acidic cluster dileucine motif is essential for UL138-mediated ...

journal_title：Journal of virology

authors： Gelbmann CB,Kalejta RF

更新日期：2019-05-15 00:00:00

abstract：:Hepatitis C virus (HCV) replication in infected patients produces large and diverse viral populations, which give rise to drug-resistant and immune escape variants. Here, we analyzed HCV populations during transmission and diversification in longitudinal and cross-sectional samples using 454/Roche pyrosequencing, in t...

journal_title：Journal of virology

authors： Wang GP,Sherrill-Mix SA,Chang KM,Quince C,Bushman FD

更新日期：2010-06-01 00:00:00

abstract：:Major histocompatibility complex E (MHC-E) is a highly conserved nonclassical MHC-Ib molecule that tightly binds peptides derived from leader sequences of classical MHC-Ia molecules for presentation to natural killer cells. However, MHC-E also binds diverse foreign and neoplastic self-peptide antigens for presentation...

journal_title：Journal of virology

authors： Abdulhaqq SA,Wu H,Schell JB,Hammond KB,Reed JS,Legasse AW,Axthelm MK,Park BS,Asokan A,Früh K,Hansen SG,Picker LJ,Sacha JB

更新日期：2019-09-12 00:00:00

abstract：UNLABELLED:Herpes simplex virus 1 (HSV-1) glycoprotein B (gB)-specific CD8(+) T cells protect mice from herpes infection and disease. However, whether and which HSV-1 gB-specific CD8(+) T cells play a key role in the "natural" protection seen in HSV-1-seropositive healthy asymptomatic (ASYMP) individuals (who have neve...

journal_title：Journal of virology

authors： Khan AA,Srivastava R,Spencer D,Garg S,Fremgen D,Vahed H,Lopes PP,Pham TT,Hewett C,Kuang J,Ong N,Huang L,Scarfone VM,Nesburn AB,Wechsler SL,BenMohamed L

更新日期：2015-04-01 00:00:00

abstract：:Replicase gene expression by the human coronavirus 229E involves the synthesis of two large polyproteins, pp1a and pp1ab. Experimental evidence suggests that these precursor molecules are subject to extensive proteolytic processing. In this study, we show that a chymotrypsin-like enzyme, the virus-encoded 3C-like prot...

journal_title：Journal of virology

authors： Ziebuhr J,Siddell SG

更新日期：1999-01-01 00:00:00

abstract：:The genome of lymphocytic choriomeningitis virus (LCMV) consists of two negative-sense single-stranded RNA segments, designated L and S. Both segments contain two viral genes in an ambisense coding strategy, with the genes being separated by an intergenic region (IGR). We have developed a reverse genetic system that a...

journal_title：Journal of virology

authors： Lee KJ,Novella IS,Teng MN,Oldstone MB,de La Torre JC

更新日期：2000-04-01 00:00:00

abstract：:Dendritic cells (DCs) play a central role in instructing antiviral immune responses. DCs, however, can become targeted by different viruses themselves. We recently demonstrated that human DCs can be productively infected with echoviruses (EVs), but not coxsackie B viruses (CVBs), both of which are RNA viruses belongin...

journal_title：Journal of virology

authors： Kramer M,Schulte BM,Toonen LW,Barral PM,Fisher PB,Lanke KH,Galama JM,van Kuppeveld FJ,Adema GJ

更新日期：2008-03-01 00:00:00

abstract：:SERINC5 is a 10-transmembrane-domain cellular protein that is incorporated into budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion. HIV-1 susceptibility to SERINC5 is determined by sequences in the viral Env glycoprotein gp120, and the antiviral effect of SERINC5 is counteracted by t...

journal_title：Journal of virology

authors： Featherstone A,Aiken C

更新日期：2020-09-29 00:00:00

abstract：:Therapeutic vaccination has the potential to boost immune responses and enhance viral control during chronic infections. However, many therapeutic vaccination approaches have fallen short of expectations, and effective boosting of antiviral T-cell responses is not always observed. To examine these issues, we studied t...

journal_title：Journal of virology

authors： Wherry EJ,Blattman JN,Ahmed R

更新日期：2005-07-01 00:00:00

abstract：:3-O-(3',3'-dimethylsuccinyl)betulinic acid (PA-457 or bevirimat) potently inhibits human immunodeficiency virus type 1 (HIV-1) maturation by blocking a late step in the Gag processing pathway, specifically the cleavage of SP1 from the C terminus of capsid (CA). To gain insights into the mechanism(s) by which HIV-1 cou...

journal_title：Journal of virology

authors： Adamson CS,Ablan SD,Boeras I,Goila-Gaur R,Soheilian F,Nagashima K,Li F,Salzwedel K,Sakalian M,Wild CT,Freed EO

更新日期：2006-11-01 00:00:00

abstract：:Longitudinal studies of T cell immune responses during viral infections in humans are essential for our understanding of how effector T cell responses develop, clear infection, and provide long-lasting immunity. Here, following an outbreak of a Puumala hantavirus infection in the human population, we longitudinally an...

journal_title：Journal of virology

authors： Lindgren T,Ahlm C,Mohamed N,Evander M,Ljunggren HG,Björkström NK

更新日期：2011-10-01 00:00:00

abstract：:A coxsackievirus B3 (CB3) isolate adapted to growth in RD cells shows an alteration in cell tropism as a result of its capacity to bind a 70-kDa cell surface molecule expressed on these cells. We now show that this molecule is the complement regulatory protein, decay-accelerating factor (DAF) (CD55). Anti-DAF antibodi...

journal_title：Journal of virology

authors： Bergelson JM,Mohanty JG,Crowell RL,St John NF,Lublin DM,Finberg RW

更新日期：1995-03-01 00:00:00

abstract：:TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested the binding of TNPO3 to the HIV-1 core and found that TNPO3 binds to t...

journal_title：Journal of virology

authors： Valle-Casuso JC,Di Nunzio F,Yang Y,Reszka N,Lienlaf M,Arhel N,Perez P,Brass AL,Diaz-Griffero F

更新日期：2012-05-01 00:00:00

abstract：:Many viruses have evolved mechanisms to evade the repression of translation mediated by protein kinase R (PKR). In the case of murine cytomegalovirus (MCMV), the protein products of two essential genes, m142 and m143, bind to double-stranded RNA (dsRNA) and block phosphorylation of PKR and eukaryotic initiation factor...

journal_title：Journal of virology

authors： Child SJ,Geballe AP

更新日期：2009-02-01 00:00:00

abstract：:The simian picornaviruses were isolated from various primate tissues during the development of general tissue culture methods in the 1950s to 1970s or from specimens derived from primates used in biomedical research. Twenty simian picornavirus serotypes are recognized, and all are presently classified within the Enter...

journal_title：Journal of virology

authors： Oberste MS,Maher K,Pallansch MA

更新日期：2002-02-01 00:00:00

abstract：UNLABELLED:PD-1 is an inhibitory receptor that has a major role in T cell dysfunction during chronic infections and cancer. While demethylation of the PD-1 promoter DNA is observed in exhausted T cells isolated from chronically infected individuals, little is known about when this stable demethylation of PD-1 promoter ...

journal_title：Journal of virology

authors： Ahn E,Youngblood B,Lee J,Lee J,Sarkar S,Ahmed R

更新日期：2016-09-12 00:00:00

abstract：:West Nile virus (WNV) replicates in the skin; however, cell targets in the skin have not been identified. In the current studies, WNV infected the epidermis and adnexal glands of mouse skin, and the epidermal cells were identified as keratinocytes by double labeling for WNV antigen and keratin 10. Inoculation of mice ...

journal_title：Journal of virology

authors： Lim PY,Behr MJ,Chadwick CM,Shi PY,Bernard KA

更新日期：2011-05-01 00:00:00

abstract：:Treatment of [3H]glucosamine-labeled Friend mink cell focus-forming virus (FrMCF) gp70 with excess peptide:N-glycanase F (PNGase F) resulted in removal of the expected seven N-linked oligosaccharide chains; however, approximately 10% of the glucosamine label was retained in the resulting 49,000-Mr (49K) product. For [...

journal_title：Journal of virology

authors： Pinter A,Honnen WJ

更新日期：1988-03-01 00:00:00

abstract：:Expression of the selectable drug resistance gene in retroviral vectors used for gene therapy can lead to a decreased expression of the gene of interest and may induce a host immune response, resulting in a decreased efficiency of gene therapy. In this study, we demonstrate that high-frequency deletion of direct repea...

journal_title：Journal of virology

authors： Delviks KA,Pathak VK

更新日期：1999-10-01 00:00:00

abstract：:A sequence of polyadenylic acid, homogeneous in composition but heterogeneous in length, was isolated from complete pancreatic RNase digests of both middle and bottom RNAs of cowpea mosaic virus. The polyadenylic acid was 3'-terminal and occurred once per molecule. A fragment consisting of the polyadenylic acid and ap...

journal_title：Journal of virology

authors： Steele KP,Frist RH

更新日期：1978-05-01 00:00:00

abstract：:Retrovirus infection is normally limited to cells within a specific host range which express a cognate receptor that is recognized by the product of the env gene. We describe retrovirus infection of cells outside of their normal host range when the infection is performed in the presence of a replication-defective aden...

journal_title：Journal of virology

authors： Adams RM,Wang M,Steffen D,Ledley FD

更新日期：1995-03-01 00:00:00

abstract：:The Moloney sarcoma virus-specific onc gene, referred to as v-mos, was used as probe to hybridize to restricted DNAs from various mouse-Chinese hamster hybrid cell lines. These hybrid cells contain, in addition to all of the Chinese hamster chromosomes, various numbers (less than a full complement) of mouse chromosome...

journal_title：Journal of virology

authors： Swan D,Oskarsson M,Keithley D,Ruddle FH,D'Eustachio P,Vande Woude GF

更新日期：1982-11-01 00:00:00

abstract：:We sequenced the genes coding for the two neutralization proteins, VP4 and VP7, of human rotavirus strains L26 and L27 with subgroup I specificity but the long RNA pattern. The deduced VP7 amino acid sequence of strains L26 and L27 showed a low homology (73.6 to 81.9%) to those of rotavirus strains of the established ...

journal_title：Journal of virology

authors： Taniguchi K,Urasawa T,Kobayashi N,Gorziglia M,Urasawa S

更新日期：1990-11-01 00:00:00

abstract：:Recombinant retroviruses containing the trans activator genes of human T-cell leukemia virus (HTLV) type II and human T-cell lymphotropic virus type III were constructed. The trans activator genes tat II and tat III were inserted into the murine retroviral vector pZIPNEOSV(X)1. Recombinant plasmids were transfected in...

journal_title：Journal of virology

authors： Rosen CA,Sodroski JG,Campbell K,Haseltine WA

更新日期：1986-01-01 00:00:00

abstract：:We analyzed a region of the capsid of canine parvovirus (CPV) which determines the ability of the virus to infect canine cells. This region is distinct from those previously shown to determine the canine host range differences between CPV and feline panleukopenia virus. It lies on a ridge of the threefold spike of the...

journal_title：Journal of virology

authors： Parker JS,Parrish CR

更新日期：1997-12-01 00:00:00

abstract：:We have used cDNA arrays to compare the activation of various cellular genes in response to infection with Sendai viruses (SeV) that contain specific mutations. Three groups of cellular genes activated by mutant SeV infection, but not by wild-type SeV, were identified in this way. While some of these genes are well kn...

journal_title：Journal of virology

authors： Strähle L,Garcin D,Le Mercier P,Schlaak JF,Kolakofsky D

更新日期：2003-07-01 00:00:00

abstract：:Initiation of herpesvirus infection requires attachment of virions to the host cell followed by fusion of virion envelope and cellular cytoplasmic membrane during penetration. In several alphaherpesviruses, glycoprotein C (gC) is the primary attachment protein, interacting with cell-surface heparan sulfate proteoglyca...

journal_title：Journal of virology

authors： Karger A,Schmidt J,Mettenleiter TC

更新日期：1998-09-01 00:00:00