Phagocytosis of picornavirus-infected cells induces an RNA-dependent antiviral state in human dendritic cells.

abstract：UNLABELLED:The cytosolic RIG-I (retinoic acid-inducible gene I) receptor plays a pivotal role in the initiation of the immune response against RNA virus infection by recognizing short 5'-triphosphate (5'ppp)-containing viral RNA and activating the host antiviral innate response. In the present study, we generated novel...

journal_title：Journal of virology

authors： Chiang C,Beljanski V,Yin K,Olagnier D,Ben Yebdri F,Steel C,Goulet ML,DeFilippis VR,Streblow DN,Haddad EK,Trautmann L,Ross T,Lin R,Hiscott J

更新日期：2015-08-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 genome encodes the Tax protein that plays essential regulatory roles in HTLV-1 replication and oncogenic transformation of T lymphocytes....

journal_title：Journal of virology

authors： Gao L,Harhaj EW

更新日期：2013-12-01 00:00:00

abstract：:In vitro translation of the three single-stranded RNAs transcribed in vitro by bacteriophage phi 6 RNA polymerase revealed that the large RNA codes for phage proteins P1, P2, P4, and P7, the medium RNA codes for P3, P6, and P10, and the smaller RNA for P5, P8, and P9. ...

journal_title：Journal of virology

authors： Cuppels DA,Van Etten JL,Burbank DE,Lane LC,Vidaver AK

更新日期：1980-07-01 00:00:00

abstract：:Intramuscular administration of inactivated influenza virus vaccine is the main vaccine platform used for the prevention of seasonal influenza virus infection. In clinical trials, inactivated H5N1 vaccines have been shown to be safe and capable of eliciting immune correlates of protection. However, the H5N1 vaccines a...

journal_title：Journal of virology

authors： Lau YF,Tang LH,McCall AW,Ooi EE,Subbarao K

更新日期：2010-09-01 00:00:00

abstract：:Major histocompatibility complex class I (MHC I)-restricted CD8(+) T-cell responses play a pivotal role in anti-human immunodeficiency virus (HIV) immunity and the control of viremia. The rhesus macaque is an important animal model for HIV-related research. Among the MHC I alleles of the rhesus macaque, Mamu-A 02 is p...

journal_title：Journal of virology

authors： Liu J,Dai L,Qi J,Gao F,Feng Y,Liu W,Yan J,Gao GF

更新日期：2011-07-01 00:00:00

abstract：:A fibrosarcoma was induced in a hamster by bovine papilloma virus type 2 (BPV2). The content of BPV2 DNA sequences was measured by DNA-DNA and cRNA-DNA hybridizations. The tumor contained approximately 300 BPV2 genome equivalents per cell. Southern blot hybridization indicated that the viral DNA was in free form, the ...

journal_title：Journal of virology

authors： Moar MH,Campo MS,Laird HM,Jarrett WF

更新日期：1981-09-01 00:00:00

abstract：:A major determinant of neurovirulence for the GDVII strain of Theiler's virus, a murine picornavirus, was mapped to the P1 capsid protein region. Chimeric viruses were constructed by using sequences from the 5' noncoding and P1 regions of the virulent GDVII strain to replace equivalent regions of the less virulent BeA...

journal_title：Journal of virology

authors： Pritchard AE,Jensen K,Lipton HL

更新日期：1993-07-01 00:00:00

abstract：:The envelope of human parainfluenza virus type 3 (HPF3) contains two viral glycoproteins, the hemagglutinin-neuraminidase (HN) and the fusion protein (F). HN, which is responsible for receptor attachment and for promoting F-mediated fusion, also possesses neuraminidase (receptor-destroying) activity. We reported previ...

journal_title：Journal of virology

authors： Porotto M,Greengard O,Poltoratskaia N,Horga MA,Moscona A

更新日期：2001-08-01 00:00:00

abstract：:The herpes simplex virus type 1 UL6 protein forms a 12-subunit ring structure at a unique capsid vertex which functions as a conduit for encapsidation of the viral genome. To characterize UL6 protein domains that are involved in intersubunit interactions and interactions with other capsid proteins, we engineered a set...

journal_title：Journal of virology

authors： Nellissery JK,Szczepaniak R,Lamberti C,Weller SK

更新日期：2007-09-01 00:00:00

abstract：:The sequence of 2,191 nucleotides encoding the env gene of murine retrovirus Akv was determined by using a molecular clone of the Akv provirus. Deduction of the encoded amino acid sequence showed that a single open reading frame encodes a 638-amino acid precursor to gp70 and p15E. In addition, there is a typical leade...

journal_title：Journal of virology

authors： Lenz J,Crowther R,Straceski A,Haseltine W

更新日期：1982-05-01 00:00:00

abstract：:The cloned murine cytolytic T-lymphocyte line IE1-IL and several sublines detect a murine cytomegalovirus immediate-early (IE) membrane determinant in conjunction with Ld class I major histocompatibility glycoprotein. The lines retained cytolytic activity, strict antigen specificity, and self-restriction even when ada...

journal_title：Journal of virology

authors： Reddehase MJ,Fibi MR,Keil GM,Koszinowski UH

更新日期：1986-12-01 00:00:00

abstract：:The development of cancer vaccines requires approaches to induce expansion and functional differentiation of tumor antigen-specific cytotoxic T lymphocyte (CTL) effectors which posses cytolytic capability and produce cytokines. Efficient induction of such cells is hindered by the poor immunogenicity of tumor antigens ...

journal_title：Journal of virology

authors： Efferson CL,Schickli J,Ko BK,Kawano K,Mouzi S,Palese P,García-Sastre A,Ioannides CG

更新日期：2003-07-01 00:00:00

abstract：:BALB/c mice infected on the scarified cornea with herpes simplex virus type 1 strain 35 [HSV-1(35)] rarely developed ocular disease even at challenge doses as high as 10(7) PFU per eye. In contrast, HSV-1(RE) consistently induced stromal keratitis at an inoculum of 2 x 10(4) PFU. The goal of this study was to determin...

journal_title：Journal of virology

authors： Su YH,Oakes JE,Lausch RN

更新日期：1990-05-01 00:00:00

abstract：:Due to increasing concerns about human infection by various H7 influenza viruses, including recent H7N9 viruses, we evaluated the genetic relationships and cross-protective efficacies of three different Eurasian H7 avian influenza viruses. Phylogenic and molecular analyses revealed that recent Eurasian H7 viruses can ...

journal_title：Journal of virology

authors： Kwon HI,Kim YI,Park SJ,Song MS,Kim EH,Kim SM,Si YJ,Lee IW,Song BM,Lee YJ,Yun SJ,Kim WJ,Choi YK

更新日期：2017-05-12 00:00:00

abstract：:A poliovirus-specific polyuridylic acid [poly(U)] polymerase that copies a polyadenylic acid template complexed to an oligouridylic acid primer was isolated from the membrane fraction of infected HeLa cells and was found to sediment at 4 to 5S on a linear 5 to 20% glycerol gradient. When the poly(U) polymerase was iso...

journal_title：Journal of virology

authors： Flanegan JB,Baltimore D

更新日期：1979-01-01 00:00:00

abstract：:The nucleotide sequence was determined for the hemagglutinin gene of the Hong Kong subtype influenza strain A/Bangkok/1/79. The amino acid sequence predicted from these data shows a total of 36 amino acid changes as compared with hemagglutinin for a 1968 Hong Kong strain, 11 more than had occurred in a 1975 strain. Th...

journal_title：Journal of virology

authors： Both GW,Sleigh MJ

更新日期：1981-09-01 00:00:00

abstract：:Prior studies demonstrated that immunization of macaques with simian immunodeficiency virus (SIV) Gag-Pol and Env recombinants of the attenuated poxvirus modified vaccinia virus Ankara (MVA) provided protection from high levels of viremia and AIDS following challenge with a pathogenic strain of SIV (V. M. Hirsch et al...

journal_title：Journal of virology

authors： Ourmanov I,Brown CR,Moss B,Carroll M,Wyatt L,Pletneva L,Goldstein S,Venzon D,Hirsch VM

更新日期：2000-03-01 00:00:00

abstract：:We have generated hexon-modified adenovirus serotype 5 (Ad5) vectors that are not neutralized by Ad5-specific neutralizing antibodies in mice. These vectors are attractive for the advancement of vaccine products because of their potential for inducing robust antigen-specific immune responses in people with prior expos...

journal_title：Journal of virology

authors： Bruder JT,Chen P,Semenova E,Thomas CA,Konovalova S,Ekberg G,Ettyreddy D,McVey D,Gall JG,King CR,Brough DE

更新日期：2013-09-01 00:00:00

abstract：:Treatment of Friend erythroleukemia cells (FLC) with gamma interferon (IFN-gamma) in the presence of anti-IFN-beta antibodies reduces the effectiveness of the antiviral state and the induction of 2'-5'-oligoadenylate synthetase activity, indicating that the antiviral activity of IFN-gamma in FLC is in part mediated by...

journal_title：Journal of virology

authors： Marziali G,Fiorucci G,Coccia EM,Percario Z,Raber J,Battistini A,Rossi GB,Affabris E,Romeo G

更新日期：1991-08-01 00:00:00

abstract：UNLABELLED:In vitro, infection of polarized human intestinal epithelial cells by coxsackievirus B3 (CVB3) depends on virus interaction with decay-accelerating factor (DAF), a receptor expressed on the apical cell surface. Although mice are highly susceptible to CVB3 infection when virus is delivered by intraperitoneal ...

journal_title：Journal of virology

authors： Pan J,Zhang L,Odenwald MA,Shen L,Turner JR,Bergelson JM

更新日期：2015-04-01 00:00:00

abstract：:The complete genome sequences of the human coronavirus OC43 (HCoV-OC43) laboratory strain from the American Type Culture Collection (ATCC), and a HCoV-OC43 clinical isolate, designated Paris, were obtained. Both genomes are 30,713 nucleotides long, excluding the poly(A) tail, and only differ by 6 nucleotides. These si...

journal_title：Journal of virology

authors： St-Jean JR,Jacomy H,Desforges M,Vabret A,Freymuth F,Talbot PJ

更新日期：2004-08-01 00:00:00

abstract：:Whole-body bioimaging was used to study dissemination of vaccinia virus (VACV) in normal and in immune deficient (nu(-)/nu(-)) mice protected from lethality by postchallenge administration of ST-246. Total fluxes were recorded in the liver, spleen, lungs, and nasal cavities of live mice after intranasal infection with...

journal_title：Journal of virology

authors： Zaitseva M,Shotwell E,Scott J,Cruz S,King LR,Manischewitz J,Diaz CG,Jordan RA,Grosenbach DW,Golding H

更新日期：2013-05-01 00:00:00

abstract：:Herpes simplex virus 1 replication initiates angiogenesis and inflammation in the cornea. This can result in herpetic stromal keratitis (HSK), which is a leading cause of infection-induced corneal blindness. Host cellular factors mediate the progression of HSK, but little is known about these cellular factors and thei...

journal_title：Journal of virology

authors： Yao HW,Chen SH,Li C,Tung YY,Chen SH

更新日期：2012-08-01 00:00:00

abstract：:Nonstructural protein 1 (NS1) of yellow fever virus (YF) is a glycoprotein localized to extracytoplasmic compartments within infected cells. We have previously shown that NS1 can be supplied in trans and is required for viral RNA replication, a process thought to occur in membrane-bound cytoplasmic complexes. Here we ...

journal_title：Journal of virology

authors： Lindenbach BD,Rice CM

更新日期：1999-06-01 00:00:00

abstract：:In latent infection, Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen 1 (LANA1)-specific binding to KSHV terminal repeat DNA mediates multicopy episome persistence. We now use electrophoretic mobility shift assays to investigate LANA1 binding to its 20-bp cognate sequence. Mutations at...

journal_title：Journal of virology

authors： Srinivasan V,Komatsu T,Ballestas ME,Kaye KM

更新日期：2004-12-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) tat protein functions at a much lower level in rodent cells than in human cells. This species-specific difference in trans activation appears to be due to the lack of a functional homolog of a human cofactor for tat in rodent cells. Using HIV-1 long terminal repeat-drive...

journal_title：Journal of virology

authors： Newstein M,Stanbridge EJ,Casey G,Shank PR

更新日期：1990-09-01 00:00:00

abstract：:The initial wave of swine-origin influenza A virus (pandemic H1N1/09) in the United States during the spring and summer of 2009 also resulted in an increased vigilance and sampling of seasonal influenza viruses (H1N1 and H3N2), even though they are normally characterized by very low incidence outside of the winter mon...

journal_title：Journal of virology

authors： Ghedin E,Wentworth DE,Halpin RA,Lin X,Bera J,DePasse J,Fitch A,Griesemer S,Hine E,Katzel DA,Overton L,Proudfoot K,Sitz J,Szczypinski B,StGeorge K,Spiro DJ,Holmes EC

更新日期：2010-06-01 00:00:00

abstract：:Retroelements are important evolutionary forces but can be deleterious if left uncontrolled. Members of the human APOBEC3 family of cytidine deaminases can inhibit a wide range of endogenous, as well as exogenous, retroelements. These enzymes are structurally organized in one or two domains comprising a zinc-coordinat...

journal_title：Journal of virology

authors： Bulliard Y,Turelli P,Röhrig UF,Zoete V,Mangeat B,Michielin O,Trono D

更新日期：2009-12-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) plays a significant role in the development of Kaposi's sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman's disease. The KSHV open reading frame K9 encodes the viral interferon (IFN) factor 1 (vIRF1), which downregulates IFN- and IRF-mediated tr...

journal_title：Journal of virology

authors： Seo T,Lee D,Shim YS,Angell JE,Chidambaram NV,Kalvakolanu DV,Choe J

更新日期：2002-09-01 00:00:00

abstract：UNLABELLED:A bat virus with high phylogenetic relatedness to human mumps virus (MuV) was identified recently at the nucleic acid level. We analyzed the functional activities of the hemagglutinin-neuraminidase (HN) and the fusion (F) proteins of the bat virus (batMuV) and compared them to the respective proteins of a hu...

journal_title：Journal of virology

authors： Krüger N,Hoffmann M,Drexler JF,Müller MA,Corman VM,Sauder C,Rubin S,He B,Örvell C,Drosten C,Herrler G

更新日期：2015-04-01 00:00:00