In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3.

abstract：:Mosquito-borne alphaviruses, which replicate alternately and obligately in mosquitoes and vertebrates, appear to experience lower rates of evolution than do many RNA viruses that replicate solely in vertebrates. This genetic stability is hypothesized to result from the alternating host cycle, which constrains evolutio...

journal_title：Journal of virology

authors： Greene IP,Wang E,Deardorff ER,Milleron R,Domingo E,Weaver SC

更新日期：2005-11-01 00:00:00

abstract：:Nonstructural protein 4 (nsp4; 204 amino acids) is the chymotrypsin-like serine main proteinase of the arterivirus Equine arteritis virus (order Nidovirales), which controls the maturation of the replicase complex. nsp4 includes a unique C-terminal domain (CTD) connected to the catalytic two-beta-barrel structure by t...

journal_title：Journal of virology

authors： van Aken D,Snijder EJ,Gorbalenya AE

更新日期：2006-04-01 00:00:00

abstract：:In vitro translation of the three single-stranded RNAs transcribed in vitro by bacteriophage phi 6 RNA polymerase revealed that the large RNA codes for phage proteins P1, P2, P4, and P7, the medium RNA codes for P3, P6, and P10, and the smaller RNA for P5, P8, and P9. ...

journal_title：Journal of virology

authors： Cuppels DA,Van Etten JL,Burbank DE,Lane LC,Vidaver AK

更新日期：1980-07-01 00:00:00

abstract：:Accurate and sensitive quantitation of infectious human immunodeficiency virus (HIV) has been difficult to achieve. In this report, a quantitative focal immunoassay (FIA) for HIV was developed using human HeLa cells rendered susceptible to HIV infection by introduction of the CD4 gene via a retrovirus vector. Infected...

journal_title：Journal of virology

authors： Chesebro B,Wehrly K

更新日期：1988-10-01 00:00:00

abstract：:Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray...

journal_title：Journal of virology

authors： Singh BK,Koromyslova A,Hefele L,Gürth C,Hansman GS

更新日期：2015-12-23 00:00:00

abstract：:Flaviviruses are enveloped viruses which accumulate in cellular vacuoles prior to release. The membrane of cell-associated virus contains the proteins pre-M and E. During release of virus the pre-M protein is cleaved, and only its carboxy-terminal segment remains associated with the virus as M protein. Studies of the ...

journal_title：Journal of virology

authors： Wengler G,Wengler G

更新日期：1989-06-01 00:00:00

abstract：:RNA plant viruses use various translational regulatory mechanisms to control their gene expression. Translational enhancement of viral mRNAs that leads to higher levels of protein synthesis from specific genes may be essential for the virus to successfully compete for cellular translational machinery. The control elem...

journal_title：Journal of virology

authors： Koh DC,Liu DX,Wong SM

更新日期：2002-02-01 00:00:00

abstract：:The fusion (F) protein of simian virus 5 (strain W3A) induced extensive cell fusion in BHK cells when expressed alone, while that of strain WR did not. Mutational analysis demonstrated that the fusing activity can be transferred to the WR F protein by a proline residue at position 22 of subunit W3A F2. ...

journal_title：Journal of virology

authors： Ito M,Nishio M,Kawano M,Kusagawa S,Komada H,Ito Y,Tsurudome M

更新日期：1997-12-01 00:00:00

abstract：:Herpesviruses utilize different origins of replication during lytic versus latent infection. Latent DNA replication depends on host cellular DNA replication machinery, whereas lytic cycle DNA replication requires virally encoded replication proteins. In lytic DNA replication, the lytic origin (ori-Lyt) is bound by a v...

journal_title：Journal of virology

authors： Lin CL,Li H,Wang Y,Zhu FX,Kudchodkar S,Yuan Y

更新日期：2003-05-01 00:00:00

abstract：:A contiguously linked T-B synthetic viral epitope (110HA120-150HA159,T-B) was investigated for its potency in inducing humoral and cellular immune responses in vivo. The T-cell epitope 110HA120 corresponds to the site 1 hemagglutinin (HA) of the A/PR/8/34 (PR8) influenza virus and is recognized by CD4 T cells in assoc...

journal_title：Journal of virology

authors： Brumeanu TD,Casares S,Bot A,Bot S,Bona CA

更新日期：1997-07-01 00:00:00

abstract：:The conversion of simian virus 40 (SV40) component II deoxyribonucleic acid to component I has been used to assay polynucleotide ligase in extracts of tissue culture cells. All cell types examined, including chicken, hamster, mouse, monkey, and human cells, contained adenosine triphosphate-dependent ligase. After infe...

journal_title：Journal of virology

authors： Sambrook J,Shatkin AJ

更新日期：1969-11-01 00:00:00

abstract：:Mitochondria are important for the viral life cycle, mainly by providing the energy required for viral replication and assembly. A highly complex interaction with mitochondria is exerted by rubella virus (RV), which includes an increase in the mitochondrial membrane potential as a general marker for mitochondrial acti...

journal_title：Journal of virology

authors： Claus C,Schönefeld K,Hübner D,Chey S,Reibetanz U,Liebert UG

更新日期：2013-08-01 00:00:00

abstract：:Purified Kunjin virus was disrupted with sodium dodecyl sulfate, urea, and mercaptoethanol or acetic acid. Electrophoresis on 7.5% polyacrylamide gel separated four proteins of high (120,000), intermediate (65,000) and low (18,000 and 13,000) molecular weights. A "core" particle was obtained by degradation of the viri...

journal_title：Journal of virology

authors： Westaway EG,Reedman BM

更新日期：1969-11-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) plays a significant role in the development of Kaposi's sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman's disease. The KSHV open reading frame K9 encodes the viral interferon (IFN) factor 1 (vIRF1), which downregulates IFN- and IRF-mediated tr...

journal_title：Journal of virology

authors： Seo T,Lee D,Shim YS,Angell JE,Chidambaram NV,Kalvakolanu DV,Choe J

更新日期：2002-09-01 00:00:00

abstract：:The nucleotide sequence of the region of human polyoma virus JC DNA between 0.5 and 0.7 map units from a unique EcoRI cleavage site was determined and compared with those of the corresponding regions of another human polyoma virus, BK, and simian virus 40 DNAs. Within this region consisting of 945 base pairs, we locat...

journal_title：Journal of virology

authors： Miyamura T,Jikuya H,Soeda E,Yoshiike K

更新日期：1983-01-01 00:00:00

abstract：UNLABELLED:Marburg virus (MARV) infection is a lethal hemorrhagic fever for which no licensed vaccines or therapeutics are available. Development of appropriate medical countermeasures requires a thorough understanding of the interaction between the host and the pathogen and the resulting disease course. In this study,...

journal_title：Journal of virology

authors： Lin KL,Twenhafel NA,Connor JH,Cashman KA,Shamblin JD,Donnelly GC,Esham HL,Wlazlowski CB,Johnson JC,Honko AN,Botto MA,Yen J,Hensley LE,Goff AJ

更新日期：2015-10-01 00:00:00

abstract：:YY1 is a zinc finger transcription factor which acts as either a repressor or an activator dependent on the promoter context. YY1 is a potent activator of the genuine human papillomavirus type 18 (HPV-18) upstream regulatory region (URR) in HeLa cells, which are known for high-level expression of the HPV-18 early gene...

journal_title：Journal of virology

authors： Bauknecht T,Jundt F,Herr I,Oehler T,Delius H,Shi Y,Angel P,Zur Hausen H

更新日期：1995-01-01 00:00:00

abstract：:Poliovirus mutants in neutralizing antigenic site 3B were constructed by replacing the glutamic acid residue at amino acid 74 of capsid protein VP2 (VP2074E), using site-specific mutagenesis methods. All viable mutants display small-plaque phenotypes. Characterization of these mutants indicates that capsid assembly is...

journal_title：Journal of virology

authors： Reynolds C,Birnby D,Chow M

更新日期：1992-03-01 00:00:00

abstract：:A deletion mutant of severe acute respiratory syndrome coronavirus (SARS-CoV) has been engineered by deleting the structural E gene in an infectious cDNA clone that was constructed as a bacterial artificial chromosome (BAC). The recombinant virus lacking the E gene (rSARS-CoV-DeltaE) was rescued in Vero E6 cells. The ...

journal_title：Journal of virology

authors： DeDiego ML,Alvarez E,Almazán F,Rejas MT,Lamirande E,Roberts A,Shieh WJ,Zaki SR,Subbarao K,Enjuanes L

更新日期：2007-02-01 00:00:00

abstract：:Rapid transmission of Borna disease virus occurred upon cohabitation of persistently infected and naive rats. Infectious virus, which was abundantly present in fresh urine samples of carrier rats, entered the brains of recipient rats via the olfactory route. Thus, susceptible farm animals possibly acquire the virus fr...

journal_title：Journal of virology

authors： Sauder C,Staeheli P

更新日期：2003-12-01 00:00:00

abstract：:FeLV-FAIDS, an immunodeficiency-inducing isolate of feline leukemia virus, is composed of a pathogenic but replication-defective genome (molecular clone 61C) and a replication-competent but non-immunodeficiency-inducing variant genome (molecular clone 61E). The chimeric virus EECC, composed of the 5' gag-pol of 61E fu...

journal_title：Journal of virology

authors： Poss ML,Quackenbush SL,Mullins JI,Hoover EA

更新日期：1990-09-01 00:00:00

abstract：:Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 ...

journal_title：Journal of virology

authors： Ouwendijk WJ,Abendroth A,Traina-Dorge V,Getu S,Steain M,Wellish M,Andeweg AC,Osterhaus AD,Gilden D,Verjans GM,Mahalingam R

更新日期：2013-03-01 00:00:00

abstract：:The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates amino acid substitutions that allow IAV to escape immunity through a mechanism known as antigenic drift. We recen...

journal_title：Journal of virology

authors： Santos JJS,Abente EJ,Obadan AO,Thompson AJ,Ferreri L,Geiger G,Gonzalez-Reiche AS,Lewis NS,Burke DF,Rajão DS,Paulson JC,Vincent AL,Perez DR

更新日期：2019-01-04 00:00:00

abstract：:Worldwide amphibian population declines have been ascribed to global warming, increasing pollution levels, and other factors directly related to human activities. These factors may additionally be favoring the emergence of novel pathogens. In this report, we have determined the complete genome sequence of the emerging...

journal_title：Journal of virology

authors： Mavian C,López-Bueno A,Balseiro A,Casais R,Alcamí A,Alejo A

更新日期：2012-04-01 00:00:00

abstract：:Bovine leukemia virus (BLV) from either persistently infected bat cells or fetal lamb kidney cells induced rapid syncytium formation in F81 indicator cells. Distinct syncytia were seen within 2 h after inoculation of cells with highly concentrated (500-fold) cell-free BLV preparations and within 4 to 8 h when unconcen...

journal_title：Journal of virology

authors： Graves DC,Jones LV

更新日期：1981-06-01 00:00:00

abstract：:We have developed a complementation assay, using transiently transfected COS cells, to facilitate a molecular analysis of the herpes simplex virus type 1 glycoprotein gH. When infected by a gH-null syncytial virus, COS cells expressing wild-type gH generate infectious progeny virions and form a syncytium with neighbor...

journal_title：Journal of virology

authors： Wilson DW,Davis-Poynter N,Minson AC

更新日期：1994-11-01 00:00:00

abstract：:Influenza A virus NS2 protein, also called nuclear export protein (NEP), is crucial for the nuclear export of viral ribonucleoproteins. However, the molecular mechanisms of NEP mediation in this process remain incompletely understood. A leucine-rich nuclear export signal (NES2) in NEP, located at the predicted N2 heli...

journal_title：Journal of virology

authors： Huang S,Chen J,Chen Q,Wang H,Yao Y,Chen J,Chen Z

更新日期：2013-01-01 00:00:00

abstract：:Removal of nucleoside triphosphates from extracts prepared from bacteriophage T7-infected Escherichia coli results in a stringent requirement for added ATP to form infective phage particles by in vitro packaging of bacteriophage T7 DNA. Optimal packaging efficiency was achieved at a concentration of about 1.25 mM. Oth...

journal_title：Journal of virology

authors： Masker WE

更新日期：1982-07-01 00:00:00

abstract：:Three plaque isolates of SV40 strain 777 and 1 plaque isolate of strain 776 were grown to high-titer stocks and serially passaged, undiluted, in monkey BS-C-1 cells. In each case, the serial passaging procedure resulted in the accumulation of closed-circular SV40 DNA molecules containing covalently linked sequences ho...

journal_title：Journal of virology

authors： Lavi S,Rozenblatt S,Singer MF,Winocour E

更新日期：1973-09-01 00:00:00

abstract：:Merkel cell polyomavirus (MCPyV) is the major cause for Merkel cell carcinoma (MCC), a rare but highly aggressive skin cancer predominantly found in elderly and immunosuppressed patients. The early viral gene products large T-antigen (LT) and small T-antigen (sT) are important for efficient viral DNA replication, and ...

journal_title：Journal of virology

authors： Czech-Sioli M,Siebels S,Radau S,Zahedi RP,Schmidt C,Dobner T,Grundhoff A,Fischer N

更新日期：2020-02-14 00:00:00