A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo.

abstract：:The adjuvant effects of cytokines in humoral and cell-mediated immunity to herpes simplex virus type 1 (HSV-1) have been examined in mice using HSV-1 recombinant viruses expressing murine interleukin-2 (IL-2), IL-4, or gamma interferon (IFN-gamma) gene. Groups of naive BALB/c mice were immunized intraperitoneally with...

journal_title：Journal of virology

authors： Osorio Y,Ghiasi H

更新日期：2003-05-01 00:00:00

abstract：:Disulfide bonds reportedly stabilize the capsids of several viruses, including papillomavirus, polyomavirus, and simian virus 40, and have been detected in herpes simplex virus (HSV) capsids. In this study, we show that in mature HSV-1 virions, capsid proteins VP5, VP23, VP19C, UL17, and UL25 participate in covalent c...

journal_title：Journal of virology

authors： Szczepaniak R,Nellissery J,Jadwin JA,Makhov AM,Kosinski A,Conway JF,Weller SK

更新日期：2011-09-01 00:00:00

abstract：:Human adenovirus 41 (HAdV-41) causes acute gastroenteritis in young children. The main characteristics of HAdV-41 infection are diarrhea and vomiting. Nevertheless, the precise mechanism of HAdV-41-induced diarrhea is unknown, as a suitable small-animal model has not been described. In this study, we used the human mi...

journal_title：Journal of virology

authors： Westerberg S,Hagbom M,Rajan A,Loitto V,Persson BD,Allard A,Nordgren J,Sharma S,Magnusson KE,Arnberg N,Svensson L

更新日期：2018-03-14 00:00:00

abstract：:The Zaire ebolavirus (EBOV) glycoprotein (GP) is cleaved into two subunits (GP1 and GP2) that are both required for virus attachment and entry into cells. Sequence changes in the GP have been proposed to increase pathogenesis and to alter virus growth properties. Mutations in GP acquired during EBOV tissue culture pas...

journal_title：Journal of virology

authors： Ruedas JB,Arnold CE,Palacios G,Connor JH

更新日期：2018-09-12 00:00:00

abstract：:The role of the cell nucleus in the development of African swine fever virus in Vero cells has been studied. No viral growth could be detected in enucleated cells under conditions that allow normal development of Sindbis virus. Furthermore, African swine fever virus DNA synthesis was inhibited more than 95% after infe...

journal_title：Journal of virology

authors： Ortin J,Vińuela E

更新日期：1977-03-01 00:00:00

abstract：:In the spherical capsid of hepatitis B virus (HBV), intermolecular disulfide bonds cross-link the approximately 180 p21.5 capsid protein subunits into a stable lattice. In this study, we used mutant capsid proteins to investigate the role that disulfide bonds and the four p21.5 Cys residues (positions 48, 61, 107, and...

journal_title：Journal of virology

authors： Zhou S,Standring DN

更新日期：1992-09-01 00:00:00

abstract：:Human La protein has been implicated in facilitating internal ribosome entry site (IRES)-mediated translation of hepatitis C virus (HCV). Earlier, we demonstrated that the RNA recognition motif (RRM) encompassing residues 112 to 184 of La protein [La (112-184)] interacts with the HCV IRES near the initiator AUG codon....

journal_title：Journal of virology

authors： Mondal T,Ray U,Manna AK,Gupta R,Roy S,Das S

更新日期：2008-12-01 00:00:00

abstract：:VP16-H is an essential structural protein of herpes simplex virus type 1 (HSV-1) and is also a potent activator of virus immediate-early (IE) gene expression. Current models of functional determinants within VP16-H indicate that it consists of two domains, an N-terminal domain involved in recruiting VP16-H to a multic...

journal_title：Journal of virology

authors： Grapes M,O'Hare P

更新日期：2000-11-01 00:00:00

abstract：:A procedure has been developed for the isolation of Newcastle disease virus (NDV) envelope proteins. The two surface glycoproteins and the non-glycosylated membrane protein were solubilized with 2% Triton X-100 and 1 m KCl. Removal of the KCl by dialysis yielded by precipitation a pure preparation of the non-glycosyla...

journal_title：Journal of virology

authors： Scheid A,Choppin PW

更新日期：1973-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a global challenge to public health. Several factors have been proven to be critical for HCV entry, including the newly identified claudin-1 (CLDN1). However, the mechanism of HCV entry is still obscure. Presently, among the 20 members of the claudin family identified in humans so far, CLDN1...

journal_title：Journal of virology

authors： Zheng A,Yuan F,Li Y,Zhu F,Hou P,Li J,Song X,Ding M,Deng H

更新日期：2007-11-01 00:00:00

abstract：:Simian virus 40 (SV40) large T antigen (SVT) interferes with normal cell regulation and thus has been used to identify cellular components controlling proliferation and homeostasis. We have previously shown that SVT-mediated transformation requires interaction with the histone acetyltransferases (HATs) CBP/p300 and no...

journal_title：Journal of virology

authors： Sáenz Robles MT,Shivalila C,Wano J,Sorrells S,Roos A,Pipas JM

更新日期：2013-12-01 00:00:00

abstract：:When mouse L cells are infected for 22 hr with vesicular stomatitis virus (VSV), a ribonucleic acid-containing enveloped virus, greater than 70% of the major histocompatibility antigen (H-2), is no longer detectable by the method of inhibition of immune cytolysis. Infected cells prelabeled with (14)C-glucosamine also ...

journal_title：Journal of virology

authors： Hecht TT,Summers DF

更新日期：1972-10-01 00:00:00

abstract：:Vaccination is the most effective way to prevent influenza virus infections. However, the diversity of antigenically distinct isolates is a challenge for vaccine development. In order to overcome the antigenic variability and improve the protective efficacy of influenza vaccines, our research group has pioneered the d...

journal_title：Journal of virology

authors： Huang Y,Owino SO,Crevar CJ,Carter DM,Ross TM

更新日期：2020-02-28 00:00:00

abstract：:The envelope glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) is posttranslationally cleaved into two subunits. We show here that this endoproteolytic processing is not required for transport to the cell surface but is essential for LCMV GP to mediate infectivity of pseudotyped retroviral vectors. By sys...

journal_title：Journal of virology

authors： Beyer WR,Pöpplau D,Garten W,von Laer D,Lenz O

更新日期：2003-03-01 00:00:00

abstract：:Vesicular stomatitis virus (VSV) is a negative-strand RNA virus with intrinsic oncolytic specificity due to substantially attenuated antiviral responses in many tumors. We have recently reported that recombinant VSV vector can be used as an effective oncolytic agent to safely treat multifocal hepatocellular carcinoma ...

journal_title：Journal of virology

authors： Shinozaki K,Ebert O,Suriawinata A,Thung SN,Woo SL

更新日期：2005-11-01 00:00:00

abstract：:The nef genes of the human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) and the related simian immunodeficiency viruses (SIVs) encode a protein (Nef) whose role in virus replication and cytopathicity remains uncertain. As an attempt to elucidate the function of nef, we characterized the nucleotide and corre...

journal_title：Journal of virology

authors： Shugars DC,Smith MS,Glueck DH,Nantermet PV,Seillier-Moiseiwitsch F,Swanstrom R

更新日期：1993-08-01 00:00:00

abstract：:Envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is an important target for the development of an HIV vaccine. Extensive glycosylation of Env is an important feature that both protects the virus from antibody responses and serves as a target for some highly potent broadly neutralizing antibod...

journal_title：Journal of virology

authors： Wang S,Voronin Y,Zhao P,Ishihara M,Mehta N,Porterfield M,Chen Y,Bartley C,Hu G,Han D,Wells L,Tiemeyer M,Lu S

更新日期：2020-03-17 00:00:00

abstract：:Blattella germanica densovirus (BgDNV) is an autonomous parvovirus that infects the German cockroach. BgDNV possesses three mRNAs for NS proteins, two of which are splice variants of the unspliced transcript. The unspliced variant encodes open reading frame 5 (ORF5) (NS3), while NSspl1 encodes ORF3 (NS1) and ORF4 (NS2...

journal_title：Journal of virology

authors： Kapelinskaya TV,Martynova EU,Schal C,Mukha DV

更新日期：2011-11-01 00:00:00

abstract：:When human A431 cells, which carry high numbers of epidermal growth factor (EGF) receptors, are exposed to EGF, the total content of phosphotyrosine in cell protein is increased, the EGF receptor becomes phosphorylated at tyrosine, and new phosphotyrosine-containing 36,000- and 81,000-dalton proteins are detected. We ...

journal_title：Journal of virology

authors： Cooper JA,Scolnick EM,Ozanne B,Hunter T

更新日期：1983-12-01 00:00:00

abstract：:To investigate the process of human immunodeficiency virus type 1 (HIV-1) evolution in vivo, a total of 179 HIV-1 V3 sequences derived from cell-free plasma were determined from serial samples in three epidemiologically linked individuals (one infected blood donor and two transfusion recipients) over a maximum period ...

journal_title：Journal of virology

authors： Zhang L,Diaz RS,Ho DD,Mosley JW,Busch MP,Mayer A

更新日期：1997-03-01 00:00:00

abstract：:Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a transmissible lung cancer of sheep known as ovine pulmonary carcinoma. Recently, we have found that the expression of the JSRV envelope (Env) is sufficient to transform mouse NIH 3T3 cells in classical transformation assays. To further investigate the mech...

journal_title：Journal of virology

authors： Palmarini M,Maeda N,Murgia C,De-Fraja C,Hofacre A,Fan H

更新日期：2001-11-01 00:00:00

abstract：:West Nile virus (WNV) is a mosquito-borne Flavivirus that causes encephalitis in a subset of susceptible humans. Current treatment for WNV infections is supportive, and no specific therapy or vaccine is available. In this study, we directly tested the prophylactic and therapeutic efficacy of polyclonal antibodies agai...

journal_title：Journal of virology

authors： Engle MJ,Diamond MS

更新日期：2003-12-01 00:00:00

abstract：:Human T-cell leukemia virus (HTLV) Tax protein has been implicated in the HTLV oncogenic process, primarily due to its pleiotropic effects on cellular genes involved in growth regulation and cell cycle control. To date, several approaches attempting to correlate Tax activation of the CREB/activating transcription fact...

journal_title：Journal of virology

authors： Ross TM,Narayan M,Fang ZY,Minella AC,Green PL

更新日期：2000-03-01 00:00:00

abstract：:During herpes simplex virus (HSV) latency, most viral genes are silenced, with the exception of one region of the genome encoding the latency-associated transcript (LAT). This long noncoding RNA was originally described as having a role in enhancing HSV-1 reactivation. However, subsequent evidence showing that the LAT...

journal_title：Journal of virology

authors： Watson ZL,Washington SD,Phelan DM,Lewin AS,Tuli SS,Schultz GS,Neumann DM,Bloom DC

更新日期：2018-07-31 00:00:00

abstract：:Despite differences in the pathogenesis and host range of alphaherpesviruses, many stages of their morphogenesis are thought to be conserved. Here, an ultrastructural study of bovine herpesvirus 1 (BoHV-1) envelopment revealed profiles similar to those previously found for herpes simplex virus 1 (HSV-1), with BoHV-1 c...

journal_title：Journal of virology

authors： Russell T,Bleasdale B,Hollinshead M,Elliott G

更新日期：2018-10-29 00:00:00

abstract：:The protein kinase C (PKC) pathway has been considered to be essential for activation of latent Epstein-Barr virus (EBV) into the lytic cycle. The phorbol ester tetradecanoyl phorbol acetate (TPA), a PKC agonist, is one of the best understood activators of EBV lytic replication. Zp, the promoter of the EBV immediate-e...

journal_title：Journal of virology

authors： Gradoville L,Kwa D,El-Guindy A,Miller G

更新日期：2002-06-01 00:00:00

abstract：:The nucleotide sequences of the termini of the mature pseudorabies virus genome and of the junction between these termini in concatemeric DNA were compared. To ensure conservation of unmodified 5' and 3' termini, the end fragments obtained directly (uncloned) from mature viral DNA were sequenced. The sequence obtained...

journal_title：Journal of virology

authors： Harper L,Demarchi J,Ben-Porat T

更新日期：1986-12-01 00:00:00

abstract：:Members of the Paramyxovirinae subfamily rely on the concerted action of two envelope glycoprotein complexes, attachment protein H and the fusion (F) protein oligomer, to achieve membrane fusion for viral entry. Despite advances in X-ray information, the organization of the physiological attachment (H) oligomer in fun...

journal_title：Journal of virology

authors： Brindley MA,Plemper RK

更新日期：2010-12-01 00:00:00

abstract：:Live attenuated human immunodeficiency virus type 1 (HIV-1) vaccines are considered unsafe because faster-replicating pathogenic virus variants may evolve after vaccination. We previously presented a conditional-live HIV-1 variant of which replication can be switched off as an alternative vaccination strategy. To impr...

journal_title：Journal of virology

authors： Das AT,Baldwin CE,Vink M,Berkhout B

更新日期：2005-03-01 00:00:00

abstract：:Several viral determinants were shown to play a role in the ability of human immunodeficiency virus type 1 (HIV-1) to infect nondividing cells. In particular, Vpr and Gag matrix (MA) were recognized to be involved in the nuclear transport of the viral preintegration complex. The goal of the present study was to evalua...

journal_title：Journal of virology

authors： Nie Z,Bergeron D,Subbramanian RA,Yao XJ,Checroune F,Rougeau N,Cohen EA

更新日期：1998-05-01 00:00:00