T-cell infiltration correlates with CXCL10 expression in ganglia of cynomolgus macaques with reactivated simian varicella virus.

Abstract:

:Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.

journal_name

J Virol

journal_title

Journal of virology

authors

Ouwendijk WJ,Abendroth A,Traina-Dorge V,Getu S,Steain M,Wellish M,Andeweg AC,Osterhaus AD,Gilden D,Verjans GM,Mahalingam R

doi

10.1128/JVI.03181-12

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

2979-82

issue

5

eissn

0022-538X

issn

1098-5514

pii

JVI.03181-12

journal_volume

87

pub_type

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