Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway.

abstract：:The secreted cytokine alpha/beta interferon (IFN-alpha/beta) binds its receptor to activate the Jak-STAT signal transduction pathway, leading to formation of the heterotrimeric IFN-stimulated gene factor 3 (ISGF3) transcription complex for induction of IFN-stimulated genes (ISGs) and establishment of an antiviral stat...

journal_title：Journal of virology

authors： Zurney J,Kobayashi T,Holm GH,Dermody TS,Sherry B

更新日期：2009-03-01 00:00:00

abstract：:We have characterized an inhibitory RNA element in the human immunodeficiency virus type 1 (HIV-1) gag coding sequence that prevents gag expression. The inhibition exerted by this element could be overcome by the presence of the Rev-responsive element in cis and of Rev protein in trans. To understand the mechanism of ...

journal_title：Journal of virology

authors： Schwartz S,Campbell M,Nasioulas G,Harrison J,Felber BK,Pavlakis GN

更新日期：1992-12-01 00:00:00

abstract：:Bacterial lipopolysaccharide (LPS) induces interferon (IFN) secretion and an antiviral state in murine peritoneal macrophages (PM). These cells secrete predominantly IFN-beta, as shown by neutralization assays with monoclonal antibodies. Secretion of IFN-beta is also induced in PM by IFN-gamma. LPS and IFN-gamma syner...

journal_title：Journal of virology

authors： Gessani S,Belardelli F,Pecorelli A,Puddu P,Baglioni C

更新日期：1989-06-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) remains latent throughout the life of the carrier, with cells containing the provirus and viral gene expression efficiently down-regulated. On a molecular level, exactly how viruses are down-regulated in vivo remains unresolved. We described here the possibility that down-re...

journal_title：Journal of virology

authors： Saiga A,Orita S,Minoura-Tada N,Maeda M,Aono Y,Asakawa M,Nakahara K,Kubota R,Osame M,Igarashi H

更新日期：1997-06-01 00:00:00

abstract：:The envelope of human parainfluenza virus type 3 (HPF3) contains two viral glycoproteins, the hemagglutinin-neuraminidase (HN) and the fusion protein (F). HN, which is responsible for receptor attachment and for promoting F-mediated fusion, also possesses neuraminidase (receptor-destroying) activity. We reported previ...

journal_title：Journal of virology

authors： Porotto M,Greengard O,Poltoratskaia N,Horga MA,Moscona A

更新日期：2001-08-01 00:00:00

abstract：:We have tested triple and quadruple combinations of human monoclonal antibodies (MAbs), which are directed against various epitopes on human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins, and a high-titer anti-HIV-1 human immunoglobulin (HIVIG) preparation for their abilities to neutralize a chimeric si...

journal_title：Journal of virology

authors： Li A,Katinger H,Posner MR,Cavacini L,Zolla-Pazner S,Gorny MK,Sodroski J,Chou TC,Baba TW,Ruprecht RM

更新日期：1998-04-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of the aggressive and fatal disease adult T-cell leukemia. Previous studies have demonstrated that the HTLV-1-encoded Tax protein inhibits the function of tumor suppressor p53 through a Tax-induced NF-kappaB pathway. Given these attributes, we were int...

journal_title：Journal of virology

authors： Jung KJ,Dasgupta A,Huang K,Jeong SJ,Pise-Masison C,Gurova KV,Brady JN

更新日期：2008-09-01 00:00:00

abstract：:The ability of certain vesicular stomatitis virus (VSV; Indiana serotype) temperature-sensitive (ts) mutants to synthesize intracellular viral complementary RNA (vcRNA) at permissive or nonpermissive temperatures for productive infections has been investigated. Mutants belonging to complementation groups II, III, and ...

journal_title：Journal of virology

authors： Repik P,Flamand A,Bishop DH

更新日期：1976-10-01 00:00:00

abstract：:The RNA-dependent RNA polymerase of influenza A virus is composed of three subunits that together synthesize all viral mRNAs and also replicate the viral genomic RNA segments (vRNAs) through intermediates known as cRNAs. Here we describe functional characterization of 16 site-directed mutants of one polymerase subunit...

journal_title：Journal of virology

authors： Regan JF,Liang Y,Parslow TG

更新日期：2006-01-01 00:00:00

abstract：:In this study, we show that human cytomegalovirus DNA synthesis is inhibited in infected confluent human embryonic lung cells treated with the DNA-intercalative topoisomerase II inhibitor 4-9'-(acridinylamino)methanesulfon-m-anisidide (m-AMSA). Similar inhibitory effects were observed with VM-26, a nonintercalative to...

journal_title：Journal of virology

authors： Benson JD,Huang ES

更新日期：1988-12-01 00:00:00

abstract：:Envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is an important target for the development of an HIV vaccine. Extensive glycosylation of Env is an important feature that both protects the virus from antibody responses and serves as a target for some highly potent broadly neutralizing antibod...

journal_title：Journal of virology

authors： Wang S,Voronin Y,Zhao P,Ishihara M,Mehta N,Porterfield M,Chen Y,Bartley C,Hu G,Han D,Wells L,Tiemeyer M,Lu S

更新日期：2020-03-17 00:00:00

abstract：:The various strains of BK virus (BKV) exhibit a remarkable degree of heterogeneity in the transcriptional control region, which may affect the biological characteristics of a BKV strain. We describe the detection and sequencing of BKV control regions directly from urine samples and after propagation in cell culture. A...

journal_title：Journal of virology

authors： Sundsfjord A,Johansen T,Flaegstad T,Moens U,Villand P,Subramani S,Traavik T

更新日期：1990-08-01 00:00:00

abstract：:Radioactive DNA complementary to nucleotide sequences in Moloney murine sarcoma virus (MSV) and Moloney leukemia virus (M-MuLV) complex was made by the endogenous reverse transcriptase reaction. These virus stocks contained a threefold excess of MSV over M-MuLV as measured by biological assay. The complementary DNA wa...

journal_title：Journal of virology

authors： Frankel AE,Neubauer RL,Fischinger PJ

更新日期：1976-05-01 00:00:00

abstract：:Understanding how HIV-1 persists during effective antiretroviral therapy (ART) should inform strategies to cure HIV-1 infection. We hypothesize that proliferation of HIV-1-infected cells contributes to persistence of HIV-1 infection during suppressive ART. This predicts that identical or monotypic HIV-1 DNA sequences ...

journal_title：Journal of virology

authors： Wagner TA,McKernan JL,Tobin NH,Tapia KA,Mullins JI,Frenkel LM

更新日期：2013-02-01 00:00:00

abstract：:Measles virus (MeV), like all viruses of the order Mononegavirales, utilizes a complex consisting of genomic RNA, nucleoprotein, the RNA-dependent RNA polymerase, and a polymerase cofactor, the phosphoprotein (P), for transcription and replication. We previously showed that a recombinant MeV that does not express anot...

journal_title：Journal of virology

authors： Pfaller CK,Bloyet LM,Donohue RC,Huff AL,Bartemes WP,Yousaf I,Urzua E,Clavière M,Zachary M,de Masson d'Autume V,Carson S,Schieferecke AJ,Meyer AJ,Gerlier D,Cattaneo R

更新日期：2020-01-31 00:00:00

abstract：:Chemokines induce the directional migration of targeted populations of leukocytes during periods of inflammation. Moreover, these molecules also regulate T-cell activation and differentiation following antigenic stimulation. In the present study, the contributions of the CC chemokine ligand 3 (CCL3) to the differentia...

journal_title：Journal of virology

authors： Trifilo MJ,Bergmann CC,Kuziel WA,Lane TE

更新日期：2003-04-01 00:00:00

abstract：:Spumaviruses, or foamy viruses, express Gag proteins that are incompletely processed by the viral protease in cell cultures. To delineate the proteolytic cleavage sites between potential Gag subdomains, recombinant human spumaretrovirus (HSRV) Gag proteins of different lengths were expressed, purified by affinity chro...

journal_title：Journal of virology

authors： Pfrepper KI,Löchelt M,Rackwitz HR,Schnölzer M,Heid H,Flügel RM

更新日期：1999-09-01 00:00:00

abstract：:We have shown previously that processing of the Sindbis virus envelope protein precursor PE2 to envelope protein E2 is not required for virus maturation in cultured vertebrate fibroblast cells and that unprocessed PE2 can be incorporated into infectious virus in place of E2 (J. F. Presley and D. T. Brown, J. Virol. 63...

journal_title：Journal of virology

authors： Presley JF,Polo JM,Johnston RE,Brown DT

更新日期：1991-04-01 00:00:00

abstract：:An adult horse infected with a virulent, cell culture-adapted strain of equine infectious anemia virus (EIAV) developed cyclical thrombocytopenia in which the nadir of platelet counts coincided with peak febrile responses. In order to investigate the mechanism of thrombocytopenia during acute febrile episodes, four ad...

journal_title：Journal of virology

authors： Clabough DL,Gebhard D,Flaherty MT,Whetter LE,Perry ST,Coggins L,Fuller FJ

更新日期：1991-11-01 00:00:00

abstract：:Protocols have been established for the preparation of large amounts of pure measles virus intracellular nucleocapsids. As a result, it has been possible to routinely achieve nucleocapsid RNA yields of approximately 200 micrograms (from approximately 5 X 10(8) infected cells). Electrophoretic analysis of this RNA unde...

journal_title：Journal of virology

authors： Udem SA,Cook KA

更新日期：1984-01-01 00:00:00

abstract：:Based on sequence divergence in the transformation-relevant region, herpesvirus saimiri strains are classified into three subgroups. Only members of subgroup C transform human T lymphocytes to continuous interleukin-2-dependent growth in culture. In this study, human cord blood T cells were immortalized by using diffe...

journal_title：Journal of virology

authors： Fickenscher H,Bökel C,Knappe A,Biesinger B,Meinl E,Fleischer B,Fleckenstein B,Bröker BM

更新日期：1997-03-01 00:00:00

abstract：:Drug susceptibility and mutations in the reverse transcriptase (RT) gene were analyzed with 167 virus isolates from 38 patients treated with nevirapine, a potent nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) RT. Resistant isolates emerged quickly and uniformly in all patients administered nevi...

journal_title：Journal of virology

authors： Richman DD,Havlir D,Corbeil J,Looney D,Ignacio C,Spector SA,Sullivan J,Cheeseman S,Barringer K,Pauletti D

更新日期：1994-03-01 00:00:00

abstract：:To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes. We report here that the ability of these envelopes to utilize different Pit1 orthologs ...

journal_title：Journal of virology

authors： Faix PH,Feldman SA,Overbaugh J,Eiden MV

更新日期：2002-12-01 00:00:00

abstract：:The inactivation of type C retroviruses by human serum may be a considerable impediment to the use of retroviral vectors in vivo for gene therapy. Here we show that virus inactivation is dependent both on the virus and on the cell line used to produce the virus. All viruses produced from murine NIH 3T3 or dog Cf2ThS+L...

journal_title：Journal of virology

authors： Takeuchi Y,Cosset FL,Lachmann PJ,Okada H,Weiss RA,Collins MK

更新日期：1994-12-01 00:00:00

abstract：:The RNA polymerase of the influenza virus is responsible for the transcription and replication of the segmented RNA viral genome during infection of host cells. Polymerase function is known to be strictly dependent on interaction with its RNA promoter, but no attempts to investigate whether the virion RNA (vRNA) promo...

journal_title：Journal of virology

authors： Brownlee GG,Sharps JL

更新日期：2002-07-01 00:00:00

abstract：:The Middle East respiratory syndrome coronavirus (MERS-CoV) nonstructural protein 16 (nsp16) is an S-adenosyl-l-methionine (SAM)-dependent 2'-O-methyltransferase (2'-O-MTase) that is thought to methylate the ribose 2'-OH of the first transcribed nucleotide (N1) of viral RNA cap structures. This 2'-O-MTase activity is ...

journal_title：Journal of virology

authors： Aouadi W,Blanjoie A,Vasseur JJ,Debart F,Canard B,Decroly E

更新日期：2017-02-14 00:00:00

abstract：UNLABELLED:Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often poorly managed with current treatments. Arthritic disease is usually characterized by high levels of the chemokine CCL2 and a...

journal_title：Journal of virology

authors： Poo YS,Nakaya H,Gardner J,Larcher T,Schroder WA,Le TT,Major LD,Suhrbier A

更新日期：2014-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a global challenge to public health. Several factors have been proven to be critical for HCV entry, including the newly identified claudin-1 (CLDN1). However, the mechanism of HCV entry is still obscure. Presently, among the 20 members of the claudin family identified in humans so far, CLDN1...

journal_title：Journal of virology

authors： Zheng A,Yuan F,Li Y,Zhu F,Hou P,Li J,Song X,Ding M,Deng H

更新日期：2007-11-01 00:00:00

abstract：:Six nonoverlapping peptides of the neuraminidase (NA) glycoprotein of influenza virus A/Puerto Rico/8/34 (H1N1) (PR8 virus) were found to be immunogenic for proliferating T cells when injected into BALB/c mice in Freund adjuvant. T cells elicited by peptide immunization could recognize PR8 virus in vitro. However, onl...

journal_title：Journal of virology

authors： Hackett CJ,Horowitz D,Wysocka M,Eisenlohr LC

更新日期：1991-02-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68 [also known as gammaHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying gammaherpesvirus virion composition. Extracellular MHV68 virions were isolated, and abundant virion-associated proteins were identif...

journal_title：Journal of virology

authors： Bortz E,Whitelegge JP,Jia Q,Zhou ZH,Stewart JP,Wu TT,Sun R

更新日期：2003-12-01 00:00:00