Abstract:
:Murine gammaherpesvirus 68 (MHV68 [also known as gammaHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying gammaherpesvirus virion composition. Extracellular MHV68 virions were isolated, and abundant virion-associated proteins were identified by mass spectrometry. Five nucleocapsid protein homologues, the tegument protein homologue encoded by open reading frame (ORF) 75c, and envelope glycoproteins B and H were detected. In addition, gene products from MHV68 ORF20, ORF24, ORF28, ORF45, ORF48, and ORF52 were identified in association with virions, suggesting that these gammaherpesvirus genes are involved in the early phase of infection or virion assembly and egress.
journal_name
J Viroljournal_title
Journal of virologyauthors
Bortz E,Whitelegge JP,Jia Q,Zhou ZH,Stewart JP,Wu TT,Sun Rdoi
10.1128/jvi.77.24.13425-13432.2003subject
Has Abstractpub_date
2003-12-01 00:00:00pages
13425-32issue
24eissn
0022-538Xissn
1098-5514journal_volume
77pub_type
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