Comparison of late mRNA splicing among class B and class C adenoviruses.

abstract：:N6-adenosine methylation (m6A) is the most common posttranscriptional RNA modification in mammalian cells. We found that most transcripts encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome undergo m6A modification. The levels of m6A-modified mRNAs increased substantially upon stimulation for lytic re...

journal_title：Journal of virology

authors： Ye F,Chen ER,Nilsen TW

更新日期：2017-07-27 00:00:00

abstract：:The influenza A virus (IAV) M2 protein is a multifunctional protein with critical roles in virion entry, assembly, and budding. M2 is targeted to the apical plasma membrane of polarized epithelial cells, and the interaction of the viral proteins M2, M1, HA, and NA near glycolipid rafts in the apical plasma membrane is...

journal_title：Journal of virology

authors： Wohlgemuth N,Lane AP,Pekosz A

更新日期：2018-10-29 00:00:00

abstract：:The human immunodeficiency virus (HIV) integrase protein (IN) catalyzes two reactions required to integrate HIV DNA into the human genome: 3' processing of the viral DNA ends and integration. IN has three domains, the N-terminal zinc-binding domain, the catalytic core, and the C-terminal SH3 domain. Previously, it was...

journal_title：Journal of virology

authors： van den Ent FM,Vos A,Plasterk RH

更新日期：1999-04-01 00:00:00

abstract：:Hepatitis C virus core protein forms the viral nucleocapsid and plays a critical role in the formation of infectious particles. In this study, we demonstrate that the highly conserved residue G33, located within domain 1 of the core protein, is important for the production of cell culture-infectious virus (HCVcc). Ala...

journal_title：Journal of virology

authors： Angus AG,Loquet A,Stack SJ,Dalrymple D,Gatherer D,Penin F,Patel AH

更新日期：2012-01-01 00:00:00

abstract：:A mutant which produces a small-headed ("petite") variant of bacteriophage T4 is described. The mutation (E920g) maps in a new gene (66) between genes 23 and 24. Petite phage particles composed up to 70% of the phage yield. The petite phage was nonviable upon single infection but produced progeny when two or more infe...

journal_title：Journal of virology

authors： Eiserling FA,Geiduschek EP,Epstein RH,Metter EJ

更新日期：1970-12-01 00:00:00

abstract：UNLABELLED:In a previous screen of putative interferon-stimulated genes, SUN2 was shown to inhibit HIV-1 infection in an uncharacterized manner. SUN2 is an inner nuclear membrane protein belonging to the linker of nucleoskeleton and cytoskeleton complex. We have analyzed here the role of SUN2 in HIV infection. We repor...

journal_title：Journal of virology

authors： Donahue DA,Amraoui S,di Nunzio F,Kieffer C,Porrot F,Opp S,Diaz-Griffero F,Casartelli N,Schwartz O

更新日期：2016-03-28 00:00:00

abstract：:Analysis of six monoclonal antibody-resistant (mar) mutants in herpes simplex virus type 1 glycoprotein B identified two type-common (II and III) and two type-specific (I and IV) antigenic sites on this molecule. To derive additional information on the location of these sites, mar mutations were mapped and nucleotide ...

journal_title：Journal of virology

authors： Highlander SL,Dorney DJ,Gage PJ,Holland TC,Cai W,Person S,Levine M,Glorioso JC

更新日期：1989-02-01 00:00:00

abstract：:Interleukin-10 (IL-10) suppresses the maturation and cytokine production of dendritic cells (DCs), key regulators of adaptive immunity, and prevents the activation and polarization of naïve T cells towards protective gamma interferon-producing effectors. We hypothesized that human cytomegalovirus (HCMV) utilizes its v...

journal_title：Journal of virology

authors： Chang WL,Baumgarth N,Yu D,Barry PA

更新日期：2004-08-01 00:00:00

abstract：:We have generated hexon-modified adenovirus serotype 5 (Ad5) vectors that are not neutralized by Ad5-specific neutralizing antibodies in mice. These vectors are attractive for the advancement of vaccine products because of their potential for inducing robust antigen-specific immune responses in people with prior expos...

journal_title：Journal of virology

authors： Bruder JT,Chen P,Semenova E,Thomas CA,Konovalova S,Ekberg G,Ettyreddy D,McVey D,Gall JG,King CR,Brough DE

更新日期：2013-09-01 00:00:00

abstract：:Host-virus interactions control disease progression in human immunodeficiency virus-infected human beings and in nonhuman primates infected with simian or simian/human immunodeficiency viruses (SHIV). These interactions evolve rapidly during acute infection and are key to the mechanisms of viral persistence and AIDS. ...

journal_title：Journal of virology

authors： Wallace M,Waterman PM,Mitchen JL,Djavani M,Brown C,Trivedi P,Horejsh D,Dykhuizen M,Kitabwalla M,Pauza CD

更新日期：1999-12-01 00:00:00

abstract：:Phosphorylation of viral proteins plays important roles in the influenza A virus (IAV) life cycle. By using mass spectrometry, we identified tyrosine 132 (Y132) as a phosphorylation site of the matrix protein (M1) of the influenza virus A/WSN/1933(H1N1). Phosphorylation at this site is essential to the process of viru...

journal_title：Journal of virology

authors： Wang S,Zhao Z,Bi Y,Sun L,Liu X,Liu W

更新日期：2013-06-01 00:00:00

abstract：:The locations and functions of DNA sequences involved in transcription of the gene encoding herpes simplex virus type 1 immediate early (IE) mRNAs 4 and 5 were analyzed by use of a transient-expression assay. The region upstream of the genes encoding IE mRNAs 4 and 5 was fused to the thymidine kinase gene coding seque...

journal_title：Journal of virology

authors： Preston CM,Cordingley MG,Stow ND

更新日期：1984-06-01 00:00:00

abstract：:3-O-(3',3'-dimethylsuccinyl)betulinic acid (PA-457 or bevirimat) potently inhibits human immunodeficiency virus type 1 (HIV-1) maturation by blocking a late step in the Gag processing pathway, specifically the cleavage of SP1 from the C terminus of capsid (CA). To gain insights into the mechanism(s) by which HIV-1 cou...

journal_title：Journal of virology

authors： Adamson CS,Ablan SD,Boeras I,Goila-Gaur R,Soheilian F,Nagashima K,Li F,Salzwedel K,Sakalian M,Wild CT,Freed EO

更新日期：2006-11-01 00:00:00

abstract：:Panicum mosaic virus (PMV) is a recently molecularly characterized RNA virus with the unique feature of supporting the replication of two subviral RNAs in a few species of the family Gramineae. The subviral agents include a satellite RNA (satRNA) that is devoid of a coding region and the unrelated satellite panicum mo...

journal_title：Journal of virology

authors： Qiu W,Scholthof KB

更新日期：2001-06-01 00:00:00

abstract：:Defensins are innate immune effector peptides expressed at mucosal surfaces throughout the human body and are potently antiviral in vitro The role of defensins in viral pathogenesis in vivo is poorly understood; however, recent studies have revealed that defensin-virus interactions in vivo are complicated and distinct...

journal_title：Journal of virology

authors： Wilson SS,Wiens ME,Holly MK,Smith JG

更新日期：2016-05-12 00:00:00

abstract：UNLABELLED:Aminoquinolines and piperazines, linked or not, have been used successfully to treat malaria, and some molecules of this family also exhibit antiviral properties. Here we tested several derivatives of 4-aminoquinolines and piperazines for their activity against hepatitis C virus (HCV). We screened 11 molecul...

journal_title：Journal of virology

authors： Vausselin T,Séron K,Lavie M,Mesalam AA,Lemasson M,Belouzard S,Fénéant L,Danneels A,Rouillé Y,Cocquerel L,Foquet L,Rosenberg AR,Wychowski C,Meuleman P,Melnyk P,Dubuisson J

更新日期：2016-09-12 00:00:00

abstract：:Varicella-zoster virus (VZV), an alphaherpesvirus restricted to humans, infects differentiated cells in vivo, including T lymphocytes, keratinocytes, and neurons, and spreads rapidly in confluent cultured dermal fibroblasts (HFFs). In VZV-infected HFFs, atypical expression of cyclins D3 and B1 occurs along with the in...

journal_title：Journal of virology

authors： Leisenfelder SA,Kinchington PR,Moffat JF

更新日期：2008-12-01 00:00:00

abstract：:Gammaherpesvirus 68 (gammaHV68, or MHV68) is a naturally occurring rodent pathogen that replicates to high titer in cell culture and is amenable to in vivo experimental evaluation of viral and host determinants of gammaherpesvirus disease. However, the inability of MHV68 to transform primary murine B cells in culture,...

journal_title：Journal of virology

authors： Forrest JC,Speck SH

更新日期：2008-08-01 00:00:00

abstract：:Normal replication of Moloney murine leukemia virus (MoMLV) requires the integration of a DNA copy of the viral RNA genome into a chromosome of the host. In this work, we characterize the DNA sequences at the ends of the linear proviral precursor that are required for integration in the presence of MoMLV integration p...

journal_title：Journal of virology

authors： Bushman FD,Craigie R

更新日期：1990-11-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) specifically incorporates the host cell peptidyl-prolyl isomerase cyclophilin A into virions via contacts with the capsid (CA) domain of the Gag polyprotein Pr55gag. The immunosuppressant drug cyclosporin A and the nonimmunosuppressive cyclosporin A analog SDZ NIM 811 bind t...

journal_title：Journal of virology

authors： Dorfman T,Göttlinger HG

更新日期：1996-09-01 00:00:00

abstract：:It is possible to oxidize in situ the 3'-terminals of the double-stranded ribonucleic acid (RNA) contained in structurally intact cytoplasmic polyhedrosis virus. The number of 3'-terminals subsequently found by reduction with tritiated sodium borohydride was equivalent to the number observed in RNA first isolated from...

journal_title：Journal of virology

authors： Lewandowski LJ,Millward S

更新日期：1971-04-01 00:00:00

abstract：:Human norovirus (HuNoV) is a leading cause of acute gastroenteritis in both developed and developing countries. Studies of HuNoV host cell interactions are limited by the lack of a simple, robust cell culture system. Due to their diverse HuNoV-like biological features, including histo-blood group antigen (HBGA) bindin...

journal_title：Journal of virology

authors： Farkas T,Yang K,Le Pendu J,Baines JD,Cardin RD

更新日期：2019-10-29 00:00:00

abstract：:Spleen cells from mice, 4 to 60 days after infection with mouse hepatitis virus type 4, produced interleukin-2, as well as interleukin-3, in the absence of exogenous stimulants in vitro. This unique lymphokine production by mouse hepatitis virus type 4 infection was controlled by host genes. ...

journal_title：Journal of virology

authors： Kyuwa S,Yamaguchi K,Hayami M,Hilgers J,Fujiwara K

更新日期：1988-09-01 00:00:00

abstract：:Cell fractionation and protein electrophoresis were used to study the intracellular sites of synthesis and intermediate structures in the assembly of the virion proteins of vesicular stomatitis virus. Each of the three major virion proteins assembled into virions through a separable pathway. The nucleocapsid (N) prote...

journal_title：Journal of virology

authors： Knipe DM,Baltimore D,Lodish HF

更新日期：1977-03-01 00:00:00

abstract：:The recently emerged highly virulent variants of porcine epidemic diarrhea virus (PEDV) have caused colossal economic losses to the worldwide swine industry. In this study, we investigated the viral virulence determinants by constructing a series of chimeric mutants between the highly virulent strain BJ2011C and the a...

journal_title：Journal of virology

authors： Wang D,Ge X,Chen D,Li J,Cai Y,Deng J,Zhou L,Guo X,Han J,Yang H

更新日期：2018-06-13 00:00:00

abstract：:The development of vaccines against bluetongue, a prevalent livestock disease, has been focused on surface antigens that induce strong neutralizing antibody responses. Because of their antigenic variability, these vaccines are usually serotype restricted. We now show that a single highly conserved nonstructural protei...

journal_title：Journal of virology

authors： Marín-López A,Calvo-Pinilla E,Barriales D,Lorenzo G,Brun A,Anguita J,Ortego J

更新日期：2018-07-31 00:00:00

abstract：:A panel of monoclonal antibodies that recognize the two major glycoproteins of bovine viral diarrhea virus (BDV) was used to evaluate the antigenic relationship between cytopathic (CP) and noncytopathic (NCP) viruses isolated from cattle dead or dying from fatal BDV infections. Various unrelated BDV isolates were init...

journal_title：Journal of virology

authors： Corapi WV,Donis RO,Dubovi EJ

更新日期：1988-08-01 00:00:00

abstract：:To analyze the association of the human immunodeficiency virus type 1 integrase (IN) protein with DNA substrates, we applied a shortwave UV cross-linking method to the in vitro integration system. Three photoadduct bands were detected on sodium dodecyl sulfate-polyacrylamide gels. The appearances of these photoadducts...

journal_title：Journal of virology

authors： Yoshinaga T,Kimura-Ohtani Y,Fujiwara T

更新日期：1994-09-01 00:00:00

abstract：:DNA vaccines have recently emerged at the forefront of approaches to harness the immune system in the prevention and treatment of viral infections, as well as the prevention and treatment of cancers. However, these vaccines suffer from limited efficacy since they often fail to produce significant antigen-specific CD8(...

journal_title：Journal of virology

authors： Mao CP,Hung CF,Kang TH,He L,Tsai YC,Wu CY,Wu TC

更新日期：2010-03-01 00:00:00

abstract：:Plus-strand RNA viruses characteristically replicate their genome in association with altered cellular membranes. In the present study, the capacity of hepatitis C virus (HCV) proteins to elicit intracellular membrane alterations was investigated by expressing, in tetracycline-regulated cell lines, a comprehensive pan...

journal_title：Journal of virology

authors： Egger D,Wölk B,Gosert R,Bianchi L,Blum HE,Moradpour D,Bienz K

更新日期：2002-06-01 00:00:00