Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex.

abstract：:The present study was designed to investigate the endocytic pathway involved in canine parvovirus (CPV) infection. Reduced temperature (18 degrees C) or the microtubule-depolymerizing drug nocodazole was found to inhibit productive infection of canine A72 cells by CPV and caused CPV to be retained in cytoplasmic vesic...

journal_title：Journal of virology

authors： Vihinen-Ranta M,Kalela A,Mäkinen P,Kakkola L,Marjomäki V,Vuento M

更新日期：1998-01-01 00:00:00

abstract：:Previous studies using wild-type Encephalomyocarditis virus (EMCV) and Mengo virus, which have long poly(C) tracts (61 to 146 C's) at the 5' nontranslated region of the genome, and variants of these viruses genetically engineered to truncate or substitute the poly(C) tracts have produced conflicting data on the role o...

journal_title：Journal of virology

authors： LaRue R,Myers S,Brewer L,Shaw DP,Brown C,Seal BS,Njenga MK

更新日期：2003-09-01 00:00:00

abstract：:Interactions between the oncogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) and dendritic cells (DCs) are poorly characterized. We show here that monocyte-derived DCs form syncytia and are infected upon coculture with HTLV-1-infected lymphocytes. We examined the role of DC-specific ICAM-3-grabbing nonint...

journal_title：Journal of virology

authors： Ceccaldi PE,Delebecque F,Prevost MC,Moris A,Abastado JP,Gessain A,Schwartz O,Ozden S

更新日期：2006-05-01 00:00:00

abstract：:NF-kappaB signaling is critical to the survival and transformation of cells infected by the human gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. Here we have examined how elimination of the NF-kappaB transcription factor p50 from mice affects the life cycle of murine gammaherpesviru...

journal_title：Journal of virology

authors： Krug LT,Collins CM,Gargano LM,Speck SH

更新日期：2009-05-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) is an emerging pathogen and is the causative infectious agent of Kaposi sarcoma and two malignancies of B cell origin. To date, there is no licensed KSHV vaccine. Development of an effective vaccine against KSHV continues to be limited by a poor understanding of how the vir...

journal_title：Journal of virology

authors： Muniraju M,Mutsvunguma LZ,Foley J,Escalante GM,Rodriguez E,Nabiee R,Totonchy J,Mulama DH,Nyagol J,Wussow F,Barasa AK,Brehm M,Ogembo JG

更新日期：2019-07-30 00:00:00

abstract：:Herpesviruses establish latency in suitable host cells after primary infection and persist in their host organisms for life. Most of the viral genes are silenced during latency, also enabling the virus to escape from an immune response. This study addresses the control of viral gene silencing by epigenetic mechanisms,...

journal_title：Journal of virology

authors： Alberter B,Vogel B,Lengenfelder D,Full F,Ensser A

更新日期：2011-06-01 00:00:00

abstract：:Sequences from the 5' end of type 1 human immunodeficiency virus RNA dimerize spontaneously in vitro in a reaction thought to mimic the initial step of genomic dimerization in vivo. Dimer initiation has been proposed to occur through a "kissing-loop" interaction involving a specific RNA stem-loop element designated SL...

journal_title：Journal of virology

authors： Clever JL,Wong ML,Parslow TG

更新日期：1996-09-01 00:00:00

abstract：:The sole immediate-early (IE) gene of equine herpesvirus 1 encodes a 1,487-amino-acid (aa) regulatory phosphoprotein that independently activates expression of early viral genes. Coimmunoprecipitation assays demonstrated that the IE protein physically interacts with the general transcription factor TFIIB. Using a vari...

journal_title：Journal of virology

authors： Jang HK,Albrecht RA,Buczynski KA,Kim SK,Derbigny WA,O'Callaghan DJ

更新日期：2001-11-01 00:00:00

abstract：:Autoradiographic analyses of deoxyribonucleic acid (DNA) synthesis in randomly growing KB cell cultures infected with equine abortion virus (EAV) suggested that viral DNA synthesis was initiated only at times that coincided with the entry of noninfected control cells into the S phase of the cell cycle. Synchronized cu...

journal_title：Journal of virology

authors： Lawrence WC

更新日期：1971-06-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection of children previously immunized with a nonlive, formalin-inactivated (FI)-RSV vaccine has been associated with serious enhanced respiratory disease (ERD). Consequently, detailed studies of potential ERD are a critical step in the development of nonlive RSV vaccines targetin...

journal_title：Journal of virology

authors： Schneider-Ohrum K,Cayatte C,Bennett AS,Rajani GM,McTamney P,Nacel K,Hostetler L,Cheng L,Ren K,O'Day T,Prince GA,McCarthy MP

更新日期：2017-03-29 00:00:00

abstract：:Longitudinal studies of T cell immune responses during viral infections in humans are essential for our understanding of how effector T cell responses develop, clear infection, and provide long-lasting immunity. Here, following an outbreak of a Puumala hantavirus infection in the human population, we longitudinally an...

journal_title：Journal of virology

authors： Lindgren T,Ahlm C,Mohamed N,Evander M,Ljunggren HG,Björkström NK

更新日期：2011-10-01 00:00:00

abstract：:Pestiviruses prevent alpha/beta interferon (IFN-alpha/beta) production by promoting proteasomal degradation of interferon regulatory factor 3 (IRF3) by means of the viral N(pro) nonstructural protein. N(pro) is also an autoprotease, and its amino-terminal coding sequence is involved in translation initiation. We previ...

journal_title：Journal of virology

authors： Ruggli N,Summerfield A,Fiebach AR,Guzylack-Piriou L,Bauhofer O,Lamm CG,Waltersperger S,Matsuno K,Liu L,Gerber M,Choi KH,Hofmann MA,Sakoda Y,Tratschin JD

更新日期：2009-01-01 00:00:00

abstract：:All known DNA tumor viruses are known to target and inactivate two main cell cycle regulatory proteins, retinoblastoma protein (pRb) and p53. Inactivation of pRb promotes host cell cycle progression into S phase, and inactivation of p53 promotes cell immortalization. The DNA tumor virus Kaposi's sarcoma associated her...

journal_title：Journal of virology

authors： Borah S,Verma SC,Robertson ES

更新日期：2004-10-01 00:00:00

abstract：:The generation of cytopathic effects by murine leukemia viruses (MLVs) in different cell types correlates with the ability of the virus to induce thymic lymphoma. We showed that the induction of apoptosis in mink epithelial cells by mink cell focus-forming (MCF) MLV infection results in the accumulation of high levels...

journal_title：Journal of virology

authors： Zhao X,Yoshimura FK

更新日期：2008-03-01 00:00:00

abstract：:Cloned avian leukosis viral DNAs were mutagenized in the long terminal repeat, in the leader sequence for env mRNA, and at the poly-env junction. The effect of these mutations in the viral DNA upon its ability to direct virus production or env mRNA synthesis was analyzed by microinjecting the mutant DNAs into chicken ...

journal_title：Journal of virology

authors： Pugatsch T,Stacey DW

更新日期：1982-08-01 00:00:00

abstract：:In this work we show evidence of mother-to-offspring transmission in a transgenic mouse line expressing bovine PrP (boTg) experimentally infected by intracerebral administration of bovine spongiform encephalopathy (BSE) prions. PrP(res) was detected in brains of newborns from infected mothers only when mating was allo...

journal_title：Journal of virology

authors： Castilla J,Brun A,Díaz-San Segundo F,Salguero FJ,Gutiérrez-Adán A,Pintado B,Ramírez MA,del Riego L,Torres JM

更新日期：2005-07-01 00:00:00

abstract：:The genome of a canine parvovirus isolate strain (CPV-N) was cloned, and the DNA sequence was determined. The entire genome, including ends, was 5,323 nucleotides in length. The terminal repeat at the 3' end of the genome shared similar structural characteristics but limited homology with the rodent parvoviruses. The ...

journal_title：Journal of virology

authors： Reed AP,Jones EV,Miller TJ

更新日期：1988-01-01 00:00:00

abstract：:Strains of Bacillus that harbor defective phage PBSX were found to be insensitive to SP-10(C), although the phage adsorbed to these insensitive strains. Strains that did not carry the phage were sensitive to SP-10(C). B. subtilis 168 ind(-), which can be tranduced by SP-10(C) but is nonpermissive for the phage, was re...

journal_title：Journal of virology

authors： Goldberg ID,Bryan T

更新日期：1968-08-01 00:00:00

abstract：:This paper reports the use of zonal ultracentrifuge techniques to conduct biophysical studies of rhinoviruses grown with WI-38 cells. Good clean-out of infectivity from rhinovirus harvests was obtained with the continuous-flow B-V and B-IX rotors. Use of the B-V rotor resulted in the successful concentration of rhinov...

journal_title：Journal of virology

authors： Gerin JL,Richter WR,Fenters JD,Holper JC

更新日期：1968-09-01 00:00:00

abstract：:Many complex viruses use an assembly pathway in which their genome is packaged into an empty procapsid which subsequently matures into its final expanded form. We utilized Pseudomonas phage 6, a well-established virus assembly model, to probe the plasticity of the procapsid maturation pathway. The 6 packaging nucleosi...

journal_title：Journal of virology

authors： Sun X,Pirttimaa MJ,Bamford DH,Poranen MM

更新日期：2013-12-01 00:00:00

abstract：:In Escherichia coli B infected with phage T4 with mutations in gene 55 the shut-off of synthesis of two early enzymes was found to be delayed 10 to 15 min as compared to wild-type T4 infection. The kinetics of early enzyme formation was very similar to that obtained after DNA-negative mutant infection. The transcripti...

journal_title：Journal of virology

authors： Bolund C

更新日期：1973-07-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) capsid is a T=16 icosahedral shell that forms in the nuclei of infected cells. Capsid assembly also occurs in vitro in reaction mixtures created from insect cell extracts containing recombinant baculovirus-expressed HSV-1 capsid proteins. During capsid formation, the major capsi...

journal_title：Journal of virology

authors： Spencer JV,Newcomb WW,Thomsen DR,Homa FL,Brown JC

更新日期：1998-05-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a single-stranded DNA virus with a unique biphasic lifestyle consisting of both a productive and a latent phase. Typically, the productive phase requires coinfection with a helper virus, for instance adenovirus, while the latent phase dominates in healthy cells. In the latent state, AAV...

journal_title：Journal of virology

authors： Hamilton H,Gomos J,Berns KI,Falck-Pedersen E

更新日期：2004-08-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) and HSV-2 are large, double-stranded DNA viruses that cause lifelong persistent infections characterized by periods of quiescence and recurrent disease. How HSV evolves within an infected individual experiencing multiple episodes of recurrent disease over time is not known. We determined...

journal_title：Journal of virology

authors： Minaya MA,Jensen TL,Goll JB,Korom M,Datla SH,Belshe RB,Morrison LA

更新日期：2017-11-14 00:00:00

abstract：:Infection by rat virus has been studied in cultures of rat embryo cells to evaluate the Margolis-Kilham hypothesis that the virus preferentially infects tissues with actively dividing cells. An enhancement of infection was seen in cultures infected 10 hr after fresh medium was added as compared to infection of station...

journal_title：Journal of virology

authors： Tennant RW,Layman KR,Hand RE

更新日期：1969-12-01 00:00:00

abstract：UNLABELLED:A hallmark of Ebola virus (EBOV) infection is the formation of viral inclusions in the cytoplasm of infected cells. These viral inclusions contain the EBOV nucleocapsids and are sites of viral replication and nucleocapsid maturation. Although there is growing evidence that viral inclusions create a protected...

journal_title：Journal of virology

authors： Nelson EV,Schmidt KM,Deflubé LR,Doğanay S,Banadyga L,Olejnik J,Hume AJ,Ryabchikova E,Ebihara H,Kedersha N,Ha T,Mühlberger E

更新日期：2016-07-27 00:00:00

abstract：:A panel of murine monoclonal antibodies (MAbs) to the human immunodeficiency virus type 1 trans-activator tat protein were characterized. The anti-tat MAbs were mapped to the different domains of the tat protein by Western blot (immunoblot) and Pepscan analyses. One-half of the MAbs tested mapped to the amino-terminal...

journal_title：Journal of virology

authors： Brake DA,Goudsmit J,Krone WJ,Schammel P,Appleby N,Meloen RH,Debouck C

更新日期：1990-02-01 00:00:00

abstract：:Rotavirus infection is one of the most common causes of diarrheal illness in humans. In neonatal mice, rhesus rotavirus (RRV) can induce biliary atresia (BA), a disease resulting in inflammatory obstruction of the extrahepatic biliary tract and intrahepatic bile ducts. We previously showed that the amino acid arginine...

journal_title：Journal of virology

authors： Mohanty SK,Donnelly B,Dupree P,Lobeck I,Mowery S,Meller J,McNeal M,Tiao G

更新日期：2017-07-12 00:00:00

abstract：:Purified Friend viruses obtained from chronically infected tissue cultures were studied under the electron microscope in an effort to correlate the fine structure of the particles to their leukemogenic activity under varied experimental conditions, i.e., temperature treatments and exposure to Tween 80, amyl acetate, o...

journal_title：Journal of virology

authors： De Tkaczevski L,De Harven E,Friend C

更新日期：1968-04-01 00:00:00

abstract：:Positional homologs to the UL51 open reading frame of herpes simplex virus type 1 have been identified throughout the herpesvirus family. However, no respective protein has so far been described for any of the herpesviruses. With rabbit antisera directed against oligopeptides predicted to comprise antigenic regions of...

journal_title：Journal of virology

authors： Lenk M,Visser N,Mettenleiter TC

更新日期：1997-07-01 00:00:00