Expression of murine leukemia virus envelope protein is sufficient for the induction of apoptosis.

Abstract:

:The generation of cytopathic effects by murine leukemia viruses (MLVs) in different cell types correlates with the ability of the virus to induce thymic lymphoma. We showed that the induction of apoptosis in mink epithelial cells by mink cell focus-forming (MCF) MLV infection results in the accumulation of high levels of both unintegrated viral DNA and the envelope precursor polyprotein (gPr80(env)). Comparisons of envelope protein expression levels of plasmid clones of the env gene of the MCF13 and noncytopathic NZB-9 MLV strains demonstrated that the accumulation of MCF13 gPr80(env) results in endoplasmic reticulum stress and is sufficient for the induction of apoptosis.

journal_name

J Virol

journal_title

Journal of virology

authors

Zhao X,Yoshimura FK

doi

10.1128/JVI.02291-07

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

2586-9

issue

5

eissn

0022-538X

issn

1098-5514

pii

JVI.02291-07

journal_volume

82

pub_type

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