Mapping the in vivo arrangement of nucleosomes on simian virus 40 chromatin by the photoaddition of radioactive hydroxymethyltrimethylpsoralen.

abstract：:Adenovirus infections cause significant morbidity and mortality in immunocompromised patients, yet little is known about the immune response to adenovirus infections. We established a system for the generation of a cytotoxic immune response to adenovirus in vitro. Cytotoxic T cells (CTLs) were derived from normal dono...

journal_title：Journal of virology

authors： Smith CA,Woodruff LS,Kitchingman GR,Rooney CM

更新日期：1996-10-01 00:00:00

abstract：UNLABELLED:Susceptibility or resistance to prion infection in humans and animals depends on single prion protein (PrP) amino acid substitutions in the host, but the agent's modulating role has not been well investigated. Compared to disease incubation times in wild-type homozygous ARQ/ARQ (where each triplet represents...

journal_title：Journal of virology

authors： Langeveld JP,Jacobs JG,Hunter N,van Keulen LJ,Lantier F,van Zijderveld FG,Bossers A

更新日期：2015-10-28 00:00:00

abstract：:Although parvoviruses are found throughout the animal kingdom, only the human pathogenic B19 virus has so far been shown to possess a limited host range, with erythroid progenitor cells as the main target cells supporting B19 propagation. The underlying mechanism of such erythroid tropism is still unexplained. Synthes...

journal_title：Journal of virology

authors： Pallier C,Greco A,Le Junter J,Saib A,Vassias I,Morinet F

更新日期：1997-12-01 00:00:00

abstract：:BALB/c mice infected on the scarified cornea with herpes simplex virus type 1 strain 35 [HSV-1(35)] rarely developed ocular disease even at challenge doses as high as 10(7) PFU per eye. In contrast, HSV-1(RE) consistently induced stromal keratitis at an inoculum of 2 x 10(4) PFU. The goal of this study was to determin...

journal_title：Journal of virology

authors： Su YH,Oakes JE,Lausch RN

更新日期：1990-05-01 00:00:00

abstract：:To explore the roles played by specific human immunodeficiency virus type 1 (HIV-1) genes in determining the in vivo replicative capacity of AIDS viruses, we have examined the replication kinetics and virus-specific immune responses in rhesus monkeys following infection with two chimeric simian/human immunodeficiency ...

journal_title：Journal of virology

authors： Reimann KA,Li JT,Voss G,Lekutis C,Tenner-Racz K,Racz P,Lin W,Montefiori DC,Lee-Parritz DE,Lu Y,Collman RG,Sodroski J,Letvin NL

更新日期：1996-05-01 00:00:00

abstract：:This study identifies memory cytotoxic T lymphocyte (CTL) epitopes to respiratory syncytial virus (RSV) in healthy South African adults and demonstrates the conservation of those epitopes in circulating field strains of RSV in South Africa. Thirty-seven healthy adults from a population with diverse HLA backgrounds wer...

journal_title：Journal of virology

authors： Venter M,Rock M,Puren AJ,Tiemessen CT,Crowe JE Jr

更新日期：2003-07-01 00:00:00

abstract：:Recent evidence supports a role for vitamin K-dependent coagulation zymogens in adenovirus serotype 5 (Ad5, subgroup C) infection of hepatocytes. Here, we assessed the effect of virus-zymogen interaction on cellular transduction using a panel of fiber (f)-pseudotyped viruses derived from subgroup D (f47, f33, f24, f45...

journal_title：Journal of virology

authors： Parker AL,McVey JH,Doctor JH,Lopez-Franco O,Waddington SN,Havenga MJ,Nicklin SA,Baker AH

更新日期：2007-04-01 00:00:00

abstract：:Rift Valley fever virus (RVFV), a phlebovirus of the Bunyaviridae family, is an arthropod-borne virus which emerges periodically throughout Africa, emphasizing that it poses a major threat for animal and human populations. To assess the genetic variability of RVFV, several isolates from diverse localities of Africa we...

journal_title：Journal of virology

authors： Sall AA,Zanotto PM,Sene OK,Zeller HG,Digoutte JP,Thiongane Y,Bouloy M

更新日期：1999-10-01 00:00:00

abstract：:The alphaherpesvirus proteins UL31 and UL34 and their homologues in other herpesvirus subfamilies cooperate at the nuclear membrane in the export of nascent herpesvirus capsids. We studied the respective betaherpesvirus proteins M53 and M50 in mouse cytomegalovirus (MCMV). Recently, we established a random approach to...

journal_title：Journal of virology

authors： Popa M,Ruzsics Z,Lötzerich M,Dölken L,Buser C,Walther P,Koszinowski UH

更新日期：2010-09-01 00:00:00

abstract：:Retroviral integration has recently been shown to be nonrandom, favoring transcriptionally active regions of chromatin. However, the mechanism for integration site selection by retroviruses is not clear. We show here the occurrence of Alu-like motifs in the sequences flanking the reported viral integration sites that ...

journal_title：Journal of virology

authors： Kumar PP,Mehta S,Purbey PK,Notani D,Jayani RS,Purohit HJ,Raje DV,Ravi DS,Bhonde RR,Mitra D,Galande S

更新日期：2007-06-01 00:00:00

abstract：:We have previously identified 11 epitopes located in two topologically nonoverlapping antigenic sites (A and B) and a third bridging site (C) on the human type 3 parainfluenza virus (PIV3) hemagglutinin-neuraminidase (HN) glycoprotein by using monoclonal antibodies (MAbs) which inhibit hemagglutination and virus infec...

journal_title：Journal of virology

authors： Coelingh KJ,Winter CC,Murphy BR,Rice JM,Kimball PC,Olmsted RA,Collins PL

更新日期：1986-10-01 00:00:00

abstract：:Infection with human papillomavirus (HPV) is a critical factor in the pathogenesis of most cervical cancers and some aerodigestive cancers. The HPV E6 oncoprotein from high-risk HPV types contributes to the immortalization and transformation of cells by multiple mechanisms, including degradation of p53, transcriptiona...

journal_title：Journal of virology

authors： James MA,Lee JH,Klingelhutz AJ

更新日期：2006-06-01 00:00:00

abstract：:Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green mon...

journal_title：Journal of virology

authors： Campillo-Gimenez L,Laforge M,Fay M,Brussel A,Cumont MC,Monceaux V,Diop O,Lévy Y,Hurtrel B,Zaunders J,Corbeil J,Elbim C,Estaquier J

更新日期：2010-02-01 00:00:00

abstract：:The RNA-dependent RNA polymerase of influenza A virus is composed of three subunits that together synthesize all viral mRNAs and also replicate the viral genomic RNA segments (vRNAs) through intermediates known as cRNAs. Here we describe functional characterization of 16 site-directed mutants of one polymerase subunit...

journal_title：Journal of virology

authors： Regan JF,Liang Y,Parslow TG

更新日期：2006-01-01 00:00:00

abstract：:The promoter P7535 of human papillomavirus type 8 and the promoter P7185 of bovine papillomavirus type 1 are negatively regulated by viral E2 proteins via the promoter proximal binding sites P2 and BS1, respectively. Mutations of these E2 binding sites can reduce basal promoter activity. This suggests binding of a tra...

journal_title：Journal of virology

authors： Schmidt HM,Steger G,Pfister H

更新日期：1997-10-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) envelope protein is required for virus spread. This study further characterizes the role of the envelope protein in HTLV-1 immortalization. Viruses with single amino acid substitutions within the SU protein at residue 75, 81, 95, 101, 105, or 195 or with a C-terminal cyt...

journal_title：Journal of virology

authors： Tsukahara T,Wielgosz MM,Ratner L

更新日期：2001-10-01 00:00:00

abstract：:Expression of the human ADA cDNA encoded by the Moloney murine leukemia virus spliced RNA form is enhanced by intron-contained sequences. The presence of sequences corresponding to the viral gag gene in a Moloney murine leukemia virus-based vector results in the generation of 10- to 40-fold higher titers of virus. ...

journal_title：Journal of virology

authors： Armentano D,Yu SF,Kantoff PW,von Ruden T,Anderson WF,Gilboa E

更新日期：1987-05-01 00:00:00

abstract：:Xenotransplantation of porcine organs carries the risk of reactivation of latent virus in donor and recipient tissues as well as transmission of viruses between species. We have investigated the activation of baboon cytomegalovirus (BCMV) and porcine CMV (PCMV) in a pig-to-primate model of xenotransplantation. Tissues...

journal_title：Journal of virology

authors： Mueller NJ,Barth RN,Yamamoto S,Kitamura H,Patience C,Yamada K,Cooper DK,Sachs DH,Kaur A,Fishman JA

更新日期：2002-05-01 00:00:00

abstract：:Infection of macaque monkeys with simian immunodeficiency virus (SIV) is probably the best animal model currently available for studying acquired immunodeficiency syndrome. In this report, we describe three infectious molecular clones of SIVmac and one of human immunodeficiency virus type 2 (HIV-2) and their use in th...

journal_title：Journal of virology

authors： Naidu YM,Kestler HW 3rd,Li Y,Butler CV,Silva DP,Schmidt DK,Troup CD,Sehgal PK,Sonigo P,Daniel MD

更新日期：1988-12-01 00:00:00

abstract：:Natural killer T (NKT) cells are unique T lymphocytes that recognize CD1d-bound lipid antigens and play an important role in both innate and acquired immune responses against infectious diseases and tumors. We have already shown that a vesicular stomatitis virus (VSV) infection results in the rapid inhibition of murin...

journal_title：Journal of virology

authors： Renukaradhya GJ,Khan MA,Shaji D,Brutkiewicz RR

更新日期：2008-12-01 00:00:00

abstract：:In order to elucidate the molecular mechanisms of action of the tat-responsive sequence, mutational analysis of the tat-responsive sequence was carried out. The most critical region comprised nucleotides +18 to +44 and included the 3-nucleotide bulge at positions +23 to +25, the loop sequence, and an intact stem. In a...

journal_title：Journal of virology

authors： Roy S,Parkin NT,Rosen C,Itovitch J,Sonenberg N

更新日期：1990-03-01 00:00:00

abstract：:We report several biological activities of a synthetic peptide whose sequence contains the highly conserved region of feline leukemia virus transmembrane protein (TM) synthetically linked to another short TM-derived sequence particularly rich in polar positive residues. This 29-amino-acid peptide blocked [3H]thymidine...

journal_title：Journal of virology

authors： Wegemer DE,Kabat KG,Kloetzer WS

更新日期：1990-04-01 00:00:00

abstract：:The genome of varicella-zoster virus (VZV) is a linear, double-stranded molecule of DNA composed of a long (L) region covalently linked to a short (S) region. The S region is capable of inverting relative to a fixed orientation of the L region, giving rise to two equimolar populations. We have investigated other forms...

journal_title：Journal of virology

authors： Kinchington PR,Reinhold WC,Casey TA,Straus SE,Hay J,Ruyechan WT

更新日期：1985-10-01 00:00:00

abstract：:The oligosaccharide processing and secretion of hepatitis B surface antigen (HBsAg) was studied in Chinese hamster ovary cells stably transfected with the gene coding HBsAg. HBsAg was secreted from cells with a relatively long half time (ca. 5 h). This appeared to be a characteristic of HBsAg itself, since HBsAg-produ...

journal_title：Journal of virology

authors： Patzer EJ,Nakamura GR,Yaffe A

更新日期：1984-08-01 00:00:00

abstract：:Three fish retroviruses infecting walleyes constitute the recently recognized genus called epsilonretrovirus. The founding member of this group, walleye dermal sarcoma virus (WDSV), induces benign skin tumors in the infected fish and replicates near 4 degrees C. While the viral genomic sequence is known, biochemical c...

journal_title：Journal of virology

authors： Fodor SK,Vogt VM

更新日期：2002-05-01 00:00:00

abstract：:Proteins specific for human herpesvirus 6 (HHV-6)-infected human T cells (HSB-2) were examined by using polyclonal rabbit antibodies and monoclonal antibodies against HHV-6-infected cells and human sera. More than 20 proteins and six glycoproteins specific for HHV-6-infected cells were identified from [35S]methionine-...

journal_title：Journal of virology

authors： Balachandran N,Amelse RE,Zhou WW,Chang CK

更新日期：1989-06-01 00:00:00

abstract：:The cloned murine cytolytic T-lymphocyte line IE1-IL and several sublines detect a murine cytomegalovirus immediate-early (IE) membrane determinant in conjunction with Ld class I major histocompatibility glycoprotein. The lines retained cytolytic activity, strict antigen specificity, and self-restriction even when ada...

journal_title：Journal of virology

authors： Reddehase MJ,Fibi MR,Keil GM,Koszinowski UH

更新日期：1986-12-01 00:00:00

abstract：:The hepadnavirus P gene contains amino acid sequences which share homology with all known RNases H. In this study, we made four mutants in which single amino acids of the duck hepatitis B virus (DHBV) RNase H region were altered. In two of them, amino acids at locations comprising the putative catalytic site were chan...

journal_title：Journal of virology

authors： Chen Y,Marion PL

更新日期：1996-09-01 00:00:00

abstract：:Efficient T-cell responses against recombinant antigens expressed by vaccinia virus vectors require expression of these antigens in the early phase of the virus replication cycle. The kinetics of recombinant gene expression in poxviruses are largely determined by the promoter chosen. We used the highly attenuated modi...

journal_title：Journal of virology

authors： Baur K,Brinkmann K,Schweneker M,Pätzold J,Meisinger-Henschel C,Hermann J,Steigerwald R,Chaplin P,Suter M,Hausmann J

更新日期：2010-09-01 00:00:00

abstract：:Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives. It has been shown previously that HRSV nonstructural proteins 1 and 2 (NS1 and NS2) inhibit th...

journal_title：Journal of virology

authors： Spann KM,Tran KC,Collins PL

更新日期：2005-05-01 00:00:00