Syncytium formation by recombinant vaccinia viruses carrying bovine parainfluenza 3 virus envelope protein genes.

abstract：:The enhancer within the long terminal repeats (LTRs) of acquired somatic mouse mammary tumor viruses (MMTV) can activate juxtaposed genes and induce mammary tumors. In contrast, germ line proviral MMTV genomes are integrated in the host genome and considered to be genetically confined transcription units. Here we demo...

journal_title：Journal of virology

authors： Stegalkina SS,Guerrero A,Walton KD,Liu X,Robinson GW,Hennighausen L

更新日期：1999-10-01 00:00:00

abstract：:The family Bunyaviridae is the most diversified family of RNA viruses. We describe a novel prototypic bunyavirus, tentatively named Gouléako virus, isolated from various mosquito species trapped in Côte d'Ivoire. The S segment comprised 1,087 nucleotides (nt), the M segment 3,188 nt, and the L segment 6,358 nt, consti...

journal_title：Journal of virology

authors： Marklewitz M,Handrick S,Grasse W,Kurth A,Lukashev A,Drosten C,Ellerbrok H,Leendertz FH,Pauli G,Junglen S

更新日期：2011-09-01 00:00:00

abstract：:The emergence of antiretroviral (ARV) drug-resistant human immunodeficiency virus type 1 (HIV-1) quasispecies is a major cause of treatment failure. These variants are usually replaced by drug-sensitive ones when the selective pressure of the drugs is removed, as the former have reduced fitness in a drug-free environm...

journal_title：Journal of virology

authors： Kijak GH,Simon V,Balfe P,Vanderhoeven J,Pampuro SE,Zala C,Ochoa C,Cahn P,Markowitz M,Salomon H

更新日期：2002-07-01 00:00:00

abstract：:Vif(IIIB), which has been a standard model for the viral infectivity factor of human immunodeficiency virus type 1 (HIV-1), binds the cytidine deaminase APOBEC3G (A3G) and induces its degradation, thereby precluding its lethal incorporation into assembling virions. Additionally, Vif(IIIB) less efficiently degrades A3F...

journal_title：Journal of virology

authors： Marin M,Golem S,Rose KM,Kozak SL,Kabat D

更新日期：2008-01-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) directed against epitopes in the V2 domain of human immunodeficiency virus type 1 gp120 often possess neutralizing activity, but these generally are highly type specific, neutralize only laboratory isolates, or have low potency. The most potent of these is C108g, directed against a type-sp...

journal_title：Journal of virology

authors： Pinter A,Honnen WJ,D'Agostino P,Gorny MK,Zolla-Pazner S,Kayman SC

更新日期：2005-06-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV), a double-stranded RNA virus belonging to the Birnaviridae family, causes immunosuppression in chickens. In this study, we defined the localization of IBDV replication complexes based on colocalization analysis of VP3, the major protein component of IBDV ribonucleoproteins (RNPs)...

journal_title：Journal of virology

authors： Delgui LR,Rodríguez JF,Colombo MI

更新日期：2013-08-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) BamHI-A rightward transcripts (BARTs) are expressed in all EBV-associated tumors as well as in latently infected B cells in vivo and cultured B-cell lines. One of the BART family transcripts contains an open reading frame, RPMS1, that encodes a nuclear protein termed RPMS. Reverse transcri...

journal_title：Journal of virology

authors： Zhang J,Chen H,Weinmaster G,Hayward SD

更新日期：2001-03-01 00:00:00

abstract：:Primary RNA transcripts from the human immunodeficiency virus type 1 (HIV-1) are processed into mature mRNA by a complex series of splicing events. Viral structural proteins and reverse transcriptase are translated from unspliced or singly spliced transcripts. Proteins which control virus replication, including tat, r...

journal_title：Journal of virology

authors： Robert-Guroff M,Popovic M,Gartner S,Markham P,Gallo RC,Reitz MS

更新日期：1990-07-01 00:00:00

abstract：:Mature nonstructural protein-15 (nsp15) from the severe acute respiratory syndrome coronavirus (SARS-CoV) contains a novel uridylate-specific Mn2+-dependent endoribonuclease (NendoU). Structure studies of the full-length form of the obligate hexameric enzyme from two CoVs, SARS-CoV and murine hepatitis virus, and its ...

journal_title：Journal of virology

authors： Joseph JS,Saikatendu KS,Subramanian V,Neuman BW,Buchmeier MJ,Stevens RC,Kuhn P

更新日期：2007-06-01 00:00:00

abstract：:Co-infection of neonatal BALB/c mice with Friend virus (FV) complex (containing defective spleen focus-forming virus [SFFV] and endogenous N-tropic leukemia-inducing helper virus [LLV-F]) and B-tropic Tennant leukemia virus (TenLV) resulted in the inhibition of LLV-F by the Fv-1(b) gene and recovery of a TenLV pseudot...

journal_title：Journal of virology

authors： Eckner RJ

更新日期：1973-09-01 00:00:00

abstract：:An active transcriptive complex was isolated from purified virions of Newcastle disease virus. After disruption with Triton X-100 and high salt, soluble and particulate fractions were separated by density gradient centrifugation. The transcriptive complex, recovered at a density of 1.275 g/cm3, appeared as a nucleocap...

journal_title：Journal of virology

authors： Colonno RJ,Stone HO

更新日期：1976-09-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV), and herpes simplex virus (HSV) have been incurable to date because effective antiviral therapies target only replicating viruses and do not eradicate latently integrated or nonreplicating episomal viral genomes. Endonucleases that can target and cle...

journal_title：Journal of virology

authors： Schiffer JT,Aubert M,Weber ND,Mintzer E,Stone D,Jerome KR

更新日期：2012-09-01 00:00:00

abstract：:Human papillomavirus (HPV) is a strongly conserved DNA virus, high-risk types of which can cause cervical cancer in persistent infections. The most common type found in HPV-attributable cancer is HPV16, which can be subdivided into four lineages (A to D) with different carcinogenic properties. Studies have shown HPV16...

journal_title：Journal of virology

authors： van der Weele P,Meijer CJLM,King AJ

更新日期：2017-09-12 00:00:00

abstract：:The herpes simplex virus genome consists of two components, L and S, that invert relative to each other to yield four isomeric arrangements, prototype (P), inversion of the S component (Is), inversion of the L component (Il), and inversion of both components (Isl). Previous studies have shown that the 500-base-pair a ...

journal_title：Journal of virology

authors： Longnecker R,Roizman B

更新日期：1986-05-01 00:00:00

abstract：:The cytopathic effect (CPE) seen with some subgroups of avian sarcoma and leukosis virus (ASLV) is associated with viral Env activation of the death-promoting activity of TVB (a tumor necrosis factor receptor-related receptor that is most closely related to mammalian TNF-related apoptosis-inducing ligand [TRAIL] recep...

journal_title：Journal of virology

authors： Klucking S,Collins AS,Young JA

更新日期：2005-07-01 00:00:00

abstract：UNLABELLED:Development of a vaccine to prevent congenital cytomegalovirus infection is a major public health priority. Live vaccines attenuated through mutations targeting viral mechanisms responsible for evasion of host defense may be both safe and efficacious. Safety and vaccine efficacy were evaluated using a guinea...

journal_title：Journal of virology

authors： Schleiss MR,Bierle CJ,Swanson EC,McVoy MA,Wang JB,Al-Mahdi Z,Geballe AP

更新日期：2015-10-01 00:00:00

abstract：:Hepatitis B virus (HBV) and woolly monkey hepatitis B virus (WMHBV) are primate hepadnaviruses that display restricted tissue and host tropisms. Hepatitis D virus (HDV) particles pseudotyped with HBV and WMHBV envelopes (HBV-HDV and WM-HDV) preferentially infect human and spider monkey hepatocytes, respectively, there...

journal_title：Journal of virology

authors： Barrera A,Guerra B,Notvall L,Lanford RE

更新日期：2005-08-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is renowned for its very low titer when grown in cultured cells. There remains no single explanation for the low infectivity. In this study, viral particles on the surfaces of infected cells were examined by several imaging technologies. Few surface particles were detected at 48 h postinfe...

journal_title：Journal of virology

authors： Carpenter JE,Hutchinson JA,Jackson W,Grose C

更新日期：2008-03-01 00:00:00

abstract：:We investigated the susceptibilities of Syrian golden hamsters to transmissible spongiform encephalopathy agents from cattle. We report efficient transmission of the L-type atypical bovine spongiform encephalopathy (BSE) agent into hamsters. Importantly, hamsters were also susceptible to the transmissible mink encepha...

journal_title：Journal of virology

authors： Nicot S,Baron T

更新日期：2011-02-01 00:00:00

abstract：:A vaccine regimen that elicits broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine research. In this study, we assessed the immunogenicity of the CAP256 superinfecting viral envelope (CAP256 SU) protein delivered by modified vaccinia virus Ankara (MVA) and DNA vaccines in different prime-boost com...

journal_title：Journal of virology

authors： van Diepen MT,Chapman R,Douglass N,Galant S,Moore PL,Margolin E,Ximba P,Morris L,Rybicki EP,Williamson AL

更新日期：2019-04-03 00:00:00

abstract：:The structural aspects of SH antigen-containing particles were investigated. These studies confirmed the existence of a large spherical particle (ca. 43 nm) and smaller (ca. 20 nm) rod- and sphere-shaped particles. The large particle consists of an outer and inner membrane and a core of "nucleic acid" as seen by posit...

journal_title：Journal of virology

authors： Jokelainen PT,Krohn K,Prince AM,Finlayson ND

更新日期：1970-11-01 00:00:00

abstract：:Previous recombinant Epstein-Barr virus molecular genetic experiments with specifically mutated LMP1 genes indicate that LMP1 is essential for primary B-lymphocyte growth transformation and that the amino-terminal cytoplasmic and first transmembrane domains are together an important mediator of transformation. EBV rec...

journal_title：Journal of virology

authors： Izumi KM,Kaye KM,Kieff ED

更新日期：1994-07-01 00:00:00

abstract：UNLABELLED:Neutralizing antibodies that target the hemagglutinin of influenza virus either inhibit binding of hemagglutinin to cellular receptors or prevent the low-pH-induced conformational change in hemagglutinin required for membrane fusion. In general, the former type of antibody binds to the globular head formed b...

journal_title：Journal of virology

authors： Iba Y,Fujii Y,Ohshima N,Sumida T,Kubota-Koketsu R,Ikeda M,Wakiyama M,Shirouzu M,Okada J,Okuno Y,Kurosawa Y,Yokoyama S

更新日期：2014-07-01 00:00:00

abstract：UNLABELLED:A balance between the functions of the influenza virus surface proteins hemagglutinin (HA) and neuraminidase (NA) is thought to be important for the transmission of viruses between humans. Here we describe two pandemic H1N1 viruses, A/swine/Virginia/1814-1/2012 and A/swine/Virginia/1814-2/2012 (pH1N1low-1 an...

journal_title：Journal of virology

authors： Zanin M,Marathe B,Wong SS,Yoon SW,Collin E,Oshansky C,Jones J,Hause B,Webby R

更新日期：2015-06-01 00:00:00

abstract：:Sequences of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) domain were determined by direct sequencing of HIV-1 RNA in successive plasma samples from eight seroconverting patients infected with virus bearing the T215Y/F amino acid substitution associated with zidovudine (ZDV) resistance. A...

journal_title：Journal of virology

authors： Yerly S,Rakik A,De Loes SK,Hirschel B,Descamps D,Brun-Vézinet F,Perrin L

更新日期：1998-05-01 00:00:00

abstract：:Infectious bursal disease virus (IBDV) is a nonenveloped virus with an icosahedral capsid composed of two proteins, VP2 and VP3, that derive from the processing of the polyprotein NH(2)-pVP2-VP4-VP3-COOH. The virion contains VP1, the viral polymerase, which is both free and covalently linked to the two double-stranded...

journal_title：Journal of virology

authors： Chevalier C,Lepault J,Da Costa B,Delmas B

更新日期：2004-04-01 00:00:00

abstract：:Successfully targeting the airway epithelium is essential for gene therapy of some pulmonary diseases. However, the airway epithelium is resistant to virus-mediated gene transfer with commonly used vectors. Vectors that interact with endogenously expressed receptors on the apical surface significantly increase gene tr...

journal_title：Journal of virology

authors： Rooney CP,Denning GM,Davis BP,Flaherty DM,Chiorini JA,Zabner J

更新日期：2002-10-01 00:00:00

abstract：:Budding of retroviruses from cell membranes requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including endosome sorting complex required for transport III (ESCRT-III) protein complex and vacuolar protein sorting 4 (VPS4) and its ATPase. In response to infection, a cellu...

journal_title：Journal of virology

authors： Kuang Z,Seo EJ,Leis J

更新日期：2011-07-01 00:00:00

abstract：:Nonenveloped gastrointestinal viruses, such as human rotavirus, can exit infected cells from the apical surface without cell lysis. The mechanism of such nonlytic exit is poorly understood. The nonenveloped Orsay virus is an RNA virus infecting the intestine cells of the nematode Caenorhabditis elegans Dye staining re...

journal_title：Journal of virology

authors： Yuan W,Zhou Y,Fan Y,Tao YJ,Zhong W

更新日期：2018-06-29 00:00:00

abstract：:In our search for novel inhibitors of herpes simplex virus type 1 (HSV-1), a new class of thiourea inhibitors was discovered. N-(4-[3-(5-Chloro-2,4-dimethoxyphenyl)-thioureido]-phenyl)-acetamide and its 2-fluoro-benzamide derivative inhibited HSV-1 replication. HSV-2, human cytomegalovirus, and varicella-zoster virus ...

journal_title：Journal of virology

authors： van Zeijl M,Fairhurst J,Jones TR,Vernon SK,Morin J,LaRocque J,Feld B,O'Hara B,Bloom JD,Johann SV

更新日期：2000-10-01 00:00:00