Abstract:
:NF-D is a ubiquitous nuclear factor that has been shown to bind specifically to a DNA element in the polyomavirus regulatory region. In this report, we demonstrate that NF-D is either identical or very similar to a transcription factor that has been variously named YY1, delta, NF-E1, UCRBP, or CF1. Moreover, we show the presence in the polyomavirus genome of a second DNA motif, located 40 bp from the first, which binds YY1/NF-D with high affinity. Both sites lie downstream of the major late transcription initiation sites. By site-directed mutagenesis, we demonstrate that both elements contribute positively to the activity of the late promoter, probably by a cooperative mechanism. We also demonstrate that the requirement of the YY1/NF-D function for late promoter activity varies with the cell line.
journal_name
J Viroljournal_title
Journal of virologyauthors
Martelli F,Iacobini C,Caruso M,Felsani Adoi
10.1128/JVI.70.3.1433-1438.1996subject
Has Abstractpub_date
1996-03-01 00:00:00pages
1433-8issue
3eissn
0022-538Xissn
1098-5514journal_volume
70pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.14.6.1611-1612.1974
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pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.12.6.1195-1203.1973
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01508-19
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.6.3930-3937.1996
更新日期:1996-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.15.4.954-963.1975
更新日期:1975-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.14.1.187-189.1974
更新日期:1974-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05809-11
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.2.3.178-181.1968
更新日期:1968-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.21.10579-10587.2002
更新日期:2002-11-01 00:00:00
abstract::In contrast to humans, several primate species are believed to have harbored simian immunodeficiency viruses (SIVs) since ancient times. In particular, the geographically dispersed species of African green monkeys (AGMs) are all infected with highly diversified SIVagm viruses at high prevalences (greater than 50% of s...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.75.18.8449-8460.2001
更新日期:2001-09-01 00:00:00
abstract::Cytomegaloviruses (CMVs) colonize blood-borne myeloid cells. Murine CMV (MCMV) spreads from the lungs via infected CD11c+ cells, consistent with an important role for dendritic cells (DC). We show here that MCMV entering via the olfactory epithelium, a natural transmission portal, also spreads via infected DC. They re...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00540-19
更新日期:2019-07-17 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01883-13
更新日期:2013-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.43.1.104-112.1982
更新日期:1982-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
abstract::Small aggregates of viral antigen were encountered in the nuclear matrix. The capsids did not tag with antibodies specific for the virus or for the host cell. This observation remains unexplained. Nuclear and cytoplasmic membranes, as well as the envelope of the virus, reacted with both types of antibodies and appear,...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.2.10.1172-1184.1968
更新日期:1968-10-01 00:00:00
abstract::Hepatitis B virus (HBV) and woolly monkey hepatitis B virus (WMHBV) are primate hepadnaviruses that display restricted tissue and host tropisms. Hepatitis D virus (HDV) particles pseudotyped with HBV and WMHBV envelopes (HBV-HDV and WM-HDV) preferentially infect human and spider monkey hepatocytes, respectively, there...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.15.9786-9798.2005
更新日期:2005-08-01 00:00:00