Characterization of two novel YY1 binding sites in the polyomavirus late promoter.


:NF-D is a ubiquitous nuclear factor that has been shown to bind specifically to a DNA element in the polyomavirus regulatory region. In this report, we demonstrate that NF-D is either identical or very similar to a transcription factor that has been variously named YY1, delta, NF-E1, UCRBP, or CF1. Moreover, we show the presence in the polyomavirus genome of a second DNA motif, located 40 bp from the first, which binds YY1/NF-D with high affinity. Both sites lie downstream of the major late transcription initiation sites. By site-directed mutagenesis, we demonstrate that both elements contribute positively to the activity of the late promoter, probably by a cooperative mechanism. We also demonstrate that the requirement of the YY1/NF-D function for late promoter activity varies with the cell line.


J Virol


Journal of virology


Martelli F,Iacobini C,Caruso M,Felsani A




Has Abstract


1996-03-01 00:00:00












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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Belser JA,Wadford DA,Pappas C,Gustin KM,Maines TR,Pearce MB,Zeng H,Swayne DE,Pantin-Jackwood M,Katz JM,Tumpey TM

    更新日期:2010-05-01 00:00:00

  • Identification of an essential region for internal initiation of translation in the aphthovirus internal ribosome entry site and implications for viral evolution.

    abstract::Translation of aphthovirus RNA is initiated at an internal ribosome entry site (IRES) element, preceding the first functional AUG initiation codon. The effect of mutations at the base of domain 3 of the aphthovirus IRES on translation activity has been analyzed by site-directed mutagenesis and expression of bicistroni...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Martínez-Salas E,Regalado MP,Domingo E

    更新日期:1996-02-01 00:00:00

  • Standardized and highly efficient expansion of Epstein-Barr virus-specific CD4+ T cells by using virus-like particles.

    abstract::Epstein-Barr virus (EBV)-specific T-cell lines generated by repeated stimulation with EBV-immortalized lymphoblastoid B-cell lines (LCL) have been successfully used to treat EBV-associated posttransplant lymphoproliferative disease (PTLD) in hematopoietic stem cell transplant recipients. However, PTLD in solid-organ t...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Adhikary D,Behrends U,Feederle R,Delecluse HJ,Mautner J

    更新日期:2008-04-01 00:00:00

  • Effects of altering the transcription termination signals of respiratory syncytial virus on viral gene expression and growth in vitro and in vivo.

    abstract::Nonsegmented negative-sense RNA viruses (mononegaviruses) control viral gene expression largely through a transcription gradient such that promoter-proximal genes are transcribed more abundantly than downstream genes. For some paramyxoviruses, naturally occurring differences in the levels of efficiency of transcriptio...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Tran KC,Collins PL,Teng MN

    更新日期:2004-01-01 00:00:00

  • Apoptosis of hepatitis B virus-infected hepatocytes prevents release of infectious virus.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Arzberger S,Hösel M,Protzer U

    更新日期:2010-11-01 00:00:00

  • Influenza A virus acquires enhanced pathogenicity and transmissibility after serial passages in swine.

    abstract::Genetic and phylogenetic analyses suggest that the pandemic H1N1/2009 virus was derived from well-established swine influenza lineages; however, there is no convincing evidence that the pandemic virus was generated from a direct precursor in pigs. Furthermore, the evolutionary dynamics of influenza virus in pigs have ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Wei K,Sun H,Sun Z,Sun Y,Kong W,Pu J,Ma G,Yin Y,Yang H,Guo X,Chang KC,Liu J

    更新日期:2014-10-01 00:00:00

  • Spatiotemporal analysis of purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Williams BL,Yaddanapudi K,Hornig M,Lipkin WI

    更新日期:2007-03-01 00:00:00

  • Equine infectious anemia virus and the ubiquitin-proteasome system.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ott DE,Coren LV,Sowder RC 2nd,Adams J,Nagashima K,Schubert U

    更新日期:2002-03-01 00:00:00

  • Expression of the Pseudorabies Virus gB Glycoprotein Triggers NK Cell Cytotoxicity and Increases Binding of the Activating NK Cell Receptor PILRβ.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: De Pelsmaeker S,Dierick E,Klupp B,Mettenleiter TC,Cantoni C,Vitale M,Favoreel HW

    更新日期:2019-03-21 00:00:00

  • Fish rhabdovirus cell entry is mediated by fibronectin.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Bearzotti M,Delmas B,Lamoureux A,Loustau AM,Chilmonczyk S,Bremont M

    更新日期:1999-09-01 00:00:00

  • Restriction endonuclease mapping of unintegrated proviral DNA of Snyder-Theilen feline sarcoma virus: localization of sarcoma-specific sequences.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Sherr CJ,Fedele LA,Donner L,Turek LP

    更新日期:1979-12-01 00:00:00

  • DNA polymerase associated with human hepatitis B antigen.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kaplan PM,Greenman RL,Gerin JL,Purcell RH,Robinson WS

    更新日期:1973-11-01 00:00:00

  • The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Calothy G,Laugier D,Cross FR,Jove R,Hanafusa T,Hanafusa H

    更新日期:1987-05-01 00:00:00

  • Granulosis virus deoxyribonucleic acid: a closed, double-stranded molecule.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Summers MD,Anderson DL

    更新日期:1972-04-01 00:00:00

  • Full genomic sequence of the prototype strain (M64) of Rio Bravo virus.

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    pub_type: 杂志文章


    authors: Volkova E,Tesh RB,Monath TP,Vasilakis N

    更新日期:2012-04-01 00:00:00

  • rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Silverman RH,Skehel JJ,James TC,Wreschner DH,Kerr IM

    更新日期:1983-06-01 00:00:00

  • Widely conserved recombination patterns among single-stranded DNA viruses.

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Lefeuvre P,Lett JM,Varsani A,Martin DP

    更新日期:2009-03-01 00:00:00

  • An Epstein-Barr Virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model.

    abstract::Immunosuppressed patients are at risk for developing Epstein-Barr Virus (EBV)-positive lymphomas that express the major EBV oncoprotein, LMP1. Although increasing evidence suggests that a small number of lytically infected cells may promote EBV-positive lymphomas, the impact of enhanced lytic gene expression on the ab...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Ma SD,Yu X,Mertz JE,Gumperz JE,Reinheim E,Zhou Y,Tang W,Burlingham WJ,Gulley ML,Kenney SC

    更新日期:2012-08-01 00:00:00

  • In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation.

    abstract::The contribution of the hepatitis B virus enhancers I and II in the regulation of the activity of the core and the X promoters was assessed in transgenic mice. Surprisingly, despite the presence of heterologous promoters linked 5' of the X gene, the transgene expression is mostly due to core promoter (Cp) activity pre...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Billet O,Grimber G,Levrero M,Seye KA,Briand P,Joulin V

    更新日期:1995-09-01 00:00:00

  • Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation.

    abstract::Paramyxoviral RNAs are synthesized by a viral RNA-dependent RNA polymerase (RdRp) consisting of the large (L) protein and its cofactor phosphoprotein (P protein). The L protein is a multifunctional protein that catalyzes RNA synthesis, mRNA capping, and mRNA polyadenylation. Growing evidence shows that the stability o...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Katoh H,Kubota T,Nakatsu Y,Tahara M,Kidokoro M,Takeda M

    更新日期:2017-02-28 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Wiegers K,Uhlig H,Dernick R

    更新日期:1988-05-01 00:00:00

  • Fusion formation by the uncleaved spike protein of murine coronavirus JHMV variant cl-2.

    abstract::The fusogenic properties of the uncleaved spike (S) protein of murine coronavirus JHMV variant cl-2 were studied by expressing the S protein with a deleted putative cleavage site. The amino acid sequence of the putative cleavage site, Arg-Arg-Ala-Arg-Arg, was replaced by Arg-Thr-Ala-Leu-Glu by in vitro mutagenesis of ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Taguchi F

    更新日期:1993-03-01 00:00:00

  • The Human Cytomegalovirus UL116 Gene Encodes an Envelope Glycoprotein Forming a Complex with gH Independently from gL.

    abstract:UNLABELLED:Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and is the leading viral cause of birth defects after congenital infection. HCMV infection relies on the recognition of cell-specific receptors by one of the viral envelope glycoprotein complexes. Either the gH/gL...

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    pub_type: 杂志文章


    authors: Caló S,Cortese M,Ciferri C,Bruno L,Gerrein R,Benucci B,Monda G,Gentile M,Kessler T,Uematsu Y,Maione D,Lilja AE,Carfí A,Merola M

    更新日期:2016-04-29 00:00:00

  • Norovirus genome circularization and efficient replication are facilitated by binding of PCBP2 and hnRNP A1.

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    pub_type: 杂志文章


    authors: López-Manríquez E,Vashist S,Ureña L,Goodfellow I,Chavez P,Mora-Heredia JE,Cancio-Lonches C,Garrido E,Gutiérrez-Escolano AL

    更新日期:2013-11-01 00:00:00

  • Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease.

    abstract::African green monkeys can maintain long-term persistent infection with simian immunodeficiency viruses (SIVagm) without developing AIDS and thus provide an important model for understanding mechanisms of natural host resistance to disease. This study assessed the levels and anatomic distribution of SIVagm in healthy, ...

    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Broussard SR,Staprans SI,White R,Whitehead EM,Feinberg MB,Allan JS

    更新日期:2001-03-01 00:00:00

  • Cell fusion by canine distemper virus-infected cells.

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    journal_title:Journal of virology

    pub_type: 杂志文章


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    更新日期:1972-12-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Kawano H,Rostapshov V,Rosen L,Lai CJ

    更新日期:1993-11-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Gerlach JT,Ulsenheimer A,Grüner NH,Jung MC,Schraut W,Schirren CA,Heeg M,Scholz S,Witter K,Zahn R,Vogler A,Zachoval R,Pape GR,Diepolder HM

    更新日期:2005-10-01 00:00:00

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    journal_title:Journal of virology

    pub_type: 杂志文章


    authors: Scofield MS,Collinsworth WL,Mathews CK

    更新日期:1974-04-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1999-10-01 00:00:00