Abstract:
:The gamma(1)34.5 protein, a virulence factor of herpes simplex viruses, redirects protein phosphatase 1 to dephosphorylate the alpha subunit of translation initiation factor 2 (eIF2alpha). Additionally, it inhibits the induction of antiviral genes by TANK-binding kinase 1. Nevertheless, its precise role in vivo remains to be established. Here we show that eIF2alpha dephosphorylation by gamma(1)34.5 is crucial for viral neuroinvasion. V(193)E and F(195)L substitutions in gamma(1)34.5 abrogate viral replication in the eye and spread to the trigeminal ganglia and brain. Intriguingly, inhibition of antiviral gene induction by gamma(1)34.5 is not sufficient to exhibit viral virulence.
journal_name
J Viroljournal_title
Journal of virologyauthors
Verpooten D,Feng Z,Valyi-Nagy T,Ma Y,Jin H,Yan Z,Zhang C,Cao Y,He Bdoi
10.1128/JVI.01431-09subject
Has Abstractpub_date
2009-12-01 00:00:00pages
12626-30issue
23eissn
0022-538Xissn
1098-5514pii
JVI.01431-09journal_volume
83pub_type
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pub_type: 杂志文章
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