p21 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature sensitive for the maintenance of transformation.

abstract：:Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus, we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replic...

journal_title：Journal of virology

authors： Jones JC,Baranovich T,Zaraket H,Guan Y,Shu Y,Webby RJ,Webster RG

更新日期：2013-11-01 00:00:00

abstract：:The Rev protein of human immunodeficiency virus type 1 (HIV-1) is essential for the expression of the structural genes of HIV-1. To determine whether a functional threshold level of Rev is required to allow efficient HIV-1 replication, CD4-positive HeLa cells, constitutively expressing a Rev-deficient provirus, were t...

journal_title：Journal of virology

authors： Pomerantz RJ,Seshamma T,Trono D

更新日期：1992-03-01 00:00:00

abstract：:The small envelope protein (E) plays a role of central importance in the assembly of coronaviruses. This was initially established by studies demonstrating that cellular expression of only E protein and the membrane protein (M) was necessary and sufficient for the generation and release of virus-like particles. To inv...

journal_title：Journal of virology

authors： Kuo L,Hurst KR,Masters PS

更新日期：2007-03-01 00:00:00

abstract：:Paramyxoviruses such as human parainfluenza viruses that bear inserts encoding protective antigens of heterologous viruses can induce an effective immunity against the heterologous viruses in experimental animals. However, vectors based on common human pathogens would be expected to be restricted in replication in the...

journal_title：Journal of virology

authors： Bukreyev A,Huang Z,Yang L,Elankumaran S,St Claire M,Murphy BR,Samal SK,Collins PL

更新日期：2005-11-01 00:00:00

abstract：:The S protein of bovine coronavirus (BCV) has been isolated from the viral membrane and purified by gradient centrifugation. Purified S protein was identified as a viral hemagglutinin. Inactivation of the cellular receptors by sialate 9-O-acetylesterase and generation of receptors by sialylation of erythrocytes with N...

journal_title：Journal of virology

authors： Schultze B,Gross HJ,Brossmer R,Herrler G

更新日期：1991-11-01 00:00:00

abstract：:Recently, significant numbers of individuals with primary human immunodeficiency virus (HIV) infection have been found to harbor viral strains with reduced susceptibility to antiretroviral drugs. In one study, HIV from 16% of such antiretroviral-naive individuals was shown to have a susceptibility to nonnucleoside rev...

journal_title：Journal of virology

authors： Brown AJ,Precious HM,Whitcomb JM,Wong JK,Quigg M,Huang W,Daar ES,D'Aquila RT,Keiser PH,Connick E,Hellmann NS,Petropoulos CJ,Richman DD,Little SJ

更新日期：2000-11-01 00:00:00

abstract：UNLABELLED:Gammaherpesviruses establish persistent, systemic infections and cause cancers. Murid herpesvirus 4 (MuHV-4) provides a unique window into the early events of host colonization. It spreads via lymph nodes. While dendritic cells (DC) pass MuHV-4 to lymph node B cells, subcapsular sinus macrophages (SSM), whic...

journal_title：Journal of virology

authors： Lawler C,Tan CS,Simas JP,Stevenson PG

更新日期：2016-09-29 00:00:00

abstract：:In vitro studies have suggested an important role for the minor capsid protein (VP1) unique region and the junction between VP1 and the major capsid protein (VP2) in the neutralizing immune response to B19 parvovirus. We investigated the role of the NH2-terminal region of the major structural protein in capsid structu...

journal_title：Journal of virology

authors： Kawase M,Momoeda M,Young NS,Kajigaya S

更新日期：1995-10-01 00:00:00

abstract：:The interaction of the human immunodeficiency virus type 1 (HIV-1) Pr55Gag molecule with the plasma membrane of an infected cell is an essential step of the viral life cycle. Myristic acid and positively charged residues within the N-terminal portion of MA constitute the membrane-binding domain of Pr55Gag. A separate ...

journal_title：Journal of virology

authors： Sandefur S,Varthakavi V,Spearman P

更新日期：1998-04-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection causes substantial morbidity and some deaths in the young and elderly worldwide. There is no safe and effective vaccine available, although it is possible to reduce the hospitalization rate for high-risk children by anti-RSV antibody prophylaxis. RSV has been shown to modify...

journal_title：Journal of virology

authors： Zhang W,Choi Y,Haynes LM,Harcourt JL,Anderson LJ,Jones LP,Tripp RA

更新日期：2010-01-01 00:00:00

abstract：:The matrix (M1) protein of influenza virus is a major structural component, involved in regulation of viral ribonucleoprotein transport into and out of the nucleus. Early in infection, M1 is distributed in the nucleus, whereas later, it is localized predominantly in the cytoplasm. Using immunofluorescence microscopy a...

journal_title：Journal of virology

authors： Whittaker G,Kemler I,Helenius A

更新日期：1995-01-01 00:00:00

abstract：:Three plaque isolates of SV40 strain 777 and 1 plaque isolate of strain 776 were grown to high-titer stocks and serially passaged, undiluted, in monkey BS-C-1 cells. In each case, the serial passaging procedure resulted in the accumulation of closed-circular SV40 DNA molecules containing covalently linked sequences ho...

journal_title：Journal of virology

authors： Lavi S,Rozenblatt S,Singer MF,Winocour E

更新日期：1973-09-01 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV), a member of the Picornaviridae, is a pathogen of cloven-hoofed animals and causes a disease of major economic importance. Picornavirus-infected cells show changes in cell morphology and rearrangement of cytoplasmic membranes, which are a consequence of virus replication. We show he...

journal_title：Journal of virology

authors： Armer H,Moffat K,Wileman T,Belsham GJ,Jackson T,Duprex WP,Ryan M,Monaghan P

更新日期：2008-11-01 00:00:00

abstract：:Polypeptides synthesized in Newcastle disease virus (NDV)-infected CHO cells in the absence of glycosylation were characterized. Incorporation of either [3H]mannose of [3H]glucosamine into NDV polypeptides was inhibited to greater than 99% by the antibiotic tunicamycin. Under these conditions, infected cells synthesiz...

journal_title：Journal of virology

authors： Morrison TG,Simpson D

更新日期：1980-10-01 00:00:00

abstract：:An immunodominant envelope glycoprotein is encoded by the human herpesvirus 8 (HHV-8) (also termed Kaposi's sarcoma-associated herpesvirus) K8.1 gene. The functional role of glycoprotein K8.1 is unknown, and recognizable sequence homology to K8.1 is not detectable in the genomes of most other closely related gammaherp...

journal_title：Journal of virology

authors： Birkmann A,Mahr K,Ensser A,Yağuboğlu S,Titgemeyer F,Fleckenstein B,Neipel F

更新日期：2001-12-01 00:00:00

abstract：:Coronaviruses that infect humans belong to the Alpha-coronavirus (including HCoV-229E) and Beta-coronavirus (including SARS-CoV and SARS-CoV-2) genera. In particular, SARS-CoV-2 is currently a major threat to public health worldwide. The spike (S) homotrimers bind to their receptors via the receptor-binding domain (RB...

journal_title：Journal of virology

authors： Shi Y,Shi J,Sun L,Tan Y,Wang G,Guo F,Hu G,Fu Y,Fu ZF,Xiao S,Peng G

更新日期：2021-01-07 00:00:00

abstract：:The Epstein-Barr virus oriP, when examined with the use of in vitro nucleosome reconstitution, was found to exhibit a partial sparing of nucleosome assembly within the 3' dyad. Analysis of the homologous region containing the origin of replication of herpesvirus papio disclosed that sparing of nucleosome assembly was ...

journal_title：Journal of virology

authors： Sexton CJ,Pagano JS

更新日期：1989-12-01 00:00:00

abstract：UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) typically displays two different phases in its life cycle, the default latent phase and the lytic phase. There is a short period of lytic gene expression in the early stage of KSHV primary infection. The factors involved in the shutdown process of lytic gene exp...

journal_title：Journal of virology

authors： Sun R,Liang D,Gao Y,Lan K

更新日期：2014-07-01 00:00:00

abstract：:The infection of cells which belong to the B-cell lineage is thought to be the primary event leading to the phenotypic and functional alterations seen in the murine AIDS (M. Huang, C. Simard, D. Kay, and P. Jolicoeur, J. Virol. 65:6562-6571, 1991). Using in situ hybridization, we studied the time course of the anatomi...

journal_title：Journal of virology

authors： Simard C,Huang M,Jolicoeur P

更新日期：1994-03-01 00:00:00

abstract：:We have studied protein synthesis in cultured cells infected with the six noncytopathic (nc) mutants of the Australia-Victoria strain (AV-WT) of Newcastle disease virus and their plaque-forming revertants. Virus-specific polypeptides accumulated at 30 to 63% of wild-type levels in nc mutant-infected cells and between ...

journal_title：Journal of virology

authors： Madansky CH,Bratt MA

更新日期：1981-12-01 00:00:00

abstract：UNLABELLED:The APOBEC3 family of DNA cytosine deaminases has important roles in innate immunity and cancer. It is unclear how DNA tumor viruses regulate these enzymes and how these interactions, in turn, impact the integrity of both the viral and cellular genomes. Polyomavirus (PyVs) are small DNA pathogens that contai...

journal_title：Journal of virology

authors： Verhalen B,Starrett GJ,Harris RS,Jiang M

更新日期：2016-06-24 00:00:00

abstract：:The major inducible 70-kDa heat shock protein (hsp70) is host protective in a mouse model of measles virus (MeV) brain infection. Transgenic constitutive expression of hsp70 in neurons, the primary target of MeV infection, abrogates neurovirulence in neonatal H-2(d) congenic C57BL/6 mice. A significant level of protec...

journal_title：Journal of virology

authors： Kim MY,Shu Y,Carsillo T,Zhang J,Yu L,Peterson C,Longhi S,Girod S,Niewiesk S,Oglesbee M

更新日期：2013-01-01 00:00:00

abstract：:The parechoviruses differ in many biological properties from other picornaviruses, and their replication strategy is largely unknown. In order to identify the viral RNA replication complex in human parechovirus type 1 (HPEV-1)-infected cells, we located viral protein and RNA in correlation to virus-induced membrane al...

journal_title：Journal of virology

authors： Krogerus C,Egger D,Samuilova O,Hyypiä T,Bienz K

更新日期：2003-08-01 00:00:00

abstract：:Adenovirus types 5 and 3 (Ad5 and Ad3), two human adenovirus serotypes of evolutionarily divergent subgroups, show very different levels of E1A gene expression early after infection of permissive cells. Since adenovirus E1A gene expression is known to be transcriptionally autoregulated, we have investigated the differ...

journal_title：Journal of virology

authors： Jones SN,Tibbetts C

更新日期：1989-04-01 00:00:00

abstract：:The regulatory proteins Nef, Rev, and Tat of human immunodeficiency virus type 1 (HIV-1) are attractive targets for vaccine development, since induction of effective immune responses targeting these early proteins may best control virus replication. Here we investigated whether vaccination with biologically active Tat...

journal_title：Journal of virology

authors： Silvera P,Richardson MW,Greenhouse J,Yalley-Ogunro J,Shaw N,Mirchandani J,Khalili K,Zagury JF,Lewis MG,Rappaport J

更新日期：2002-04-01 00:00:00

abstract：:A monoclonal antibody, MAb vpg15, inhibits feline immunodeficiency virus (FIV) infection in tissue culture. The antibody is directed to a determinant of the feline cell surface marker, CD9, implying that CD9 may serve as a viral receptor or coreceptor in this system. In cells expressing CD9, MAb vpg15 markedly delayed...

journal_title：Journal of virology

authors： de Parseval A,Lerner DL,Borrow P,Willett BJ,Elder JH

更新日期：1997-08-01 00:00:00

abstract：:Herpes simplex virus establishes latent infections in the nuclei of sensory neurons. These infections are characterized by the abundant expression of a series of 5' coterminal transcripts termed the latency-associated transcripts (LATs). Available evidence indicates that LAT expression is specifically regulated in lat...

journal_title：Journal of virology

authors： Frazier DP,Cox D,Godshalk EM,Schaffer PA

更新日期：1996-11-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a ubiquitously distributed pathogen that causes severe disease in immunosuppressed patients and newborn infants infected in utero. The viral envelope glycoprotein B (gB) is an attractive molecule for active vaccination and passive immunoprophylaxis and therapy. Using human monoclonal an...

journal_title：Journal of virology

authors： Spindler N,Rücker P,Pötzsch S,Diestel U,Sticht H,Martin-Parras L,Winkler TH,Mach M

更新日期：2013-08-01 00:00:00

abstract：:Oligomer formation of the gB glycoprotein of herpes simplex virus type 1 was studied by sedimentation analysis of radioactively labeled infected cell and virion lysates. Fractions from sucrose gradients were precipitated with a pool of gB-specific monoclonal antibodies and analyzed by sodium dodecyl sulfate-polyacryla...

journal_title：Journal of virology

authors： Highlander SL,Goins WF,Person S,Holland TC,Levine M,Glorioso JC

更新日期：1991-08-01 00:00:00

abstract：:The transcription map of the Aedes albopictus densovirus (AalDNV) brevidensovirus was identified by Northern blotting, rapid amplification of cDNA ends (RACE) analysis, and RNase protection assays. AalDNV produced mRNAs of 3,359 (NS1), 3,345 (NS2), and 1,246 (VP) nucleotides. The two overlapping P7/7.4 NS promoters em...

journal_title：Journal of virology

authors： Pham HT,Jousset FX,Perreault J,Shike H,Szelei J,Bergoin M,Tijssen P

更新日期：2013-09-01 00:00:00