Mapping the landscape of host-pathogen coevolution: HLA class I binding and its relationship with evolutionary conservation in human and viral proteins.

abstract：:The major obstacle to human immunodeficiency type 1 virus (HIV-1) eradication is a reservoir of latently infected cells that persists despite long-term antiretroviral therapy (ART) and is maintained through cellular proliferation. Long-lived memory CD4+ T cells with high self-renewal capacity, such as central memory (...

journal_title：Journal of virology

authors： Mavigner M,Zanoni M,Tharp GK,Habib J,Mattingly CR,Lichterfeld M,Nega MT,Vanderford TH,Bosinger SE,Chahroudi A

更新日期：2019-12-12 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) infects >90% of the population and establishes a latent infection with asymptomatic episodes of reactivation. However, HHV-6 reactivation is associated with morbidity and sometimes mortality in immunocompromised patients. To date, control of the virus in healthy virus carriers and the failu...

journal_title：Journal of virology

authors： Fastenackels S,Bayard C,Larsen M,Magnier P,Bonnafous P,Seddiki N,Appay V,Gautheret-Dejean A,Sauce D

更新日期：2019-06-14 00:00:00

abstract：:Molluscum contagiosum virus (MCV), a member of the human poxvirus family, encodes the MC159 protein that inhibits Fas-, tumor necrosis factor (TNF)-, and TNF-related apoptosis-inducing ligant (TRAIL)-induced apoptosis. We used site-directed mutagenesis to change charged or hydrophobic amino acid residues to alanines t...

journal_title：Journal of virology

authors： Garvey TL,Bertin J,Siegel RM,Wang GH,Lenardo MJ,Cohen JI

更新日期：2002-01-01 00:00:00

abstract：UNLABELLED:Generalized immune activation during HIV infection is associated with an increased risk of cardiovascular disease, neurocognitive disease, osteoporosis, metabolic disorders, and physical frailty. The mechanisms driving this immune activation are poorly understood, particularly for individuals effectively tre...

journal_title：Journal of virology

authors： Liang EC,Sceats L,Bayless NL,Strauss-Albee DM,Kubo J,Grant PM,Furman D,Desai M,Katzenstein DA,Davis MM,Zolopa AR,Blish CA

更新日期：2014-08-01 00:00:00

abstract：:In resting CD4(+) T lymphocytes harboring human immunodeficiency virus type 1 (HIV-1), replication-competent virus persists in patients responding to highly active antiretroviral therapy (HAART). This small latent reservoir represents between 10(3) and 10(7) cells per patient. However, the efficiency of HIV-1 DNA-posi...

journal_title：Journal of virology

authors： Fondere JM,Petitjean G,Huguet MF,Salhi SL,Baillat V,Macura-Biegun A,Becquart P,Reynes J,Vendrell JP

更新日期：2004-10-01 00:00:00

abstract：:Activation of microglia and astroglia is seen in many neurodegenerative diseases including prion diseases. Activated glial cells produce cytokines as a protective response against certain pathogens and as part of the host inflammatory response to brain damage. In addition, cytokines might also exacerbate tissue damage...

journal_title：Journal of virology

authors： Tribouillard-Tanvier D,Striebel JF,Peterson KE,Chesebro B

更新日期：2009-11-01 00:00:00

abstract：:LA3382 is a temperature-sensitive replication-defective mutant of Rous sarcoma virus that contains four active mutations. In this study we performed experiments to determine the biochemical defect that blocks the synthesis of infections virus late in the replication cycle. At the nonpermissive temperature (41 degrees ...

journal_title：Journal of virology

authors： Hardwick JM,Hunter E

更新日期：1981-12-01 00:00:00

abstract：:Rhabdoviruses such as rabies virus (RV) encode only five multifunctional proteins accomplishing viral gene expression and virus formation. The viral phosphoprotein, P, is a structural component of the viral ribonucleoprotein (RNP) complex and an essential cofactor for the viral RNA-dependent RNA polymerase. We show he...

journal_title：Journal of virology

authors： Finke S,Brzózka K,Conzelmann KK

更新日期：2004-11-01 00:00:00

abstract：:The goose parvovirus (GPV) Rep 1 and Rep 2 proteins are encoded by P9-generated mRNAs that are either unspliced or spliced within the rep gene region, respectively. These mRNAs are present in an approximately equal ratio. The translation of Rep 1 was initiated from the first AUG in unspliced P9-generated mRNA; however...

journal_title：Journal of virology

authors： Li L,Qiu J,Pintel DJ

更新日期：2009-10-01 00:00:00

abstract：:Strong determinants of the host range of influenza A viruses have been identified on the polymerase complex formed by the PB1, PB2, and PA subunits and on the nucleoprotein (NP). In the present study, molecular mechanisms that may involve these four core proteins and contribute to the restriction of avian influenza vi...

journal_title：Journal of virology

authors： Rameix-Welti MA,Tomoiu A,Dos Santos Afonso E,van der Werf S,Naffakh N

更新日期：2009-02-01 00:00:00

abstract：:The expression and predicted products of rat c-ros-1 gene, the proto-oncogene of v-ros in UR2 sarcoma virus, were characterized. The c-ros-1 gene was found to be expressed in a tissue-specific manner, and the sizes of its transcripts were heterogeneous: 8.2 kilobases (kb) long in lung and kidney tissues, 6.9 kb in hea...

journal_title：Journal of virology

authors： Matsushime H,Shibuya M

更新日期：1990-05-01 00:00:00

abstract：:The M2-2 protein of respiratory syncytial virus (RSV) is involved in regulation of viral RNA transcription and replication. Encoded by the next-to-last gene of RSV, the M2-2 open reading frame (ORF) overlaps with the upstream M2-1 ORF, suggesting that the production of the M2-2 protein might be tightly regulated durin...

journal_title：Journal of virology

authors： Cheng X,Park H,Zhou H,Jin H

更新日期：2005-11-01 00:00:00

abstract：:The characteristics of a rotaviruslike (SBR) virus isolated from striped bass (Morone saxatilis) were examined following purification of viruses from infected cell cultures. Virions had a double-layered capsid of icosahedral symmetry and a diameter of 75 nm. Purified viruses contained five polypeptides ranging in mole...

journal_title：Journal of virology

authors： Samal SK,Dopazo CP,McPhillips TH,Baya A,Mohanty SB,Hetrick FM

更新日期：1990-11-01 00:00:00

abstract：:To evaluate the possibility of producing transducible replication-defective hepadnaviruses, cloned mutant duck hepatitis B virus genomes were tested both for virus antigen production and viral DNA synthesis following transfection into the human hepatoma cell line HuH7. Deletion of a cis-acting 12-nucleotide sequence i...

journal_title：Journal of virology

authors： Horwich AL,Furtak K,Pugh J,Summers J

更新日期：1990-02-01 00:00:00

abstract：:The vaccinia virus Western Reserve A38L protein is a hydrophobic integral membrane glycoprotein with amino acid similarity to mammalian integrin-associated protein. The protein has an N-terminal immunoglobulin superfamily domain, followed by five membrane-spanning domains and a short cytoplasmic tail. Deletion of the ...

journal_title：Journal of virology

authors： Sanderson CM,Parkinson JE,Hollinshead M,Smith GL

更新日期：1996-02-01 00:00:00

abstract：:We previously reported the establishment of several lymphoid cell lines from X-ray-induced thymomas of C57BL/Ka mice, and all, except one, produce retroviruses (P. Sankar-Mistry and P. Jolicoeur, J. Virol.35:270-275, 1980). Biological characterization of five of these new primary radiation leukemia viruses (RadLVs) in...

journal_title：Journal of virology

authors： Rassart E,Sankar-Mistry P,Lemay G,DesGroseillers L,Jolicoeur P

更新日期：1983-02-01 00:00:00

abstract：:The Vpu protein is a human immunodeficiency virus type 1 (HIV-1)-specific accessory protein that is required for the efficient release of viral particles from infected cells. Even though HIV-2 does not encode Vpu, we found that this virus is nevertheless capable of efficiently releasing virus particles. In fact, the r...

journal_title：Journal of virology

authors： Bour S,Schubert U,Peden K,Strebel K

更新日期：1996-02-01 00:00:00

abstract：:The configuration of latent varicella-zoster virus (VZV) DNA was analyzed by PCR. Template DNA for both internal and terminal VZV primers was present in a 1:1 ratio in ganglionic DNA, compared with a 15:1 ratio in DNA extracted from VZV virions, indicating that the VZV genomic termini are adjacent in latently infected...

journal_title：Journal of virology

authors： Clarke P,Beer T,Cohrs R,Gilden DH

更新日期：1995-12-01 00:00:00

abstract：:Molluscum contagiosum virus (MCV), the only member of the Molluscipoxvirus genus, causes benign papules in healthy people but disfiguring lesions in immunocompromised patients. The sequence of MCV has been completed, revealing that MCV encodes a probable type I topoisomerase enzyme. All poxviruses sequenced to date al...

journal_title：Journal of virology

authors： Hwang Y,Wang B,Bushman FD

更新日期：1998-04-01 00:00:00

abstract：:Due to increasing concerns about human infection by various H7 influenza viruses, including recent H7N9 viruses, we evaluated the genetic relationships and cross-protective efficacies of three different Eurasian H7 avian influenza viruses. Phylogenic and molecular analyses revealed that recent Eurasian H7 viruses can ...

journal_title：Journal of virology

authors： Kwon HI,Kim YI,Park SJ,Song MS,Kim EH,Kim SM,Si YJ,Lee IW,Song BM,Lee YJ,Yun SJ,Kim WJ,Choi YK

更新日期：2017-05-12 00:00:00

abstract：:Vaccines preventing HIV-1 infection will likely elicit antibodies that neutralize diverse strains. However, the capacity for lentiviruses to escape broadly neutralizing antibodies (NAbs) is not completely understood, nor is it known whether NAbs alone can control heterologous infection. Here, we determined that conval...

journal_title：Journal of virology

authors： Taylor SD,Leib SR,Carpenter S,Mealey RH

更新日期：2010-07-01 00:00:00

abstract：:Naked DNA vaccines expressing the prM and E genes of two tick-borne flaviviruses, Russian spring summer encephalitis (RSSE) virus and Central European encephalitis (CEE) virus were evaluated in mice. The vaccines were administered by particle bombardment of DNA-coated gold beads by Accell gene gun inoculation. Two imm...

journal_title：Journal of virology

authors： Schmaljohn C,Vanderzanden L,Bray M,Custer D,Meyer B,Li D,Rossi C,Fuller D,Fuller J,Haynes J,Huggins J

更新日期：1997-12-01 00:00:00

abstract：:The St-1 genome is about 6,050 base pairs in size, approximately 10% larger than phiX174 (5,375 base pairs). The DNA fragments obtained by HincII, HaeIII, and EcoRI digestion were ordered and aligned into a colinear map, and the single BglI cleavage site was located. ...

journal_title：Journal of virology

authors： Grindley JN,Godson GN

更新日期：1978-09-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68, or MHV-68) is a genetically tractable, small animal model for the analysis of gammaherpesvirus pathogenesis. The gammaHV68 genome is colinear with the genomes of other sequence gammaherpesviruses, containing large blocks of conserved genes interspersed by a number of putative gen...

journal_title：Journal of virology

authors： Clambey ET,Virgin HW 4th,Speck SH

更新日期：2000-02-01 00:00:00

abstract：:Inoculation of 3-day-old (3D) or 3-week-old (3W) ducklings with duck hepatitis B virus results in chronic or transient infection, respectively. We previously showed that rapid production of neutralizing antibody following inoculation of 3W ducklings prevents virus from spreading in the liver and leads to a transient i...

journal_title：Journal of virology

authors： Zhang YY,Theele DP,Summers J

更新日期：2005-08-01 00:00:00

abstract：:The relative contributions of interleukin-12 (IL-12) and IL-23 to viral pathogenesis have not been extensively studied. IL-12p40 mRNA rapidly increases after neurotropic coronavirus infection. Infection of mice defective in both IL-12 and IL-23 (p40(-/-)), in IL-12 alone (p35(-/-)), and in IL-23 alone (p19(-/-)) revea...

journal_title：Journal of virology

authors： Kapil P,Atkinson R,Ramakrishna C,Cua DJ,Bergmann CC,Stohlman SA

更新日期：2009-06-01 00:00:00

abstract：:Simian varicella virus (SVV) and varicella-zoster virus (VZV) are closely related alphaherpesviruses that cause varicella (chickenpox) in nonhuman primates and humans, respectively. After resolution of the primary disease, SVV and VZV establish latent infection of neural ganglia and may later reactivate to cause a sec...

journal_title：Journal of virology

authors： Ou Y,Davis KA,Traina-Dorge V,Gray WL

更新日期：2007-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV in...

journal_title：Journal of virology

authors： Çevik RE,Cesarec M,Da Silva Filipe A,Licastro D,McLauchlan J,Marcello A

更新日期：2017-08-24 00:00:00

abstract：:A recombinant vesicular stomatitis virus (VSV-PeGFP-M-MmRFP) encoding enhanced green fluorescent protein fused in frame with P (PeGFP) in place of P and a fusion matrix protein (monomeric red fluorescent protein fused in frame at the carboxy terminus of M [MmRFP]) at the G-L gene junction, in addition to wild-type (wt...

journal_title：Journal of virology

authors： Das SC,Panda D,Nayak D,Pattnaik AK

更新日期：2009-03-01 00:00:00

abstract：:The viral early-to-late switch of papillomavirus infection is tightly linked to keratinocyte differentiation and is mediated in part by alternative mRNA splicing. Here, we report that SRp20, a cellular splicing factor, controls the early-to-late switch via interactions with A/C-rich RNA elements. An A/C-rich SE4 eleme...

journal_title：Journal of virology

authors： Jia R,Liu X,Tao M,Kruhlak M,Guo M,Meyers C,Baker CC,Zheng ZM

更新日期：2009-01-01 00:00:00