Abstract:
:The structure of recombinant virus-like particles of malabaricus grouper nervous necrosis virus (MGNNV), a fish nodavirus isolated from the grouper Epinephelus malabaricus, was determined by electron cryomicroscopy (cryoEM) and three-dimensional reconstruction at 23-A resolution. The cryoEM structure, sequence comparison, and protein fold recognition analysis indicate that the coat protein of MGNNV has two domains resembling those of tomato bushy stunt virus and Norwalk virus, rather than the expected single-domain coat protein of insect nodaviruses. The analysis implies that residues 83 to 216 fold as a beta-sandwich which forms the inner shell of the T=3 capsid and residues 217 to 308 form the trimeric surface protrusions observed in the cryoEM map. The structural similarities between fish nodaviruses and members of the tombusvirus and calicivirus groups provide significant new data for understanding the evolution of the nodavirus family.
journal_name
J Viroljournal_title
Journal of virologyauthors
Tang L,Lin CS,Krishna NK,Yeager M,Schneemann A,Johnson JEdoi
10.1128/jvi.76.12.6370-6375.2002subject
Has Abstractpub_date
2002-06-01 00:00:00pages
6370-5issue
12eissn
0022-538Xissn
1098-5514journal_volume
76pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1977-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.9.4107-4109.1989
更新日期:1989-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.57.1.379-384.1986
更新日期:1986-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00555-06
更新日期:2006-09-01 00:00:00
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更新日期:1980-02-01 00:00:00
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1984-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
abstract::The human papillomavirus type 11 (HPV-11) L1 major capsid protein can be trypsinized to generate recombinant capsomeres that retain HPV genotype-restricted capsid antigenicity (M. Li, T. P. Cripe, P. A. Estes, M. K. Lyon, R. C. Rose, and R. L. Garcea, J. Virol. 71:2988-2995, 1997). In the present study, HPV-11 virion-...
journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.12.3.523-533.1973
更新日期:1973-09-01 00:00:00