Abstract:
:Herpes simplex virus 1 genome consists of two covalently linked components, L and S, that invert relative to each other to yield four equimolar isomeric populations designated P (prototype), Is (inversion of S component), Il (inversion of L component), and Ils (inversion of L and S components) differing in the orientation of the two components. Previous studies have yielded recombinant genomes frozen in the P isomeric arrangement, reinforcing suggestions that the four isomers may not be functionally equivalent. We report the isolation of recombinants produced by insertional mutagenesis with alpha TK mini-Mu that are frozen in Is and Ils arrangements. Thus, all isomeric forms of herpes simplex virus DNA appear to be capable of independent replication and must be considered as functionally equivalent.
journal_name
J Viroljournal_title
Journal of virologyauthors
Jenkins FJ,Roizman Bdoi
10.1128/JVI.59.2.494-499.1986subject
Has Abstractpub_date
1986-08-01 00:00:00pages
494-9issue
2eissn
0022-538Xissn
1098-5514journal_volume
59pub_type
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.8.3635-3642.1990
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doi:10.1128/JVI.35.3.812-823.1980
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.2.820-829.1996
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pub_type: 杂志文章
doi:10.1128/JVI.66.10.6233-6236.1992
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
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pub_type: 杂志文章
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