Coding assignment and nucleotide sequence of simian rotavirus SA11 gene segment 10: location of glycosylation sites suggests that the signal peptide is not cleaved.

Abstract:

:A cloned DNA copy of simian rotavirus SA11 genomic segment 10 was used to confirm the assignment of the nonstructural glycoprotein NCVP5 to this gene. Determination of the nucleotide sequence for gene 10 indicated that NCVP5 is 175 amino acids in length and has an N-terminal hydrophobic region with the characteristics of a signal sequence for membrane translocation. Unexpectedly, this region was also the location for the only two potential glycosylation sites within the molecule, asparagine residues 8 and 18. The carbohydrates carried by NCVP5 were of the high-mannose type, Man9GlcNAc and Man8GlcNAc, with the mannose 9 species predominating; no complex oligosaccharides were present. If these asparagine residues are the sites for carbohydrate attachment, this implies that cleavage of the putative signal peptide does not occur during the maturation of this nonstructural glycoprotein.

journal_name

J Virol

journal_title

Journal of virology

authors

Both GW,Siegman LJ,Bellamy AR,Atkinson PH

doi

10.1128/JVI.48.2.335-339.1983

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

335-9

issue

2

eissn

0022-538X

issn

1098-5514

journal_volume

48

pub_type

杂志文章
  • Intramolecular recombinations of Moloney murine leukemia virus occur during minus-strand DNA synthesis.

    abstract::Retroviral recombination can occur between two viral RNA molecules (intermolecular) or between two sequences within the same RNA molecule (intramolecular). The rate of retroviral intramolecular recombination is high. Previous studies showed that, after a single round of replication, 50 to 60% of retroviral recombinati...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.76.19.9614-9623.2002

    authors: Li T,Zhang J

    更新日期:2002-10-01 00:00:00

  • Minute virus of mice infection modifies cellular transcription elongation.

    abstract::Our previous observations indicated that upon infection with minute virus of mice (MVM), Ehrlich ascites cells lose a transcription elongation activity which is essential for the readthrough of the MVM attenuator. This was monitored by the ability of extracts from uninfected but not from infected cells to support read...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.68.4.2741-2745.1994

    authors: Krauskopf A,Ben-Asher E,Aloni Y

    更新日期:1994-04-01 00:00:00

  • Genetic assay for multimerization of retroviral gag polyproteins.

    abstract::We have established a genetic assay for the multimerization of retroviral gag polyproteins. This assay is based on the GAL4 two-hybrid system for studying protein-protein interactions (S. Fields and O. Song, Nature (London) 340:245-246, 1989). In our initial experiments, we generated Saccharomyces cerevisiae plasmids ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.66.8.5157-5160.1992

    authors: Luban J,Alin KB,Bossolt KL,Humaran T,Goff SP

    更新日期:1992-08-01 00:00:00

  • Mutational analysis of the central domain of adenovirus virus-associated RNA mandates a revision of the proposed secondary structure.

    abstract::Protein synthesis in adenovirus-infected cells is regulated during the late phase of infection. The rate of initiation is maintained by a small viral RNA, virus-associated (VA) RNAI, which prevents the phosphorylation of eukaryotic initiation factor eIF-2 by a double-stranded RNA-activated protein kinase, DAI. On the ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.67.6.3534-3543.1993

    authors: Pe'ery T,Mellits KH,Mathews MB

    更新日期:1993-06-01 00:00:00

  • Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity.

    abstract::Vaccinia virus (VACV) stimulates long-term immunity against highly pathogenic orthopoxvirus infection of humans (smallpox) and mice (mousepox [ectromelia virus {ECTV}]) despite the lack of a natural host-pathogen relationship with either of these species. Previous research revealed that VACV is able to induce polyfunc...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00038-12

    authors: Hersperger AR,Siciliano NA,Eisenlohr LC

    更新日期:2012-07-01 00:00:00

  • Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice.

    abstract::During viral infection, inflammation and recovery are tightly controlled by competing proinflammatory and regulatory immune pathways. Respiratory syncytial virus (RSV) is the leading global cause of infantile bronchiolitis, which is associated with recurrent wheeze and asthma diagnosis in later life. Th2-driven diseas...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01295-13

    authors: Durant LR,Makris S,Voorburg CM,Loebbermann J,Johansson C,Openshaw PJ

    更新日期:2013-10-01 00:00:00

  • Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes.

    abstract::Recently, we demonstrated that inverted repeat sequences inserted into first-generation adenovirus (Ad) vector genomes mediate precise genomic rearrangements resulting in vector genomes devoid of all viral genes that are efficiently packaged into functional Ad capsids. As a specific application of this finding, we gen...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.73.11.9314-9324.1999

    authors: Lieber A,Steinwaerder DS,Carlson CA,Kay MA

    更新日期:1999-11-01 00:00:00

  • 1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread.

    abstract::Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that causes neurological diseases in a variety of warm-blooded animal species. There is general consensus that BDV can also infect humans, being a possible zoonosis. Although the clinical consequences of human BDV infection are still controversial,...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.76.12.6268-6286.2002

    authors: Bajramovic JJ,Syan S,Brahic M,de la Torre JC,Gonzalez-Dunia D

    更新日期:2002-06-01 00:00:00

  • Complete genome sequence of a new circular DNA virus from grapevine.

    abstract::A novel circular DNA virus sequence is reported from grapevine. The corresponding genomic organization, coding potential, and conserved origin of replication are similar to those of members of the family Geminiviridae, but the genome of 3,206 nucleotides is 4% larger than the largest reported geminiviral genome and sh...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00943-12

    authors: Krenz B,Thompson JR,Fuchs M,Perry KL

    更新日期:2012-07-01 00:00:00

  • West Nile Virus Infection Blocks Inflammatory Response and T Cell Costimulatory Capacity of Human Monocyte-Derived Dendritic Cells.

    abstract::West Nile virus (WNV) is a neurotropic flavivirus and the leading cause of mosquito-borne encephalitis in the United States. Recent studies in humans have found that dysfunctional T cell responses strongly correlate with development of severe WNV neuroinvasive disease. However, the contributions of human dendritic cel...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00664-19

    authors: Zimmerman MG,Bowen JR,McDonald CE,Pulendran B,Suthar MS

    更新日期:2019-11-13 00:00:00

  • The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein.

    abstract::The Epstein-Barr virus nuclear antigen 2 (EBNA-2) acidic domain is essential for B-lymphocyte growth transformation and can activate transcription when brought to a promoter by a sequence-specific DNA-binding domain. We now show that the EBNA-2 acidic domain has slightly less activity than the proteotypic acidic trans...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.69.1.585-588.1995

    authors: Tong X,Wang F,Thut CJ,Kieff E

    更新日期:1995-01-01 00:00:00

  • Evolutionary pattern of the hemagglutinin gene of influenza B viruses isolated in Japan: cocirculating lineages in the same epidemic season.

    abstract::The unexpectedly low efficacy of influenza vaccine during school outbreaks of influenza B virus in the spring of 1987 in Japan was probably attributable to a poor antibody response of vaccinees to the epidemic viruses. An antigenic analysis of the causative B viruses isolated in 1987 and 1988 showed much variation in ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.64.6.2860-2865.1990

    authors: Kanegae Y,Sugita S,Endo A,Ishida M,Senya S,Osako K,Nerome K,Oya A

    更新日期:1990-06-01 00:00:00

  • In vitro infection of human hepatoma (HepG2) cells with hepatitis B virus.

    abstract::An in vitro system for production of hepatitis B virus (HBV) was established by infection of human hepatoma (HepG2) cells. HBV particles obtained from the serum of a chronic hepatitis B surface antigen (subtype ad) carrier were used to inoculate HepG2 cells. HBV envelope and core proteins were synthesized de novo by t...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.64.6.3025-3032.1990

    authors: Bchini R,Capel F,Dauguet C,Dubanchet S,Petit MA

    更新日期:1990-06-01 00:00:00

  • Kissing of the two predominant hairpin loops in the coxsackie B virus 3' untranslated region is the essential structural feature of the origin of replication required for negative-strand RNA synthesis.

    abstract::Higher-order RNA structures in the 3' untranslated region (3'UTR) of enteroviruses are thought to play a pivotal role in viral negative-strand RNA synthesis. The structure of the 3'UTR was predicted by thermodynamic calculations using the STAR (structural analysis of RNA) computer program and experimentally verified u...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.71.1.686-696.1997

    authors: Melchers WJ,Hoenderop JG,Bruins Slot HJ,Pleij CW,Pilipenko EV,Agol VI,Galama JM

    更新日期:1997-01-01 00:00:00

  • Cas-Br-E murine leukemia virus: sequencing of the paralytogenic region of its genome and derivation of specific probes to study its origin and the structure of its recombinant genomes in leukemic tissues.

    abstract::The ecotropic Cas-Br-E murine leukemia virus (MuLV) and its molecularly cloned derivative pBR-NE-8 MuLV are capable of inducing hind-limb paralysis and leukemia after inoculation into susceptible mice. T1 oligonucleotide fingerprinting, molecular hybridization, and restriction enzyme analysis previously showed that th...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.60.3.910-919.1986

    authors: Rassart E,Nelbach L,Jolicoeur P

    更新日期:1986-12-01 00:00:00

  • Cellular transformation by subgenomic feline sarcoma virus DNA.

    abstract::The genome of the Snyder-Theilen strain of feline sarcoma virus (ST-FeSV) is a 4.3-kilobase-pair (kbp) RNA molecule that contains a 1.5-kbp cellular insertion (fes gene) flanked by feline leukemia virus sequences at its 5' end (1.6 kbp) and 3' end (1.2 kbp) (Sherr et al., J. Virol. 34:200-212, 1980). DNA transfection ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.37.1.518-523.1981

    authors: Barbacid M

    更新日期:1981-01-01 00:00:00

  • Inducible gene expression from African swine fever virus recombinants: analysis of the major capsid protein p72.

    abstract::A method to study the function of individual African swine fever virus (ASFV) gene products utilizing the Escherichia coli lac repressor-operator system has been developed. Recombinant viruses containing both the lacI gene encoding the lac repressor and a strong virus late promoter modified by the insertion of one or ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.72.4.3185-3195.1998

    authors: García-Escudero R,Andrés G,Almazán F,Viñuela E

    更新日期:1998-04-01 00:00:00

  • Temperature-sensitive defect of mutants isolated from L cells persistently infected with Newcastle disease virus.

    abstract::The temperature-sensitive defects of virus mutants isolated from L cells persistently infected with Newcastle disease virus (NDV) were analyzed. Genetic grouping of the mutants by complementation tests was attempted by using several different methods, including yield analysis, RNA synthesis, and heterozygote formation...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.12.3.472-480.1973

    authors: Preble OT,Youngner JS

    更新日期:1973-09-01 00:00:00

  • Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase.

    abstract::A rapid assay for retroviral reverse transcriptase activity released into the culture medium by infected cells was developed. With the assay, 4,000 clonally infected cell lines could be tested in a few hours. We have adapted the assay for use as a screen for the detection of spontaneous viral mutants. Mutants of Molon...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.38.1.239-248.1981

    authors: Goff S,Traktman P,Baltimore D

    更新日期:1981-04-01 00:00:00

  • Rotavirus-induced structural and functional alterations in tight junctions of polarized intestinal Caco-2 cell monolayers.

    abstract::We provide here new insights into rotavirus (RRV) pathogenicity by showing that RRV infection promotes structural and functional injuries localized at the tight junctions (TJ) in the cell-cell junctional complex of cultured polarized human intestinal Caco-2 cells forming monolayers. RRV infection resulted in a progres...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.74.10.4645-4651.2000

    authors: Obert G,Peiffer I,Servin AL

    更新日期:2000-05-01 00:00:00

  • Lymphocyte activation during acute simian/human immunodeficiency virus SHIV(89.6PD) infection in macaques.

    abstract::Host-virus interactions control disease progression in human immunodeficiency virus-infected human beings and in nonhuman primates infected with simian or simian/human immunodeficiency viruses (SHIV). These interactions evolve rapidly during acute infection and are key to the mechanisms of viral persistence and AIDS. ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.73.12.10236-10244.1999

    authors: Wallace M,Waterman PM,Mitchen JL,Djavani M,Brown C,Trivedi P,Horejsh D,Dykhuizen M,Kitabwalla M,Pauza CD

    更新日期:1999-12-01 00:00:00

  • Marine Snails and Slugs: a Great Place To Look for Antiviral Drugs.

    abstract::Molluscs, comprising one of the most successful phyla, lack clear evidence of adaptive immunity and yet thrive in the oceans, which are rich in viruses. There are thought to be nearly 120,000 species of Mollusca, most living in marine habitats. Despite the extraordinary abundance of viruses in oceans, molluscs often h...

    journal_title:Journal of virology

    pub_type: 杂志文章,评审

    doi:10.1128/JVI.00287-15

    authors: Dang VT,Benkendorff K,Green T,Speck P

    更新日期:2015-08-01 00:00:00

  • The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus form a complex and function together to down-regulate the epidermal growth factor receptor.

    abstract::In adenovirus-infected cells, the epidermal growth factor receptor (EGF-R) is internalized from the cell surface via endosomes and is degraded, and the E3 10,400-dalton protein (10.4K protein) is required for this effect (C. R. Carlin, A. E. Tollefson, H. A. Brady, B. L. Hoffman, and W. S. M. Wold, Cell 57:135-144, 19...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.65.6.3095-3105.1991

    authors: Tollefson AE,Stewart AR,Yei SP,Saha SK,Wold WS

    更新日期:1991-06-01 00:00:00

  • Japanese Encephalitis Virus Induces Apoptosis and Encephalitis by Activating the PERK Pathway.

    abstract::Accumulated evidence demonstrates that Japanese encephalitis virus (JEV) infection triggers endoplasmic reticulum (ER) stress and neuron apoptosis. ER stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) has been reported to induce apoptosis under acute or prolonged ER stress. However, the precise r...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.00887-19

    authors: Wang Q,Xin X,Wang T,Wan J,Ou Y,Yang Z,Yu Q,Zhu L,Guo Y,Wu Y,Ding Z,Zhang Y,Pan Z,Tang Y,Li S,Kong L

    更新日期:2019-08-13 00:00:00

  • Genesis and Spread of Newly Emerged Highly Pathogenic H7N9 Avian Viruses in Mainland China.

    abstract::The novel low-pathogenic avian influenza A H7N9 viruses (LPAI H7N9 viruses) have been a threat to public health since their emergence in 2013 because of the high rates of mortality and morbidity that they cause. Recently, highly pathogenic variants of these avian influenza A H7N9 viruses (HPAI H7N9 viruses) have emerg...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01277-17

    authors: Yang L,Zhu W,Li X,Chen M,Wu J,Yu P,Qi S,Huang Y,Shi W,Dong J,Zhao X,Huang W,Li Z,Zeng X,Bo H,Chen T,Chen W,Liu J,Zhang Y,Liang Z,Shi W,Shu Y,Wang D

    更新日期:2017-11-14 00:00:00

  • Effects of 2'-deoxy-2'-azidocytidine on polyoma virus DNA replication: evidence for rolling circle-type mechanism.

    abstract::Rolling circle-type molecules were found in polyoma virus-infected cells after inhibition of DNA synthesis with 2'-deoxy-2'-azidocytidine. The circular DNA molecules were always relaxed and of polyoma length. Most of the attached tails were less than two times the length of the polyoma genome, but tails with a length ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.26.1.136-142.1978

    authors: Bjursell G

    更新日期:1978-04-01 00:00:00

  • Induction of P1 prophage and superinfection by bacteriophage T1.

    abstract::Induction of the resident prophage did not permit restricted phage T1 to replicate freely in P1-lysogenic hosts. A few induced cells did become infectible. ...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.3.4.448-449.1969

    authors: Christensen JR,Werner ER

    更新日期:1969-04-01 00:00:00

  • Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity.

    abstract:UNLABELLED:Despite the nutritional and health benefits of breast milk, breast milk can serve as a vector for mother-to-child HIV transmission. Most HIV-infected infants acquire HIV through breastfeeding. Paradoxically, most infants breastfed by HIV-positive women do not become infected. This is potentially attributed t...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01702-15

    authors: Wahl A,Baker C,Spagnuolo RA,Stamper LW,Fouda GG,Permar SR,Hinde K,Kuhn L,Bode L,Aldrovandi GM,Garcia JV

    更新日期:2015-11-01 00:00:00

  • Characterization of the Herpes Simplex Virus (HSV) Tegument Proteins That Bind to gE/gI and US9, Which Promote Assembly of HSV and Transport into Neuronal Axons.

    abstract::The herpes simplex virus (HSV) heterodimer gE/gI and another membrane protein, US9, which has neuron-specific effects, promote the anterograde transport of virus particles in neuronal axons. Deletion of both HSV gE and US9 blocks the assembly of enveloped particles in the neuronal cytoplasm, which explains why HSV vir...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/JVI.01113-20

    authors: DuRaine G,Wisner TW,Johnson DC

    更新日期:2020-11-09 00:00:00

  • Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity.

    abstract::Passage of foot-and-mouth disease virus (FMDV) in cell culture in the presence of the mutagenic base analog 5-fluorouracil or 5-azacytidine resulted in decreases of infectivity and occasional extinction of the virus. Low viral loads and low viral fitness enhanced the frequency of extinction events; this finding was sh...

    journal_title:Journal of virology

    pub_type: 杂志文章

    doi:10.1128/jvi.74.18.8316-8323.2000

    authors: Sierra S,Dávila M,Lowenstein PR,Domingo E

    更新日期:2000-09-01 00:00:00