In vitro infection of human hepatoma (HepG2) cells with hepatitis B virus.

abstract：UNLABELLED:Generalized immune activation during HIV infection is associated with an increased risk of cardiovascular disease, neurocognitive disease, osteoporosis, metabolic disorders, and physical frailty. The mechanisms driving this immune activation are poorly understood, particularly for individuals effectively tre...

journal_title：Journal of virology

authors： Liang EC,Sceats L,Bayless NL,Strauss-Albee DM,Kubo J,Grant PM,Furman D,Desai M,Katzenstein DA,Davis MM,Zolopa AR,Blish CA

更新日期：2014-08-01 00:00:00

abstract：:Alpha/beta interferons (IFN-alpha/beta) are key mediators of innate immunity and important modulators of adaptive immunity. The mechanisms by which IFN-alpha/beta are induced are becoming increasingly well understood. Recent studies showed that Toll-like receptors 7 and 8 expressed by plasmacytoid dendritic cells (pDC...

journal_title：Journal of virology

authors： Hidmark AS,McInerney GM,Nordström EK,Douagi I,Werner KM,Liljeström P,Karlsson Hedestam GB

更新日期：2005-08-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV) is an emerging pathogen and is the causative infectious agent of Kaposi sarcoma and two malignancies of B cell origin. To date, there is no licensed KSHV vaccine. Development of an effective vaccine against KSHV continues to be limited by a poor understanding of how the vir...

journal_title：Journal of virology

authors： Muniraju M,Mutsvunguma LZ,Foley J,Escalante GM,Rodriguez E,Nabiee R,Totonchy J,Mulama DH,Nyagol J,Wussow F,Barasa AK,Brehm M,Ogembo JG

更新日期：2019-07-30 00:00:00

abstract：:The influenza A virus nucleoprotein (NP) is a single-stranded RNA-binding protein that encapsidates the virus genome and has essential functions in viral-RNA synthesis. Here, we report the characterization of a temperature-sensitive (ts) NP mutant (US3) originally generated in fowl plague virus (A/chicken/Rostock/34)....

journal_title：Journal of virology

authors： Noton SL,Simpson-Holley M,Medcalf E,Wise HM,Hutchinson EC,McCauley JW,Digard P

更新日期：2009-01-01 00:00:00

abstract：:The protein (p59rel) encoded by the transforming gene of reticuloendotheliosis virus strain T (REV-T) has been identified in REV-T-transformed avian lymphoid cells by using antisera raised against synthetic peptides whose sequences were derived from three nonoverlapping regions of v-rel (N. R. Rice, T. D. Copeland, S....

journal_title：Journal of virology

authors： Simek SL,Stephens RM,Rice NR

更新日期：1986-07-01 00:00:00

abstract：:The E5 protein of human papillomavirus type 16 is a small, hydrophobic protein that localizes predominantly to membranes of the endoplasmic reticulum (ER). To define the orientation of E5 in these membranes, we employed a differential, detergent permeabilization technique that makes use of the ability of low concentra...

journal_title：Journal of virology

authors： Krawczyk E,Suprynowicz FA,Sudarshan SR,Schlegel R

更新日期：2010-02-01 00:00:00

abstract：:ts1 and ts7, two temperature-sensitive mutants of Moloney murine leukemia virus strain TB induce hind-limb paralysis in 100% of CFW/D mice injected. These two paralytogenic mutants also share a defect in their inability to process the env precursor protein, Pr80env, at the restrictive temperature. To identify the muta...

journal_title：Journal of virology

authors： Yuen PH,Malehorn D,Knupp C,Wong PK

更新日期：1985-05-01 00:00:00

abstract：:Pseudomonas aeruginosa myovirus KZ has a 270-kb genome within a T=27 icosahedral capsid that contains a large, unusual, and structurally well-defined protein cylindrical inner body (IB) spanning its interior. Proteolysis forms a pivotal stage in KZ head and IB morphogenesis, with the protease gp175 cleaving at least 1...

journal_title：Journal of virology

authors： Thomas JA,Black LW

更新日期：2013-08-01 00:00:00

abstract：UNLABELLED:Influenza A viruses (IAVs) rely on host factors to support their life cycle, as viral proteins hijack or interact with cellular proteins to execute their functions. Identification and understanding of these factors would increase our knowledge of the molecular mechanisms manipulated by the viruses. In this s...

journal_title：Journal of virology

authors： Gao S,Wu J,Liu RY,Li J,Song L,Teng Y,Sheng C,Liu D,Yao C,Chen H,Jiang W,Chen S,Huang W

更新日期：2015-01-01 00:00:00

abstract：:BALB/c mice infected on the scarified cornea with herpes simplex virus type 1 strain 35 [HSV-1(35)] rarely developed ocular disease even at challenge doses as high as 10(7) PFU per eye. In contrast, HSV-1(RE) consistently induced stromal keratitis at an inoculum of 2 x 10(4) PFU. The goal of this study was to determin...

journal_title：Journal of virology

authors： Su YH,Oakes JE,Lausch RN

更新日期：1990-05-01 00:00:00

abstract：:The efficiency of processing of polyoma viral RNA and of its export from nucleus to cytoplasm was measured in primary mouse kidney cells by comparing the initial rates of incorporation of [3H]uridine into cytoplasmic and nuclear viral RNA. Appropriate methods of cell fractionation were chosen to maximize yields of cyt...

journal_title：Journal of virology

authors： Acheson NH

更新日期：1981-02-01 00:00:00

abstract：:The monoclonal antibody PAb280 binds to small t antigen but not to large T antigen. Its binding site within the unique region of small t antigen was localized by studying its reaction with simian virus 40 mutants, other papovaviruses, and bacterial expression vectors coding for fragments of small t antigen. The antibo...

journal_title：Journal of virology

authors： Montano X,Lane DP

更新日期：1989-07-01 00:00:00

abstract：:The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and th...

journal_title：Journal of virology

authors： Xiao H,Killip MJ,Staeheli P,Randall RE,Jackson D

更新日期：2013-12-01 00:00:00

abstract：:Infection of cells with enveloped viruses is accomplished through membrane fusion. The binding and fusion processes are mediated by the spike proteins in the envelope of the virus particle and usually involve a series of conformational changes in these proteins. We have studied the low-pH-mediated fusion process of th...

journal_title：Journal of virology

authors： Wahlberg JM,Bron R,Wilschut J,Garoff H

更新日期：1992-12-01 00:00:00

abstract：:In this study, we have extensively modified the Rb-binding domain of polyomavirus large T antigen. Mutant polyomavirus large T antigens were tested for their ability to bind pRb and p107 in vitro and assayed for their capacity to immortalize primary rat embryo fibroblasts in vivo. Polyomavirus large T antigen bound pR...

journal_title：Journal of virology

authors： Pilon AA,Desjardins P,Hassell JA,Mes-Masson AM

更新日期：1996-07-01 00:00:00

abstract：:Newcastle disease virus (NDV) edits its P-gene mRNA by inserting a nontemplated G residue(s) at a conserved editing site (3'-UUUUUCCC-template strand). In the wild-type virus, three amino-coterminal P-gene-derived proteins, P, V, and W, are produced at frequencies of approximately 68, 29, and 2%, respectively. By appl...

journal_title：Journal of virology

authors： Mebatsion T,Verstegen S,De Vaan LT,Römer-Oberdörfer A,Schrier CC

更新日期：2001-01-01 00:00:00

abstract：:Nondefective reticuloendotheliosis virus induces chicken bursal lymphoma in a manner similar to that of avian leukosis virus. The provirus integrates in the c-myc locus and uses a promoter insertion mechanism to activate c-myc expression. We cloned a provirus involved in c-myc activation from a B lymphoma. Detailed st...

journal_title：Journal of virology

authors： Swift RA,Boerkoel C,Ridgway A,Fujita DJ,Dodgson JB,Kung HJ

更新日期：1987-07-01 00:00:00

abstract：:African green monkeys can maintain long-term persistent infection with simian immunodeficiency viruses (SIVagm) without developing AIDS and thus provide an important model for understanding mechanisms of natural host resistance to disease. This study assessed the levels and anatomic distribution of SIVagm in healthy, ...

journal_title：Journal of virology

authors： Broussard SR,Staprans SI,White R,Whitehead EM,Feinberg MB,Allan JS

更新日期：2001-03-01 00:00:00

abstract：:The inclusion of Mimiviridae members in the putative monophyletic nucleocytoplasmic large DNA virus (NCLDV) group is based on genomic and phylogenomic patterns. This shows that, along with other viral families, they share a set of genes known as core or "hallmark genes," including the gene for the major capsid protein...

journal_title：Journal of virology

authors： Boratto PVM,Dornas FP,da Silva LCF,Rodrigues RAL,Oliveira GP,Cortines JR,Drumond BP,Abrahão JS

更新日期：2018-01-02 00:00:00

abstract：:We have previously described a nonconditional mutant of avian sarcoma virus (SE21Q1b) which fails to package viral RNA (Gallis et al., Virology 94:146-161, 1979; Linial et al., Cell 15:1371-1381, 1978). Quail cells transformed by SE21Q1b contain normal amounts of intracellular viral mRNA's for src, env, and gag-pol an...

journal_title：Journal of virology

authors： Shank PR,Linial M

更新日期：1980-11-01 00:00:00

abstract：:We sought proof of principle that one of the safest human vaccines, measles virus Edmonston B (MV-Edm), can be genetically modified to allow entry via cell surface molecules other than its receptor CD46. Hybrid proteins consisting of the epidermal growth factor (EGF) or the insulin-like growth factor 1 (IGF1) linked t...

journal_title：Journal of virology

authors： Schneider U,Bullough F,Vongpunsawad S,Russell SJ,Cattaneo R

更新日期：2000-11-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) tegument is the least understood component of the virion, and the mechanism of tegument assembly and incorporation into virions during viral egress has not yet been elucidated. In the present study, the addition of tegument proteins (VP13/14, VP16, VP22, and US9) and envelope gl...

journal_title：Journal of virology

authors： Miranda-Saksena M,Boadle RA,Armati P,Cunningham AL

更新日期：2002-10-01 00:00:00

abstract：UNLABELLED:Influenza virus hemagglutinin (HA) mediates virus entry by binding to cell surface receptors and fusing the viral and endosomal membranes following uptake by endocytosis. The acidic environment of endosomes triggers a large-scale conformational change in the transmembrane subunit of HA (HA2) involving a loop...

journal_title：Journal of virology

authors： Wang W,DeFeo CJ,Alvarado-Facundo E,Vassell R,Weiss CD

更新日期：2015-10-01 00:00:00

abstract：:The M2-1 protein of respiratory syncytial (RS) virus is a transcriptional processivity and antitermination factor. The M2-1 protein has a Cys3His1 zinc binding motif which is essential for function, is phosphorylated, and has been shown to interact with the RS virus nucleocapsid (N) protein. In the work reported here,...

journal_title：Journal of virology

authors： Cartee TL,Wertz GW

更新日期：2001-12-01 00:00:00

abstract：:Published work (D. J. McGeoch, Nucleic Acids Res. 18:4105-4110, 1990; J. E. McGeehan, N. W. Depledge, and D. J. McGeoch, Curr. Protein Peptide Sci. 2:325-333, 2001) has indicated that evolution of dUTPase in the class of herpesviruses that infect mammals and birds involved capture of a host gene followed by a duplicat...

journal_title：Journal of virology

authors： Davison AJ,Stow ND

更新日期：2005-10-01 00:00:00

abstract：:Capsid (core) assembly is essential for hepatitis B virus (HBV) replication. We hypothesize that assembly kinetics and stability are tuned for optimal viral replication, not maximal assembly. Assembly effectors (AEfs) are small molecules proposed to disrupt this balance by inappropriately enhancing core assembly. Guid...

journal_title：Journal of virology

authors： Tan Z,Maguire ML,Loeb DD,Zlotnick A

更新日期：2013-03-01 00:00:00

abstract：:The transcription of human papillomavirus type 16 (HPV-16) is mediated by the viral enhancer. Epithelial cell-specific activation is achieved by the cooperative interaction of apparently ubiquitous transcriptional factors. One of them, nuclear factor I (NFI), binds seven sites within the HPV-16 enhancer. Point mutatio...

journal_title：Journal of virology

authors： Apt D,Chong T,Liu Y,Bernard HU

更新日期：1993-08-01 00:00:00

abstract：:Using a DNA probe from an avian transforming virus, NK24, that contains the fos gene and that was newly isolated and characterized (M. Nishizawa, N. Goto, and S. Kawai, J. Virol. 61:3733-3740, 1987), we cloned and sequenced the chicken c-fos gene. Results showed that this gene, like the mouse or human c-fos gene, cont...

journal_title：Journal of virology

authors： Fujiwara KT,Ashida K,Nishina H,Iba H,Miyajima N,Nishizawa M,Kawai S

更新日期：1987-12-01 00:00:00

abstract：:A large percentage of the repetitive elements in mammalian genomes are retroelements, which have been moved primarily by LINE-1 retrotransposons and endogenous retroviruses. Although LINE-1 elements have remained active throughout the mammalian radiation, specific groups of endogenous retroviruses generally remain act...

journal_title：Journal of virology

authors： Cantrell MA,Ederer MM,Erickson IK,Swier VJ,Baker RJ,Wichman HA

更新日期：2005-12-01 00:00:00

abstract：:The present study was designed to investigate the endocytic pathway involved in canine parvovirus (CPV) infection. Reduced temperature (18 degrees C) or the microtubule-depolymerizing drug nocodazole was found to inhibit productive infection of canine A72 cells by CPV and caused CPV to be retained in cytoplasmic vesic...

journal_title：Journal of virology

authors： Vihinen-Ranta M,Kalela A,Mäkinen P,Kakkola L,Marjomäki V,Vuento M

更新日期：1998-01-01 00:00:00