Role of recombinant ecotropic and polytropic viruses in the development of spontaneous thymic lymphomas in HRS/J mice.

abstract：:An in vitro system is described for the assembly of herpes simplex virus type 1 (HSV-1) procapsids beginning with three purified components, the major capsid protein (VP5), the triplexes (VP19C plus VP23), and a hybrid scaffolding protein. Each component was purified from insect cells expressing the relevant protein(s...

journal_title：Journal of virology

authors： Newcomb WW,Homa FL,Thomsen DR,Trus BL,Cheng N,Steven A,Booy F,Brown JC

更新日期：1999-05-01 00:00:00

abstract：:In July 1991, an influenza A virus, designated A/Maryland/12/91 (A/MD), was isolated from the bronchial secretions of a 27-year-old animal caretaker. He had been admitted to the hospital with bilateral pneumonia and died of acute respiratory distress syndrome 13 days later. Antigenic analyses with postinfection ferret...

journal_title：Journal of virology

authors： Wentworth DE,Thompson BL,Xu X,Regnery HL,Cooley AJ,McGregor MW,Cox NJ,Hinshaw VS

更新日期：1994-04-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a member of the Parvoviridae, belonging to the Dependovirus genus. Currently, several distinct isolates of AAV are in development for use in human gene therapy applications due to their ability to transduce different target cells. The need to manipulate AAV capsids for specific tissue d...

journal_title：Journal of virology

authors： Padron E,Bowman V,Kaludov N,Govindasamy L,Levy H,Nick P,McKenna R,Muzyczka N,Chiorini JA,Baker TS,Agbandje-McKenna M

更新日期：2005-04-01 00:00:00

abstract：:Heat shock protein 70 (Hsp70) is incorporated within the membrane of primate lentiviral virions. Here we demonstrate that Hsp70 is also incorporated into oncoretroviral virions and that it remains associated with membrane-stripped human immunodeficiency virus type 1 (HIV-1) virion cores. To determine if Hsp70 promotes...

journal_title：Journal of virology

authors： Gurer C,Höglund A,Höglund S,Luban J

更新日期：2005-05-01 00:00:00

abstract：:The influenza A virus (IAV) envelope protein hemagglutinin binds α2,6- or α2,3-linked sialic acid as a host cell receptor. Bat IAV subtypes H17N10 and H18N11 form an exception to this rule and do not bind sialic acid but enter cells via major histocompatibility complex (MHC) class II. Here, we review current knowledge...

journal_title：Journal of virology

authors： Karakus U,Pohl MO,Stertz S

更新日期：2020-01-31 00:00:00

abstract：:Monoclonal antibodies (MAbs) directed against the E2 glycoprotein of mouse hepatitis virus (MHV) have been classified according to their ability to bind to either of the two purified 90,000-molecular-weight subunits (90K subunits) of the 180K peplomeric glycoprotein E2. Correlation with previously reported information...

journal_title：Journal of virology

authors： Weismiller DG,Sturman LS,Buchmeier MJ,Fleming JO,Holmes KV

更新日期：1990-06-01 00:00:00

abstract：:Domains required late in the virus budding process (L domains) have been identified in the Gag proteins of a number of retroviruses. Here we show that the human T-cell leukemia virus type 1 candidate L domain motif PPPY is indeed required for virus production. Strikingly, however, mutation of this motif arrested virus...

journal_title：Journal of virology

authors： Le Blanc I,Prévost MC,Dokhélar MC,Rosenberg AR

更新日期：2002-10-01 00:00:00

abstract：:By using an isothermal multiply primed rolling-circle amplification protocol, the complete genomic DNA of a novel papillomavirus was amplified from a skin lesion biopsy of a Florida manatee (Trichechus manatus latirostris), one of the most endangered marine mammals in United States coastal waters. The nucleotide seque...

journal_title：Journal of virology

authors： Rector A,Bossart GD,Ghim SJ,Sundberg JP,Jenson AB,Van Ranst M

更新日期：2004-11-01 00:00:00

abstract：:Several lines of evidence indicate that cutaneous human papillomavirus (HPV) types belonging to the beta genus of the HPV phylogenetic tree synergize with UV radiation in the development of skin cancer. Accordingly, the E6 and E7 oncoproteins from some beta HPV types are able to deregulate pathways related to immune r...

journal_title：Journal of virology

authors： Pacini L,Ceraolo MG,Venuti A,Melita G,Hasan UA,Accardi R,Tommasino M

更新日期：2017-09-12 00:00:00

abstract：:Some retroviruses contain monoubiquitinated Gag and do not bud efficiently from cells treated with proteasome inhibitors, suggesting an interaction between the ubiquitin-proteasome system and retrovirus assembly. We examined equine infectious anemia virus (EIAV) particles and found that approximately 2% of the p9(Gag)...

journal_title：Journal of virology

authors： Ott DE,Coren LV,Sowder RC 2nd,Adams J,Nagashima K,Schubert U

更新日期：2002-03-01 00:00:00

abstract：:We have investigated the molecular basis of biological differences observed among cell line-adapted isolates of the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and the simian immunodeficiency virus (SIV) in response to receptor binding by using a soluble form of CD4 (sCD4) as a receptor mimic. We find...

journal_title：Journal of virology

authors： Sattentau QJ,Moore JP,Vignaux F,Traincard F,Poignard P

更新日期：1993-12-01 00:00:00

abstract：:Mosquito-borne alphaviruses, which replicate alternately and obligately in mosquitoes and vertebrates, appear to experience lower rates of evolution than do many RNA viruses that replicate solely in vertebrates. This genetic stability is hypothesized to result from the alternating host cycle, which constrains evolutio...

journal_title：Journal of virology

authors： Greene IP,Wang E,Deardorff ER,Milleron R,Domingo E,Weaver SC

更新日期：2005-11-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with a variety of immunoregulatory disorders. HTLV-1 has been shown to bind to and infect a variety of hematopoietic and nonhematopoietic cells. However, both in vivo and in vitro, the provirus is mos...

journal_title：Journal of virology

authors： Newbound GC,Andrews JM,O'Rourke JP,Brady JN,Lairmore MD

更新日期：1996-04-01 00:00:00

abstract：:Maintenance of Kaposi's sarcoma-associated herpesvirus (KSHV) latent infection depends on the viral episomes in the nucleus being distributed to daughter cells following cell division. The latency-associated nuclear antigen (LANA) is constitutively expressed in all KSHV-infected cells. LANA binds sequences in the term...

journal_title：Journal of virology

authors： Krithivas A,Fujimuro M,Weidner M,Young DB,Hayward SD

更新日期：2002-11-01 00:00:00

abstract：:Purified avian myeloblastosis virus was iodinated by the lactoperoxidase method. Disruption of the labeled virions and chromatography of the viral proteins showed that radioiodine was associated only with the glycoproteins of the viral envelope. Reaction of the radiolabeled virus with antiviral antibody followed by mi...

journal_title：Journal of virology

authors： Fritz RB

更新日期：1974-01-01 00:00:00

abstract：:Budding of retroviruses from cell membranes requires ubiquitination of Gag and recruitment of cellular proteins involved in endosome sorting, including endosome sorting complex required for transport III (ESCRT-III) protein complex and vacuolar protein sorting 4 (VPS4) and its ATPase. In response to infection, a cellu...

journal_title：Journal of virology

authors： Kuang Z,Seo EJ,Leis J

更新日期：2011-07-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC famil...

journal_title：Journal of virology

authors： Siu YT,Chin KT,Siu KL,Yee Wai Choy E,Jeang KT,Jin DY

更新日期：2006-07-01 00:00:00

abstract：:The varicella-zoster virus major transactivator, IE62, contains a potent N-terminal acidic transcriptional activation domain (TAD). Our experiments revealed that the minimal IE62 TAD encompasses amino acids (aa) 19 to 67. We showed that the minimal TAD interacts with the human Mediator complex. Site-specific mutations...

journal_title：Journal of virology

authors： Yamamoto S,Eletsky A,Szyperski T,Hay J,Ruyechan WT

更新日期：2009-06-01 00:00:00

abstract：:Circulating leukocytes are important in dissemination of cytomegalovirus (CMV) infection in humans. In the mouse model of murine CMV infection (MCMV), it has been shown that infection peaks on days 5 to 7 after experimental infection, when 0.01 to 0.1% of the circulating leukocytes contain viral DNA. In our laboratory...

journal_title：Journal of virology

authors： Collins TM,Quirk MR,Jordan MC

更新日期：1994-10-01 00:00:00

abstract：:Analysis of large and small plaque mutants of simian virus 40 using antisera prepared against each has revealed quantitative and possibly qualitative antigenic differences for each plaque type. A sensitive micro radioisotope precipitation test permitted evaluation of immunochemical similarities and differences of caps...

journal_title：Journal of virology

authors： Ozer HL,Takemoto KK,Kirschstein RL,Axelrod D

更新日期：1969-01-01 00:00:00

abstract：:Interactions between host factors and the viral replication complex play important roles in host adaptation and regulation of influenza virus replication. A cellular protein, nuclear factor 90 (NF90), was copurified with H5N1 viral nucleoprotein (NP) from human cells in which NP was transiently expressed and identifie...

journal_title：Journal of virology

authors： Wang P,Song W,Mok BW,Zhao P,Qin K,Lai A,Smith GJ,Zhang J,Lin T,Guan Y,Chen H

更新日期：2009-08-01 00:00:00

abstract：:Late (L) domains containing the highly conserved sequence PPXY were first described for retroviruses, and later research confirmed their conservation and importance for efficient budding of several negative-stranded RNA viruses. Rabies virus (RV), a member of the Rhabdoviridae family, contains the sequence PPEY (amino...

journal_title：Journal of virology

authors： Wirblich C,Tan GS,Papaneri A,Godlewski PJ,Orenstein JM,Harty RN,Schnell MJ

更新日期：2008-10-01 00:00:00

abstract：:The interaction of the mouse hepatitis virus (MHV) nucleocapsid protein (N) and viral RNA was examined. Monoclonal antibody specific for N protein coimmunoprecipitated MHV genomic RNA as well as all six MHV subgenomic mRNAs found in MHV-infected cells. In contrast, monoclonal antibodies to the MHV E2 or E1 envelope gl...

journal_title：Journal of virology

authors： Baric RS,Nelson GW,Fleming JO,Deans RJ,Keck JG,Casteel N,Stohlman SA

更新日期：1988-11-01 00:00:00

abstract：:Expression of the selectable drug resistance gene in retroviral vectors used for gene therapy can lead to a decreased expression of the gene of interest and may induce a host immune response, resulting in a decreased efficiency of gene therapy. In this study, we demonstrate that high-frequency deletion of direct repea...

journal_title：Journal of virology

authors： Delviks KA,Pathak VK

更新日期：1999-10-01 00:00:00

abstract：:RNA structures play key roles in the replication of RNA viruses. Sequence alignment software, thermodynamic RNA folding programs, and classical comparative phylogenetic analysis were used to build models of six RNA elements in the coding region of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B. The imp...

journal_title：Journal of virology

authors： You S,Stump DD,Branch AD,Rice CM

更新日期：2004-02-01 00:00:00

abstract：:HIV-1 causes a persistent infection of the immune system that is associated with chronic comorbidities. The mechanisms that underlie this inflammation are poorly understood. Emerging literature has implicated proinflammatory purinergic receptors and downstream signaling mediators in HIV-1 infection. This study probed ...

journal_title：Journal of virology

authors： Soare AY,Durham ND,Gopal R,Tweel B,Hoffman KW,Brown JA,O'Brien M,Bhardwaj N,Lim JK,Chen BK,Swartz TH

更新日期：2018-12-10 00:00:00

abstract：:The gB glycoprotein of herpes simplex virus type 1 is involved in viral entry and fusion and contains a predicted membrane-anchoring sequence of 69 hydrophobic amino acids, which can span the membrane three times, near the carboxy terminus. To define the membrane-anchoring sequence and the role of this hydrophobic str...

journal_title：Journal of virology

authors： Rasile L,Ghosh K,Raviprakash K,Ghosh HP

更新日期：1993-08-01 00:00:00

abstract：:Mice were infected with lymphocytic choriomeningitis virus and injected once 24 h later with a monoclonal antibody directed against gamma interferon. In comparison with controls, the increase of numbers of CD8+ T cells and the generation of virus-specific cytotoxic T lymphocytes in spleens and virus clearance from org...

journal_title：Journal of virology

authors： Utermöhlen O,Dangel A,Tárnok A,Lehmann-Grube F

更新日期：1996-03-01 00:00:00

abstract：:Virion capture assays, in which immobilized antibodies (Abs) capture virus particles, have been used to suggest that nonneutralizing Abs bind effectively to human immunodeficiency virus type 1 (HIV-1) primary viruses. Here, we show that virion capture assays, under conditions commonly reported in the literature, give ...

journal_title：Journal of virology

authors： Poignard P,Moulard M,Golez E,Vivona V,Franti M,Venturini S,Wang M,Parren PW,Burton DR

更新日期：2003-01-01 00:00:00

abstract：:Human metapneumovirus (hMPV), a recently described paramyxovirus, is a major etiological agent for lower respiratory tract disease in young children that can manifest with severe cough, bronchiolitis, and pneumonia. The hMPV fusion glycoprotein (F) shares conserved functional domains with other paramyxovirus F protein...

journal_title：Journal of virology

authors： Schickli JH,Kaur J,Ulbrandt N,Spaete RR,Tang RS

更新日期：2005-08-01 00:00:00