Multiple isoelectric forms of poliovirus RNA-dependent RNA polymerase: evidence for phosphorylation.

abstract：:The herpes simplex virus type 1 (HSV-1) capsid is a T=16 icosahedral shell that forms in the nuclei of infected cells. Capsid assembly also occurs in vitro in reaction mixtures created from insect cell extracts containing recombinant baculovirus-expressed HSV-1 capsid proteins. During capsid formation, the major capsi...

journal_title：Journal of virology

authors： Spencer JV,Newcomb WW,Thomsen DR,Homa FL,Brown JC

更新日期：1998-05-01 00:00:00

abstract：:Poliovirus proteins 3A and 3AB are small, membrane-binding proteins that play multiple roles in viral RNA replication complex formation and function. In the infected cell, these proteins associate with other viral and cellular proteins as part of a supramolecular complex whose structure and composition are unknown. We...

journal_title：Journal of virology

authors： Teterina NL,Pinto Y,Weaver JD,Jensen KS,Ehrenfeld E

更新日期：2011-05-01 00:00:00

abstract：:HIV circumvents HLA class I-restricted CD8+ T-cell responses through selection of escape mutations that leave characteristic mutational "footprints," also known as HLA-associated polymorphisms (HAPs), on HIV sequences at the population level. While many HLA footprints are universal across HIV subtypes and human popula...

journal_title：Journal of virology

authors： Soto-Nava M,Avila-Ríos S,Valenzuela-Ponce H,García-Morales C,Carlson JM,Tapia-Trejo D,Garrido-Rodriguez D,Alva-Hernández SN,García-Tellez TA,Murakami-Ogasawara A,International HIV Adaptation Collaborative.,Mallal SA,John M,Broc

更新日期：2018-01-02 00:00:00

abstract：:The involvement of mouse mammary tumor virus (MTV) in the development of mammary tumors of nonviral etiology in BALB/c mice was studied by measuring the levels of MTV RNA, MTV DNA, and MTV proteins in spontaneously arising and hormonally, chemically, and/or physically induced mammary tumors of BALB/c females. The foll...

journal_title：Journal of virology

authors： Michalides R,van Deemter L,Nusse R,Hageman P

更新日期：1979-07-01 00:00:00

abstract：:Further advances are required in understanding protection from AIDS by T-cell immunity. We analyzed a set of multigenic simian/human immunodeficiency virus (SHIV) DNA and fowlpox virus priming and boosting vaccines for immunogenicity and protective efficacy in outbred pigtail macaques. The number of vaccinations requi...

journal_title：Journal of virology

authors： Dale CJ,De Rose R,Stratov I,Chea S,Montefiori DC,Thomson S,Ramshaw IA,Coupar BE,Boyle DB,Law M,Kent SJ

更新日期：2004-12-01 00:00:00

abstract：:Broad and potent neutralizing antibodies (bnAbs) with multiple epitope specificities evolve in HIV-1-infected children. Herein, we studied two antiretroviral-naive chronically HIV-1 clade C-infected monozygotic pediatric twins, AIIMS_329 and AIIMS_330, with potent plasma bnAbs. Elite plasma neutralizing activity was o...

journal_title：Journal of virology

authors： Mishra N,Makhdoomi MA,Sharma S,Kumar S,Dobhal A,Kumar D,Chawla H,Singh R,Kanga U,Das BK,Lodha R,Kabra SK,Luthra K

更新日期：2019-08-13 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) infection in the central nervous system (CNS) is characterized by replication in macrophages or brain microglia that express low levels of the CD4 receptor and is the cause of HIV-associated dementia and related cognitive and motor disorders that affect 20 to 30% o...

journal_title：Journal of virology

authors： Zhuang K,Leda AR,Tsai L,Knight H,Harbison C,Gettie A,Blanchard J,Westmoreland S,Cheng-Mayer C

更新日期：2014-08-01 00:00:00

abstract：:Influenza viruses and rhinoviruses are responsible for a large number of acute respiratory viral infections in human populations and are detected as copathogens within hosts. Clinical and epidemiological studies suggest that coinfection by rhinovirus and influenza virus may reduce disease severity and that they may al...

journal_title：Journal of virology

authors： Gonzalez AJ,Ijezie EC,Balemba OB,Miura TA

更新日期：2018-11-12 00:00:00

abstract：:The positive-strand RNA bromoviruses encode two nonstructural proteins, 1a and 2a, involved in RNA-dependent RNA replication. These proteins have extensive sequence similarities with methyltransferase, helicase, and polymerase proteins of other plant and animal viruses. 1a and 2a can also form a complex in vitro. To e...

journal_title：Journal of virology

authors： Dinant S,Janda M,Kroner PA,Ahlquist P

更新日期：1993-12-01 00:00:00

abstract：:The tetrameric paramyxovirus hemagglutinin-neuraminidase (HN) protein mediates attachment to sialic acid-containing receptors as well as cleavage of the same moiety via its neuraminidase (NA) activity. The X-ray crystallographic structure of an HN dimer from Newcastle disease virus (NDV) suggests that a single site in...

journal_title：Journal of virology

authors： Corey EA,Mirza AM,Levandowsky E,Iorio RM

更新日期：2003-06-01 00:00:00

abstract：:Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus, we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replic...

journal_title：Journal of virology

authors： Jones JC,Baranovich T,Zaraket H,Guan Y,Shu Y,Webby RJ,Webster RG

更新日期：2013-11-01 00:00:00

abstract：UNLABELLED:During HIV-1 assembly, the Gag viral proteins are targeted and assemble at the inner leaflet of the cell plasma membrane. This process could modulate the cortical actin cytoskeleton, located underneath the plasma membrane, since actin dynamics are able to promote localized membrane reorganization. In additio...

journal_title：Journal of virology

authors： Thomas A,Mariani-Floderer C,López-Huertas MR,Gros N,Hamard-Péron E,Favard C,Ohlmann T,Alcamí J,Muriaux D

更新日期：2015-08-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68, or MHV-68) is a genetically tractable, small animal model for the analysis of gammaherpesvirus pathogenesis. The gammaHV68 genome is colinear with the genomes of other sequence gammaherpesviruses, containing large blocks of conserved genes interspersed by a number of putative gen...

journal_title：Journal of virology

authors： Clambey ET,Virgin HW 4th,Speck SH

更新日期：2000-02-01 00:00:00

abstract：:Tryptic digests of the internal proteins p30, p15, p12, and p10 of mouse xenotropic, ecotropic, and amphotropic type C viruses were subjected to cation-exchange chromatography. Analysis of these maps revealed that the p30 proteins from representative isolates of all three viral subgroups were distinguishable. The p15 ...

journal_title：Journal of virology

authors： Albino A,Korngold L,Mellors RC

更新日期：1979-01-01 00:00:00

abstract：:The murine monoclonal antibody (MAb) 5A8, which is reactive with domain 2 of CD4, blocks human immunodeficiency virus type 1 (HIV-1) infection and syncytium formation of CD4+ cells (L. C. Burkly, D. Olson, R. Shapiro, G. Winkler, J. J. Rosa, D. W. Thomas, C. Williams, and P. Chisholm, J. Immunol., in press). Here we s...

journal_title：Journal of virology

authors： Moore JP,Sattentau QJ,Klasse PJ,Burkly LC

更新日期：1992-08-01 00:00:00

abstract：:For viruses with segmented genomes, genetic diversity is generated by genetic drift, reassortment, and recombination. Recombination produces RNA populations distinct from full-length gene segments and can influence viral population dynamics, persistence, and host immune responses. Viruses in the Reoviridae family, inc...

journal_title：Journal of virology

authors： Smith SC,Gribble J,Diller JR,Wiebe MA,Thoner TW Jr,Denison MR,Ogden KM

更新日期：2021-01-20 00:00:00

abstract：:Phage XP-12, which has complete substitution of the cytosine residues in its DNA with 5-methylcytosine residues, was shown to inhibit incorporation of uracil into host DNA and RNA during the latent period. This apparent inhibition of host macromolecular synthesis was not accompanied by extensive degradation of the hos...

journal_title：Journal of virology

authors： Ehrlich M,Lin FH,Ehrlich K,Brown SL,Mayo JA

更新日期：1977-09-01 00:00:00

abstract：:Infection with various human papillomaviruses (HPVs) induces cervical cancers. Cell surface heparan sulfates (HS) have been shown to serve as primary attachment receptors, and molecules with structural similarity to cell surface HS, like heparin, function as competitive inhibitors of HPV infection. Here we demonstrate...

journal_title：Journal of virology

authors： Selinka HC,Florin L,Patel HD,Freitag K,Schmidtke M,Makarov VA,Sapp M

更新日期：2007-10-01 00:00:00

abstract：:B cells secreting IgG antibodies, but not IgM, are thought to be solely responsible for vaccine-induced protection against rabies virus (RABV) infections in postexposure settings. In this report, we reinvestigated the potential for IgM to mediate protection in a mouse model of RABV vaccination. Immunocompetent mice im...

journal_title：Journal of virology

authors： Dorfmeier CL,Shen S,Tzvetkov EP,McGettigan JP

更新日期：2013-08-01 00:00:00

abstract：:Varicella-zoster virus (VZV) encodes within its unique long region a gene product with protein kinase motifs. In a previous study, we demonstrated that immunoprecipitated VZV open reading frame (ORF) 47 protein was associated with a functional protein kinase activity, on the basis of its ability to both autophosphoryl...

journal_title：Journal of virology

authors： Ng TI,Keenan L,Kinchington PR,Grose C

更新日期：1994-03-01 00:00:00

abstract：:NYVAC has been engineered as a safe, attenuated vaccinia virus (VV) vector for use in vaccination against a broad spectrum of pathogens and tumors. Due to the interest in NYVAC-based vectors as vaccines and current phase I/II clinical trials with this vector, there is a need to analyze the human host response to NYVAC...

journal_title：Journal of virology

authors： Guerra S,López-Fernández LA,Pascual-Montano A,Nájera JL,Zaballos A,Esteban M

更新日期：2006-01-01 00:00:00

abstract：:We have examined the exposure and conservation of antigenic epitopes on the surface envelope glycoproteins (gp120 and gp41) of 26 intact, native, primary human immunodeficiency virus type 1 (HIV-1) group M virions of clades A to H. For this, 47 monoclonal antibodies (MAbs) derived from HIV-1-infected patients were use...

journal_title：Journal of virology

authors： Nyambi PN,Mbah HA,Burda S,Williams C,Gorny MK,Nádas A,Zolla-Pazner S

更新日期：2000-08-01 00:00:00

abstract：:Coinfection with HIV-1 and Kaposi's sarcoma-associated herpesvirus (KSHV) often leads to AIDS-related malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The interaction between HIV and KSHV plays a pivotal role in the progression of these malignancies. We have previously demonstrated th...

journal_title：Journal of virology

authors： Yan Q,Zhao R,Shen C,Wang F,Li W,Gao SJ,Lu C

更新日期：2018-08-29 00:00:00

abstract：:The D4R gene of vaccinia virus encodes a functional uracil-DNA glycosylase that is essential for viral viability (D. T. Stuart, C. Upton, M. A. Higman, E. G. Niles, and G. McFadden, J. Virol. 67:2503-2513, 1993), and a D4R mutant, ts4149, confers a conditional lethal defect in viral DNA replication (A. K. Millns, M. S...

journal_title：Journal of virology

authors： Ellison KS,Peng W,McFadden G

更新日期：1996-11-01 00:00:00

abstract：:A series of recombinant molecules were constructed which direct the expression of the easily assayed gene chloramphenicol acetyltransferase. We have used these recombinants to show that the 73/72-base-pair tandem repeat unit from the Moloney murine sarcoma virus long terminal repeat shares a number of properties with ...

journal_title：Journal of virology

authors： Laimins LA,Gruss P,Pozzatti R,Khoury G

更新日期：1984-01-01 00:00:00

abstract：:Recombinant strains of replication-competent rhesus monkey rhadinovirus (RRV) were constructed in which strong promoter/enhancer elements were used to drive expression of simian immunodeficiency virus (SIV) Env or Gag or a Rev-Tat-Nef fusion protein. Cultured rhesus monkey fibroblasts infected with each recombinant st...

journal_title：Journal of virology

authors： Bilello JP,Manrique JM,Shin YC,Lauer W,Li W,Lifson JD,Mansfield KG,Johnson RP,Desrosiers RC

更新日期：2011-12-01 00:00:00

abstract：:The herpes simplex virus glycoprotein designated VP7(B2) is extracted from virions by nonionic detergent in the form of an oligomer, whereas the other detergent-soluble envelope proteins appear to be extracted as monomers. The subunits of the VP7(B2) oligomer cannot be dissociated by 2-mercaptoethanol and are also res...

journal_title：Journal of virology

authors： Sarmiento M,Spear PG

更新日期：1979-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV) can be reactivated from latency into the lytic cycle by many stimuli believed to operate by different mechanisms. Cell lines containing EBV differ in their responses to inducing stimuli, yet all stimuli require de novo protein synthesis (44). A crucial step preliminary to identifying these pro...

journal_title：Journal of virology

authors： Countryman J,Gradoville L,Bhaduri-McIntosh S,Ye J,Heston L,Himmelfarb S,Shedd D,Miller G

更新日期：2009-10-01 00:00:00

abstract：:In Escherichia coli B infected with phage T4 with mutations in gene 55 the shut-off of synthesis of two early enzymes was found to be delayed 10 to 15 min as compared to wild-type T4 infection. The kinetics of early enzyme formation was very similar to that obtained after DNA-negative mutant infection. The transcripti...

journal_title：Journal of virology

authors： Bolund C

更新日期：1973-07-01 00:00:00

abstract：:The mechanism by which bovine herpesvirus 1 (BHV-1) predisposes cattle to bacterial pneumonia was investigated by using an in vitro system to demonstrate immunosuppression. At a multiplicity of infection of 0.001, live or inactivated BHV-1 induced a 50% inhibition of the proliferative response of peripheral blood mono...

journal_title：Journal of virology

authors： Hutchings DL,Campos M,Qualtiere L,Babiuk LA

更新日期：1990-09-01 00:00:00