Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus.

abstract：:We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/gammac(null) (NOG) mice. This model is very useful for investigating the mechanism of tumorigenesis and malignant cell growth of adult T-cell leukemia (ATL)/lymphoma, which still remains unclear. Nine...

journal_title：Journal of virology

authors： Dewan MZ,Terashima K,Taruishi M,Hasegawa H,Ito M,Tanaka Y,Mori N,Sata T,Koyanagi Y,Maeda M,Kubuki Y,Okayama A,Fujii M,Yamamoto N

更新日期：2003-05-01 00:00:00

abstract：:Recombination studies have established that retroviral long terminal repeats (LTRs) are important genetic determinants of the viral capacity to induce hematopoietic tumors and to specify the type of cell making up the tumor. Plasmids containing LTRs of several murine leukemia viruses linked to the chloramphenicol acet...

journal_title：Journal of virology

authors： Short MK,Okenquist SA,Lenz J

更新日期：1987-04-01 00:00:00

abstract：:The human cytomegalovirus (HCMV) UL138 protein downregulates the cell surface expression of the multidrug resistance-associated protein 1 (MRP1) transporter. We examined the genetic requirements within UL138 for MRP1 downregulation. We determined that the acidic cluster dileucine motif is essential for UL138-mediated ...

journal_title：Journal of virology

authors： Gelbmann CB,Kalejta RF

更新日期：2019-05-15 00:00:00

abstract：UNLABELLED:Numerous experimental studies have demonstrated that CD8(+) T cells contribute to immunity against influenza by limiting viral replication. It is therefore surprising that rigorous statistical tests have failed to find evidence of positive selection in the epitopes targeted by CD8(+) T cells. Here we use a n...

journal_title：Journal of virology

authors： Machkovech HM,Bedford T,Suchard MA,Bloom JD

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:Chikungunya virus (CHIKV) is a member of a globally distributed group of arthritogenic alphaviruses that cause weeks to months of debilitating polyarthritis/arthralgia, which is often poorly managed with current treatments. Arthritic disease is usually characterized by high levels of the chemokine CCL2 and a...

journal_title：Journal of virology

authors： Poo YS,Nakaya H,Gardner J,Larcher T,Schroder WA,Le TT,Major LD,Suhrbier A

更新日期：2014-06-01 00:00:00

abstract：:Natural killer (NK) cells serve as a crucial first-line defense against tumors and virus-infected cells. We previously showed that lysis of influenza virus (IV)-infected cells is mediated by the interaction between the NK receptor, NKp46, and the IV hemagglutinin (HA) type 1 expressed by the infected cells. This inter...

journal_title：Journal of virology

authors： Mendelson M,Tekoah Y,Zilka A,Gershoni-Yahalom O,Gazit R,Achdout H,Bovin NV,Meningher T,Mandelboim M,Mandelboim O,David A,Porgador A

更新日期：2010-04-01 00:00:00

abstract：:Although monkey B virus (herpesvirus simiae; BV) is common in all macaque species, fatal human infections appear to be associated with exposure to rhesus macaques (Macaca mulatta), suggesting that BV isolates from rhesus monkeys may be more lethal to nonmacaques than are BV strains indigenous to other macaque species....

journal_title：Journal of virology

authors： Smith AL,Black DH,Eberle R

更新日期：1998-11-01 00:00:00

abstract：:Two murine leukemia viruses were isolated from JLS-V9 cells which had been infected with Rauscher plasma virus. One virus was XC positive and failed to grow on mink or cat cells and thus was an ecotropic virus. The other virus formed cytopathic foci on mink cells, was XC negative, and fell into the mink cell focus-for...

journal_title：Journal of virology

authors： Schultz A,Rein A,Henderson L,Oroszlan S

更新日期：1983-03-01 00:00:00

abstract：:We identified the domains of CD26 involved in the binding of Middle East respiratory syndrome coronavirus (MERS-CoV) using distinct clones of anti-CD26 monoclonal antibodies (MAbs). One clone, named 2F9, almost completely inhibited viral entry. The humanized anti-CD26 MAb YS110 also significantly inhibited infection. ...

journal_title：Journal of virology

authors： Ohnuma K,Haagmans BL,Hatano R,Raj VS,Mou H,Iwata S,Dang NH,Bosch BJ,Morimoto C

更新日期：2013-12-01 00:00:00

abstract：:Growth kinetics in lymphocytic H9 and M8166 cells of two mutants of human immunodeficiency virus type 1 (HIV-1) with deleted gp41 cytoplasmic tails were examined. While the mutant viruses designated CTdel-44 and CTdel-144 were able to grow in M8166 cells, they were unable to grow in H9 cells. Transfection and single-r...

journal_title：Journal of virology

authors： Akari H,Fukumori T,Adachi A

更新日期：2000-05-01 00:00:00

abstract：:Recent in vitro proteomics screens revealed that many host proteins could interact with the replication proteins of Tomato bushy stunt virus (TBSV), which is a small, plus-stranded RNA virus (Z. Li, D. Barajas, T. Panavas, D. A. Herbst, and P. D. Nagy, J. Virol. 82:6911-6926, 2008). To further our understanding of the...

journal_title：Journal of virology

authors： Barajas D,Li Z,Nagy PD

更新日期：2009-11-01 00:00:00

abstract：UNLABELLED:The HIV-1 virion infectivity factor (Vif) targets the cellular cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) for degradation via the host ubiquitin-proteasome pathway. Vif recruits a cellular E3 ubiquitin ligase to polyubiquitinate A3G/F. The activity of Vif critically depends on the cellular core bi...

journal_title：Journal of virology

authors： Fribourgh JL,Nguyen HC,Wolfe LS,Dewitt DC,Zhang W,Yu XF,Rhoades E,Xiong Y

更新日期：2014-03-01 00:00:00

abstract：:Herpes simplex virus type 1 packages its DNA genome into a precursor capsid, referred to as the procapsid. Of the three capsid-associated DNA-packaging proteins, UL17, UL25, and UL6, only UL17 and UL6 appear to be components of the procapsid, with UL25 being added subsequently. To determine whether the association of ...

journal_title：Journal of virology

authors： Thurlow JK,Murphy M,Stow ND,Preston VG

更新日期：2006-03-01 00:00:00

abstract：:RNA silencing is a conserved eukaryotic gene regulatory system in which sequence specificity is determined by small RNAs. Plant RNA silencing also acts as an antiviral mechanism; therefore, viral infection requires expression of a silencing suppressor. The mechanism and the evolution of silencing suppression are still...

journal_title：Journal of virology

authors： Mérai Z,Kerényi Z,Molnár A,Barta E,Válóczi A,Bisztray G,Havelda Z,Burgyán J,Silhavy D

更新日期：2005-06-01 00:00:00

abstract：:The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that pRB degradation is a direct activity of E7 and does not reflect a property of cell lines acquired during the selection pr...

journal_title：Journal of virology

authors： Gonzalez SL,Stremlau M,He X,Basile JR,Münger K

更新日期：2001-08-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is the most common opportunistic infection in immunosuppressed individuals, such as transplant recipients or people living with HIV/AIDS, and congenital CMV is the leading viral cause of developmental disabilities in infants. Due to the highly species-specific nature of CMV, animal mode...

journal_title：Journal of virology

authors： Marsh AK,Willer DO,Ambagala AP,Dzamba M,Chan JK,Pilon R,Fournier J,Sandstrom P,Brudno M,MacDonald KS

更新日期：2011-12-01 00:00:00

abstract：:The replication of many positive-strand RNA viruses [(+)RNA viruses] depends on the cellular protein GBF1, but its role in the replication process is not clear. In uninfected cells, GBF1 activates small GTPases of the Arf family and coordinates multiple steps of membrane metabolism, including functioning of the cellul...

journal_title：Journal of virology

authors： Viktorova EG,Gabaglio S,Meissner JM,Lee E,Moghimi S,Sztul E,Belov GA

更新日期：2019-10-15 00:00:00

abstract：:Human adenovirus type 12 was propagated on human embryonic kidney cells, and the specific infectivities of intra- and extracellular virus particles were compared between 48 and 104 h after infection. Released virions exhibited a specific infectivity of up to 10 times higher than that of intracellular particles. The in...

journal_title：Journal of virology

authors： Brüggemann U,Klenk HD,Doerfler W

更新日期：1985-07-01 00:00:00

abstract：:HBI is a recombinant avian retrovirus with novel pathogenic properties that was derived from the myc-containing virus MC29. In contrast to MC29, which causes endotheliomas in chickens, HBI induces lymphoid tumors. The results of molecular cloning and nucleotide sequencing of HBI reported here show that the virus conta...

journal_title：Journal of virology

authors： Smith DR,Vennstrom B,Hayman MJ,Enrietto PJ

更新日期：1985-12-01 00:00:00

abstract：:West Nile virus (WNV) replicates in the skin; however, cell targets in the skin have not been identified. In the current studies, WNV infected the epidermis and adnexal glands of mouse skin, and the epidermal cells were identified as keratinocytes by double labeling for WNV antigen and keratin 10. Inoculation of mice ...

journal_title：Journal of virology

authors： Lim PY,Behr MJ,Chadwick CM,Shi PY,Bernard KA

更新日期：2011-05-01 00:00:00

abstract：:The simian virus 40 (SV40) core origin of replication consists of three functional domains. The sequence 5'-CACTACTTCTGGAATAG-3' with an imperfect inverted repeat (underlined), a palindrome with four 5'-GAGGC-3' pentanucleotide repeats, and a 17-base-pair A + T-rich segment. We have been able to assign primary functio...

journal_title：Journal of virology

authors： Parsons R,Anderson ME,Tegtmeyer P

更新日期：1990-02-01 00:00:00

abstract：:Replication and assembly of hepatitis C virus (HCV) depend on the host's secretory and lipid-biosynthetic machinery. Viral replication occurs on endoplasmic reticulum (ER)-derived modified membranes, while viral assembly is thought to occur on lipid droplets (LDs). A physical association and coordination between the v...

journal_title：Journal of virology

authors： Nevo-Yassaf I,Yaffe Y,Asher M,Ravid O,Eizenberg S,Henis YI,Nahmias Y,Hirschberg K,Sklan EH

更新日期：2012-06-01 00:00:00

abstract：:The nonstructural 4B (NS4B) protein of hepatitis C virus (HCV) plays a central role in the formation of the HCV replication complex. To gain insight into the role of charged residues for NS4B function in HCV RNA replication, alanine substitutions were engineered in place of 28 charged residues residing in the N- and C...

journal_title：Journal of virology

authors： Blight KJ

更新日期：2011-08-01 00:00:00

abstract：:The two canine adenoviruses, infectious canine hepatitis (ICH) virus and infectious canine laryngotracheitis (ICL) virus (also designated as Toronto A26/61 virus), were studied with respect to their morphology and the biological properties of their soluble components. The two viruses were found to be composed of solub...

journal_title：Journal of virology

authors： Marusyk RG,Norrby E,Lundqvist U

更新日期：1970-04-01 00:00:00

abstract：:The Epstein-Barr virus (EBV)-determined nuclear antigens EBNA 1, 2, 3, 4, and 6, regularly expressed in EBV-transformed lymphoblastoid cell lines, vary in size among viral strains. We have used this characteristic to trace the spread of the virus within seven families by using an approach called Ebnotyping. Among 33 e...

journal_title：Journal of virology

authors： Gratama JW,Oosterveer MA,Klein G,Ernberg I

更新日期：1990-10-01 00:00:00

abstract：:Recent studies have demonstrated that influenza A virus infection activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by binding of influenza NS1 protein to the p85 regulatory subunit of PI3K. Our previous study proposed that two polyproline motifs in NS1 (amino acids 164 to 167 [PXXP], SH3 bindin...

journal_title：Journal of virology

authors： Shin YK,Li Y,Liu Q,Anderson DH,Babiuk LA,Zhou Y

更新日期：2007-12-01 00:00:00

abstract：:To examine the pathway of the coreceptor switching of CCR5-using (R5) virus to CXCR4-using (X4) virus in simian-human immunodeficiency virus SHIV(SF162P3N)-infected rhesus macaque BR24, analysis was performed on variants present at 20 weeks postinfection, the time when the signature gp120 V3 loop sequence of the X4 sw...

journal_title：Journal of virology

authors： Tasca S,Ho SH,Cheng-Mayer C

更新日期：2008-07-01 00:00:00

abstract：:The complete nucleotide sequences of the vesicular stomatitis virus mRNA's encoding the glycoprotein (G) and the matrix protein (M) have been determined from cDNA clones that contain the complete coding sequences from each mRNA. The G protein mRNA is 1,665 nucleotides long, excluding polyadenylic acid, and encodes a p...

journal_title：Journal of virology

authors： Rose JK,Gallione CJ

更新日期：1981-08-01 00:00:00

abstract：:The development of cancer vaccines requires approaches to induce expansion and functional differentiation of tumor antigen-specific cytotoxic T lymphocyte (CTL) effectors which posses cytolytic capability and produce cytokines. Efficient induction of such cells is hindered by the poor immunogenicity of tumor antigens ...

journal_title：Journal of virology

authors： Efferson CL,Schickli J,Ko BK,Kawano K,Mouzi S,Palese P,García-Sastre A,Ioannides CG

更新日期：2003-07-01 00:00:00

abstract：:We have used an antisense RNA approach in the analysis of gene function in human cytomegalovirus (HCMV). An astrocytoma cell line (U373-MG) that is permissive for virus replication was permanently transfected with a construct bearing sequence from HCMV UL44 (coding for the major late DNA-binding protein, ppUL44, also ...

journal_title：Journal of virology

authors： Ripalti A,Boccuni MC,Campanini F,Landini MP

更新日期：1995-04-01 00:00:00