Abstract:
:Recombination studies have established that retroviral long terminal repeats (LTRs) are important genetic determinants of the viral capacity to induce hematopoietic tumors and to specify the type of cell making up the tumor. Plasmids containing LTRs of several murine leukemia viruses linked to the chloramphenicol acetyltransferase gene were tested in transient assays to measure relative rates of transcriptional activity in different types of hematopoietic cells. LTRs of the thymomagenic viruses SL3-3, Moloney leukemia virus, and a Moloney mink cell focus-forming virus all expressed to higher levels than other LTRs in T-lymphocyte cell lines. Conversely, the LTRs of Friend leukemia virus and a polycythemic spleen focus-forming virus expressed to higher levels than other LTRs in erythroleukemia cells. The LTR of nonleukemogenic Akv virus induced a relatively low level of activity compared with the others in all cells tested. Thus the relative level of LTR-driven expression in various types of cells corresponds to the type of tumor caused by the intact virus in vivo. These results provide direct evidence that the tissue specificity of the transcriptional activity of LTRs plays a critical role in determining the target cell for retroviral oncogenesis.
journal_name
J Viroljournal_title
Journal of virologyauthors
Short MK,Okenquist SA,Lenz Jdoi
10.1128/JVI.61.4.1067-1072.1987subject
Has Abstractpub_date
1987-04-01 00:00:00pages
1067-72issue
4eissn
0022-538Xissn
1098-5514journal_volume
61pub_type
杂志文章abstract::We have used a V3-specific heteroduplex tracking assay (V3-HTA) with probes from two different human immunodeficiency virus type 1 (HIV-1) subtypes to examine the extent and pace of HIV-1 evolution late in infection. Twenty-four subjects with advanced HIV-1 infection (CD4(+) T-cell count, <100/microl) and stable viral...
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doi:10.1128/jvi.74.18.8494-8501.2000
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doi:10.1128/JVI.70.5.3108-3117.1996
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doi:10.1128/JVI.66.3.1432-1441.1992
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doi:10.1128/JVI.1.5.948-955.1967
更新日期:1967-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.8.4301-4308.1991
更新日期:1991-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.3.847-850.1988
更新日期:1988-03-01 00:00:00
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更新日期:2004-07-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.4.2178-2183.1996
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.29.3.1107-1117.1979
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更新日期:1995-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
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journal_title:Journal of virology
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更新日期:2002-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.20.3.621-626.1976
更新日期:1976-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.10.5196-5202.1991
更新日期:1991-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00317-09
更新日期:2009-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1991-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.6.3470-3480.1993
更新日期:1993-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.5.3033-3041.1995
更新日期:1995-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.6.4663-4670.1997
更新日期:1997-06-01 00:00:00