SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation.

abstract：UNLABELLED:We searched The Cancer Genome Atlas (TCGA) database for viruses by comparing non-human reads present in transcriptome sequencing (RNA-Seq) and whole-exome sequencing (WXS) data to viral sequence databases. Human papillomavirus 18 (HPV18) is an etiologic agent of cervical cancer, and as expected, we found rob...

journal_title：Journal of virology

authors： Cantalupo PG,Katz JP,Pipas JM

更新日期：2015-04-01 00:00:00

abstract：:Rift Valley fever virus (RVFV), a phlebovirus of the Bunyaviridae family, is an arthropod-borne virus which emerges periodically throughout Africa, emphasizing that it poses a major threat for animal and human populations. To assess the genetic variability of RVFV, several isolates from diverse localities of Africa we...

journal_title：Journal of virology

authors： Sall AA,Zanotto PM,Sene OK,Zeller HG,Digoutte JP,Thiongane Y,Bouloy M

更新日期：1999-10-01 00:00:00

abstract：:Numerous RNA viruses generate subgenomic mRNAs (sgRNAs) for expression of their 3'-proximal genes. A major step in control of viral gene expression is the regulation of sgRNA synthesis by specific promoter elements. We used barley yellow dwarf virus (BYDV) as a model system to study transcriptional control in a virus ...

journal_title：Journal of virology

authors： Koev G,Miller WA

更新日期：2000-07-01 00:00:00

abstract：:Replication of the plus-stranded RNA genome of hepatitis C virus (HCV) occurs in a membrane-bound replication complex consisting of viral and cellular proteins and viral RNA. NS5B, the RNA polymerase of HCV, is anchored to the membranes via a C-terminal 20-amino-acid-long hydrophobic domain, which is flanked on each s...

journal_title：Journal of virology

authors： Lee H,Liu Y,Mejia E,Paul AV,Wimmer E

更新日期：2006-11-01 00:00:00

abstract：:Dendritic cells (DC) are considered to be important contributors to human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis. As the first target cells in mucosal tissues, they can be become productively infected and can also capture virions and transfer them efficiently to CD4(+) T cells located with...

journal_title：Journal of virology

authors： Barat C,Gilbert C,Tremblay MJ

更新日期：2009-03-01 00:00:00

abstract：:A radioimmunoassay (RIA) has been used to measure the quantity of protein P27 (mol wt 27,000; group specific-1 [gs-1]) of avian leukoviruses in different types of chicken embryos and tissues of adult chickens. The RIA used was 200- to 300-fold more sensitive than the complement fixation test and was able to detect as ...

journal_title：Journal of virology

authors： Chen JH,Hanafusa H

更新日期：1974-02-01 00:00:00

abstract：:3-O-(3',3'-dimethylsuccinyl)betulinic acid (PA-457 or bevirimat) potently inhibits human immunodeficiency virus type 1 (HIV-1) maturation by blocking a late step in the Gag processing pathway, specifically the cleavage of SP1 from the C terminus of capsid (CA). To gain insights into the mechanism(s) by which HIV-1 cou...

journal_title：Journal of virology

authors： Adamson CS,Ablan SD,Boeras I,Goila-Gaur R,Soheilian F,Nagashima K,Li F,Salzwedel K,Sakalian M,Wild CT,Freed EO

更新日期：2006-11-01 00:00:00

abstract：:BALB/c mice sensitized to herpes simplex virus type 1 (HSV-1) develop a vigorous delayed-type hypersensitivity (DTH) response upon intradermal virus antigen challenge. Although CD4(+) T cells are a key mediator of this response, neutrophils are the most abundant cells at the antigen challenge site both initially and a...

journal_title：Journal of virology

authors： Tumpey TM,Fenton R,Molesworth-Kenyon S,Oakes JE,Lausch RN

更新日期：2002-08-01 00:00:00

abstract：:The 2009 pandemic influenza virus (pdm/09) has been frequently introduced to pigs and has reassorted with other swine viruses. Recently, H3N2 reassortants with pdm/09-like internal genes were isolated in Guangxi and Hong Kong, China. Genetic and epidemiological analyses suggest that these viruses have circulated in sw...

journal_title：Journal of virology

authors： Fan X,Zhu H,Zhou B,Smith DK,Chen X,Lam TT,Poon LL,Peiris M,Guan Y

更新日期：2012-02-01 00:00:00

abstract：:Multispecific CD8(+) T-cell responses are thought to be important for the control of acute hepatitis C virus (HCV) infection, but to date little information is actually available on the breadth of responses at early time points. Additionally, the influence of early therapy on these responses and their relationships to...

journal_title：Journal of virology

authors： Lauer GM,Lucas M,Timm J,Ouchi K,Kim AY,Day CL,Schulze Zur Wiesch J,Paranhos-Baccala G,Sheridan I,Casson DR,Reiser M,Gandhi RT,Li B,Allen TM,Chung RT,Klenerman P,Walker BD

更新日期：2005-10-01 00:00:00

abstract：:Sections of normal and diseased brain and kidney tissues were screened for the presence of JC virus (JCV) DNA by using the polymerase chain reaction. As expected, all samples obtained from patients with progressive multifocal leukoencephalopathy (PML) tested positive when multiple JCV-specific primer and probe combina...

journal_title：Journal of virology

authors： White FA 3rd,Ishaq M,Stoner GL,Frisque RJ

更新日期：1992-10-01 00:00:00

abstract：:Previous studies have established that chlorella viruses encode K(+) channels with different structural and functional properties. In the current study, we exploit the different sensitivities of these channels to Cs(+) to determine if the membrane depolarization observed during virus infection is caused by the activit...

journal_title：Journal of virology

authors： Frohns F,Käsmann A,Kramer D,Schäfer B,Mehmel M,Kang M,Van Etten JL,Gazzarrini S,Moroni A,Thiel G

更新日期：2006-03-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) is known to infect stem cells in the neonatal central nervous system. Here, we evaluated the effects of CVB3 infection on the major source and repository of stem cells, the bone marrow (BM). Viral genome was detectable in BM within 24 h of infection, and productive infection of BM cells was ev...

journal_title：Journal of virology

authors： Althof N,Whitton JL

更新日期：2013-03-01 00:00:00

abstract：:Human herpesvirus 7 (HHV-7) is a recently isolated betaherpesvirus that is prevalent in the human population, with primary infection usually occurring in early childhood. HHV-7 is related to human herpesvirus 6 (HHV-6) in terms of both biological and, from limited prior DNA sequence analysis, genetic criteria. However...

journal_title：Journal of virology

authors： Nicholas J

更新日期：1996-09-01 00:00:00

abstract：:The human antibody response to flavivirus infection is dominantly directed against a cross-reactive epitope on the fusion loop of domain II (DII-FL) of the envelope (E) protein. Although antibodies against this epitope fail to recognize fully mature West Nile virus (WNV) virions and accordingly neutralize infection po...

journal_title：Journal of virology

authors： Vogt MR,Dowd KA,Engle M,Tesh RB,Johnson S,Pierson TC,Diamond MS

更新日期：2011-11-01 00:00:00

abstract：UNLABELLED:As a herpesvirus, Epstein-Barr virus (EBV) establishes a latent infection that can periodically undergo reactivation, resulting in lytic replication and the production of new infectious virus. Latent membrane protein-1 (LMP1), the principal viral oncoprotein, is a latency-associated protein implicated in reg...

journal_title：Journal of virology

authors： Bentz GL,Moss CR 2nd,Whitehurst CB,Moody CA,Pagano JS

更新日期：2015-08-01 00:00:00

abstract：:The mechanisms involved in the emergence of virulent mammalian viruses were investigated in the adult immunodeficient SCID mouse infected by the attenuated prototype strain of the parvovirus Minute Virus of Mice (MVMp). Cloned MVMp intravenously inoculated in mice consistently evolved during weeks of subclinical infec...

journal_title：Journal of virology

authors： Rubio MP,López-Bueno A,Almendral JM

更新日期：2005-09-01 00:00:00

abstract：:Although xenotropic murine leukemia viruses cannot productively infect cells of laboratory mice, cells from various wild-derived mice can support replication of these viruses. Although the virus-sensitive wild mice generally lack all or most of the xenotropic proviral genes characteristic of inbred strains, susceptibi...

journal_title：Journal of virology

authors： Kozak CA

更新日期：1985-09-01 00:00:00

abstract：:Vaccination is the most effective way to prevent influenza virus infections. However, the diversity of antigenically distinct isolates is a challenge for vaccine development. In order to overcome the antigenic variability and improve the protective efficacy of influenza vaccines, our research group has pioneered the d...

journal_title：Journal of virology

authors： Huang Y,Owino SO,Crevar CJ,Carter DM,Ross TM

更新日期：2020-02-28 00:00:00

abstract：:We present data that retroviral gene expression in early hematopoietic cells is subjected to transcriptional controls similar to those previously described for embryonic stem cells. Transient transfection experiments revealed that both the viral enhancer region in the U3 region of the long terminal repeat as well as a...

journal_title：Journal of virology

authors： Baum C,Hegewisch-Becker S,Eckert HG,Stocking C,Ostertag W

更新日期：1995-12-01 00:00:00

abstract：:Multiple steps of the life cycle of hepatitis B virus (HBV) are known to be coupled to hepatic metabolism. However, the details of involvement of the hepatic metabolic milieu in HBV infection remain incompletely understood. Hepatic lipid metabolism is controlled by a complicated transcription factor network centered o...

journal_title：Journal of virology

authors： Song M,Sun Y,Tian J,He W,Xu G,Jing Z,Li W

更新日期：2018-03-28 00:00:00

abstract：:Vilyuisk human encephalitis virus (VHEV) is a picornavirus related to Theiler's murine encephalomyelitis virus (TMEV). VHEV was isolated from human material passaged in mice. Whether this VHEV is of human or mouse origin is therefore unclear. We took advantage of the species-specific activity of the nonstructural L* p...

journal_title：Journal of virology

authors： Drappier M,Opperdoes FR,Michiels T

更新日期：2017-06-26 00:00:00

abstract：:Infection of cells with poliovirus induces a massive intracellular membrane reorganization to form vesicle-like structures where viral RNA replication occurs. The mechanism of membrane remodeling remains unknown, although some observations have implicated components of the cellular secretory and/or autophagy pathways....

journal_title：Journal of virology

authors： Belov GA,Altan-Bonnet N,Kovtunovych G,Jackson CL,Lippincott-Schwartz J,Ehrenfeld E

更新日期：2007-01-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) immediate-early protein BZLF1 mediates the switch between the latent and lytic forms of EBV infection and has been previously shown to induce a G(1)/S block in cell cycle progression in some cell types. To examine the effect of BZLF1 on cellular gene expression, we performed microarray ana...

journal_title：Journal of virology

authors： Mauser A,Holley-Guthrie E,Zanation A,Yarborough W,Kaufmann W,Klingelhutz A,Seaman WT,Kenney S

更新日期：2002-12-01 00:00:00

abstract：:In an attempt to identify the molecules involved in the pathogenesis of prion diseases, we performed cDNA subtraction on the brain tissues of mice affected with an experimental prion disease and the unaffected control. The genes identified as being upregulated in the prion-affected brain tissue included those encoding...

journal_title：Journal of virology

authors： Kopacek J,Sakaguchi S,Shigematsu K,Nishida N,Atarashi R,Nakaoke R,Moriuchi R,Niwa M,Katamine S

更新日期：2000-01-01 00:00:00

abstract：:Interactions between host factors and the viral replication complex play important roles in host adaptation and regulation of influenza virus replication. A cellular protein, nuclear factor 90 (NF90), was copurified with H5N1 viral nucleoprotein (NP) from human cells in which NP was transiently expressed and identifie...

journal_title：Journal of virology

authors： Wang P,Song W,Mok BW,Zhao P,Qin K,Lai A,Smith GJ,Zhang J,Lin T,Guan Y,Chen H

更新日期：2009-08-01 00:00:00

abstract：:We analyzed the CD4+ T-lymphocyte responses to dengue, West Nile, and yellow fever viruses 4 months after immunization of a volunteer with an experimental live-attenuated dengue virus type 1 vaccine (DEN-1 45AZ5). We examined bulk culture proliferation to noninfectious antigens, determined the precursor frequency of s...

journal_title：Journal of virology

authors： Green S,Kurane I,Edelman R,Tacket CO,Eckels KH,Vaughn DW,Hoke CH Jr,Ennis FA

更新日期：1993-10-01 00:00:00

abstract：:Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with...

journal_title：Journal of virology

authors： Djavani MM,Crasta OR,Zapata JC,Fei Z,Folkerts O,Sobral B,Swindells M,Bryant J,Davis H,Pauza CD,Lukashevich IS,Hammamieh R,Jett M,Salvato MS

更新日期：2007-08-01 00:00:00

abstract：:Infectious pancreatic necrosis virus (IPNV) is a bisegmented, double-stranded RNA (dsRNA) virus of the Birnaviridae family that causes widespread disease in salmonids. Its two genomic segments are encapsulated together with the viral RNA-dependent RNA polymerase, VP1, and the assumed internal protein, VP3, in a single...

journal_title：Journal of virology

authors： Pedersen T,Skjesol A,Jørgensen JB

更新日期：2007-06-01 00:00:00

abstract：:NS5A of the hepatitis C virus (HCV) is a highly phosphorylated protein involved in resistance against interferon and required most likely for replication of the viral genome. Phosphorylation of this protein is mediated by a cellular kinase(s) generating multiple proteins with different electrophoretic mobilities. In t...

journal_title：Journal of virology

authors： Koch JO,Bartenschlager R

更新日期：1999-09-01 00:00:00