Human cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface.

abstract：UNLABELLED:Replication-deficient rabies virus (RABV)-based vaccines induce rapid and potent antibody responses via T cell-independent and T cell-dependent mechanisms. To further investigate early events in vaccine-induced antibody responses against RABV infections, we studied the role of macrophages as mediators of RAB...

journal_title：Journal of virology

authors： Lytle AG,Shen S,McGettigan JP

更新日期：2015-03-01 00:00:00

abstract：:Adaptation of field isolates of foot-and-mouth disease virus (FMDV) to grow in cells in culture can result in changes in viral properties that include acquisition of the ability to bind to cell surface heparan sulfate (HS). After 13 passages on BHK cells to produce a vaccine, a Cathay topotype isolate of FMDV serotype...

journal_title：Journal of virology

authors： Zhao Q,Pacheco JM,Mason PW

更新日期：2003-03-01 00:00:00

abstract：:Autographa californica nuclear polyhedrosis virus late and very late mRNAs are transcribed by an RNA polymerase consisting of four virus-encoded polypeptides: LEF-8, LEF-9, LEF-4, and p47. The 464-amino-acid LEF-4 subunit contains the signature motifs of GTP:RNA guanylyltransferases (capping enzymes). Here, we show th...

journal_title：Journal of virology

authors： Gross CH,Shuman S

更新日期：1998-12-01 00:00:00

abstract：:Bovine bone marrow-derived macrophages infected with the cytopathic biotype of bovine viral diarrhea virus released an antiviral activity into the supernatant which was tentatively characterized as type I interferon because of its physicochemical properties. Such supernatants primed both infected and uninfected macrop...

journal_title：Journal of virology

authors： Adler B,Adler H,Pfister H,Jungi TW,Peterhans E

更新日期：1997-04-01 00:00:00

abstract：:RNA viruses of filamentous fungi fall into two broad categories, those that contain double-stranded RNA (dsRNA) genomes in rigid particles and those that are more closely related to positive-sense, single-stranded RNA viruses with dsRNA replicative intermediates found within lipid vesicles. Effective infectivity syste...

journal_title：Journal of virology

authors： Hillman BI,Supyani S,Kondo H,Suzuki N

更新日期：2004-01-01 00:00:00

abstract：:We have studied the fate of CD4 in CEM T cells expressing a human immunodeficiency virus type 1 HIV-1 Nef protein. Nef triggered a rapid endocytosis and a degradation of CD4, while most of the p56lck was upheld at the cell membrane. In the presence of Nef, CD4 accumulated in acidic intracellular vesicles that were not...

journal_title：Journal of virology

authors： Schwartz O,Dautry-Varsat A,Goud B,Maréchal V,Subtil A,Heard JM,Danos O

更新日期：1995-01-01 00:00:00

abstract：UNLABELLED:In a previous screen of putative interferon-stimulated genes, SUN2 was shown to inhibit HIV-1 infection in an uncharacterized manner. SUN2 is an inner nuclear membrane protein belonging to the linker of nucleoskeleton and cytoskeleton complex. We have analyzed here the role of SUN2 in HIV infection. We repor...

journal_title：Journal of virology

authors： Donahue DA,Amraoui S,di Nunzio F,Kieffer C,Porrot F,Opp S,Diaz-Griffero F,Casartelli N,Schwartz O

更新日期：2016-03-28 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) Tat protein, which is essential for HIV gene expression and viral replication, is known to mediate pleiotropic effects on various cell functions. For instance, Tat protein is able to regulate the rate of transcription of host cellular genes and to interact with the signa...

journal_title：Journal of virology

authors： Calzado MA,Sancho R,Muñoz E

更新日期：2004-07-01 00:00:00

abstract：:The genome of infectious bursal disease virus consists of two segments of double-stranded RNA of 2.5 X 10(6) and 2.2 X 10(6) molecular weight. Polyacrylamide gel electrophoresis of purified virus resolved four structural polypeptides: VP-1 (90,000), VP-2 (41,000), VP-3 (35,000), and VP-4 (28,000). Peptide map comparis...

journal_title：Journal of virology

authors： Dobos P

更新日期：1979-12-01 00:00:00

abstract：:Herpesviruses are members of a diverse family of viruses that colonize all vertebrates from fish to mammals. Although more than one hundred herpesviruses exist, all are nearly identical architecturally, with a genome consisting of a linear double-stranded DNA molecule (100 to 225 kbp) protected by an icosahedral capsi...

journal_title：Journal of virology

authors： Morissette G,Flamand L

更新日期：2010-12-01 00:00:00

abstract：:Infectious cDNA clones of mild (CHV1-Euro7) and severe (CHV1-EP713) hypovirus strains responsible for virulence attenuation (hypovirulence) of the chestnut blight fungus Cryphonectria parasitica were used to construct viable chimeric viruses. Differences in virus-mediated alterations of fungal colony morphology, growt...

journal_title：Journal of virology

authors： Chen B,Geletka LM,Nuss DL

更新日期：2000-08-01 00:00:00

abstract：:The entire genome of the reference strain of bluetongue virus (BTV) serotype 16 (strain RSArrrr/16) was sequenced (a total of 23,518 base pairs). The virus was obtained from the Orbivirus Reference Collection (ORC) at IAH, Pirbright, United Kingdom. The virus strain, which was previously provided by the Onderstepoort ...

journal_title：Journal of virology

authors： Maan S,Maan NS,Singh KP,Belaganahalli MN,Guimera M,Pullinger G,Nomikou K,Mertens PP

更新日期：2012-09-01 00:00:00

abstract：:Activation of the interferon-inducible, double-stranded RNA-dependent protein kinase was monitored in monolayer cultures of control and interferon-treated HeLa cells infected with encephalomyocarditis virus. The extent of phosphorylation in the intact cell of the alpha-subunit of eucaryotic protein synthesis initiatio...

journal_title：Journal of virology

authors： Rice AP,Duncan R,Hershey JW,Kerr IM

更新日期：1985-06-01 00:00:00

abstract：:Human oncolytic adenoviruses have been used in clinical trials targeting cancers of epithelial origin. To gain a better understanding of the infectious cycle of adenovirus in normal human squamous tissues, we examined the viral infection process in organotypic cultures of primary human keratinocytes. We show that for ...

journal_title：Journal of virology

authors： Noya F,Balagué C,Banerjee NS,Curiel DT,Broker TR,Chow LT

更新日期：2003-06-01 00:00:00

abstract：:MVL2, an enveloped double-stranded DNA mycoplasmavirus, causes a nonlytic infection of Acholeplasma laidlawii leading to the establishment of a persistent infection. Persistently infected clones were found to be resistant to superinfection by homologous virus, but could be infected by heterologous virus. Cells in a pe...

journal_title：Journal of virology

authors： Putzrath RM,Maniloff J

更新日期：1978-10-01 00:00:00

abstract：:Bovine herpesvirus 1 (BHV-1) specifies and unspliced early 2.6-kb RNA (ER2.6) which is 3' coterminal with exon 2 of the 2.9-kb immediate-early (IE) RNA. The two transcripts have a common open reading frame (676 codons). The predicted protein, designated BHV-1 infected cell protein 0 (BICP0), contains a zinc finger dom...

journal_title：Journal of virology

authors： Fraefel C,Zeng J,Choffat Y,Engels M,Schwyzer M,Ackermann M

更新日期：1994-05-01 00:00:00

abstract：:The RNAs of replication-defective murine and primate type C transforming viruses were analyzed for the presence of nucleotide sequences homologous to the genomes of their respective helper type C viruses by using DNAs complementary (cDNA) to either the 5'-terminal (cDNA5') or total (cDNAtotal) nucleotide sequences of ...

journal_title：Journal of virology

authors： Tronick SR,Cabradilla CD,Aaronson SA,Haseltine WA

更新日期：1978-06-01 00:00:00

abstract：:The XC rat cell line was found to support the replication of a strain of the Moloney murine sarcoma-leukemia virus. In growth curve experiments cytopathology was paralleled by the production of murine sarcoma virus and leukemia virus progeny having the biologic, antigenic, and biophysical properties of the infecting v...

journal_title：Journal of virology

authors： Trowbridge ST,Benyesh-Melnick M,Biswal N

更新日期：1973-01-01 00:00:00

abstract：:We investigated the synergism between influenza virus and Streptococcus pneumoniae, particularly the role of deletions in the stalk region of the neuraminidase (NA) of H2N2 and H9N2 avian influenza viruses. Deletions in the NA stalk (ΔNA) had no effect on NA activity or on the adherence of S. pneumoniae to virus-infec...

journal_title：Journal of virology

authors： Chockalingam AK,Hickman D,Pena L,Ye J,Ferrero A,Echenique JR,Chen H,Sutton T,Perez DR

更新日期：2012-04-01 00:00:00

abstract：:Skin fibroblast cultures were established from eight individuals. These cell cultures, together with WI-38 cells, were examined for susceptibility to transformation by SV40 virus. Four transformation-susceptible cell lines (TS), established from patients with Down's syndrome, were found to be three to four times more ...

journal_title：Journal of virology

authors： Potter CW,Potter AM,Oxford JS

更新日期：1970-03-01 00:00:00

abstract：:Immunosuppressed patients are at risk for developing Epstein-Barr Virus (EBV)-positive lymphomas that express the major EBV oncoprotein, LMP1. Although increasing evidence suggests that a small number of lytically infected cells may promote EBV-positive lymphomas, the impact of enhanced lytic gene expression on the ab...

journal_title：Journal of virology

authors： Ma SD,Yu X,Mertz JE,Gumperz JE,Reinheim E,Zhou Y,Tang W,Burlingham WJ,Gulley ML,Kenney SC

更新日期：2012-08-01 00:00:00

abstract：:Autophagy is an intracellular degradation pathway that provides a host defense mechanism against intracellular pathogens. However, many viruses exploit this mechanism to promote their replication. This study shows that lytic induction of Epstein-Barr virus (EBV) increases the membrane-bound form of LC3 (LC3-II) and LC...

journal_title：Journal of virology

authors： Hung CH,Chen LW,Wang WH,Chang PJ,Chiu YF,Hung CC,Lin YJ,Liou JY,Tsai WJ,Hung CL,Liu ST

更新日期：2014-10-01 00:00:00

abstract：:Integrated retroviruses or retroviral vectors may be transcriptionally inactive although their promoter-enhancer regions are able to direct transcription in the host cell. We have used single-gene retroviral vectors with a long terminal repeat-directed neo marker gene to determine if the level of transcription relates...

journal_title：Journal of virology

authors： Duch M,Paludan K,Jørgensen P,Pedersen FS

更新日期：1994-09-01 00:00:00

abstract：:Lymphomas induced by pure HIX murine leukemia virus in two mouse strains contained large amounts of virus with amphotropic properties. Analysis of tumor derived virus purified by limiting dilution techniques indicated that its interference and neutralization spectra were essentially identical to parental HIX virus and...

journal_title：Journal of virology

authors： Fischinger PJ,Dunlop NM,Blevins CS

更新日期：1978-05-01 00:00:00

abstract：:Wild-type simian virus 40 A protein (large T antigen) bound to three tandem regions of simian virus 40 DNA. The binding regions were defined by the ability of A protein to protect simian virus 40 DNA from digestion with limited (footprint assay) or excess (fragment assay) amounts of DNase I. At low concentrations, pro...

journal_title：Journal of virology

authors： Wilson VG,Tevethia MJ,Lewton BA,Tegtmeyer P

更新日期：1982-11-01 00:00:00

abstract：:Membrane-containing extracts isolated from tobacco plants infected with the plus-strand RNA virus, potato virus X (PVX), supported synthesis of four major, high-molecular-weight PVX RNA products (R1 to R4). Nuclease digestion and hybridization studies indicated that R1 and R2 are a mixture of partially single-stranded...

journal_title：Journal of virology

authors： Doronin SV,Hemenway C

更新日期：1996-07-01 00:00:00

abstract：:The identification of tumor-inducing genes is a driving force for elucidating the molecular mechanisms underlying cancer. Many retroviruses induce tumors by insertion of viral DNA adjacent to cellular oncogenes, resulting in altered expression and/or structure of the encoded proteins. The availability of the mouse gen...

journal_title：Journal of virology

authors： Kim R,Trubetskoy A,Suzuki T,Jenkins NA,Copeland NG,Lenz J

更新日期：2003-02-01 00:00:00

abstract：:It was shown previously that the Matrix (M), Phosphoprotein (P), and the Fusion (F) proteins of Respiratory syncytial virus (RSV) are sufficient to produce virus-like particles (VLPs) that resemble the RSV infection-induced virions. However, the exact mechanism and interactions among the three proteins are not known. ...

journal_title：Journal of virology

authors： Bajorek M,Galloux M,Richard CA,Szekely O,Rosenzweig R,Sizun C,Eleouet JF

更新日期：2021-01-06 00:00:00

abstract：:Zyxin, a focal adhesion molecule, interacts specifically with the E6 protein from human papillomavirus (HPV) type 6 in a yeast two-hybrid screen of a cDNA library prepared from human keratinocytes. Zyxin does not interact significantly with E6 proteins from HPV types 11, 16, or 18. The interaction was confirmed by in ...

journal_title：Journal of virology

authors： Degenhardt YY,Silverstein S

更新日期：2001-12-01 00:00:00

abstract：:Whole-body bioimaging was used to study dissemination of vaccinia virus (VACV) in normal and in immune deficient (nu(-)/nu(-)) mice protected from lethality by postchallenge administration of ST-246. Total fluxes were recorded in the liver, spleen, lungs, and nasal cavities of live mice after intranasal infection with...

journal_title：Journal of virology

authors： Zaitseva M,Shotwell E,Scott J,Cruz S,King LR,Manischewitz J,Diaz CG,Jordan RA,Grosenbach DW,Golding H

更新日期：2013-05-01 00:00:00