Abstract:
:Monoclonal antibodies (MAbs) were raised against human immunodeficiency virus type 1 gp120. One MAb, P4/D10, was found to mediate highly efficient antibody-dependent cellular cytotoxicity and virus neutralization. The reactivity was located to a major neutralizing region (amino acids 304 to 323) on gp120. Five other MAbs with a similar epitopic reactivity did not show any antibody-dependent cellulan cytotoxicity activity but had a virus-neutralizing capacity.
journal_name
J Viroljournal_title
Journal of virologyauthors
Broliden PA,Ljunggren K,Hinkula J,Norrby E,Akerblom L,Wahren Bdoi
10.1128/JVI.64.2.936-940.1990subject
Has Abstractpub_date
1990-02-01 00:00:00pages
936-40issue
2eissn
0022-538Xissn
1098-5514journal_volume
64pub_type
杂志文章abstract::The long terminal repeat U3 sequences were determined for multiple feline leukemia virus proviruses isolated from naturally occurring T-cell tumors. Heterogeneity was evident, even among proviruses cloned from individual tumors. Proviruses with one, two, or three repeats of the long terminal repeat enhancer sequences ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.4.1675-1682.1990
更新日期:1990-04-01 00:00:00
abstract::The Cas-Br-E murine leukemia virus is a nondefective retrovirus that induces non-T-, non-B-cell lymphomas in susceptible NIH/Swiss mice. By using a DNA probe derived from Cas-Br-E provirus-flanking sequences, we identified a DNA region, originally called Sic-1, rearranged in 16 of 24 tumors analyzed (67%). All proviru...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.1.7-15.1991
更新日期:1991-01-01 00:00:00
abstract::Mutants of polyomavirus with altered host specificities were isolated in undifferentiated C2 myoblast cells (L. Ricci, R. Maione, C. Passananti, A. Felsani, and P. Amati, J. Virol. 66:7153-7158, 1992). The mutations responsible for this phenotype belonged to either of the two classes: a large duplication of the enhanc...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.2.1196-1199.1994
更新日期:1994-02-01 00:00:00
abstract::All hepadnaviruses known so far have a very limited host range, restricted to their natural hosts and a few closely related species. This is thought to be due mainly to sequence divergence in the large envelope protein and species-specific differences in host components essential for virus propagation. Here we report ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.3.1964-1976.2003
更新日期:2003-02-01 00:00:00
abstract::The U(L)17 protein (pU(L)17) of herpes simplex virus 1 (HSV-1) likely associates with the surfaces of DNA-containing capsids in a heterodimer with pU(L)25. pU(L)17 is also associated with viral light particles that lack capsid proteins, suggesting its presence in the tegument of the HSV-1 virion. To help determine how...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00277-10
更新日期:2010-08-01 00:00:00
abstract::The small-ruminant lentiviruses ovine maedi-visna virus (MVV) and caprine arthritis-encephalitis virus (CAEV) cause encephalitis, progressive pneumonia, arthritis, and mastitis in sheep and goats. Icelandic MVV strains, which are lytic in tissue culture, have a wide species distribution of functional receptors, which ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.16.7384-7391.2001
更新日期:2001-08-01 00:00:00
abstract::Minimal transformants of rat F111 fibroblasts were established after infection with the large T antigen (large T)-encoding retroviral expression vector pZIPTEX (M. Brown, M. McCormack, K. Zinn, M. Farrell, I. Bikel, and D. Livingston, J. Virol. 60:290-293, 1986). Coexpression of small t antigen (small t) in these cell...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.3.1555-1563.1993
更新日期:1993-03-01 00:00:00
abstract::HIV-1 transmission occurs mainly through mucosal tissues. During mucosal transmission, HIV-1 preferentially infects α4β7+ gut-homing CCR7- CD4+ effector/effector memory T cells (TEM) and results in massive depletion of these cells and other subsets of TEM in gut-associated lymphoid tissues. However, besides being elim...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01510-17
更新日期:2018-03-28 00:00:00
abstract::A new purification procedure was adopted for Eastern equine encephalitis virus which does not subject the virus to pelleting at any stage. Three- to 4-liter volumes were passed through a diethylaminoethyl cellulose column. The virus-containing fractions were banded on a sucrose cushion and finally concentrated in an i...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.7.2.233-240.1971
更新日期:1971-02-01 00:00:00
abstract::Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus and one of the most common agents of viral encephalitis. The infectious entry process of JEV into host cells remains largely unknown. Here, we present a systemic study concerning the cellular entry mechanism of JEV to B104 rat neuroblastoma cells. It was...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00903-12
更新日期:2012-12-01 00:00:00
abstract::The roles of the capsid protein (CP) and the CP coding sequence of tobacco etch potyvirus (TEV) in genome amplification were analyzed. A series of frameshift-stop codon mutations that interrupted translation of the CP coding sequence at various positions were introduced into the TEV genome. A series of 3' deletion mut...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.7.4370-4379.1996
更新日期:1996-07-01 00:00:00
abstract::The distantly related lentiviruses human immunodeficiency virus type 1 (HIV-1) and visna virus each encode a posttranscriptional regulatory protein, termed Rev, that is critical for expression of the viral structural proteins. We genetically mapped the cis-acting target sequence for visna virus Rev, the visna virus Re...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.6.3609-3615.1992
更新日期:1992-06-01 00:00:00
abstract::Human immunodeficiency virus type 1 Tat exerts prominent angiogenic effects which may lead to a variety of vasculopathic conditions in AIDS patients. Because endothelial cells undergo prominent cytoskeletal rearrangement during angiogenesis, we investigated the specific effects of Tat on the endothelial cell actin cyt...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.2.779-789.2004
更新日期:2004-01-01 00:00:00
abstract::Biological and genetic variability is a prominent feature of human immunodeficiency virus (HIV) strains, especially in tropism, syncytium formation, and replicative capacity. To determine whether there were variable host cell effects on HIV replication in monocytes, three different strains of low-passage-number monocy...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.11.7792-7803.1996
更新日期:1996-11-01 00:00:00
abstract::Adeno-associated virus (AAV) codes for four related nonstructural Rep proteins. AAV both replicates and assembles in the nucleus and requires coinfection with a helper virus, either adenovirus (Ad) or herpesvirus, for a productive infection. Like other more complex DNA viruses, it is believed that AAV interacts or mod...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01939-08
更新日期:2009-01-01 00:00:00
abstract::The binding specificities of a panel of avian influenza virus subtype H5 hemagglutinin (HA) proteins bearing mutations at key residues in the receptor binding site were investigated. The results demonstrate that two simultaneous mutations in the receptor binding site resulted in H5 HA binding in a pattern similar to t...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.1.502-507.2004
更新日期:2004-01-01 00:00:00
abstract::We have previously shown that delivery of the porcine type I interferon gene (poIFN-α/β) with a replication-defective human adenovirus vector (adenovirus 5 [Ad5]) can sterilely protect swine challenged with foot-and-mouth disease virus (FMDV) 1 day later. However, the need of relatively high doses of Ad5 limits the ap...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03462-12
更新日期:2013-05-01 00:00:00
abstract::Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines. Here, we describe the generation of retrovirus-based pseudoparticles (HCVpp) incorporating a panel of full-length E1E2 clon...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.17.11095-11104.2005
更新日期:2005-09-01 00:00:00
abstract::Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle deregulation, resulting in a G(1)/S arrest, which can be partly attributed to the inactivation of the anaphase-promoting complex (APC). As we previously reported, the premature phosphorylation of its coactivator Cdh1 and/or the diss...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01260-10
更新日期:2010-10-01 00:00:00
abstract::High-risk human papillomaviruses (HPVs) are the causative agents of certain human cancers. HPV type 16 (HPV16) is the papillomavirus most frequently associated with cervical cancer in women. The E6 and E7 genes of HPV are expressed in cells derived from these cancers and can transform cells in tissue culture. Animal e...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.7.5887-5893.1999
更新日期:1999-07-01 00:00:00
abstract::There are two types of infectious vaccinia virus particles: intracellular naked virions and extracellular enveloped virions (EEV). To determine the biological role of the enveloped form of vaccinia virus, we produced and characterized a mutant that is defective in EEV formation. The strategy involved replacement by ho...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.11.5910-5920.1991
更新日期:1991-11-01 00:00:00
abstract::Many of the approximately 165 proteins encoded by the African swine fever virus (ASFV) genome do not have significant similarity to known proteins and have not been studied experimentally. One such protein is DP148R. We showed that the DP148R gene is transcribed at early times postinfection. Deletion of this gene did ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01428-17
更新日期:2017-11-30 00:00:00
abstract::To reliably infect a primate model for human immunodeficiency virus (HIV), approximately 10,000-fold more virus must be delivered vaginally than intravenously. However, the vaginal mechanisms that help protect against HIV are poorly understood. Here, we report that human cervicovaginal mucus (CVM), obtained from donor...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01899-08
更新日期:2009-11-01 00:00:00
abstract::The retroviral Gag protein is capable of directing the production and release of virus-like particles in the absence of all other viral components. Budding normally occurs after Gag is transported to the plasma membrane by its membrane-targeting and -binding (M) domain. In the Rous sarcoma virus (RSV) Gag protein, the...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.18.8692-8699.2000
更新日期:2000-09-01 00:00:00
abstract::Interferon (IFN)-stimulated gene factor 2 (ISGF2) plays a role in transcription of the beta IFN (IFN-beta) gene and IFN-stimulated genes (ISGs) and may function as a central mediator of cytokine responses. Constitutive ISGF2 transgene expression resulted in substantial resistance to three RNA virus families. This phen...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.7.4470-4478.1992
更新日期:1992-07-01 00:00:00
abstract::HeLa cells infected with human rhinovirus type 2 synthesize a mixture of single-and double-stranded ribonucleic acid (RNA). The RNA synthesized by the membrane-bound RNA polymerase complex in vitro is also a mixture of single- and double-stranded RNA, whereas the deoxycholate-treated RNA polymerase complex synthesized...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.10.1.93-98.1972
更新日期:1972-07-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) uses a variety of chemokine receptors as coreceptors for virus entry, and the ability of the virus to be neutralized by antibody may depend on which coreceptors are used. In particular, laboratory-adapted variants of the virus that use CXCR4 as a coreceptor are highly sensit...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.3.1886-1893.1998
更新日期:1998-03-01 00:00:00
abstract::Epstein-Barr virus (EBV) uses nasal mucosa-associated lymphoid tissue (NALT) as a portal of entry to establish life-long persistence in memory B cells. We previously showed that naïve and memory B cells from NALT are equally susceptible to EBV infection. Here we show that memory B cells from NALT are significantly mor...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02675-09
更新日期:2010-07-01 00:00:00
abstract::We investigated properties of the rotavirus genome segment 11 protein. A rotavirus SA11 genome segment 11 cDNA which contains the entire coding region was sequenced and inserted into the baculovirus transfer vector pVL941. Recombinants containing gene 11 cDNA were selected, and the gene 11 product expressed in Spodopt...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.9.3974-3982.1989
更新日期:1989-09-01 00:00:00
abstract::The Epstein-Barr virus (EBV) lytic activator genes bzlf1 and brlf1 are conventionally referred to as immediate-early (IE) genes. However, previous studies showed that the earliest expression of these genes was blocked by cycloheximide when the EBV lytic cycle was induced by histone deacetylase (HDAC) inhibitors and pr...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01415-10
更新日期:2010-12-01 00:00:00