Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.

abstract：:Borna disease virus (BDV) uses a unique strategy of replication and transcription which takes place in the nucleus, unlike other known, nonsegmented, negative-stranded RNA viruses of animal origin. In this process, viral constituents necessary for replication must be transported to the nucleus from the cytoplasm. We r...

journal_title：Journal of virology

authors： Shoya Y,Kobayashi T,Koda T,Ikuta K,Kakinuma M,Kishi M

更新日期：1998-12-01 00:00:00

abstract：:A malignant glioma cell line was infected with the human T-lymphotropic virus type IIIB isolate of the human immunodeficiency virus. Infection appeared to be latent rather than productive. Through contact with monocytic or lymphoid cells, the virus present in the glioma cells could be transmitted and gave rise to a fu...

journal_title：Journal of virology

authors： Chiodi F,Fuerstenberg S,Gidlund M,Asjö B,Fenyö EM

更新日期：1987-04-01 00:00:00

abstract：:We reported previously that the movement protein (MP) of tomato mosaic tobamovirus is phosphorylated, and we proposed that MP phosphorylation is important for viral pathogenesis. Experimental data indicated that phosphorylation enhances the stability of MP in vivo and enables the protein to assume the correct intracel...

journal_title：Journal of virology

authors： Kawakami S,Hori K,Hosokawa D,Okada Y,Watanabe Y

更新日期：2003-01-01 00:00:00

abstract：:The human foamy virus (HFV) contains within the U3 region of its long terminal repeat (LTR) three perfect consensus sequences for the binding of the inducible transcription factor AP-1. Results of DNase I footprint protection and gel retardation assays demonstrated that proteins in extracts of HeLa and BHK-21 cells as...

journal_title：Journal of virology

authors： Maurer B,Serfling E,ter Meulen V,Rethwilm A

更新日期：1991-11-01 00:00:00

abstract：:Members of the tripartite interaction motif (TRIM) family of E3 ligases are emerging as critical regulators of innate immunity. To identify new regulators, we carried out a screen of 43 human TRIM proteins for the ability to activate NF-κB, AP-1, and interferon, hallmarks of many innate immune signaling pathways. We i...

journal_title：Journal of virology

authors： Uchil PD,Hinz A,Siegel S,Coenen-Stass A,Pertel T,Luban J,Mothes W

更新日期：2013-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs)...

journal_title：Journal of virology

authors： Kim DN,Chae HS,Oh ST,Kang JH,Park CH,Park WS,Takada K,Lee JM,Lee WK,Lee SK

更新日期：2007-01-01 00:00:00

abstract：:Eucaryotic, viral, and bacteriophage DNA polymerases of the alpha-like family share blocks of sequence similarity, the most conserved of which has been designated region I. Region I includes a YGDTDS motif that is almost invariant within the alpha-like family and that is similar to a motif conserved among RNA-directed...

journal_title：Journal of virology

authors： Marcy AI,Hwang CB,Ruffner KL,Coen DM

更新日期：1990-12-01 00:00:00

abstract：:Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1) transforms human T cells in vitro, and Tax, a potent transactivator of viral and cellular genes, plays a key role in cell immortalization. Tax activity is mediated by interaction with cellular transcription factors including members of the CREB/ATF family, the N...

journal_title：Journal of virology

authors： Mulloy JC,Kislyakova T,Cereseto A,Casareto L,LoMonico A,Fullen J,Lorenzi MV,Cara A,Nicot C,Giam C,Franchini G

更新日期：1998-11-01 00:00:00

abstract：:This paper reports the use of zonal ultracentrifuge techniques to conduct biophysical studies of rhinoviruses grown with WI-38 cells. Good clean-out of infectivity from rhinovirus harvests was obtained with the continuous-flow B-V and B-IX rotors. Use of the B-V rotor resulted in the successful concentration of rhinov...

journal_title：Journal of virology

authors： Gerin JL,Richter WR,Fenters JD,Holper JC

更新日期：1968-09-01 00:00:00

abstract：:The biological activity encoded in the putative protease gene (pro) of human T-cell leukemia virus type I was investigated by using a vaccinia virus expression vector. The 53-kilodalton gag precursor polyprotein was processed into the mature p19, p24, and p15 gag proteins when the gag and protease-coding sequence was ...

journal_title：Journal of virology

authors： Nam SH,Kidokoro M,Shida H,Hatanaka M

更新日期：1988-10-01 00:00:00

abstract：:The E6 oncoproteins encoded by the cancer-associated human papillomaviruses (HPVs) can associate with and promote the degradation of wild-type p53 in vitro. To gain further insight into this process, the ability of HPV-16 E6 to complex with and promote the degradation of mutant forms of p53 was studied. A correlation ...

journal_title：Journal of virology

authors： Scheffner M,Takahashi T,Huibregtse JM,Minna JD,Howley PM

更新日期：1992-08-01 00:00:00

abstract：:Previous in vitro analyses have shown that the human immunodeficiency virus type 1 (HIV-1) integrase uses either manganese or magnesium to assemble as a stable complex on the donor substrate and to catalyze strand transfer. We now demonstrate that subsequent to assembly, catalysis of both 3' end processing and strand ...

journal_title：Journal of virology

authors： Hazuda DJ,Felock PJ,Hastings JC,Pramanik B,Wolfe AL

更新日期：1997-09-01 00:00:00

abstract：:We are exploring the use of interferon (IFN) genes for somatic cell gene therapy and have investigated the possibility of transforming cells into low constitutive IFN producers over prolonged periods of time without impeding cell survival or replication. Here we report the possibility of conferring a permanent antivir...

journal_title：Journal of virology

authors： Seif I,De Maeyer E,Riviere I,De Maeyer-Guignard J

更新日期：1991-02-01 00:00:00

abstract：:The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition wa...

journal_title：Journal of virology

authors： Hansen JE,Nielsen C,Arendrup M,Olofsson S,Mathiesen L,Nielsen JO,Clausen H

更新日期：1991-12-01 00:00:00

abstract：UNLABELLED:The live attenuated measles virus vaccine is highly immunostimulatory. Identification and characterization of its components that activate the innate immune response might provide new strategies and agents for the rational design and development of chemically defined adjuvants. In this study, we report on th...

journal_title：Journal of virology

authors： Ho TH,Kew C,Lui PY,Chan CP,Satoh T,Akira S,Jin DY,Kok KH

更新日期：2015-11-25 00:00:00

abstract：:Neutralizing antibodies may have critical importance in immunity against human immunodeficiency virus type 1 (HIV-1) infection. However, the amount of protective antibody needed at mucosal surfaces has not been fully established. Here, we evaluated systemic and mucosal pharmacokinetics (PK) and pharmacodynamics (PD) o...

journal_title：Journal of virology

authors： Klein K,Veazey RS,Warrier R,Hraber P,Doyle-Meyers LA,Buffa V,Liao HX,Haynes BF,Shaw GM,Shattock RJ

更新日期：2013-11-01 00:00:00

abstract：:Vesicular stomatitis virus Indiana strain G protein (VSVind.G) is the most commonly used envelope glycoprotein to pseudotype lentiviral vectors (LV) for experimental and clinical applications. Recently, G proteins derived from other vesiculoviruses (VesG), for example, Cocal virus, have been proposed as alternative LV...

journal_title：Journal of virology

authors： Munis AM,Tijani M,Hassall M,Mattiuzzo G,Collins MK,Takeuchi Y

更新日期：2018-11-12 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for KS tumors, multicentric Castleman's disease, and primary effusion lymphomas. Like other herpesvirus capsids, the KSHV capsid is an icosahedral structure composed of six proteins. The capsid shell is made up of the major capsid protein, two tripl...

journal_title：Journal of virology

authors： Perkins EM,Anacker D,Davis A,Sankar V,Ambinder RF,Desai P

更新日期：2008-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) evokes a strong immune response, but the virus persists. Polymorphisms within known antigenic sites result in loss of immune recognition and can be positively selected. Amino acid variation outside known HLA class I restricted epitopes can also enable immune escape by interf...

journal_title：Journal of virology

authors： Zimbwa P,Milicic A,Frater J,Scriba TJ,Willis A,Goulder PJ,Pillay T,Gunthard H,Weber JN,Zhang HT,Phillips RE

更新日期：2007-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) displays both interstrain and intrastrain genetic variability. Virus populations with extensive microheterogeneity have been defined as swarms or quasispecies. Many of the genomes within HIV-1 swarms appear to be defective in one or more genes required for viral replication....

journal_title：Journal of virology

authors： Lori F,Hall L,Lusso P,Popovic M,Markham P,Franchini G,Reitz MS Jr

更新日期：1992-09-01 00:00:00

abstract：:Despite the long-standing observation that herpes simplex virus (HSV) latency-associated transcript (LAT) promoter deletion viruses show impaired recurrence phenotypes in relevant animal models, the mechanism by which these sequences exert this phenotypic effect is unknown. We constructed and evaluated four mutant HSV...

journal_title：Journal of virology

authors： Kawamura Y,Bosch-Marce M,Tang S,Patel A,Krause PR

更新日期：2018-06-29 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpu enhances virus particle release by counteracting a host factor that retains virions at the surfaces of infected cells. It was recently demonstrated that cellular protein BST-2/CD317/Tetherin restricts HIV-1 release in a Vpu-dependent manner. Calcium...

journal_title：Journal of virology

authors： Bego MG,Dubé M,Mercier J,Cohen EA

更新日期：2009-12-01 00:00:00

abstract：:Work in this laboratory previously demonstrated that the tropism of different human immunodeficiency type 1 isolates for infection of human CD4+ continuous cell lines (e.g., T-cell lines and HeLa-CD4 transformants) versus primary macrophages is associated with parallel intrinsic fusogenic specificities of the correspo...

journal_title：Journal of virology

authors： Alkhatib G,Broder CC,Berger EA

更新日期：1996-08-01 00:00:00

abstract：:A human cell line (293) transformed by adenovirus type 5 encodes mRNA's and proteins from the early region 1 (E1) of the viral genome. These products correspond to those synthesized early after adenovirus infection of normal cells. This pattern of expression is different from that observed at later times in the lytic ...

journal_title：Journal of virology

authors： Spector DJ,Halbert DN,Raskas HJ

更新日期：1980-12-01 00:00:00

abstract：:The full-length viral RNA of human immunodeficiency virus type 1 (HIV-1) functions both as the mRNA for the viral structural proteins Gag and Gag/Pol and as the genomic RNA packaged within viral particles. The packaging signal which Gag recognizes to initiate genome encapsidation is in the 5' untranslated region (UTR)...

journal_title：Journal of virology

authors： Anderson EC,Lever AM

更新日期：2006-11-01 00:00:00

abstract：:HLA-B*52:01 is strongly associated with protection against HIV disease progression. However, the mechanisms of HLA-B*52:01-mediated immune control have not been well studied. We here describe a cohort with a majority of HIV C-clade-infected individuals from Delhi, India, where HLA-B*52:01 is highly prevalent (phenotyp...

journal_title：Journal of virology

authors： Tsai MC,Singh S,Adland E,Goulder P

更新日期：2020-06-16 00:00:00

abstract：:The trans-activator Tat proteins coded by human immunodeficiency virus type 1 (HIV-1) and HIV-2 appear to be similar in structure and function. However, the Tat protein of HIV-2 (Tat2) activates the HIV-1 long terminal repeat (LTR) less efficiently than Tat1 (M. Emerman, M. Guyader, L. Montagnier, D. Baltimore, and M....

journal_title：Journal of virology

authors： Elangovan B,Subramanian T,Chinnadurai G

更新日期：1992-04-01 00:00:00

abstract：:Infection of cells with poliovirus induces a massive intracellular membrane reorganization to form vesicle-like structures where viral RNA replication occurs. The mechanism of membrane remodeling remains unknown, although some observations have implicated components of the cellular secretory and/or autophagy pathways....

journal_title：Journal of virology

authors： Belov GA,Altan-Bonnet N,Kovtunovych G,Jackson CL,Lippincott-Schwartz J,Ehrenfeld E

更新日期：2007-01-01 00:00:00

abstract：:Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific T helper cells contribute to effective antiviral control, but their functional characteristics and the precise epitopes targeted by this response remain to be defined. In this study, we generated CD4(+) T-cell clones specific for ...

journal_title：Journal of virology

authors： Norris PJ,Sumaroka M,Brander C,Moffett HF,Boswell SL,Nguyen T,Sykulev Y,Walker BD,Rosenberg ES

更新日期：2001-10-01 00:00:00

abstract：:Synthesis of polynucleotide 5'-triphosphatase, which is presumably involved in the initial modification in the series of reactions by which 5'-termini of vaccinia mRNA become capped and methylated, has been demonstrated in vaccinia virus infected HeLa cells. Synthesis of the enzyme is prevented by actinomycin D and cy...

journal_title：Journal of virology

authors： Tutas DJ,Paoletti E

更新日期：1978-01-01 00:00:00