Abstract:
:Synthesis of polynucleotide 5'-triphosphatase, which is presumably involved in the initial modification in the series of reactions by which 5'-termini of vaccinia mRNA become capped and methylated, has been demonstrated in vaccinia virus infected HeLa cells. Synthesis of the enzyme is prevented by actinomycin D and cycloheximide, suggesting that both de novo DNA-dependent RNA and protein syntheses are required. On the other hand, cytosine arabinoside, an inhibitor of viral DNA replication, does not prevent induction of the enzyme. The latter observation, together with the kinetics of synthesis of the enzyme in vaccinia virus-infected HeLa cells, suggests that polynucleotide 5'-triphosphatase is an "early" or prereplicative viral protein. Immunologlobulin produced against the purified virion-associated polynucleotide 5'-triphosphatase as antigen neutralized the activity of the induced polynucleotide 5'-triphosphatase, thus indicating the identity of the two enzymes.
journal_name
J Viroljournal_title
Journal of virologyauthors
Tutas DJ,Paoletti Edoi
10.1128/JVI.25.1.37-41.1978subject
Has Abstractpub_date
1978-01-01 00:00:00pages
37-41issue
1eissn
0022-538Xissn
1098-5514journal_volume
25pub_type
杂志文章abstract::Nucleocapsid assembly in hepadnavirus replication requires selective encapsidation of the pregenomic RNA template and the viral polymerase by the core proteins. It has been shown that an encapsidation signal located at the 5' end of the pregenomic RNA is responsible for its interaction with the polymerase. In the pres...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.8.5035-5042.1996
更新日期:1996-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.12.7712-7717.1995
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.2.1186-1194.1999
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journal_title:Journal of virology
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doi:10.1128/JVI.71.7.5051-5059.1997
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01108-16
更新日期:2016-09-29 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.12.6953-6959.1992
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更新日期:2011-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.6.3889-3892.1995
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pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2016-01-20 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01484-08
更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/jvi.74.16.7261-7269.2000
更新日期:2000-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.5.3033-3041.1995
更新日期:1995-05-01 00:00:00
abstract::Human hepatitis B virus (HBV) HBx protein is a multifunctional protein that activates cellular signaling pathways and is thought to be essential for viral infection. Woodchuck HBV mutants that lack HBx are unable to replicate in vivo or are severely impaired. HBV replication in HepG2 cells, a human hepatoblastoma cell...
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pub_type: 杂志文章
doi:10.1128/jvi.77.14.7713-7719.2003
更新日期:2003-07-01 00:00:00
abstract::Previous studies in our laboratory showed that the RNA debranching enzyme (DBR1) is not required for early steps in HIV cDNA formation but is necessary for synthesis of intermediate and late cDNA products. To further characterize this effect, we evaluated the topology of the 5' end of the HIV-1 RNA genome during early...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01377-17
更新日期:2017-11-14 00:00:00
abstract::JC virus (JCV), along with other members of the polyomavirus family, encodes a class of highly conserved proteins, T antigens, that are capable of inducing aneuploidy in cultured cells. We have previously isolated T-antigen DNA variants of JCV from both colon cancer tissues and the corresponding nonneoplastic gastroin...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.4.1996-2001.2001
更新日期:2001-02-01 00:00:00
abstract::A promoter-trap retrovirus has been constructed in which a promoterless polyomavirus middle T antigen gene was inserted in the U3 region of the long terminal repeat of a replication-competent Moloney murine leukemia virus. The resulting virus, designated PyT, was used to infect mouse mammary glands in situ. As expecte...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.10.6810-6815.1996
更新日期:1996-10-01 00:00:00
abstract::Griffithsin, which binds N-linked glycans on gp120 to prevent HIV entry, has the most potent HIV-1 inhibitory activity described for any antiviral lectin and is being developed for topical preexposure prophylaxis. The current studies were designed to further assess its potential by exploring its activity against herpe...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00012-13
更新日期:2013-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.12.9654-9663.1997
更新日期:1997-12-01 00:00:00
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journal_title:Journal of virology
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doi:10.1128/JVI.00058-07
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.5.4157-4160.1997
更新日期:1997-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.11.5774-5781.1991
更新日期:1991-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.1.1-12.1995
更新日期:1995-01-01 00:00:00
abstract::APOBEC3G (APO3G) is a cytidine deaminase that restricts replication of vif-defective human immunodeficiency virus type 1 (HIV-1). Like other members of the cellular deaminase family, APO3G has the propensity to form homo-multimers. In the current study, we investigated the functional determinants for multimerization o...
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pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.2.1210-1218.1998
更新日期:1998-02-01 00:00:00
abstract::The M2-1 protein of respiratory syncytial (RS) virus is a transcriptional processivity and antitermination factor. The M2-1 protein has a Cys3His1 zinc binding motif which is essential for function, is phosphorylated, and has been shown to interact with the RS virus nucleocapsid (N) protein. In the work reported here,...
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pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2020-02-14 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
abstract::Infectious hematopoietic necrosis virus (IHNV) is a rhabdovirus that produces an acute, lethal infection in rainbow trout (Oncorhynchus mykiss). Fish that survive infection cease to produce detectable infectious virus at approximately 46 days after infection, yet there is evidence that survivor fish continue to harbor...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.1.843-849.1999
更新日期:1999-01-01 00:00:00
abstract::TMC114, a newly designed human immunodeficiency virus type 1 (HIV-1) protease inhibitor, is extremely potent against both wild-type (wt) and multidrug-resistant (MDR) viruses in vitro as well as in vivo. Although chemically similar to amprenavir (APV), the potency of TMC114 is substantially greater. To examine the bas...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.21.12012-12021.2004
更新日期:2004-11-01 00:00:00