Abstract:
:The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition was found in infection of both lymphocytic cells and monocytoid cells. Viruses tested included six HIV-1 and five HIV-2 isolates propagated in different cells, as well as infectious plasma from AIDS patients. The antiviral effect of anti-Tn MAbs occurred by specific binding of the MAb to the virus; this binding was inhibitable by pure Tn antigen, and indications were found that this inhibition occurred at a pre-entry step. Boosting the naturally occurring low-titer anti-Tn activity may be of prophylactic value, as suggested by the in vitro neutralization found in this study.
journal_name
J Viroljournal_title
Journal of virologyauthors
Hansen JE,Nielsen C,Arendrup M,Olofsson S,Mathiesen L,Nielsen JO,Clausen Hdoi
10.1128/JVI.65.12.6461-6467.1991subject
Has Abstractpub_date
1991-12-01 00:00:00pages
6461-7issue
12eissn
0022-538Xissn
1098-5514journal_volume
65pub_type
杂志文章abstract::Detailed phylogenetic analyses were performed to characterize an HIV-1 outbreak among injection drug users (IDUs) in Stockholm, Sweden, in 2006. This study investigated the source and dynamics of HIV-1 spread during the outbreak as well as associated demographic and clinical factors. Seventy Swedish IDUs diagnosed dur...
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journal_title:Journal of virology
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doi:10.1128/JVI.66.9.5224-5231.1992
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pub_type: 杂志文章
doi:10.1128/JVI.64.4.1675-1682.1990
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.12.9803-9807.1997
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pub_type: 杂志文章
doi:10.1128/JVI.45.2.565-575.1983
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.9.5299-5302.1993
更新日期:1993-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.62.2.629-632.1988
更新日期:1988-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.15.6911-6921.2000
更新日期:2000-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.8.4037-4047.2004
更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.00558-06
更新日期:2006-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.18.8692-8699.2000
更新日期:2000-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.9.5824-5828.1995
更新日期:1995-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.41.2.674-685.1982
更新日期:1982-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2018-06-29 00:00:00
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pub_type: 杂志文章
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更新日期:1989-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.2.1097-1106.1997
更新日期:1997-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03233-12
更新日期:2013-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.9.2857-2863.1987
更新日期:1987-09-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.2.995-998.2004
更新日期:2004-01-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.26.2.243-248.1978
更新日期:1978-05-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.2.785-793.2006
更新日期:2006-01-01 00:00:00