Abstract:
:Murine gammaherpesvirus 68 (MHV-68) glycoprotein B (gB) was identified in purified virions by immunoblotting, immunoprecipitation, and immunoelectron microscopy. It was synthesized as a 120-kDa precursor in infected cells and cleaved into 65-kDa and 55-kDa disulfide-linked subunits close to the time of virion release. The N-linked glycans on the cleaved, virion gB remained partially endoglycosidase H sensitive. The processing of MHV-68 gB therefore appears similar to that of Kaposi's sarcoma-associated herpesvirus gB and human cytomegalovirus gB.
journal_name
J Viroljournal_title
Journal of virologyauthors
Lopes FB,Colaco S,May JS,Stevenson PGdoi
10.1128/JVI.78.23.13370-13375.2004subject
Has Abstractpub_date
2004-12-01 00:00:00pages
13370-5issue
23eissn
0022-538Xissn
1098-5514pii
78/23/13370journal_volume
78pub_type
杂志文章abstract::Maintenance of Kaposi's sarcoma-associated herpesvirus (KSHV) latent infection depends on the viral episomes in the nucleus being distributed to daughter cells following cell division. The latency-associated nuclear antigen (LANA) is constitutively expressed in all KSHV-infected cells. LANA binds sequences in the term...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.22.11596-11604.2002
更新日期:2002-11-01 00:00:00
abstract::Adenovirus type 35 (Ad35) is a group B adenovirus that has been isolated primarily from patients with acquired immunodeficiency syndrome and other immunodeficiency disorders. We have studied the interaction of this unique adenovirus with the immune system by analyzing Ad35 early viral proteins in infected HeLa cells. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.61.12.3665-3671.1987
更新日期:1987-12-01 00:00:00
abstract::Regulation of immediate-early gene expression in human cytomegalovirus is subject to complex controls. The major immediate-early (mIE) gene is regulated by both positive and negative regulatory signals, including autoregulation mediated by a cis-repressive sequence. A second immediate-early gene, the US3 gene, is tran...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.69.9.5362-5367.1995
更新日期:1995-09-01 00:00:00
abstract::Human papillomaviruses (HPVs) infect keratinocytes and induce proliferative lesions. In infected cells, viral gene products alter the activities of cellular proteins, such as Rb and p53, resulting in altered cell cycle response. It is likely that HPV gene products also alter expression of cellular genes. In this study...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.9.4174-4182.2000
更新日期:2000-05-01 00:00:00
abstract::The Epstein-Barr virus (EBV)-determined nuclear antigens EBNA 1, 2, 3, 4, and 6, regularly expressed in EBV-transformed lymphoblastoid cell lines, vary in size among viral strains. We have used this characteristic to trace the spread of the virus within seven families by using an approach called Ebnotyping. Among 33 e...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.10.4703-4708.1990
更新日期:1990-10-01 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for KS tumors, multicentric Castleman's disease, and primary effusion lymphomas. Like other herpesvirus capsids, the KSHV capsid is an icosahedral structure composed of six proteins. The capsid shell is made up of the major capsid protein, two tripl...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00423-08
更新日期:2008-07-01 00:00:00
abstract::p21((WAF1/SDII/CIP1)) (p21) arrests cell growth by inhibiting cyclin-depend kinases. To explore the potential of using p21 for the gene therapy of cervical cancer, we infected human papillomavirus (HPV)-positive cervical cancer cells (HeLa, SiHa, and Z172) and HPV-negative cervical cancer cells (C33A) with recombinant...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.6.4983-4990.1999
更新日期:1999-06-01 00:00:00
abstract::The complement pathway is involved in eliminating antigen immune complexes. However, the role of the C3 complement system remains largely unknown in influenza virus M2 extracellular (M2e) domain or hemagglutinin (HA) vaccine-mediated protection after vaccination. Using a C3 knockout (C3 KO) mouse model, we found that ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00969-18
更新日期:2018-09-26 00:00:00
abstract::We have previously demonstrated that two mouse cell lines that are poorly infectible by reovirus become highly susceptible upon transfection with the gene encoding the epidermal growth factor receptor (EGFR) (J. E. Strong, D. Tang, and P. W. K. Lee, Virology 197:405-411, 1993). This enhancement of infection efficiency...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.1.612-616.1996
更新日期:1996-01-01 00:00:00
abstract::The unique region of the capsid protein VP1 (VP1u) of human parvovirus B19 (B19) elicits a dominant immune response and has a phospholipase A(2) (PLA(2)) activity, which is necessary for the infection. In contrast to the rest of the parvoviruses, the VP1u of B19 is thought to occupy an external position in the virion,...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01435-06
更新日期:2006-12-01 00:00:00
abstract:UNLABELLED:The vaccinia virus (VACV) E3 protein has been shown to be important for blocking activation of the cellular innate immune system and allowing viral replication to occur unhindered. Mutation or deletion of E3L severely affects viral host range and pathogenesis. While the monkeypox virus (MPXV) genome encodes ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00304-15
更新日期:2015-10-01 00:00:00
abstract::The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a formidable battle horse for the study of viral immunology, as well as viral persistence and associated diseases. Investigations with LCMV have uncovered basic mechanisms by which viruses avoid elimination by the host adaptive immune response. In ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00555-06
更新日期:2006-09-01 00:00:00
abstract::In most human immunodeficiency virus type 1 (HIV-1)-infected individuals who achieve viral loads of <50 copies/ml during highly active antiretroviral therapy (HAART), low levels of plasma virus remain detectable for years by ultrasensitive methods. The relative contributions of ongoing virus replication and virus prod...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00570-09
更新日期:2009-10-01 00:00:00
abstract::The transmission bottleneck is defined as the number of viral particles that transmit from one host to establish an infection in another. Genome sequence data have been used to evaluate the size of the transmission bottleneck between humans infected with the influenza virus; however, the methods used to make these est...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00014-20
更新日期:2020-06-16 00:00:00
abstract::Herpesvirus proteins pUL34 and pUL31 form a complex at the inner nuclear membrane (INM) which is necessary for efficient nuclear egress. Pseudorabies virus (PrV) pUL34 is a type II membrane protein of 262 amino acids (aa). The transmembrane region (TM) is predicted to be located between aa 245 and 261, leaving only on...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05484-11
更新日期:2012-02-01 00:00:00
abstract::The infection of human fetal thymus organ cultures (FTOC) with coxsackievirus B4 E2 (CVB4 E2) was investigated. Both positive- and negative-strand viral RNA were detected by real-time quantitative reverse transcription-PCR (RT-PCR) in CVB4 E2-infected FTOC, which supported high yields of virus production (approximatel...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.18.9854-9861.2004
更新日期:2004-09-01 00:00:00
abstract::Syncytial (syn) mutants of herpes simplex virus cause cell fusion. Many syn mutations map to the syn1 locus, which has been identified with the gK (UL53) gene. In this work, the gK genes of eight syn mutants derived from the KOS strain were sequenced to identify residues and, possibly, domains important for the fusion...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.12.8277-8281.1994
更新日期:1994-12-01 00:00:00
abstract::Human group C adenoviruses cause an acute infection in respiratory epithelia and establish a long-term or persistent infection, possibly in lymphocytes. The mechanism by which this persistence is maintained is unknown; however, it would require that persistently infected lymphocytes not be deleted. The adenovirus geno...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.19.9716-9723.2002
更新日期:2002-10-01 00:00:00
abstract::The morphogenesis of vesicular stomatitis virus was examined using freeze-fracture techniques, and the results obtained were compared with those from previously published experiments carried out with influenza viruses and togaviruses. The process of conversion of the host cell plasma membrane into the vesicular stomat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.21.2.601-609.1977
更新日期:1977-02-01 00:00:00
abstract::Human cytomegalovirus (HCMV) infection is well controlled mainly by cytotoxic CD8(+) T lymphocytes (CTL) directed against the matrix protein pp65 despite the numerous immune escape mechanisms developed by the virus. Dendritic cells (DCs) are key antigen-presenting cells for the generation of an immune response which h...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.74.21.10018-10024.2000
更新日期:2000-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.22.10906-10911.2001
更新日期:2001-11-01 00:00:00
abstract::Enhancement of cell death is a distinguishing feature of H1N1 influenza virus A/Puerto Rico/8/34 protein PB1-F2. Comparing the sequences (amino acids [aa] 61 to 87 using PB1-F2 amino acid numbering) of the PB1-F2-derived C-terminal peptides from influenza A viruses inducing high or low levels of cell death, we identif...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01373-13
更新日期:2014-01-01 00:00:00
abstract::Human cytomegalovirus (HCMV) encodes four putative G protein-coupled receptors, including pUL78, whose rodent orthologues are known to be important for replication and spread in their hosts. To investigate the mechanism by which pUL78 contributes to viral replication and pathogenesis, we generated a derivative of the ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05900-11
更新日期:2012-11-01 00:00:00
abstract::The specificity of binding of wheat germ ribosomes to mRNA was greatly altered by cleavage of the message. Fragmentation of reovirus mRNA allowed wheat germ ribosomes to bind and protect a variety of internal sequences which were not accessible to ribosomes in the intact message. In experiments using the polycistronic...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.35.3.748-756.1980
更新日期:1980-09-01 00:00:00
abstract::Human cytomegalovirus (HCMV) protein pUL38 has been shown to prevent premature cell death by antagonizing cellular stress responses; however, the underlying mechanism remains unknown. In this study, we identified the host protein ubiquitin-specific protease 24 (USP24) as an interaction partner of pUL38. Mutagenesis an...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00191-18
更新日期:2018-06-13 00:00:00
abstract::Fanconi anemia (FA) patients have an increased risk for squamous cell carcinomas (SCCs) at sites of predilection for infection with high-risk human papillomavirus (HPV) types, including the oral cavity and the anogenital tract. We show here that activation of the FA pathway is a frequent event in cervical SCCs. We fou...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01121-07
更新日期:2007-12-01 00:00:00
abstract:UNLABELLED:The measles virus (MeV) membrane fusion apparatus consists of a fusion protein trimer and an attachment protein tetramer. To trigger membrane fusion, the heads of the MeV attachment protein, hemagglutinin (H), bind cellular receptors while the 96-residue-long H stalk transmits the triggering signal. Structur...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02846-13
更新日期:2014-06-01 00:00:00
abstract::The cytomegalovirus (CMV) serine proteinase assemblin is synthesized as a precursor that undergoes three principal autoproteolytic cleavages. Two of these are common to the assemblin homologs of all herpes group viruses: one at the maturational site near the carboxyl end of the precursor and another at the release sit...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.8.5395-5404.1996
更新日期:1996-08-01 00:00:00
abstract::Previous studies have established that chlorella viruses encode K(+) channels with different structural and functional properties. In the current study, we exploit the different sensitivities of these channels to Cs(+) to determine if the membrane depolarization observed during virus infection is caused by the activit...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.80.5.2437-2444.2006
更新日期:2006-03-01 00:00:00
abstract::Infection with various human papillomaviruses (HPVs) induces cervical cancers. Cell surface heparan sulfates (HS) have been shown to serve as primary attachment receptors, and molecules with structural similarity to cell surface HS, like heparin, function as competitive inhibitors of HPV infection. Here we demonstrate...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00998-07
更新日期:2007-10-01 00:00:00