Structural determinants for nuclear envelope localization and function of pseudorabies virus pUL34.

abstract：:Our previous study has shown that recombinant adeno-associated virus (rAAV) vector integrates preferentially in genes, near transcription start sites and CpG islands in mouse liver (H. Nakai, X. Wu, S. Fuess, T. A. Storm, D. Munroe, E. Montini, S. M. Burgess, M. Grompe, and M. A. Kay, J. Virol. 79:3606-3614, 2005). Ho...

journal_title：Journal of virology

authors： Inagaki K,Lewis SM,Wu X,Ma C,Munroe DJ,Fuess S,Storm TA,Kay MA,Nakai H

更新日期：2007-10-01 00:00:00

abstract：:Some strains of the protozoan parasite genus Leishmania are persistently infected with single-segmented double-stranded RNA viruses, which are termed LRV. The function of these cytoplasmic viruses is unknown. In order to address the question of whether LRV affects the parasite's phenotype, pairs of isogenic LRV(+)-LRV...

journal_title：Journal of virology

authors： Widmer G

更新日期：1995-07-01 00:00:00

abstract：:The membrane fusion reaction promoted by the paramyxovirus simian virus 5 (SV5) and human parainfluenza virus type 3 (HPIV-3) fusion (F) proteins and hemagglutinin-neuraminidase (HN) proteins was characterized when the surface densities of F and HN were varied. Using a quantitative content mixing assay, it was found t...

journal_title：Journal of virology

authors： Dutch RE,Joshi SB,Lamb RA

更新日期：1998-10-01 00:00:00

abstract：:Two foot-and-mouth disease virus (FMDV) genome sequences have been determined for isolates collected from recent field outbreaks in North Africa (Egypt) and the Middle East (Palestinian Autonomous Territories). These data represent the first examples of complete genomic sequences for the FMDV SAT 2 topotype VII, which...

journal_title：Journal of virology

authors： Valdazo-González B,Knowles NJ,Hammond J,King DP

更新日期：2012-08-01 00:00:00

abstract：:Generating durable humoral immunity through vaccination depends upon effective interactions of follicular helper T (Tfh) cells with germinal center (GC) B cells. Th1 polarization of Tfh cells is an important process shaping the success of Tfh-GC B cell interactions by influencing costimulatory and cytokine-dependent T...

journal_title：Journal of virology

authors： Verma A,Schmidt BA,Elizaldi SR,Nguyen NK,Walter KA,Beck Z,Trinh HV,Dinasarapu AR,Lakshmanappa YS,Rane NN,Matyas GR,Rao M,Shen X,Tomaras GD,LaBranche CC,Reimann KA,Foehl DH,Gach JS,Forthal DN,Kozlowski PA,Amara RR

更新日期：2020-02-28 00:00:00

abstract：:The retroviral primary transcription product is a multifunctional RNA that is utilized as pre-mRNA, mRNA, and genomic RNA. The relationship between human immunodeficiency virus type 1 (HIV-1) unspliced transcripts used as mRNA for viral protein synthesis and as virion precursor RNA (vpRNA) for encapsidation remains an...

journal_title：Journal of virology

authors： Butsch M,Boris-Lawrie K

更新日期：2000-12-01 00:00:00

abstract：:Molecularly cloned proviral DNA of avian oncogenic retrovirus CMII was isolated by screening a genomic library of a CMII-transformed quail cell line with a myc-specific probe. On a 10.4-kilobase EcoRI fragment, the cloned DNA contained 4.4 kilobases of CMII proviral sequences extending from the 5' long terminal repeat...

journal_title：Journal of virology

authors： Walther N,Lurz R,Patschinsky T,Jansen HW,Bister K

更新日期：1985-05-01 00:00:00

abstract：:Differentiating infected from vaccinated animals (DIVA) strategies have been central enabling techniques in several successful viral disease elimination programs. However, owing to their long and uncertain development process, no DIVA-compatible vaccines are available for many important diseases. We report herein a ne...

journal_title：Journal of virology

authors： Xue Q,Xu H,Liu H,Pan J,Yang J,Sun M,Chen Y,Xu W,Cai X,Ma H

更新日期：2020-02-28 00:00:00

abstract：:Type C RNA viruses initially isolated from a lymphosarcoma of a gibbon ape and from a fibrosarcoma of a woolly monkey are very closely related immunologically. However, recent studies have shown that these viruses are distinguishable in a radioimmunoassay for the 12,000-molecular-weight polypeptide (p12) of the woolly...

journal_title：Journal of virology

authors： Tronick SR,Stephenson JR,Aaronson SA,Kawakami TG

更新日期：1975-01-01 00:00:00

abstract：:It is not yet clear to what extent depletion of intracellular GTP pools contributes to the antiviral activity of ribavirin. Therefore, the antiviral activities of (i) ribavirin, (ii) its 5-ethynyl analogue, 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), and (iii) mycophenolic acid (MPA) (a compound t...

journal_title：Journal of virology

authors： Leyssen P,Balzarini J,De Clercq E,Neyts J

更新日期：2005-02-01 00:00:00

abstract：:Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of the extracellular (SU) envelope glycoproteins with cellular receptors. To gain insight into the mechanisms governing thi...

journal_title：Journal of virology

authors： Gatot JS,Callebaut I,Van Lint C,Demonté D,Kerkhofs P,Portetelle D,Burny A,Willems L,Kettmann R

更新日期：2002-08-01 00:00:00

abstract：:We have selected an HXB2 variant which can replicate in the presence of a neutralizing human serum. Sequencing of the gp120 region of the env gene from the variant and parental viruses identified a single amino acid substitution in the third conserved region of gp120 at residue 375 (AGT-->AAT, Ser-->Asn; designated 37...

journal_title：Journal of virology

authors： McKeating JA,Bennett J,Zolla-Pazner S,Schutten M,Ashelford S,Brown AL,Balfe P

更新日期：1993-09-01 00:00:00

abstract：:Early in infection by bacteriophage T4, before replication has commenced, one can detect the presence of newly synthesized DNA which cosediments with parental phage DNA on sucrose gradients. As shown earlier (R. E. Murray and C. K. Mathews, 1969), some of this represents covalent attachment of new material to parental...

journal_title：Journal of virology

authors： Scofield MS,Collinsworth WL,Mathews CK

更新日期：1974-04-01 00:00:00

abstract：:We established previously that the temperature-dependent host range mutant, td CE 3, of vesicular stomatitis virus (VSV) New Jersey possesses temperature-sensitive RNA transcriptase activity. In this paper, we describe dissociation and reconstitution experiments designed to determine which VSV polypeptide is affected ...

journal_title：Journal of virology

authors： Szilágyi JF,Pringle CR,Macpherson TM

更新日期：1977-05-01 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) experience a marked loss of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the depletion of these cells are not yet understood. In this study, we observed that CD4+ T lymphocytes from HIV type 1 (HIV-1)-infected and uninfec...

journal_title：Journal of virology

authors： Heinkelein M,Sopper S,Jassoy C

更新日期：1995-11-01 00:00:00

abstract：:A specific endoribonucleolytic activity was detected when detergent-lysed vesicular stomatitis of Sendai virus was incubated with the precursor to Escherichia coli tRNA Tyr. The cleavage products produced and the characteristics of the reaction were similar to those previously reported for human KB cell RNase NU. Like...

journal_title：Journal of virology

authors： Kolakofsky D,Altman S

更新日期：1978-01-01 00:00:00

abstract：:The full repertoire of hepatitis B virus (HBV) peptides that bind to the common HLA class I molecules found in areas with a high prevalence of chronic HBV infection has not been determined. This information may be useful for designing immunotherapies for chronic hepatitis B. We identified amino acid residues under pos...

journal_title：Journal of virology

authors： Abbott WG,Tsai P,Leung E,Trevarton A,Ofanoa M,Hornell J,Gane EJ,Munn SR,Rodrigo AG

更新日期：2010-01-01 00:00:00

abstract：:TT virus (TTV) is a recently identified widespread DNA virus of humans that produces persistent viremia in the absence of overt clinical manifestations. In an attempt to shed light on the dynamics of chronic infection, we measured the levels of TTV in the plasma of 25 persistently infected patients during the first 3 ...

journal_title：Journal of virology

authors： Maggi F,Pistello M,Vatteroni M,Presciuttini S,Marchi S,Isola P,Fornai C,Fagnani S,Andreoli E,Antonelli G,Bendinelli M

更新日期：2001-12-01 00:00:00

abstract：:In contrast to infrequent and low-titer cross-neutralization of human immunodeficiency virus type 1 (HIV-1) isolates by HIV-2- and simian immunodeficiency virus (SIV)-positive sera, extensive cross-neutralization of HIV-2NIH-Z, SIVMAC251, and SIVAGM208K occurs with high titer, suggesting conservation of epitopes and m...

journal_title：Journal of virology

authors： Robert-Guroff M,Aldrich K,Muldoon R,Stern TL,Bansal GP,Matthews TJ,Markham PD,Gallo RC,Franchini G

更新日期：1992-06-01 00:00:00

abstract：:Due to increasing concerns about human infection by various H7 influenza viruses, including recent H7N9 viruses, we evaluated the genetic relationships and cross-protective efficacies of three different Eurasian H7 avian influenza viruses. Phylogenic and molecular analyses revealed that recent Eurasian H7 viruses can ...

journal_title：Journal of virology

authors： Kwon HI,Kim YI,Park SJ,Song MS,Kim EH,Kim SM,Si YJ,Lee IW,Song BM,Lee YJ,Yun SJ,Kim WJ,Choi YK

更新日期：2017-05-12 00:00:00

abstract：:All plus-strand RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that functions as the catalytic subunit of the viral replication/transcription complex, directing viral RNA synthesis in concert with other viral proteins and, sometimes, host proteins. RNA synthesis essentially can be initiated by two different...

journal_title：Journal of virology

authors： Beerens N,Selisko B,Ricagno S,Imbert I,van der Zanden L,Snijder EJ,Canard B

更新日期：2007-08-01 00:00:00

abstract：:Under the immune pressure of cytotoxic T cells (CTLs), hepatitis B virus (HBV) evolves to accumulate mutations more likely within epitopes to evade immune detection. However, little is known about the specific patterns of the immune pressure-associated HBV mutation of T-cell epitopes and their link to disease progress...

journal_title：Journal of virology

authors： Zhang Y,Wu Y,Deng M,Xu D,Li X,Xu Z,Hu J,Zhang H,Liu K,Zhao Y,Gao F,Bi S,Gao GF,Zhao J,Liu WJ,Meng S

更新日期：2018-08-16 00:00:00

abstract：:A number of positive-strand RNA viruses, such as hepatitis C virus (HCV) and poliovirus, use double-membrane vesicles (DMVs) as replication sites. However, the role of cellular proteins in DMV formation during virus replication is poorly understood. HCV NS4B protein induces the formation of a "membranous web" structur...

journal_title：Journal of virology

authors： Kong L,Aoyagi H,Yang Z,Ouyang T,Matsuda M,Fujimoto A,Watashi K,Suzuki R,Arita M,Yamagoe S,Dohmae N,Suzuki T,Suzuki T,Muramatsu M,Wakita T,Aizaki H

更新日期：2020-01-06 00:00:00

abstract：:The inclusion of Mimiviridae members in the putative monophyletic nucleocytoplasmic large DNA virus (NCLDV) group is based on genomic and phylogenomic patterns. This shows that, along with other viral families, they share a set of genes known as core or "hallmark genes," including the gene for the major capsid protein...

journal_title：Journal of virology

authors： Boratto PVM,Dornas FP,da Silva LCF,Rodrigues RAL,Oliveira GP,Cortines JR,Drumond BP,Abrahão JS

更新日期：2018-01-02 00:00:00

abstract：:Passage of native classical swine fever virus (CSFV) in cultured swine kidney cells (SK6 cells) selects virus variants that attach to the surface of cells by interaction with membrane-associated heparan sulfate (HS). A Ser-to-Arg change in the C terminus of envelope glycoprotein E(rns) (amino acid 476 in the open read...

journal_title：Journal of virology

authors： Hulst MM,van Gennip HG,Vlot AC,Schooten E,de Smit AJ,Moormann RJ

更新日期：2001-10-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) genome contains three origins of DNA replication, one copy of oriL and two copies of oriS. Although oriL and oriS are structurally different, they have extensive nucleotide sequence similarity and can substitute for each other to initiate viral DNA replication. A fundamental que...

journal_title：Journal of virology

authors： Hardwicke MA,Schaffer PA

更新日期：1997-05-01 00:00:00

abstract：:Antigens detected by the complement-fixation (CF) test were prepared from BHK-21 cells infected with Pichinde virus. The preparations contained two antigens demonstrable by immunodiffusion. The antigen present in abundance was heat stable, Pronase resistant, and had a molecular weight of 20,000 to 30,000 as estimated ...

journal_title：Journal of virology

authors： Buchmeier MJ,Gee SR,Rawls WE

更新日期：1977-04-01 00:00:00

abstract：:Alkylation of T7 bacteriophage by methyl methane sulfonate blocked superinfection exclusion. This blockage could be correlated with a delay in the synthesis of phage-specific proteins. Therefore we conclude that protein synthesis directed by the primary infecting phage is required for efficient exclusion of superinfec...

journal_title：Journal of virology

authors： Karska-Wysocki B,Racine JF,Mamet-Bratley MD

更新日期：1982-11-01 00:00:00

abstract：:The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease. To find genes that protect cells from apoptosis, we used an expression cloning strategy and identifi...

journal_title：Journal of virology

authors： Foghsgaard L,Jäättelä M

更新日期：1997-10-01 00:00:00

abstract：:Control of HIV-1 replication following nonsterilizing HIV-1 vaccination could be achieved by vaccine-elicited CD8(+) T-cell-mediated antiviral activity. To date, neither the functional nor the phenotypic profiles of CD8(+) T cells capable of this activity are clearly understood; consequently, little is known regarding...

journal_title：Journal of virology

authors： Freel SA,Lamoreaux L,Chattopadhyay PK,Saunders K,Zarkowsky D,Overman RG,Ochsenbauer C,Edmonds TG,Kappes JC,Cunningham CK,Denny TN,Weinhold KJ,Ferrari G,Haynes BF,Koup RA,Graham BS,Roederer M,Tomaras GD

更新日期：2010-05-01 00:00:00