Antigenic characterization of type C RNA virus isolates of gibbon apes.

Abstract:

:Type C RNA viruses initially isolated from a lymphosarcoma of a gibbon ape and from a fibrosarcoma of a woolly monkey are very closely related immunologically. However, recent studies have shown that these viruses are distinguishable in a radioimmunoassay for the 12,000-molecular-weight polypeptide (p12) of the woolly monkey virus. In the present report, an immunoassay has been developed for the p12 polypeptide of the gibbon ape type C virus. This assay is shown to further distinguish the woolly monkey and gibbon ape viruses. In type-specific assays for the p12 polypeptides of these viruses, two new type C viruses isolated from gibbons in a second colony, characterized by high incidence of hemopoietic neoplasia, are immunologically distinguishable from the original gibbon ape virus. The p12 type-specific immunoassays described in the present report may be of importance in studying the natural history of these viruses and their relationship to tumors of primates.

journal_name

J Virol

journal_title

Journal of virology

authors

Tronick SR,Stephenson JR,Aaronson SA,Kawakami TG

doi

10.1128/JVI.15.1.115-120.1975

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

115-20

issue

1

eissn

0022-538X

issn

1098-5514

journal_volume

15

pub_type

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