Membrane fusion promoted by increasing surface densities of the paramyxovirus F and HN proteins: comparison of fusion reactions mediated by simian virus 5 F, human parainfluenza virus type 3 F, and influenza virus HA.

abstract：UNLABELLED:Based on an explant reactivation model, it has been proposed that CD8(+) T cells maintain latency in trigeminal ganglia (TG) of mice latently infected with herpes simplex virus 1 (HSV-1) [T. Liu, K. M. Khanna, X. Chen, D. J. Fink, and R. L. Hendricks, J Exp Med 191:1459-1466, 2000, doi:10.1084/jem.191.9.1459...

journal_title：Journal of virology

authors： Mott KR,Gate D,Matundan HH,Ghiasi YN,Town T,Ghiasi H

更新日期：2016-04-29 00:00:00

abstract：:Chloramphenicol affects several steps in the DNA replication of mycoplasma virus L51, a noncytocidal, naked, bullet-shaped virion containing circular single-stranded (SS) DNA of 1.5 X 10(6) daltons (4.5 kilobases). In the presence of chloramphenicol, adsorption was normal and parental SS DNA was converted to double-st...

journal_title：Journal of virology

authors： Das J,Maniloff J

更新日期：1982-12-01 00:00:00

abstract：:A 4,500-bp BamHI fragment, located within the HindIII A segment of the vaccinia virus genome, was found to contain eight potential coding regions for polypeptides of 78 to 346 amino acids. The open reading frames with 133, 346, and 125 codons were homologous to profilin (an actin-binding protein), 3-beta-hydroxysteroi...

journal_title：Journal of virology

authors： Blasco R,Cole NB,Moss B

更新日期：1991-09-01 00:00:00

abstract：:The γ134.5 gene of herpes simplex virus 1 (HSV-1) encodes a virulence factor that promotes viral pathogenesis. Although it perturbs TANK-binding kinase 1 (TBK1) in the complex network of innate immune pathways, the underlying mechanism is obscure. Here we report that HSV-1 γ134.5 targets stimulator of interferon genes...

journal_title：Journal of virology

authors： Pan S,Liu X,Ma Y,Cao Y,He B

更新日期：2018-09-26 00:00:00

abstract：UNLABELLED:The interaction between viruses and immune cells of the host may lead to modulation of intracellular signaling pathways and to subsequent changes in cellular behavior that are of benefit for either virus or host. ERK1/2 (extracellular signal regulated kinase 1/2) signaling represents one of the key cellular ...

journal_title：Journal of virology

authors： Setas Pontes M,Devriendt B,Favoreel HW

更新日期：2015-02-01 00:00:00

abstract：:The Rep78 and Rep68 proteins of adeno-associated virus type 2 (AAV) are multifunctional proteins which are required for viral replication, regulation of AAV promoters, and preferential integration of the AAV genome into a region of human chromosome 19. These proteins bind the hairpin structures formed by the AAV inver...

journal_title：Journal of virology

authors： Davis MD,Wonderling RS,Walker SL,Owens RA

更新日期：1999-03-01 00:00:00

abstract：:We have used feline immunodeficiency virus (FIV) protease (PR) as a mutational system to study the molecular basis of substrate-inhibitor specificity for lentivirus PRs, with a focus on human immunodeficiency virus type 1 (HIV-1) PR. Our previous mutagenesis studies demonstrated that discrete substitutions in the acti...

journal_title：Journal of virology

authors： Lin YC,Brik A,de Parseval A,Tam K,Torbett BE,Wong CH,Elder JH

更新日期：2006-08-01 00:00:00

abstract：:Foxp3(+) CD4(+) regulatory T cells (Tregs) represent a highly suppressive T cell subset with well-characterized immunosuppressive effects during immune homeostasis and chronic infections, although the role of these cells in acute viral infections is poorly understood. The present study sought to examine the induction ...

journal_title：Journal of virology

authors： Betts RJ,Prabhu N,Ho AW,Lew FC,Hutchinson PE,Rotzschke O,Macary PA,Kemeny DM

更新日期：2012-03-01 00:00:00

abstract：UNLABELLED:The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3). IRF3 pl...

journal_title：Journal of virology

authors： Pattabhi S,Wilkins CR,Dong R,Knoll ML,Posakony J,Kaiser S,Mire CE,Wang ML,Ireton RC,Geisbert TW,Bedard KM,Iadonato SP,Loo YM,Gale M Jr

更新日期：2015-12-16 00:00:00

abstract：:Alpha/beta interferons (IFN-alpha/beta) are key mediators of innate immunity and important modulators of adaptive immunity. The mechanisms by which IFN-alpha/beta are induced are becoming increasingly well understood. Recent studies showed that Toll-like receptors 7 and 8 expressed by plasmacytoid dendritic cells (pDC...

journal_title：Journal of virology

authors： Hidmark AS,McInerney GM,Nordström EK,Douagi I,Werner KM,Liljeström P,Karlsson Hedestam GB

更新日期：2005-08-01 00:00:00

abstract：:Herpes simplex virus (HSV)-infected cells can activate the human complement system without interference of specific anti-HSV antibodies. Analysis by flow cytometry showed that C3-like molecules were deposited on the membrane of the infected cell when incubated with human serum without specific antibodies. Depletion of...

journal_title：Journal of virology

authors： van Strijp JA,van Kessel KP,Miltenburg LA,Fluit AC,Verhoef J

更新日期：1988-03-01 00:00:00

abstract：:Intracellular mature vaccinia virions are wrapped by cisternae, derived from virus-modified trans-Golgi or endosomal membranes, and then transported via microtubules to the cell periphery. Two viral proteins, encoded by the F13L and B5R open reading frames, are essential for the membrane-wrapping step. Previous transf...

journal_title：Journal of virology

authors： Husain M,Moss B

更新日期：2002-08-01 00:00:00

abstract：:To replicate its segmented, double-stranded RNA (dsRNA) genome, the rotavirus RNA-dependent RNA polymerase, VP1, must recognize viral plus-strand RNAs (+RNAs) and guide them into the catalytic center. VP1 binds to the conserved 3' end of rotavirus +RNAs via both sequence-dependent and sequence-independent contacts. Se...

journal_title：Journal of virology

authors： Ogden KM,Ramanathan HN,Patton JT

更新日期：2011-03-01 00:00:00

abstract：:The sequence relations between Kirsten murine sarcoma virus (Ki-SV), Harvey murine sarcoma virus (Ha-SV), and a rat endogenous 30S RNA were studied by electron microscope heteroduplex analysis. The sequence relationships between the sarcoma viruses and their respective parental murine leukemia viruses (Kirsten and Mol...

journal_title：Journal of virology

authors： Chien UH,Lai M,Shih TY,Verma IM,Scolnick EM,Roy-Burman P,Davidson N

更新日期：1979-09-01 00:00:00

abstract：UNLABELLED:Uracil DNA glycosylases (UNG) are highly conserved proteins that preserve DNA fidelity by catalyzing the removal of mutagenic uracils. All herpesviruses encode a viral UNG (vUNG), and yet the role of the vUNG in a pathogenic course of gammaherpesvirus infection is not known. First, we demonstrated that the v...

journal_title：Journal of virology

authors： Minkah N,Macaluso M,Oldenburg DG,Paden CR,White DW,McBride KM,Krug LT

更新日期：2015-03-01 00:00:00

abstract：:Removal of nucleoside triphosphates from extracts prepared from bacteriophage T7-infected Escherichia coli results in a stringent requirement for added ATP to form infective phage particles by in vitro packaging of bacteriophage T7 DNA. Optimal packaging efficiency was achieved at a concentration of about 1.25 mM. Oth...

journal_title：Journal of virology

authors： Masker WE

更新日期：1982-07-01 00:00:00

abstract：:Some retroviruses with an extended repeat (R) region encode the polyadenylation signal within the R region such that this signal is present at both the 5' and 3' ends of the viral transcript. This necessitates differential regulation to either repress recognition of the 5' polyadenylation signal or enhance usage of th...

journal_title：Journal of virology

authors： Das AT,Klaver B,Berkhout B

更新日期：1999-01-01 00:00:00

abstract：:The RNAs of replication-defective murine and primate type C transforming viruses were analyzed for the presence of nucleotide sequences homologous to the genomes of their respective helper type C viruses by using DNAs complementary (cDNA) to either the 5'-terminal (cDNA5') or total (cDNAtotal) nucleotide sequences of ...

journal_title：Journal of virology

authors： Tronick SR,Cabradilla CD,Aaronson SA,Haseltine WA

更新日期：1978-06-01 00:00:00

abstract：:Herpesvirus lytic DNA replication requires both the cis-acting element, the origin, and trans-acting factors, including virally encoded origin-binding protein, DNA replication enzymes, and auxiliary factors. Two lytic DNA replication origins (ori-Lyt) of Kaposi's sarcoma-associated herpesvirus (KSHV) have been identif...

journal_title：Journal of virology

authors： Wang Y,Li H,Tang Q,Maul GG,Yuan Y

更新日期：2008-03-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV), and herpes simplex virus (HSV) have been incurable to date because effective antiviral therapies target only replicating viruses and do not eradicate latently integrated or nonreplicating episomal viral genomes. Endonucleases that can target and cle...

journal_title：Journal of virology

authors： Schiffer JT,Aubert M,Weber ND,Mintzer E,Stone D,Jerome KR

更新日期：2012-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is typically acquired asymptomatically in childhood. In contrast, infection later in life often leads to infectious mononucleosis (IM), a febrile illness characterized by anti-EBV IgM antibody positivity, high loads of circulating latently infected B cells, and a marked lymphocytosis caused by...

journal_title：Journal of virology

authors： Abbott RJ,Pachnio A,Pedroza-Pacheco I,Leese AM,Begum J,Long HM,Croom-Carter D,Stacey A,Moss PAH,Hislop AD,Borrow P,Rickinson AB,Bell AI

更新日期：2017-10-13 00:00:00

abstract：:Previous work by our laboratory and others has shown that mouse cells normally resistant to tumor necrosis factor can be made sensitive to the cytokine by the expression of adenovirus E1A. The E1A gene can be introduced by either infection or transfection, and either of the two major E1A proteins, 289R or 243R, can in...

journal_title：Journal of virology

authors： Duerksen-Hughes PJ,Hermiston TW,Wold WS,Gooding LR

更新日期：1991-03-01 00:00:00

abstract：:Lentiviruses are nononcogenic retroviruses that cause persistent infections and slowly progressive diseases. Visna virus, a lentivirus of sheep, persists in cells of the macrophage lineage despite the presence of neutralizing antibodies in the animal. These antibodies are measured by prevention of virus replication in...

journal_title：Journal of virology

authors： Kennedy-Stoskopf S,Narayan O

更新日期：1986-07-01 00:00:00

abstract：:DNA of the avian hepadnavirus, duck hepatitis B virus, was found to be integrated at low abundance into the cellular DNA extracted from the livers of infected ducklings. The frequency of integration was estimated to be at least one viral genome per 10(3) to 10(4) cells by 6 days postinfection. The structures of virus-...

journal_title：Journal of virology

authors： Yang W,Summers J

更新日期：1999-12-01 00:00:00

abstract：:We have proposed a general algorithm for identification of potential immunoprotective domains (cassettes) on the envelope E2 polypeptide of alphaviruses (H. Grosfeld, B. Velan, M. Leitner, S. Cohen, S. Lustig, B.E. Lachmi, and A. Shafferman, J. Virol. 63:3416-3422, 1989). To assess the generality of our approach, we c...

journal_title：Journal of virology

authors： Grosfeld H,Lustig S,Gozes Y,Velan B,Cohen S,Leitner M,Lachmi B,Katz D,Olshevski U,Shafferman A

更新日期：1992-02-01 00:00:00

abstract：:Far-upstream element-binding protein 2 (FBP2) is an internal ribosomal entry site (IRES) trans-acting factor (ITAF) that negatively regulates enterovirus 71 (EV71) translation. This study shows that EV71 infection cleaved FBP2. Live EV71 and the EV71 replicon (but not UV-inactivated virus particles) induced FBP2 cleav...

journal_title：Journal of virology

authors： Chen LL,Kung YA,Weng KF,Lin JY,Horng JT,Shih SR

更新日期：2013-04-01 00:00:00

abstract：:Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensit...

journal_title：Journal of virology

authors： Vigant F,Hollmann A,Lee J,Santos NC,Jung ME,Lee B

更新日期：2014-02-01 00:00:00

abstract：:We have characterized an inhibitory RNA element in the human immunodeficiency virus type 1 (HIV-1) gag coding sequence that prevents gag expression. The inhibition exerted by this element could be overcome by the presence of the Rev-responsive element in cis and of Rev protein in trans. To understand the mechanism of ...

journal_title：Journal of virology

authors： Schwartz S,Campbell M,Nasioulas G,Harrison J,Felber BK,Pavlakis GN

更新日期：1992-12-01 00:00:00

abstract：:Region 1 DNA sequences (map positions 0 to 11% on the linear adenovirus 2 genome) are expressed both early and late in lytic infection and are required for transformation by the virus. During productive infection six distinct cytoplasmic RNAs are synthesized from this region. These RNAs comprise two families, each con...

journal_title：Journal of virology

authors： Halbert DN,Spector DJ,Raskas HJ

更新日期：1979-09-01 00:00:00

abstract：UNLABELLED:Despite the nutritional and health benefits of breast milk, breast milk can serve as a vector for mother-to-child HIV transmission. Most HIV-infected infants acquire HIV through breastfeeding. Paradoxically, most infants breastfed by HIV-positive women do not become infected. This is potentially attributed t...

journal_title：Journal of virology

authors： Wahl A,Baker C,Spagnuolo RA,Stamper LW,Fouda GG,Permar SR,Hinde K,Kuhn L,Bode L,Aldrovandi GM,Garcia JV

更新日期：2015-11-01 00:00:00