Dengue virus-specific human CD4+ T-lymphocyte responses in a recipient of an experimental live-attenuated dengue virus type 1 vaccine: bulk culture proliferation, clonal analysis, and precursor frequency determination.

abstract：:The genome of a human papillomavirus (HPV) found in a patient with Bowen's disease of the skin was molecularly cloned. Blot hybridization experiments, performed under stringent conditions, revealed no cross-hybridization between this HPV DNA and the other known HPV DNAs, showing that this HPV represents a new type, te...

journal_title：Journal of virology

authors： Kawashima M,Jablonska S,Favre M,Obalek S,Croissant O,Orth G

更新日期：1986-02-01 00:00:00

abstract：:Sequence analysis of the Lymantria dispar multicapsid nucleopolyhedrovirus (LdMNPV) genome identified an open reading frame (ORF) encoding a 548-amino-acid (62-kDa) protein that showed 35% amino acid sequence identity with vaccinia virus ATP-dependent DNA ligase. Ligase homologs have not been reported from other bacul...

journal_title：Journal of virology

authors： Pearson MN,Rohrmann GF

更新日期：1998-11-01 00:00:00

abstract：:A protamine-like protein named P6.9 is thought to play a role in the condensation of genomes of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) during an infection. Previous studies have shown that P6.9 is phosphorylated immediately upon synthesis and dephosphorylated upon the entry of th...

journal_title：Journal of virology

authors： Liu X,Zhao H,Fang Z,Yuan M,Yang K,Pang Y

更新日期：2012-11-01 00:00:00

abstract：:Various mechanisms are used by single-stranded RNA viruses to initiate and control their replication via the synthesis of replicative intermediates. In general, the same virus-encoded polymerase is responsible for both genome and antigenome strand synthesis from two different, although related promoters. Here we aimed...

journal_title：Journal of virology

authors： Deng T,Vreede FT,Brownlee GG

更新日期：2006-03-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) infection causes adult T-cell leukemia (ATL), which is frequently resistant to currently available therapies and has a very poor prognosis. To prevent the development of ATL among carriers, it is important to control HTLV-1-infected cells in infected individuals. Therefore, ...

journal_title：Journal of virology

authors： Tezuka K,Okuma K,Kuramitsu M,Matsuoka S,Tanaka R,Tanaka Y,Hamaguchi I

更新日期：2018-01-30 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) UL25 gene contains a 580-amino-acid open reading frame that codes for an essential protein. Previous studies have shown that the UL25 gene product is a virion component (M. A. Ali et al., Virology 216:278-283, 1996) involved in virus penetration and capsid assembly (C. Addison e...

journal_title：Journal of virology

authors： McNab AR,Desai P,Person S,Roof LL,Thomsen DR,Newcomb WW,Brown JC,Homa FL

更新日期：1998-02-01 00:00:00

abstract：:Molecularly defined vaccine formulations capable of inducing antiviral CD8+ T-cell-specific immunity in a manner compatible with human delivery are limited. Few molecules achieve this target without the support of an appropriate immunological adjuvant. In this study, we investigate the potential of totally synthetic p...

journal_title：Journal of virology

authors： Zhang X,Issagholian A,Berg EA,Fishman JB,Nesburn AB,BenMohamed L

更新日期：2005-12-01 00:00:00

abstract：:An alternatively spliced form of c-myb exists that encodes an additional 120 amino acids in chicken and 121 amino acids in human and mouse. These amino acids are encoded by an additional exon, termed exon 9A. This exon is not present in v-myb, and proteins containing these amino acids have never been tested for oncoge...

journal_title：Journal of virology

authors： Woo CH,Sopchak L,Lipsick JS

更新日期：1998-08-01 00:00:00

abstract：:Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of the extracellular (SU) envelope glycoproteins with cellular receptors. To gain insight into the mechanisms governing thi...

journal_title：Journal of virology

authors： Gatot JS,Callebaut I,Van Lint C,Demonté D,Kerkhofs P,Portetelle D,Burny A,Willems L,Kettmann R

更新日期：2002-08-01 00:00:00

abstract：:Virus-induced cell fusion of the fusion-from-without type was observed in SC-1 cells infected with Moloney murine leukemia virus when grown in NIH 3T3 cells. Replication-competent virus mutants with altered surface protein gp70 were examined. Fusion mutations were found in the proline-rich region of gp70. They acted o...

journal_title：Journal of virology

authors： Andersen KB

更新日期：1994-05-01 00:00:00

abstract：:Heterozygous replicative form molecules of bacteriophage phiX174 deoxyribonucleic acid (DNA) have been constructed in vitro. These are composed of viral strands extracted from purified preparations of phage bearing ts mutations and complementary strands of either half length or full length synthesized with purified DN...

journal_title：Journal of virology

authors： Merriam V,Dumas LB,Sinsheimer RL

更新日期：1971-05-01 00:00:00

abstract：:We previously observed that when human immunodeficiency virus (HIV)-infected T lymphocytes are added to epithelial cells, they adhere, polarize, and secrete virions unidirectionally onto the epithelium. Epithelial cells subsequently take up virus and become productively infected. We report here that colchicine treatme...

journal_title：Journal of virology

authors： Pearce-Pratt R,Malamud D,Phillips DM

更新日期：1994-05-01 00:00:00

abstract：:The pneumopathogenicity of a trypsin-sensitive revertant of Sendai virus, TSrev-58, which was derived from a trypsin-resistant mutant, TR-5, was examined in mice. In comparison with TR-5, the revertant had a single amino acid substitution at residue 116 (Ile----Arg) on F protein, which was the cleavage site, and had t...

journal_title：Journal of virology

authors： Mochizuki Y,Tashiro M,Homma M

更新日期：1988-08-01 00:00:00

abstract：:Circulating leukocytes are important in dissemination of cytomegalovirus (CMV) infection in humans. In the mouse model of murine CMV infection (MCMV), it has been shown that infection peaks on days 5 to 7 after experimental infection, when 0.01 to 0.1% of the circulating leukocytes contain viral DNA. In our laboratory...

journal_title：Journal of virology

authors： Collins TM,Quirk MR,Jordan MC

更新日期：1994-10-01 00:00:00

abstract：:RIG-I is a major cytoplasmic sensor of viral pathogen-associated molecular pattern (PAMP) RNA and induces type I interferon (IFN) production upon viral infection. A double-stranded RNA (dsRNA)-binding protein, PACT, plays an important role in potentiating RIG-I function. We have shown previously that arenaviral nucleo...

journal_title：Journal of virology

authors： Shao J,Huang Q,Liu X,Di D,Liang Y,Ly H

更新日期：2018-06-13 00:00:00

abstract：:The major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type C viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (RD-114), is the polypeptide of about 12,000 molecular weight. The protein-phosphate bond in this polypepti...

journal_title：Journal of virology

authors： Pal BK,McAllister RM,Gardner MB,Roy-Burman P

更新日期：1975-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are potent RNA regulators of gene expression. Some viruses encode miRNAs, most of unknown function. The majority of viral miRNAs are not conserved, and whether any have conserved functions remains unclear. Here, we report that two human polyomaviruses associated with serious disease in immunocomprom...

journal_title：Journal of virology

authors： Seo GJ,Fink LH,O'Hara B,Atwood WJ,Sullivan CS

更新日期：2008-10-01 00:00:00

abstract：:Poliovirus-specific RNA-dependent RNA polymerase (3Dpol) was purified to apparent homogeneity. A single polypeptide of an apparent molecular weight of 63,000 catalyzes the synthesis of dimeric and monomeric RNA products in response to the poliovirion RNA template. Analysis of purified 3Dpol by two-dimensional electrop...

journal_title：Journal of virology

authors： Ransone LJ,Dasgupta A

更新日期：1989-11-01 00:00:00

abstract：UNLABELLED:Influenza A viruses (IAVs) rely on host factors to support their life cycle, as viral proteins hijack or interact with cellular proteins to execute their functions. Identification and understanding of these factors would increase our knowledge of the molecular mechanisms manipulated by the viruses. In this s...

journal_title：Journal of virology

authors： Gao S,Wu J,Liu RY,Li J,Song L,Teng Y,Sheng C,Liu D,Yao C,Chen H,Jiang W,Chen S,Huang W

更新日期：2015-01-01 00:00:00

abstract：:Broad, multispecific CD4(+) and CD8(+) T-cell responses to the hepatitis C virus (HCV), as well as virus-cross-neutralizing antibodies, are associated with recovery from acute infection and may also be associated in chronic HCV patients with a favorable response to antiviral treatment. In order to recapitulate all of ...

journal_title：Journal of virology

authors： Lin Y,Kwon T,Polo J,Zhu YF,Coates S,Crawford K,Dong C,Wininger M,Hall J,Selby M,Coit D,Medina-Selby A,McCoin C,Ng P,Drane D,Chien D,Han J,Vajdy M,Houghton M

更新日期：2008-08-01 00:00:00

abstract：:The extracellular virion form (EV) of vaccinia virus (VACV) is essential for viral pathogenesis and is difficult to neutralize with antibodies. Why this is the case and how the smallpox vaccine overcomes this challenge remain incompletely understood. We previously showed that high concentrations of anti-B5 antibodies ...

journal_title：Journal of virology

authors： Benhnia MR,Maybeno M,Blum D,Aguilar-Sino R,Matho M,Meng X,Head S,Felgner PL,Zajonc DM,Koriazova L,Kato S,Burton DR,Xiang Y,Crowe JE Jr,Peters B,Crotty S

更新日期：2013-02-01 00:00:00

abstract：:We isolated a simian virus 40 mutant, dl2194, which carried deletions in both early genes. One deletion removed 234 base pairs in the 54/59 region within the small-t-antigen coding sequence and the large-T-antigen gene intron. The second deletion removed 57 base pairs at the C terminus of the large-T-antigen coding se...

journal_title：Journal of virology

authors： Feunteun J,Carmichael G,Nicolas JC,Kress M

更新日期：1981-12-01 00:00:00

abstract：:We have examined the transcriptional utilization of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) under differentiating conditions by using the embryonal carcinoma cell line NTERA-2. NTERA-2 cells undergo two distinct pathways of terminal differentiation, to a neuronal phenotype in respons...

journal_title：Journal of virology

authors： Zeichner SL,Hirka G,Andrews PW,Alwine JC

更新日期：1992-04-01 00:00:00

abstract：:In this study, we have extensively modified the Rb-binding domain of polyomavirus large T antigen. Mutant polyomavirus large T antigens were tested for their ability to bind pRb and p107 in vitro and assayed for their capacity to immortalize primary rat embryo fibroblasts in vivo. Polyomavirus large T antigen bound pR...

journal_title：Journal of virology

authors： Pilon AA,Desjardins P,Hassell JA,Mes-Masson AM

更新日期：1996-07-01 00:00:00

abstract：:Previous analyses using in situ hybridization alone or together with PCR have yielded conflicting results regarding the cell type in which latent varicella-zoster virus (VZV) resides. We separated human trigeminal ganglia (TG) into neuronal and nonneuronal fractions, followed by primary and nested PCR to quantitate VZ...

journal_title：Journal of virology

authors： LaGuardia JJ,Cohrs RJ,Gilden DH

更新日期：1999-10-01 00:00:00

abstract：UNLABELLED:JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers results...

journal_title：Journal of virology

authors： Nelson CD,Ströh LJ,Gee GV,O'Hara BA,Stehle T,Atwood WJ

更新日期：2015-04-01 00:00:00

abstract：:Wide application of the gene-targeting technique has been hampered by its low level of efficiency. A replication-defective adenovirus vector was used for efficient delivery of donor DNA in order to bypass this problem. Homologous recombination was selected between a donor neo gene inserted in the adenovirus vector and...

journal_title：Journal of virology

authors： Fujita A,Sakagami K,Kanegae Y,Saito I,Kobayashi I

更新日期：1995-10-01 00:00:00

abstract：:Genetic and phylogenetic analyses suggest that the pandemic H1N1/2009 virus was derived from well-established swine influenza lineages; however, there is no convincing evidence that the pandemic virus was generated from a direct precursor in pigs. Furthermore, the evolutionary dynamics of influenza virus in pigs have ...

journal_title：Journal of virology

authors： Wei K,Sun H,Sun Z,Sun Y,Kong W,Pu J,Ma G,Yin Y,Yang H,Guo X,Chang KC,Liu J

更新日期：2014-10-01 00:00:00

abstract：:Mutations in several subgenomic regions of hepatitis C virus (HCV) have been implicated in influencing the response to interferon (IFN) therapy. Sequences within HCV NS5A (PKR binding domain [PKRBD], IFN sensitivity-determining region [ISDR], and variable region 3 [V3]) were analyzed for the pretreatment serum samples...

journal_title：Journal of virology

authors： Muñoz de Rueda P,Casado J,Patón R,Quintero D,Palacios A,Gila A,Quiles R,León J,Ruiz-Extremera A,Salmerón J

更新日期：2008-07-01 00:00:00

abstract：:We have proposed a general algorithm for identification of potential immunoprotective domains (cassettes) on the envelope E2 polypeptide of alphaviruses (H. Grosfeld, B. Velan, M. Leitner, S. Cohen, S. Lustig, B.E. Lachmi, and A. Shafferman, J. Virol. 63:3416-3422, 1989). To assess the generality of our approach, we c...

journal_title：Journal of virology

authors： Grosfeld H,Lustig S,Gozes Y,Velan B,Cohen S,Leitner M,Lachmi B,Katz D,Olshevski U,Shafferman A

更新日期：1992-02-01 00:00:00