The large delta antigen of hepatitis delta virus potently inhibits genomic but not antigenomic RNA synthesis: a mechanism enabling initiation of viral replication.

abstract：:The pluripotent cytokine tumor necrosis factor alpha (TNF-alpha) binds to its cognate TNF receptor I (TNF-RI) to stimulate inflammation via activation of the NF-kappaB transcription factor. To prevent the detrimental effects of TNF-alpha in keratinocytes infected with the molluscum contagiosum virus (MCV), this poxvir...

journal_title：Journal of virology

authors： Nichols DB,Shisler JL

更新日期：2006-01-01 00:00:00

abstract：:Polyoma virus complementary RNA, synthesized in vitro by using highly purified Escherichia coli RNA polymerase and nondefective form I polyoma DNA, was translated in a wheat germ cell-free system. Polypeptides were synthesized that comigrated on sodium dodecyl sulfate-polyacrylamide gels with the polyoma capsid protei...

journal_title：Journal of virology

authors： Mangel WF,Hewick RM,Bayley ST,Wheeler T,Harvey R,Waterfield MD,Smith AE

更新日期：1978-02-01 00:00:00

abstract：:Passage of native classical swine fever virus (CSFV) in cultured swine kidney cells (SK6 cells) selects virus variants that attach to the surface of cells by interaction with membrane-associated heparan sulfate (HS). A Ser-to-Arg change in the C terminus of envelope glycoprotein E(rns) (amino acid 476 in the open read...

journal_title：Journal of virology

authors： Hulst MM,van Gennip HG,Vlot AC,Schooten E,de Smit AJ,Moormann RJ

更新日期：2001-10-01 00:00:00

abstract：:To study the variability of human immunodeficiency virus type 1 (HIV-1), we used immunotoxins to select for variants within a population of H9 cells persistently infected with a molecular clone of HIV-1 designated NL4-3. Chimeric immunotoxin CD4-PE40 (a chimeric fusion protein consisting of the amino-terminal two doma...

journal_title：Journal of virology

authors： Fang H,Pincus SH

更新日期：1995-01-01 00:00:00

abstract：:Persistent hepatitis B virus (HBV) infection is characterized by a weak and narrowly focused CD8+ T-cell response to HBV that is thought to reflect the induction of central and/or peripheral tolerance to HBV proteins in neonatal and adult onset infections, respectively. Immunotherapeutic strategies that overcome toler...

journal_title：Journal of virology

authors： Kakimi K,Isogawa M,Chung J,Sette A,Chisari FV

更新日期：2002-09-01 00:00:00

abstract：:In 2010 and 2011, several devastating Newcastle disease (ND) outbreaks occurred in China, affecting broilers, layers, and breeders. The CK-JSX1-201005 virus was isolated from broiler breeder flocks vaccinated with the classical ND virus (NDV) vaccine program, but laying rate decreased from 80% to 30 to 40% in the clin...

journal_title：Journal of virology

authors： Chen F,Liu J,Liu D,Yan Z,Ji J,Qin J,Li H,Ma J,Bi Y,Xie Q

更新日期：2012-11-01 00:00:00

abstract：:Rapid transmission of Borna disease virus occurred upon cohabitation of persistently infected and naive rats. Infectious virus, which was abundantly present in fresh urine samples of carrier rats, entered the brains of recipient rats via the olfactory route. Thus, susceptible farm animals possibly acquire the virus fr...

journal_title：Journal of virology

authors： Sauder C,Staeheli P

更新日期：2003-12-01 00:00:00

abstract：:The murine monoclonal antibody (MAb) 5A8, which is reactive with domain 2 of CD4, blocks human immunodeficiency virus type 1 (HIV-1) infection and syncytium formation of CD4+ cells (L. C. Burkly, D. Olson, R. Shapiro, G. Winkler, J. J. Rosa, D. W. Thomas, C. Williams, and P. Chisholm, J. Immunol., in press). Here we s...

journal_title：Journal of virology

authors： Moore JP,Sattentau QJ,Klasse PJ,Burkly LC

更新日期：1992-08-01 00:00:00

abstract：:Sequencing and reversion analysis of murine hepatitis virus (MHV) temperature-sensitive (ts) viruses has identified putative ts mutations in the replicase nonstructural proteins (nsp's) of these coronaviruses. In this study, reverse transcriptase PCR sequencing of the RNA genome of an isolate of the MHV ts virus Alb t...

journal_title：Journal of virology

authors： Sparks JS,Donaldson EF,Lu X,Baric RS,Denison MR

更新日期：2008-06-01 00:00:00

abstract：:The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intrace...

journal_title：Journal of virology

authors： Hillaire ML,van Trierum SE,Bodewes R,van Baalen CA,van Binnendijk RS,Koopmans MP,Fouchier RA,Osterhaus AD,Rimmelzwaan GF

更新日期：2011-11-01 00:00:00

abstract：:Tick-borne encephalitis virus (TBEV), a major tick-borne viral pathogen of humans, is known to cause neurological diseases such as meningitis, encephalitis, and meningoencephalitis. However, the life cycle and pathogenesis of TBEV are not well understood. Here, we show that the knockdown or knockout of ADAM15 (a disin...

journal_title：Journal of virology

authors： Yang Q,Pei R,Wang Y,Zhou Y,Yang M,Chen X,Chen J

更新日期：2021-01-28 00:00:00

abstract：:Recently, novel H7N9 influenza viruses have caused an unprecedented outbreak in humans. Pigs are an important intermediate host for influenza; thus, we assessed the replication ability of three human H7N9 viruses (A/Anhui/1/2013, A/Shanghai/1/2013, A/Shanghai/2/2013) in swine tissue explants. All viruses tested replic...

journal_title：Journal of virology

authors： Jones JC,Baranovich T,Zaraket H,Guan Y,Shu Y,Webby RJ,Webster RG

更新日期：2013-11-01 00:00:00

abstract：:A technique of continuous filtration of T4-infected Escherichia coli has been devised to study the phenomenon of lysis inhibition. Studies using this technique revealed that the length of the lysis delay caused by superinfection can attain only certain discrete values, which for low average multiplicity of superinfect...

journal_title：Journal of virology

authors： Bode W

更新日期：1967-10-01 00:00:00

abstract：:Vaccinia virus does not grow in Chinese hamster ovary (CHO-K1) cells in the absence of a viral host range factor, cowpox protein CP77. In this study, CP77 was fused to the C terminus of green fluorescence protein (GFP-CP77) and a series of nested deletion mutants of GFP-CP77 was constructed for insertion into a vaccin...

journal_title：Journal of virology

authors： Hsiao JC,Chao CC,Young MJ,Chang YT,Cho EC,Chang W

更新日期：2006-08-01 00:00:00

abstract：:Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) transactivates EBV genes in latently infected B cells. We have shown that mitotic hyperphosphorylation of EBNA2 suppresses its ability to transactivate the latent membrane protein 1 (LMP1) promoter. In this follow-up study, we identify EBNA2 Ser243 as a phosphorylatio...

journal_title：Journal of virology

authors： Yue W,Shackelford J,Pagano JS

更新日期：2006-02-01 00:00:00

abstract：:Myeloblastosis-associated virus type 1 (MAV1) derived from a molecular clone of infectious proviral DNA (B. Perbal, J. S. Lipsick, J. Svoboda, R. F. Silva, and M. A. Baluda, J. Virol. 56:240-244, 1985) was shown to specifically induce nephroblastoma in chickens and therefore belongs to the MAV-N class. We show that ne...

journal_title：Journal of virology

authors： Soret J,Dambrine G,Perbal B

更新日期：1989-04-01 00:00:00

abstract：:We have identified nucleotide sequences that regulate transcription in both a cell-type-specific and general manner in the long terminal repeat of the MCF13 murine leukemia virus. Besides the enhancer element, we have observed that the region between the enhancer and promoter (DEN) has a profound effect on transcripti...

journal_title：Journal of virology

authors： Tupper JC,Chen H,Hays EF,Bristol GC,Yoshimura FK

更新日期：1992-12-01 00:00:00

abstract：:The vaccinia virus H5 gene encodes a 22.3-kDa phosphoprotein that is expressed during both the early and late phases of viral gene expression. It is a major component of virosomes and has been implicated in viral transcription and, as a substrate of the B1 kinase, may participate in genome replication. To enable a gen...

journal_title：Journal of virology

authors： DeMasi J,Traktman P

更新日期：2000-03-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) displays both interstrain and intrastrain genetic variability. Virus populations with extensive microheterogeneity have been defined as swarms or quasispecies. Many of the genomes within HIV-1 swarms appear to be defective in one or more genes required for viral replication....

journal_title：Journal of virology

authors： Lori F,Hall L,Lusso P,Popovic M,Markham P,Franchini G,Reitz MS Jr

更新日期：1992-09-01 00:00:00

abstract：:Infection of the chestnut blight fungus Cryphonectria parasitica with Cryphonectria hypovirus 1 (CHV1) causes disruption of virulence, pigmentation, and sporulation. Transcriptional downregulation of key developmentally regulated fungal genes occurs during infection, but vegetative growth is unaffected. Previous studi...

journal_title：Journal of virology

authors： Kazmierczak P,McCabe P,Turina M,Jacob-Wilk D,Van Alfen NK

更新日期：2012-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes four putative G protein-coupled receptors, including pUL78, whose rodent orthologues are known to be important for replication and spread in their hosts. To investigate the mechanism by which pUL78 contributes to viral replication and pathogenesis, we generated a derivative of the ...

journal_title：Journal of virology

authors： O'Connor CM,Shenk T

更新日期：2012-11-01 00:00:00

abstract：:Cleavage of varicella-zoster virus DNA with the restriction endonucleases PstI, XbaI, and BglII resulted in 18, 22, and 20 fragments, respectively. Based on the molecular weights and molarities of these fragments, a molecular weight of 84 x 10(6) could be calculated for the varicella-zoster virus genome. In both the X...

journal_title：Journal of virology

authors： Dumas AM,Geelen JL,Weststrate MW,Wertheim P,van der Noordaa J

更新日期：1981-08-01 00:00:00

abstract：:Several lines of evidence indicate that cutaneous human papillomavirus (HPV) types belonging to the beta genus of the HPV phylogenetic tree synergize with UV radiation in the development of skin cancer. Accordingly, the E6 and E7 oncoproteins from some beta HPV types are able to deregulate pathways related to immune r...

journal_title：Journal of virology

authors： Pacini L,Ceraolo MG,Venuti A,Melita G,Hasan UA,Accardi R,Tommasino M

更新日期：2017-09-12 00:00:00

abstract：:Human herpesvirus 7 (HHV-7) is a recently isolated betaherpesvirus that is prevalent in the human population, with primary infection usually occurring in early childhood. HHV-7 is related to human herpesvirus 6 (HHV-6) in terms of both biological and, from limited prior DNA sequence analysis, genetic criteria. However...

journal_title：Journal of virology

authors： Nicholas J

更新日期：1996-09-01 00:00:00

abstract：:The replication of the simian herpesvirus SA8 in Vero cells was examined. The time course of replication of the simian herpesvirus SA8 was found to be similar to that of the herpes simplex viruses. Infectious progeny virions were first detectable by 6 h postinfection and were readily released into the extracellular fl...

journal_title：Journal of virology

authors： Eberle R,Hilliard JK

更新日期：1984-05-01 00:00:00

abstract：:By using an isothermal multiply primed rolling-circle amplification protocol, the complete genomic DNA of a novel papillomavirus was amplified from a skin lesion biopsy of a Florida manatee (Trichechus manatus latirostris), one of the most endangered marine mammals in United States coastal waters. The nucleotide seque...

journal_title：Journal of virology

authors： Rector A,Bossart GD,Ghim SJ,Sundberg JP,Jenson AB,Van Ranst M

更新日期：2004-11-01 00:00:00

abstract：:The Arabidopsis flowering locus T (FT) gene encodes the mobile florigen essential for floral induction. While movement of the FT protein has been shown to occur within plants, systemic spread of FT mRNA remains to be unequivocally demonstrated. Utilizing novel RNA mobility assay vectors based on two distinct movement-...

journal_title：Journal of virology

authors： Li C,Zhang K,Zeng X,Jackson S,Zhou Y,Hong Y

更新日期：2009-04-01 00:00:00

abstract：:Identification of cellular receptors used by coronavirus (CoV) entry into the host cells is critical to an understanding of pathogenesis and to development of intervention strategies. The fourth CoV genus, Deltacoronavirus, evolutionarily related to the Gammacoronavirus, has just been defined recently. In the current ...

journal_title：Journal of virology

authors： Wang B,Liu Y,Ji CM,Yang YL,Liang QZ,Zhao P,Xu LD,Lei XM,Luo WT,Qin P,Zhou J,Huang YW

更新日期：2018-05-29 00:00:00

abstract：:A number of retrovirus-like sequences have been cloned from chimpanzee DNA which constitute the chimpanzee homologs of the endogenous colobus type C virus CPC-1. One of the clones contains a nearly complete viral genome, but others have sustained deletions of 1 to 2 kilobases in the polymerase gene. The pattern of rel...

journal_title：Journal of virology

authors： Bonner TI,Birkenmeier EH,Gonda MA,Mark GE,Searfoss GH,Todaro GJ

更新日期：1982-09-01 00:00:00

abstract：:The human foamy virus (HFV) contains within the U3 region of its long terminal repeat (LTR) three perfect consensus sequences for the binding of the inducible transcription factor AP-1. Results of DNase I footprint protection and gel retardation assays demonstrated that proteins in extracts of HeLa and BHK-21 cells as...

journal_title：Journal of virology

authors： Maurer B,Serfling E,ter Meulen V,Rethwilm A

更新日期：1991-11-01 00:00:00