CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry.

abstract：:Spanins are bacteriophage lysis proteins responsible for disruption of the outer membrane, the final step of Gram-negative host lysis. The absence of spanins results in a terminal phenotype of fragile spherical cells. The phage T1 employs a unimolecular spanin gp11 that has an N-terminal lipoylation signal and a C-ter...

journal_title：Journal of virology

authors： Kongari R,Snowden J,Berry JD,Young R

更新日期：2018-10-29 00:00:00

abstract：:Nonstructural protein 1 (NS1) of yellow fever virus (YF) is a glycoprotein localized to extracytoplasmic compartments within infected cells. We have previously shown that NS1 can be supplied in trans and is required for viral RNA replication, a process thought to occur in membrane-bound cytoplasmic complexes. Here we ...

journal_title：Journal of virology

authors： Lindenbach BD,Rice CM

更新日期：1999-06-01 00:00:00

abstract：UNLABELLED:Like most positive-strand RNA viruses, infection by plant tombusviruses results in extensive rearrangement of specific host cell organelle membranes that serve as the sites of viral replication. The tombusvirus Tomato bushy stunt virus (TBSV) replicates within spherules derived from the peroxisomal boundary ...

journal_title：Journal of virology

authors： Richardson LG,Clendening EA,Sheen H,Gidda SK,White KA,Mullen RT

更新日期：2014-06-01 00:00:00

abstract：:Three amber mutations were introduced proximal to the syn3 locus of the herpes simplex virus type 1 glycoprotein B (gB) gene specifying gB derivatives lacking the carboxy-terminal 28, 49, or 64 amino acids. A complementation system that utilized gBs expressed in COS cells to complement gB-null virus K delta T was esta...

journal_title：Journal of virology

authors： Baghian A,Huang L,Newman S,Jayachandra S,Kousoulas KG

更新日期：1993-04-01 00:00:00

abstract：:Adeno-associated virus (AAV) integrates site specifically into the AAVS1 locus on human chromosome 19. Although recruitment of the AAV nonstructural protein Rep78/68 to the Rep binding site (RBS) on AAVS1 is thought to be an essential step, the mechanism of the site-specific integration, particularly, how the site of ...

journal_title：Journal of virology

authors： Yamamoto N,Suzuki M,Kawano MA,Inoue T,Takahashi RU,Tsukamoto H,Enomoto T,Yamaguchi Y,Wada T,Handa H

更新日期：2007-02-01 00:00:00

abstract：:Neonatal infection of most mouse strains with lymphocytic choriomeningitis virus (LCMV) leads to a life-long persistent infection characterized by high virus loads in the central nervous system (CNS) in the absence of inflammation and tissue destruction. These mice, however, exhibit impaired learning and memory. The o...

journal_title：Journal of virology

authors： Kunz S,Rojek JM,Roberts AJ,McGavern DB,Oldstone MB,de la Torre JC

更新日期：2006-09-01 00:00:00

abstract：UNLABELLED:Foamy viruses (FVs) are complex retroviruses that establish lifelong persistent infection without evident pathology. However, the roles of cellular factors in FV latency are poorly understood. This study revealed that N-Myc interactor (Nmi) could inhibit the replication of prototype foamy virus (PFV). Overex...

journal_title：Journal of virology

authors： Hu X,Yang W,Liu R,Geng Y,Qiao W,Tan J

更新日期：2014-06-01 00:00:00

abstract：:We previously established a genetic assay for retroviral Gag polyprotein multimerization (J. Luban, K. B. Alin, K. L. Bossolt, T. Humaran, and S. P. Goff, J. Virol. 66:5157-5160, 1992). Here we use this assay to demonstrate homomeric interactions between Gag polyproteins encoded by six different retroviruses. Of the G...

journal_title：Journal of virology

authors： Franke EK,Yuan HE,Bossolt KL,Goff SP,Luban J

更新日期：1994-08-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (gammaHV68) provides an important experimental model for understanding mechanisms of immune control of the latent human gammaherpesviruses. Antiviral CD8 T cells play a key role throughout three separate phases of the infection: clearance of lytic virus, control of the latency amplification ...

journal_title：Journal of virology

authors： Freeman ML,Lanzer KG,Cookenham T,Peters B,Sidney J,Wu TT,Sun R,Woodland DL,Sette A,Blackman MA

更新日期：2010-03-01 00:00:00

abstract：:The alphaherpesvirus proteins UL31 and UL34 and their homologues in other herpesvirus subfamilies cooperate at the nuclear membrane in the export of nascent herpesvirus capsids. We studied the respective betaherpesvirus proteins M53 and M50 in mouse cytomegalovirus (MCMV). Recently, we established a random approach to...

journal_title：Journal of virology

authors： Popa M,Ruzsics Z,Lötzerich M,Dölken L,Buser C,Walther P,Koszinowski UH

更新日期：2010-09-01 00:00:00

abstract：:The sequence of 2,191 nucleotides encoding the env gene of murine retrovirus Akv was determined by using a molecular clone of the Akv provirus. Deduction of the encoded amino acid sequence showed that a single open reading frame encodes a 638-amino acid precursor to gp70 and p15E. In addition, there is a typical leade...

journal_title：Journal of virology

authors： Lenz J,Crowther R,Straceski A,Haseltine W

更新日期：1982-05-01 00:00:00

abstract：:Plus-strand RNA viruses characteristically replicate their genome in association with altered cellular membranes. In the present study, the capacity of hepatitis C virus (HCV) proteins to elicit intracellular membrane alterations was investigated by expressing, in tetracycline-regulated cell lines, a comprehensive pan...

journal_title：Journal of virology

authors： Egger D,Wölk B,Gosert R,Bianchi L,Blum HE,Moradpour D,Bienz K

更新日期：2002-06-01 00:00:00

abstract：:The 2009 pandemic influenza H1N1 (H1N1pdm) virus was generated by reassortment of swine influenza viruses of different lineages. This was the first influenza pandemic to emerge in over 4 decades and the first to occur after the realization that influenza pandemics arise from influenza viruses of animals. In order to u...

journal_title：Journal of virology

authors： Chan RW,Kang SS,Yen HL,Li AC,Tang LL,Yu WC,Yuen KM,Chan IW,Wong DD,Lai WW,Kwong DL,Sihoe AD,Poon LL,Guan Y,Nicholls JM,Peiris JS,Chan MC

更新日期：2011-11-01 00:00:00

abstract：:RmI, a circular chimera made of the polyomavirus (Py) genome with an insertion of mouse DNA (Ins), effectively undergoes intramolecular recombination in normal mouse cells, as indicated by the conversion of cloned RmI (RmIc) into unit-length Py DNA in transfected cultures. To follow the fate of the cellular component ...

journal_title：Journal of virology

authors： Piché A,Bourgaux P

更新日期：1987-03-01 00:00:00

abstract：:In addition to encoding the structural and regulatory proteins, many viruses encode auxiliary proteins, some of which have been shown to play important roles in lytic and latent states of the viruses. The human neurotropic JC virus (JCV) genome encodes an auxiliary protein called Agno whose function remains unknown. H...

journal_title：Journal of virology

authors： Safak M,Barrucco R,Darbinyan A,Okada Y,Nagashima K,Khalili K

更新日期：2001-02-01 00:00:00

abstract：:Koala retrovirus (KoRV) is of an interest to virologists due to its currently active endogenization into the koala (Phascolarctos cinereus) genome. Although KoRV has frequently been isolated in wild and captive koala populations, its pathogenesis and transmission remain to be fully characterized, and most previous res...

journal_title：Journal of virology

authors： Hashem MA,Maetani F,Kayesh MEH,Eiei T,Mochizuki K,Ito A,Sakurai H,Asai T,Tsukiyama-Kohara K

更新日期：2020-05-18 00:00:00

abstract：:The abilities to infect and transmit efficiently among humans are essential for a novel influenza A virus to cause a pandemic. To evaluate the pandemic potential of widely disseminated H5N1 influenza viruses, a ferret contact model using experimental groups comprised of one inoculated ferret and two contact ferrets wa...

journal_title：Journal of virology

authors： Yen HL,Lipatov AS,Ilyushina NA,Govorkova EA,Franks J,Yilmaz N,Douglas A,Hay A,Krauss S,Rehg JE,Hoffmann E,Webster RG

更新日期：2007-07-01 00:00:00

abstract：:In December 2016, a low-pathogenic avian influenza (LPAI) A(H7N2) virus was identified to be the causative source of an outbreak in a cat shelter in New York City, which subsequently spread to multiple shelters in the states of New York and Pennsylvania. One person with occupational exposure to infected cats became in...

journal_title：Journal of virology

authors： Belser JA,Pulit-Penaloza JA,Sun X,Brock N,Pappas C,Creager HM,Zeng H,Tumpey TM,Maines TR

更新日期：2017-07-12 00:00:00

abstract：:Our previous studies have argued persuasively that in murine sarcoma virus ts110 (MuSVts110) the gag and mos genes are fused out of frame due to a approximately 1.5-kilobase (kb) deletion of wild-type murine sarcoma virus 349 (MuSV-349) viral information. As a consequence of this deletion, infected cells grown at 39 d...

journal_title：Journal of virology

authors： Nash MA,Brizzard BL,Wong JL,Murphy EC Jr

更新日期：1985-02-01 00:00:00

abstract：:The pregenomic RNA (pgRNA) of hepatitis B virus (HBV) serves as the messenger for both core and P proteins, with the downstream P gene translated by ribosomal leaky scanning. HBV replication begins with packaging of the pgRNA and P protein into core protein particles, followed by conversion of RNA into DNA. Genotype G...

journal_title：Journal of virology

authors： Gutelius D,Li J,Wands J,Tong S

更新日期：2011-12-01 00:00:00

abstract：:Wild-type Sindbis virus (SINV) strain MRE16 efficiently infects Aedes aegypti midgut epithelial cells (MEC), but laboratory-derived neurovirulent SINV strain TE/5'2J infects MEC poorly. SINV determinants for MEC infection have been localized to the E2 glycoprotein. The E2 amino acid sequences of MRE16 and TE/5'2J diff...

journal_title：Journal of virology

authors： Pierro DJ,Powers EL,Olson KE

更新日期：2008-03-01 00:00:00

abstract：:Coronavirus nonstructural protein 8 (nsp8) has been suggested to have diverse activities, including noncanonical template-dependent polymerase activities. Here, we characterized a recombinant form of the human coronavirus 229E (HCoV-229E) nsp8 and found that the protein has metal ion-dependent RNA 3'-terminal adenylyl...

journal_title：Journal of virology

authors： Tvarogová J,Madhugiri R,Bylapudi G,Ferguson LJ,Karl N,Ziebuhr J

更新日期：2019-05-29 00:00:00

abstract：:Under the immune pressure of cytotoxic T cells (CTLs), hepatitis B virus (HBV) evolves to accumulate mutations more likely within epitopes to evade immune detection. However, little is known about the specific patterns of the immune pressure-associated HBV mutation of T-cell epitopes and their link to disease progress...

journal_title：Journal of virology

authors： Zhang Y,Wu Y,Deng M,Xu D,Li X,Xu Z,Hu J,Zhang H,Liu K,Zhao Y,Gao F,Bi S,Gao GF,Zhao J,Liu WJ,Meng S

更新日期：2018-08-16 00:00:00

abstract：:Inoculation of 3-day-old (3D) or 3-week-old (3W) ducklings with duck hepatitis B virus results in chronic or transient infection, respectively. We previously showed that rapid production of neutralizing antibody following inoculation of 3W ducklings prevents virus from spreading in the liver and leads to a transient i...

journal_title：Journal of virology

authors： Zhang YY,Theele DP,Summers J

更新日期：2005-08-01 00:00:00

abstract：:Herpesviruses encode a set of core proteins essential for lytic replication of their genomes. Three of these proteins form a tripartite helix-primase complex that, in the case of Epstein-Barr virus (EBV), consists of the helicase BBLF4, the primase BSLF1, and the linker protein BBLF2/3. BBLF2/3 and its homologs in the...

journal_title：Journal of virology

authors： Liao G,Huang J,Fixman ED,Hayward SD

更新日期：2005-01-01 00:00:00

abstract：:The preintegration complex of human immunodeficiency virus type 1 (HIV-1) is a large nucleoprotein complex containing viral nucleic acids in association with products of the viral gag and pol genes. One of these proteins, integrase, is absolutely required for the integration and formation of the provirus. Although HIV...

journal_title：Journal of virology

authors： Bukrinsky M,Sharova N,Stevenson M

更新日期：1993-11-01 00:00:00

abstract：:Beta interferon (IFN-beta) expression is triggered by double-stranded RNA, a common intermediate in the replication of many viruses including hepatitis C virus (HCV). The recent development of cell culture-grown HCV allowed us to analyze the IFN signaling pathway following virus infection. In this study, we have exami...

journal_title：Journal of virology

authors： Kanda T,Steele R,Ray R,Ray RB

更新日期：2007-11-01 00:00:00

abstract：:Among the members of the paramyxovirus family, the transcription process and the components involved have been studied under in vitro conditions thus far. Here, we reexamined the function of the viral RNA-dependent RNA polymerase through infection studies with Sendai virus (SeV) N and P deletion (Delta) mutants. To el...

journal_title：Journal of virology

authors： Wiegand MA,Bossow S,Schlecht S,Neubert WJ

更新日期：2007-12-01 00:00:00

abstract：:Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has traditionally circulated in Africa and Asia, causing human febrile illness accompanied by severe, chronic joint pain. In Africa, epidemic emergence of CHIKV involves the transition from an enzootic, sylvatic cycle involving arboreal mosquito vectors and nonhu...

journal_title：Journal of virology

authors： Volk SM,Chen R,Tsetsarkin KA,Adams AP,Garcia TI,Sall AA,Nasar F,Schuh AJ,Holmes EC,Higgs S,Maharaj PD,Brault AC,Weaver SC

更新日期：2010-07-01 00:00:00

abstract：:The enhancer unit present in the retrovirus equine infectious anemia virus (EIAV) was previously shown to contain binding sites for proteins belonging to MDBP, PEA2, AP-1, and ets families. The EIAV ets motif matches the consensus sequence for both PEA3- and PU.1-binding sites. Here, we show by gel shift analysis that...

journal_title：Journal of virology

authors： Carvalho M,Derse D

更新日期：1993-07-01 00:00:00