Abstract:
:We molecularly cloned JC polyomavirus DNAs from urine samples of eight nonimmunosuppressed patients and two healthy individuals. The cloned viral DNAs all contained an archetypal regulatory sequence from which various regulatory sequences of JC polyomavirus isolates derived from patients with progressive multifocal leukoencephalopathy could have evolved by deletion and amplification.
journal_name
J Viroljournal_title
Journal of virologyauthors
Yogo Y,Kitamura T,Sugimoto C,Ueki T,Aso Y,Hara K,Taguchi Fdoi
10.1128/JVI.64.6.3139-3143.1990subject
Has Abstractpub_date
1990-06-01 00:00:00pages
3139-43issue
6eissn
0022-538Xissn
1098-5514journal_volume
64pub_type
杂志文章abstract::Retrovirus particles each contain two copies of the viral genome in the form of a noncovalently linked RNA dimer. Earlier studies have mapped a cis-acting region near the 5' end of the human immunodeficiency virus type 1 (HIV-1) genome, termed the psi locus, which appears essential for initiation of genomic dimerizati...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.5.3407-3414.1997
更新日期:1997-05-01 00:00:00
abstract::To examine the pathway of the coreceptor switching of CCR5-using (R5) virus to CXCR4-using (X4) virus in simian-human immunodeficiency virus SHIV(SF162P3N)-infected rhesus macaque BR24, analysis was performed on variants present at 20 weeks postinfection, the time when the signature gp120 V3 loop sequence of the X4 sw...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00570-08
更新日期:2008-07-01 00:00:00
abstract::Chimeric human immunodeficiency virus type 1 (HIV-1) molecular clones differing only in the envelope V3 region were constructed. The V3 regions were derived from two HIV-1 isolates with a non-syncytium-inducing, non-T-cell-tropic phenotype and from four HIV-1 isolates with a syncytium-inducing, T-cell-tropic phenotype...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.2.757-765.1992
更新日期:1992-02-01 00:00:00
abstract::Mice infected with myopathic coxsackievirus B1 Tucson (CVB1(T)) develop chronic inflammatory myopathy (CIM) consisting of hind limb weakness and inflammation. Amyopathic virus variants are infectious but attenuated for CIM. In this report, viral clones, chimeras, and sequencing were used to identify viral determinants...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.21.11849-11854.2003
更新日期:2003-11-01 00:00:00
abstract::Members of the Flaviviridae encode a serine proteinase termed NS3 that is responsible for processing at several sites in the viral polyproteins. In this report, we show that the NS3 proteinase of the pestivirus bovine viral diarrhea virus (BVDV) (NADL strain) is required for processing at nonstructural (NS) protein si...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.71.7.5312-5322.1997
更新日期:1997-07-01 00:00:00
abstract::Adeno-associated virus serotype 9 (AAV9) vectors show promise for gene therapy of a variety of diseases due to their ability to transduce multiple tissues, including heart, skeletal muscle, and the alveolar epithelium of the lung. In addition, AAV9 is unique compared to other AAV serotypes in that it is capable of sur...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00448-12
更新日期:2012-07-01 00:00:00
abstract::The major immediate-early (MIE) gene of human cytomegalovirus (HCMV) encodes several MIE proteins (MIEPs) produced as a result of alternative splicing and polyadenylation of the primary transcript. Previously we demonstrated that the HCMV MIEPs expressed from the entire MIE gene could rescue the temperature-sensitive ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.4.2825-2831.1999
更新日期:1999-04-01 00:00:00
abstract::Scrapie-associated fibrils (SAFs) are abnormal filamentous structures that are uniquely associated with unconventional slow virus diseases. The antigenic relationships of SAFs from animals infected with four biologically distinct scrapie strains were investigated by using antisera raised to purified SAF proteins. Rabb...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.59.3.676-683.1986
更新日期:1986-09-01 00:00:00
abstract::The neuraminidase inhibitors zanamivir and oseltamivir are marketed for the treatment and prophylaxis of influenza and have been stockpiled by many countries for use in a pandemic. Although recent surveillance has identified a striking increase in the frequency of oseltamivir-resistant seasonal influenza A (H1N1) viru...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01200-09
更新日期:2009-10-01 00:00:00
abstract::We have constructed a series of vectors based on simian foamy virus type 1 (SFV-1) to define the minimum cis-acting elements required for gene transfer. To characterize these vectors, we inserted the coding sequence of the bacterial lacZ gene linked to the cytomegalovirus immediate-early gene promoter. Introduction of...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.4.3451-3454.1998
更新日期:1998-04-01 00:00:00
abstract::In this work we show evidence of mother-to-offspring transmission in a transgenic mouse line expressing bovine PrP (boTg) experimentally infected by intracerebral administration of bovine spongiform encephalopathy (BSE) prions. PrP(res) was detected in brains of newborns from infected mothers only when mating was allo...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.13.8665-8668.2005
更新日期:2005-07-01 00:00:00
abstract::Following subcutaneous inoculation of newborn Wistar-Furth rats with human adenovirus type 9 (Ad9), 16 of 16 female and 0 of 11 male rats developed mammary tumors. Tumor-positive animals usually developed tumors in multiple glands. Histopathological analyses indicated that three general categories of tumor could be id...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.6.3192-3202.1991
更新日期:1991-06-01 00:00:00
abstract::Hepatitis C virus (HCV) core protein forms the nucleocapsid of the HCV particle. Although many functions of core protein have been reported, how the HCV particle is assembled is not well understood. Here we show that the nucleocapsid-like particle of HCV is composed of a disulfide-bonded core protein complex (dbc-comp...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00402-10
更新日期:2010-09-01 00:00:00
abstract::Members of the Paramyxovirinae subfamily rely on the concerted action of two envelope glycoprotein complexes, attachment protein H and the fusion (F) protein oligomer, to achieve membrane fusion for viral entry. Despite advances in X-ray information, the organization of the physiological attachment (H) oligomer in fun...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01222-10
更新日期:2010-12-01 00:00:00
abstract::Two strains of minute virus of mice (MVM) show different host cell specificities. The prototype strain MVM(p) grows in fibroblasts, whereas the immunosuppressive variant MVM(i) grows in T lymphocytes. In this study, we have mapped on the viral genome a cell type-specific determinant: it is located between 69 and 85 ma...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.62.2.552-557.1988
更新日期:1988-02-01 00:00:00
abstract::Infection of humans with wild-type measles virus leads to strong immune suppression and secondary infections, whereas immunization with an attenuated vaccine strain does not. Using the cotton rat model (Sigmodon hispidus), we investigated whether vaccine and wild-type viruses differ in viral spread and whether this is...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.1.150-158.2003
更新日期:2003-01-01 00:00:00
abstract::We engineered a disulfide-stabilized influenza virus hemagglutinin (HA) trimer, termed HA3-SS, by introducing cysteine residues into the HA stem to covalently bridge the three protomers. HA3-SS has increased thermostability compared to wild-type HA, and binding of head- and stem-targeted antibodies (Abs) is preserved;...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00808-15
更新日期:2015-07-01 00:00:00
abstract::Retroviral capsid assembly can occur by either of two distinct morphogenic processes: in type C viruses, the capsid assembles and buds at the plasma membrane, while in type B and D viruses, the capsid assembles within the cytoplasm and is then transported to the plasma membrane for budding. We have previously reported...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.7.5431-5437.1999
更新日期:1999-07-01 00:00:00
abstract::Through their hemagglutinin-neuraminidase glycoprotein, parainfluenza viruses bind to sialic acid-containing glycoconjugates to initiate infection. Although the virus-receptor interaction is a key factor of infection, the exact nature of the receptors that human parainfluenza viruses recognize has not been determined....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.10.4604-4613.2001
更新日期:2001-05-01 00:00:00
abstract::The nef genes of the human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) and the related simian immunodeficiency viruses (SIVs) encode a protein (Nef) whose role in virus replication and cytopathicity remains uncertain. As an attempt to elucidate the function of nef, we characterized the nucleotide and corre...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.67.8.4639-4650.1993
更新日期:1993-08-01 00:00:00
abstract::Efforts to induce broadly reactive immunity against human immunodeficiency virus type 1 (HIV-1) have been impaired by the extent of sequence variation exhibited by this lentivirus. Cytotoxic T lymphocytes (CTL) specific for other viruses such as influenza virus have been shown to mediate immunity against divergent vir...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.5.3145-3153.1994
更新日期:1994-05-01 00:00:00
abstract::More often than not, analyses of virus evolution have considered that virus populations are so large that evolution can be explained by purely deterministic models. However, virus populations could have much smaller effective numbers than the huge reported census numbers, and random genetic drift could be important in...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.18.9906-9911.2003
更新日期:2003-09-01 00:00:00
abstract::The region of the UL component of the herpes simplex virus type 1 genome between nucleotides 17,793 and 25,150 includes three open reading frames that code for the protein products of the UL8, UL9, and UL10 genes (D.J. McGeogh, M.A. Dalrymple, A.J. Davison, A. Dolan, M.C. Frame, D. McNab, L.J. Perry, J.E. Scott, and P...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.7.4251-4261.1994
更新日期:1994-07-01 00:00:00
abstract::Recently, novel arenaviruses were found in snakes with boid inclusion body disease (BIBD); these form the new genus Reptarenavirus within the family Arenaviridae. We used next-generation sequencing and de novo sequence assembly to investigate reptarenavirus isolates from our previous study. Four of the six isolates an...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01112-15
更新日期:2015-08-01 00:00:00
abstract::Lassa fever (LF) is a zoonotic viral hemorrhagic fever caused by Lassa virus (LASV), which is endemic to West African countries. Previous studies have suggested an important role for T-cell-mediated immunopathology in LF pathogenesis, but the mechanisms by which T cells influence disease severity and outcome are not w...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01367-20
更新日期:2020-10-14 00:00:00
abstract::A well-characterized mechanism by which anti-HLA class I monoclonal antibodies (MAb) inhibit human immunodeficiency virus type 1 (HIV-1) propagation in in vitro cell cultures is the neutralization of the virus through interactions with HLA molecules associated with the virion envelope. Yet, the possibility that anothe...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.8.5213-5220.1996
更新日期:1996-08-01 00:00:00
abstract::With the aid of three monoclonal antibodies (MAbs), a glycoprotein specifically localized to the outer envelope of vaccinia virus was shown to be encoded by the A33R gene. These MAbs reacted with a glycosylated protein that migrated as 23- to 28-kDa and 55-kDa species under reducing and nonreducing conditions, respect...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.6.3753-3762.1996
更新日期:1996-06-01 00:00:00
abstract::Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PM...
journal_title:Journal of virology
pub_type: 杂志文章,评审
doi:10.1128/JVI.01979-15
更新日期:2016-06-10 00:00:00
abstract::Measles virus (MV) interacts with cellular receptors on the surface of peripheral blood lymphocytes (PBL) which mediate virus binding and uptake. Simultaneously, the direct contact of the viral glycoproteins with the cell surface induces a negative signal blocking progression to the S phase of the cell cycle, resultin...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.75.10.4499-4505.2001
更新日期:2001-05-01 00:00:00
abstract::We have recently reported the isolation and molecular cloning of a human immunodeficiency virus type 1 isolate (HIV-1 DH125) that exhibits rapid replication kinetics and marked cytopathicity in both human and chimpanzee peripheral blood mononuclear cells (PBMC). To identify the viral determinants responsible for infec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.10.7318-7321.1996
更新日期:1996-10-01 00:00:00