Role for complement in the development of seizures following acute viral infection.

abstract：:Tobacco necrosis virus, strain D (TNV-D), is a positive-strand RNA virus in the genus Betanecrovirus and family Tombusviridae The production of its RNA-dependent RNA polymerase, p82, is achieved by translational readthrough. This process is stimulated by an RNA structure that is positioned immediately downstream of th...

journal_title：Journal of virology

authors： Newburn LR,White KA

更新日期：2017-03-29 00:00:00

abstract：:Hepadnaviruses contain a relaxed circular DNA genome (RC-DNA) with discontinuities in both strands. Upon infectious entry into a host cell, this genome is converted into a covalently closed superhelical form (CCC-DNA), which later serves as the template for transcription. Here we examined whether the viral polymerase ...

journal_title：Journal of virology

authors： Köck J,Schlicht HJ

更新日期：1993-08-01 00:00:00

abstract：:The various strains of BK virus (BKV) exhibit a remarkable degree of heterogeneity in the transcriptional control region, which may affect the biological characteristics of a BKV strain. We describe the detection and sequencing of BKV control regions directly from urine samples and after propagation in cell culture. A...

journal_title：Journal of virology

authors： Sundsfjord A,Johansen T,Flaegstad T,Moens U,Villand P,Subramani S,Traavik T

更新日期：1990-08-01 00:00:00

abstract：:We investigated the synergism between influenza virus and Streptococcus pneumoniae, particularly the role of deletions in the stalk region of the neuraminidase (NA) of H2N2 and H9N2 avian influenza viruses. Deletions in the NA stalk (ΔNA) had no effect on NA activity or on the adherence of S. pneumoniae to virus-infec...

journal_title：Journal of virology

authors： Chockalingam AK,Hickman D,Pena L,Ye J,Ferrero A,Echenique JR,Chen H,Sutton T,Perez DR

更新日期：2012-04-01 00:00:00

abstract：:We have detected a mouse mammary tumor virus (MMTV)-specific 1.7-kilobase (kb) polyadenylated RNA in mammary glands of several mouse strains. In BALB/c mice, it is the only MMTV-specific RNA species present. C3H and GR mammary glands and tumors contain, in addition, 3.8- and 7.8-kb MMTV RNAs. Nuclease S1 analysis was ...

journal_title：Journal of virology

authors： van Ooyen AJ,Michalides RJ,Nusse R

更新日期：1983-05-01 00:00:00

abstract：:Proviral clones of human immunodeficiency virus type 1 which contained single amino acid changes in the envelope V3 region were constructed. PCR amplification of Sup-T1 T cells transfected with one such mutant, G312T, revealed low levels of virus that resulted in the generation of a revertant virus, in which an alanin...

journal_title：Journal of virology

authors： Morris JF,Sternberg EJ,Gutshall L,Petteway SR Jr,Ivanoff LA

更新日期：1994-12-01 00:00:00

abstract：:In this paper, we report that the DNA of bovine mammillitis virus (BMV) consists of two covalently linked components that are 71.5 x 10(6) and 15.7 x 10(6) in molecular weight and designated L and S, respectively. We further report that the BMV DNA consists of four equimolar populations differing only in the orientati...

journal_title：Journal of virology

authors： Buchman TG,Roizman B

更新日期：1978-01-01 00:00:00

abstract：:Human papillomaviruses (HPV) link their life cycles to epithelial differentiation and induce productive replication of viral DNA in suprabasal cells. Viral-DNA amplification requires cells to remain active in the cell cycle upon differentiation. This is in contrast to normal cells, which lose proliferative capability ...

journal_title：Journal of virology

authors： Melar-New M,Laimins LA

更新日期：2010-05-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) specifically incorporates the host cell peptidyl-prolyl isomerase cyclophilin A into virions via contacts with the capsid (CA) domain of the Gag polyprotein Pr55gag. The immunosuppressant drug cyclosporin A and the nonimmunosuppressive cyclosporin A analog SDZ NIM 811 bind t...

journal_title：Journal of virology

authors： Dorfman T,Göttlinger HG

更新日期：1996-09-01 00:00:00

abstract：:Two hundred forty pyridazinamine derivatives were tested for the ability to stabilize the antigenicity and infectivity of oral poliovirus vaccine subjected to 45 degrees C for 2 h. Seven compounds stabilized the antigenicity of all three vaccine strains and neutralized the viral particles in a way that is reversible b...

journal_title：Journal of virology

authors： Andries K,Rombaut B,Dewindt B,Boeyé A

更新日期：1994-05-01 00:00:00

abstract：:Deletion of the entire leader polypeptide of the GDVII strain of Theiler's murine encephalomyelitis virus (TMEV) results in the production of an attenuated virus that grows in baby hamster kidney (BHK) cells but cannot grow at all in mouse L-929 cells. This study examined the reasons for the failure of dl-L, the GDVII...

journal_title：Journal of virology

authors： Badshah C,Calenoff MA,Rundell K

更新日期：2000-01-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SI...

journal_title：Journal of virology

authors： Schmitz JE,Ma ZM,Hagan EA,Wilks AB,Furr KL,Linde CH,Zahn RC,Brenchley JM,Miller CJ,Permar SR

更新日期：2012-10-01 00:00:00

abstract：:A method for obtaining large quantities of defective interfering (DI) rabies virus particles that fulfill all the criteria delineated by Huang and Baltimore (1970) is described. The purified rabies DI virion was found to be much shorter (60 to 80 nm) than the complete virion (180 nm) and to have a viral genome of abou...

journal_title：Journal of virology

authors： Wiktor TJ,Dietzschold B,Leamnson RN,Koprowski H

更新日期：1977-02-01 00:00:00

abstract：:Hemorrhage is a common clinical manifestation in dengue patients. However, the pathogenic mechanism of dengue virus (DV)-induced hemorrhage awaits clarification. We established a mouse model of DV hemorrhage using immunocompetent C57BL/6 mice by injecting DV serotype 2 strain 16681 intradermally. While inoculation of ...

journal_title：Journal of virology

authors： Chen HC,Hofman FM,Kung JT,Lin YD,Wu-Hsieh BA

更新日期：2007-06-01 00:00:00

abstract：:The RNA genome of influenza virus is transcribed and replicated by the viral RNA polymerase complex in the cell nucleus. We have generated green fluorescent protein (GFP)-tagged polymerase subunits to study the assembly of the polymerase complex. Our results show that individually expressed polymerase basic protein 1 ...

journal_title：Journal of virology

authors： Fodor E,Smith M

更新日期：2004-09-01 00:00:00

abstract：:Expression of several major histocompatibility complex (MHC) class I alleles is associated with a protective effect against disease progression in both human immunodeficiency virus type 1 and simian immunodeficiency virus infection. To understand the mechanism underlying this effect, we investigated the expression of ...

journal_title：Journal of virology

authors： Zhang ZQ,Fu TM,Casimiro DR,Davies ME,Liang X,Schleif WA,Handt L,Tussey L,Chen M,Tang A,Wilson KA,Trigona WL,Freed DC,Tan CY,Horton M,Emini EA,Shiver JW

更新日期：2002-12-01 00:00:00

abstract：:By marker rescue of bacteriophage SP02 sus mutants with purified bacteriophage SP02 DNA fragments, 11 of the 17 known bacteriophage SP02 sus loci were assigned to discrete DNA fragments. The left-most genetic locus, susA, was found to reside near one bacteriophage SP02 terminus (EcoRI-C1 fragment), whereas the right-m...

journal_title：Journal of virology

authors： Graham S,Sutton S,Yoneda Y,Young FE

更新日期：1982-04-01 00:00:00

abstract：:Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with the exacerbation of clinical symptoms and the induction of recurrences in humans and animal models. T...

journal_title：Journal of virology

authors： Ives AM,Bertke AS

更新日期：2017-06-09 00:00:00

abstract：:Encephalomyocarditis (EMC) virus (K-2 strain) was separated into two distinct peaks of optical density by chromatography on calcium phosphate, eluting at 0.17 and 0.31 m, respectively. The virus in these peaks could not be distinguished by infectivity (plaque-forming units), hemagglutinin activity, electron microscopi...

journal_title：Journal of virology

authors： Burness AT

更新日期：1967-04-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) poorly replicate human immunodeficiency virus type 1 (HIV-1) but efficiently transfer HIV-1 to adjacent CD4 T lymphocytes. We found that coculture with T lymphocytes downregulates SAMHD1 expression, enhances HIV-1 replication, and increases pDC maturation and alpha interferon (IFN-α)...

journal_title：Journal of virology

authors： Su B,Lederle A,Laumond G,Ducloy C,Schmidt S,Decoville T,Moog C

更新日期：2014-09-01 00:00:00

abstract：:The preintegration complex of human immunodeficiency virus type 1 (HIV-1) is a large nucleoprotein complex containing viral nucleic acids in association with products of the viral gag and pol genes. One of these proteins, integrase, is absolutely required for the integration and formation of the provirus. Although HIV...

journal_title：Journal of virology

authors： Bukrinsky M,Sharova N,Stevenson M

更新日期：1993-11-01 00:00:00

abstract：:The host cell receptor for Moloney murine leukemia virus was solubilized from murine L-cell membranes and characterized. In initial studies designed to identify a receptor-rich cell line, different mouse cells were screened for binding to Moloney gp70, the viral envelope glycoprotein which determines host cell-binding...

journal_title：Journal of virology

authors： Johnson PA,Rosner MR

更新日期：1986-06-01 00:00:00

abstract：:The human papillomavirus (HPV) type 16 (HPV16) E6 protein can stimulate mechanistic target of rapamycin complex 1 (mTORC1) signaling and cap-dependent translation through activation of the PDK1 and mTORC2 kinases. Here we report that HPV18 E6 also enhances cap-dependent translation. The integrity of LXXLL and PDZ prot...

journal_title：Journal of virology

authors： Spangle JM,Ghosh-Choudhury N,Munger K

更新日期：2012-07-01 00:00:00

abstract：:Interaction of the C-terminal domains of Sendai virus (SeV) P and N proteins is crucial for RNA synthesis by correctly positioning the polymerase complex (L+P) onto the nucleocapsid (N/RNA). To better understand this mechanism within the paramyxovirus family, we have studied the complex formed by the SeV C-terminal do...

journal_title：Journal of virology

authors： Houben K,Marion D,Tarbouriech N,Ruigrok RW,Blanchard L

更新日期：2007-07-01 00:00:00

abstract：:We have designed a DNA cassette to transcribe defective interfering (DI) RNAs of tomato bushy stunt virus (TBSV) and have investigated their potential to protect transgenic Nicotiana benthamiana plants from tombusvirus infections. To produce RNAs with authentic 5' and 3' termini identical to those of the native B10 DI...

journal_title：Journal of virology

authors： Rubio T,Borja M,Scholthof HB,Feldstein PA,Morris TJ,Jackson AO

更新日期：1999-06-01 00:00:00

abstract：UNLABELLED:Neutralizing antibodies that target the hemagglutinin of influenza virus either inhibit binding of hemagglutinin to cellular receptors or prevent the low-pH-induced conformational change in hemagglutinin required for membrane fusion. In general, the former type of antibody binds to the globular head formed b...

journal_title：Journal of virology

authors： Iba Y,Fujii Y,Ohshima N,Sumida T,Kubota-Koketsu R,Ikeda M,Wakiyama M,Shirouzu M,Okada J,Okuno Y,Kurosawa Y,Yokoyama S

更新日期：2014-07-01 00:00:00

abstract：:Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) disease is associated with an increased viral burden in the peripheral blood and a loss of circulating CD4+ T cells. HIV-1 isolates obtained prior to this stage of disease often have a "slow-low," non-syncytium-inducing (NSI) phenotype, whereas thos...

journal_title：Journal of virology

authors： Kaneshima H,Su L,Bonyhadi ML,Connor RI,Ho DD,McCune JM

更新日期：1994-12-01 00:00:00

abstract：:Three polyadenylated RNAs, 9, 7.3, and 3.5 kilobases long, of a human endogenous retrovirus, ERV3, are abundant in human placental chorion, representing about 0.03 to 0.05% of the total mRNA. We characterized the structure of these mRNAs by Northern blot and S1 nuclease mapping analyses. We found that all three RNAs w...

journal_title：Journal of virology

authors： Kato N,Pfeifer-Ohlsson S,Kato M,Larsson E,Rydnert J,Ohlsson R,Cohen M

更新日期：1987-07-01 00:00:00

abstract：:Herpes simplex virus (HSV) glycoprotein B (gB) is an integral part of the multicomponent fusion system required for virus entry and cell-cell fusion. Here we investigated the mechanism of viral neutralization by the monoclonal antibody (MAb) 2c, which specifically recognizes the gB of HSV type 1 (HSV-1) and HSV-2. Bin...

journal_title：Journal of virology

authors： Krawczyk A,Krauss J,Eis-Hübinger AM,Däumer MP,Schwarzenbacher R,Dittmer U,Schneweis KE,Jäger D,Roggendorf M,Arndt MA

更新日期：2011-02-01 00:00:00

abstract：:The human genome contains more than half a million human endogenous retrovirus (HERV) long terminal repeats (LTRs) that can be regarded as mobile regulatory modules. Many of these HERV LTRs have been recruited during evolution as transcriptional control elements for cellular gene expression. We have cloned LTR sequenc...

journal_title：Journal of virology

authors： Schön U,Diem O,Leitner L,Günzburg WH,Mager DL,Salmons B,Leib-Mösch C

更新日期：2009-12-01 00:00:00