Abstract:
:Plasmacytoid dendritic cells (pDC) poorly replicate human immunodeficiency virus type 1 (HIV-1) but efficiently transfer HIV-1 to adjacent CD4 T lymphocytes. We found that coculture with T lymphocytes downregulates SAMHD1 expression, enhances HIV-1 replication, and increases pDC maturation and alpha interferon (IFN-α) secretion. HIV-1 transfer to T lymphocytes is inhibited by broadly neutralizing antibody VRC01 with efficiency similar to that of cell-free infection of T lymphocytes. Interestingly, prevention of HIV-1 transmission by VRC01 retains IFN-α secretion. These results emphasize the multiple functions of VRC01 in protection against HIV-1 acquisition.
journal_name
J Viroljournal_title
Journal of virologyauthors
Su B,Lederle A,Laumond G,Ducloy C,Schmidt S,Decoville T,Moog Cdoi
10.1128/JVI.01748-14subject
Has Abstractpub_date
2014-09-01 00:00:00pages
10975-81issue
18eissn
0022-538Xissn
1098-5514pii
JVI.01748-14journal_volume
88pub_type
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