Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response.

abstract：:In this study, we have extensively modified the Rb-binding domain of polyomavirus large T antigen. Mutant polyomavirus large T antigens were tested for their ability to bind pRb and p107 in vitro and assayed for their capacity to immortalize primary rat embryo fibroblasts in vivo. Polyomavirus large T antigen bound pR...

journal_title：Journal of virology

authors： Pilon AA,Desjardins P,Hassell JA,Mes-Masson AM

更新日期：1996-07-01 00:00:00

abstract：:We have found that the burst size of bacteriophage T7 was decreased in two Escherichia coli temperature-sensitive gyrase mutants incubated at the restrictive temperature. This reduction in burst size indicates that gyrase may be required for T7 growth. ...

journal_title：Journal of virology

authors： Steck TR,Drlica K

更新日期：1985-01-01 00:00:00

abstract：:A promoter-trap retrovirus has been constructed in which a promoterless polyomavirus middle T antigen gene was inserted in the U3 region of the long terminal repeat of a replication-competent Moloney murine leukemia virus. The resulting virus, designated PyT, was used to infect mouse mammary glands in situ. As expecte...

journal_title：Journal of virology

authors： Coulombe J,Avis Y,Gray DA

更新日期：1996-10-01 00:00:00

abstract：:Both CD4(+) and CD8(+) T cells are required for clearance of the murine coronavirus mouse hepatitis virus (MHV) during acute infection. We investigated the effects of an epitope-specific CD8(+) T-cell response on acute infection of MHV, strain A59, in the murine CNS. Mice with CD8(+) T cells specific for gp33-41 (an H...

journal_title：Journal of virology

authors： Chua MM,MacNamara KC,San Mateo L,Shen H,Weiss SR

更新日期：2004-02-01 00:00:00

abstract：:During Epstein-Barr virus (EBV) latent infection of B lymphocytes in vitro, six EBV nuclear antigens (EBNAs) are expressed from one of two promoters, Cp and Wp, whose activities are mutually exclusive. Upon infection, Wp is initially active, followed by a switch to Cp for the duration of latency. In this study, the im...

journal_title：Journal of virology

authors： Puglielli MT,Desai N,Speck SH

更新日期：1997-01-01 00:00:00

abstract：:The influenza A virus NS1 protein contains a conserved 4-amino-acid-residue PDZ-ligand binding motif (PBM) at the carboxyl terminus that can function as a virulence determinant by targeting cellular PDZ proteins. The NS1 proteins from avian and human viral isolates have consensus PBM sequences ESEV and RSKV, respectiv...

journal_title：Journal of virology

authors： Golebiewski L,Liu H,Javier RT,Rice AP

更新日期：2011-10-01 00:00:00

abstract：:Human keratinocytes immortalized by full-length or early-region simian virus 40 (SV40) DNA grow in agarose and form tumors in nude mice, in contrast to keratinocytes immortalized by the E6/E7 genes of human papillomaviruses. To determine the molecular basis for this biological difference in growth, we have used the in...

journal_title：Journal of virology

authors： Yuan H,Veldman T,Rundell K,Schlegel R

更新日期：2002-11-01 00:00:00

abstract：:Koala retrovirus (KoRV) is of an interest to virologists due to its currently active endogenization into the koala (Phascolarctos cinereus) genome. Although KoRV has frequently been isolated in wild and captive koala populations, its pathogenesis and transmission remain to be fully characterized, and most previous res...

journal_title：Journal of virology

authors： Hashem MA,Maetani F,Kayesh MEH,Eiei T,Mochizuki K,Ito A,Sakurai H,Asai T,Tsukiyama-Kohara K

更新日期：2020-05-18 00:00:00

abstract：:The multiplicity of attachment (MOA) of a virion in any particular time interval is the average number of cellular attachment opportunities that must be blocked to keep the virion in suspension. MOA is usually proportional to incubation time and cell concentration. Low MOA (like low multiplicity of infection) is requi...

journal_title：Journal of virology

authors： Spouge JL

更新日期：1994-03-01 00:00:00

abstract：:A virulent porcine epidemic diarrhea virus (PEDV) strain, DR13, was obtained from suckling pigs suspected of having porcine epidemic diarrhea in 1999 in Korea, and its attenuated counterpart was derived from virulent strain DR13 by serial propagation in Vero cells. This report describes the first complete genome seque...

journal_title：Journal of virology

authors： Park SJ,Kim HK,Song DS,An DJ,Park BK

更新日期：2012-05-01 00:00:00

abstract：:CM2 is the second membrane protein of the influenza C virus and has been demonstrated to play a role in the uncoating and genome packaging processes in influenza C virus replication. Although the effects of N-linked glycosylation, disulfide-linked oligomerization, and palmitoylation of CM2 on virus replication have be...

journal_title：Journal of virology

authors： Goto T,Shimotai Y,Matsuzaki Y,Muraki Y,Sho R,Sugawara K,Hongo S

更新日期：2017-10-27 00:00:00

abstract：:We have constructed two point mutants of Rous sarcoma virus in which the amino-terminal glycine residue of the transforming protein, p60src, was changed to an alanine or a glutamic acid residue. Both mutant proteins failed to become myristylated and, more importantly, no longer transformed cells. The lack of transform...

journal_title：Journal of virology

authors： Buss JE,Kamps MP,Gould K,Sefton BM

更新日期：1986-05-01 00:00:00

abstract：:H9N2 avian influenza virus (AIV) has an extended host range, but the molecular basis underlying H9N2 AIV transmission to mammals remains unclear. We isolated more than 900 H9N2 AIVs in our 3-year surveillance in live bird markets in China from 2009 to 2012. Thirty-seven representative isolates were selected for furthe...

journal_title：Journal of virology

authors： Teng Q,Xu D,Shen W,Liu Q,Rong G,Li X,Yan L,Yang J,Chen H,Yu H,Ma W,Li Z

更新日期：2016-10-14 00:00:00

abstract：:The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein la...

journal_title：Journal of virology

authors： Tran EE,Simmons JA,Bartesaghi A,Shoemaker CJ,Nelson E,White JM,Subramaniam S

更新日期：2014-09-01 00:00:00

abstract：:We previously reported the establishment of several lymphoid cell lines from X-ray-induced thymomas of C57BL/Ka mice, and all, except one, produce retroviruses (P. Sankar-Mistry and P. Jolicoeur, J. Virol.35:270-275, 1980). Biological characterization of five of these new primary radiation leukemia viruses (RadLVs) in...

journal_title：Journal of virology

authors： Rassart E,Sankar-Mistry P,Lemay G,DesGroseillers L,Jolicoeur P

更新日期：1983-02-01 00:00:00

abstract：:Human endogenous retrovirus K (HERV-K) is the most intact retrovirus in the human genome. However, no single HERV-K provirus in the human genome today appears to be infectious. Since the Gag protein is the central component for the production of retrovirus particles, we investigated the abilities of Gag from two HERV-...

journal_title：Journal of virology

authors： Heslin DJ,Murcia P,Arnaud F,Van Doorslaer K,Palmarini M,Lenz J

更新日期：2009-01-01 00:00:00

abstract：:A major difference between vaccine and wild-type strains of measles virus (MV) in vitro is the wider cell specificity of vaccine strains, resulting from the receptor usage of the hemagglutinin (H) protein. Wild-type H proteins recognize the signaling lymphocyte activation molecule (SLAM) (CD150), which is expressed on...

journal_title：Journal of virology

authors： Takeuchi K,Nagata N,Kato SI,Ami Y,Suzaki Y,Suzuki T,Sato Y,Tsunetsugu-Yokota Y,Mori K,Van Nguyen N,Kimura H,Nagata K

更新日期：2012-03-01 00:00:00

abstract：:During primary varicella-zoster virus (VZV) infection, it is presumed that virus is transmitted from mucosal sites to regional lymph nodes, where T cells become infected. The cell type responsible for VZV transport from the mucosa to the lymph nodes has not been defined. In this study, we assessed the susceptibility o...

journal_title：Journal of virology

authors： Abendroth A,Morrow G,Cunningham AL,Slobedman B

更新日期：2001-07-01 00:00:00

abstract：:The early proteins of simian virus 40 (SV40) large T and small t antigen (T/t antigen) can each cause the transcriptional activation of a variety of cellular and viral promoters. We showed previously that simian cellular DNA-binding factors (the Band A factors) bind to sequences within the SV40 late promoter which are...

journal_title：Journal of virology

authors： Gallo GJ,Gruda MC,Manuppello JR,Alwine JC

更新日期：1990-01-01 00:00:00

abstract：:The entry of the viral genomic DNA of cauliflower mosaic virus into the nucleus is a critical step of viral infection. We have shown by transient expression in plant protoplasts that the viral coat protein (CP), which is processed from the product of open reading frame IV, contains an N-terminal nuclear localization s...

journal_title：Journal of virology

authors： Leclerc D,Chapdelaine Y,Hohn T

更新日期：1999-01-01 00:00:00

abstract：:The existence of novel endogenous retrovirus elements in the chicken genome, designated EAV-HP, with close sequence identity to the env gene of avian leukosis virus (ALV) subgroup J has been reported (L. M. Smith, A. A. Toye, K. Howes, N. Bumstead, L. N. Payne, and K. Venugopal, J. Gen. Virol. 80:261-268, 1999). To re...

journal_title：Journal of virology

authors： Sacco MA,Flannery DM,Howes K,Venugopal K

更新日期：2000-02-01 00:00:00

abstract：:Cells that express glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) resist infection by HSV-1 and HSV-2 because of interference with viral penetration. The results presented here show that both HSV-1 and HSV-2 gD can mediate interference and that various HSV-1 and HSV-2 strains differ in sensitivity to this ...

journal_title：Journal of virology

authors： Dean HJ,Warner MS,Terhune SS,Johnson RM,Spear PG

更新日期：1995-08-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) evokes a strong immune response, but the virus persists. Polymorphisms within known antigenic sites result in loss of immune recognition and can be positively selected. Amino acid variation outside known HLA class I restricted epitopes can also enable immune escape by interf...

journal_title：Journal of virology

authors： Zimbwa P,Milicic A,Frater J,Scriba TJ,Willis A,Goulder PJ,Pillay T,Gunthard H,Weber JN,Zhang HT,Phillips RE

更新日期：2007-02-01 00:00:00

abstract：:Treatment with sodium dodecyl sulfate (SDS) converted the vaccinia virus strain IHD-J into particles of two types: (i) ghosts which possessed a thin-membrane vesicle derived from basement part of the virus membrane with attached lateral bodies and a membranous structure derived from the core wall and (ii) aggregates o...

journal_title：Journal of virology

authors： Ichihashi Y,Oie M,Tsuruhara T

更新日期：1984-06-01 00:00:00

abstract：:Feline panleukopenia virus (FPV) and its host range variant, canine parvovirus (CPV), can bind the feline transferrin receptor (TfR), while only CPV binds to the canine TfR. Introducing two CPV-specific changes into FPV (at VP2 residues 93 and 323) endowed that virus with the canine TfR binding property and allowed ca...

journal_title：Journal of virology

authors： Hueffer K,Govindasamy L,Agbandje-McKenna M,Parrish CR

更新日期：2003-09-01 00:00:00

abstract：:Bluetongue virus (BTV), an insect-vectored emerging pathogen of both wild ruminants and livestock, has had a severe economic impact in agriculture in many parts of the world. The investigation of BTV replication and pathogenesis has been hampered by the lack of a reverse genetics system. Recovery of infectious BTV is ...

journal_title：Journal of virology

authors： Boyce M,Celma CC,Roy P

更新日期：2008-09-01 00:00:00

abstract：:The avian and Nelson Bay reoviruses are two of only a limited number of nonenveloped viruses capable of inducing cell-cell membrane fusion. These viruses encode the smallest known membrane fusion proteins (p10). We now show that a region of moderate hydrophobicity we call the hydrophobic patch (HP), present in the sma...

journal_title：Journal of virology

authors： Shmulevitz M,Epand RF,Epand RM,Duncan R

更新日期：2004-03-01 00:00:00

abstract：:The arterivirus equine arteritis virus nonstructural protein 10 (nsp10) has previously been predicted to contain a Zn finger structure linked to a superfamily 1 (SF1) helicase domain. A recombinant form of nsp10, MBP-nsp10, was produced in Escherichia coli as a fusion protein with the maltose-binding protein. The prot...

journal_title：Journal of virology

authors： Seybert A,van Dinten LC,Snijder EJ,Ziebuhr J

更新日期：2000-10-01 00:00:00

abstract：:Newcastle disease virus (NDV) California strain reportedly grows poorly in L cells but replicates very well in chicken embryo cells. NDV-infected L cell cultures show a characteristic virus growth curve with respect to uridine incorporation, but plaque assays of the virus produced 24 h postinfection (PI) show no infec...

journal_title：Journal of virology

authors： Hecht TT,Summers DF

更新日期：1974-07-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection of children previously immunized with a nonlive, formalin-inactivated (FI)-RSV vaccine has been associated with serious enhanced respiratory disease (ERD). Consequently, detailed studies of potential ERD are a critical step in the development of nonlive RSV vaccines targetin...

journal_title：Journal of virology

authors： Schneider-Ohrum K,Cayatte C,Bennett AS,Rajani GM,McTamney P,Nacel K,Hostetler L,Cheng L,Ren K,O'Day T,Prince GA,McCarthy MP

更新日期：2017-03-29 00:00:00