Structural analysis of a 1.7-kilobase mouse mammary tumor virus-specific RNA.

abstract：:Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for ...

journal_title：Journal of virology

authors： Rinaldo C,Huang XL,Fan ZF,Ding M,Beltz L,Logar A,Panicali D,Mazzara G,Liebmann J,Cottrill M

更新日期：1995-09-01 00:00:00

abstract：:To examine the prerequisites for cleavage activation of the hemagglutinin of human influenza viruses, a cDNA clone obtained from strain A/Port Chalmers/1/73 (serotype H3) was subjected to site-directed mutagenesis and expressed in CV-1 cells by using a simian virus 40 vector. The number of basic residues at the cleava...

journal_title：Journal of virology

authors： Ohuchi R,Ohuchi M,Garten W,Klenk HD

更新日期：1991-07-01 00:00:00

abstract：:Human T-cell leukemia virus (HTLV) Tax protein has been implicated in the HTLV oncogenic process, primarily due to its pleiotropic effects on cellular genes involved in growth regulation and cell cycle control. To date, several approaches attempting to correlate Tax activation of the CREB/activating transcription fact...

journal_title：Journal of virology

authors： Ross TM,Narayan M,Fang ZY,Minella AC,Green PL

更新日期：2000-03-01 00:00:00

abstract：:The cottontail rabbit papillomavirus (CRPV) a and b subtypes display a conserved E8 open reading frame encoding a 50-amino-acid hydrophobic protein, with structural similarities to the E5 transmembrane oncoprotein of genital human PVs (HPVs). CRPV E8 has been reported to play a role in papilloma growth but not to be e...

journal_title：Journal of virology

authors： Nonnenmacher M,Salmon J,Jacob Y,Orth G,Breitburd F

更新日期：2006-05-01 00:00:00

abstract：:Vaccine-elicited humoral immune responses comprise an array of antibody forms and specificities, with only a fraction contributing to protective host immunity. Elucidation of antibody effector functions responsible for protective immunity against human immunodeficiency virus type 1 (HIV-1) acquisition is a major goal ...

journal_title：Journal of virology

authors： Wills S,Hwang KK,Liu P,Dennison SM,Tay MZ,Shen X,Pollara J,Lucas JT,Parks R,Rerks-Ngarm S,Pitisuttithum P,Nitayapan S,Kaewkungwal J,Thomas R,Kim JH,Michael NL,Robb ML,McRaven M,Montefiori DC,Hope TJ,Liao HX,Mood

更新日期：2018-03-14 00:00:00

abstract：:Recognition of viruses by germ line-encoded pattern recognition receptors of the innate immune system is essential for rapid production of type I interferon (IFN) and early antiviral defense. We investigated the mechanisms of viral recognition governing production of type I IFN during herpes simplex virus (HSV) infect...

journal_title：Journal of virology

authors： Rasmussen SB,Sørensen LN,Malmgaard L,Ank N,Baines JD,Chen ZJ,Paludan SR

更新日期：2007-12-01 00:00:00

abstract：:One unique feature of the shrimp white spot syndrome virus (WSSV) genome is the presence of a giant open reading frame (ORF) of 18,234 nucleotides that encodes a long polypeptide of 6,077 amino acids with a hitherto unknown function. In the present study, by applying proteomic methodology to analyze the sodium dodecyl...

journal_title：Journal of virology

authors： Leu JH,Tsai JM,Wang HC,Wang AH,Wang CH,Kou GH,Lo CF

更新日期：2005-01-01 00:00:00

abstract：:We compared the intracellular location of the product of the c-fps proto-oncogene, NCP98, with that of its viral homolog P140, the transforming protein of Fujinami sarcoma virus. Using the technique of biochemical subcellular fractionation, we determined that 60 to 90% of NCP98 and its associated kinase activity are i...

journal_title：Journal of virology

authors： Young JC,Martin GS

更新日期：1984-12-01 00:00:00

abstract：:Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct sub...

journal_title：Journal of virology

authors： Zhang L,Mohan PM,Padmanabhan R

更新日期：1992-12-01 00:00:00

abstract：:The inbred mouse strain RIII has long been known for shedding large amounts of mouse mammary tumor virus (MMTV) particles in milk and for the development of hormone-dependent early mammary tumors at a very high incidence (>90%). We have established one RIII subline (RIII/Sa) that shows a pattern of virus expression an...

journal_title：Journal of virology

authors： Sarkar NH,Golovkina T,Uz-Zaman T

更新日期：2004-01-01 00:00:00

abstract：:Aichi virus, a member of the family Picornaviridae, encodes a leader (L) protein of 170 amino acids (aa). The Aichi virus L protein exhibits no significant sequence homology to those of other picornaviruses. In this study, we investigated the function of the Aichi virus L protein in virus growth. In vitro translation ...

journal_title：Journal of virology

authors： Sasaki J,Nagashima S,Taniguchi K

更新日期：2003-10-01 00:00:00

abstract：UNLABELLED:Venezuelan and western equine encephalitis viruses (VEEV and WEEV; Alphavirus; Togaviridae) are mosquito-borne pathogens causing central nervous system (CNS) disease in humans and equids. Adult CD-1 mice also develop CNS disease after infection with VEEV and WEEV. Adult CD-1 mice infected by the intranasal (...

journal_title：Journal of virology

authors： Phillips AT,Rico AB,Stauft CB,Hammond SL,Aboellail TA,Tjalkens RB,Olson KE

更新日期：2016-05-27 00:00:00

abstract：:Drug resistance remains a major concern for human immunodeficiency virus (HIV) treatment. To date, very few resistance mutations have emerged in first-line combination therapy that includes the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG). In vitro, DTG selects for several primary mutations that indu...

journal_title：Journal of virology

authors： Van Rompay KKA,Hassounah S,Keele BF,Lifson JD,Ardeshir A,Watanabe J,Pham HT,Chertova E,Sowder R,Balzarini J,Mesplède T,Wainberg MA

更新日期：2019-01-04 00:00:00

abstract：:Infection of cells with enveloped viruses is accomplished through membrane fusion. The binding and fusion processes are mediated by the spike proteins in the envelope of the virus particle and usually involve a series of conformational changes in these proteins. We have studied the low-pH-mediated fusion process of th...

journal_title：Journal of virology

authors： Wahlberg JM,Bron R,Wilschut J,Garoff H

更新日期：1992-12-01 00:00:00

abstract：:Virus-specific CD4(+) T-cell function is thought to play a central role in induction and maintenance of effective CD8(+) T-cell responses in experimental animals or humans. However, the reasons that diminished proliferation of human immunodeficiency virus (HIV)-specific CD4(+) T cells is observed in the majority of in...

journal_title：Journal of virology

authors： Iyasere C,Tilton JC,Johnson AJ,Younes S,Yassine-Diab B,Sekaly RP,Kwok WW,Migueles SA,Laborico AC,Shupert WL,Hallahan CW,Davey RT Jr,Dybul M,Vogel S,Metcalf J,Connors M

更新日期：2003-10-01 00:00:00

abstract：:Expression of the hepatitis B virus core antigen (HBcAg) in mouse NIH 3T3 fibroblasts has been shown previously (A. McLachlan et al., J. Virol. 61:683-692, 1987) to result in the nuclear localization of this polypeptide. Since the carboxyl terminus of HBcAg contains four clusters of arginine residues which resemble nu...

journal_title：Journal of virology

authors： Eckhardt SG,Milich DR,McLachlan A

更新日期：1991-02-01 00:00:00

abstract：:Ribonucleic acid extracted from influenza virus was labeled at the 3' termini with (3)H and analyzed by polyacrylamide gel electrophoresis. Influenza virus was found to contain a minimum of seven and possibly as many as 10 polynucleotide chains, most of which appear to terminate at the 3' end in uridine. ...

journal_title：Journal of virology

authors： Lewandowski LJ,Content J,Leppla SH

更新日期：1971-11-01 00:00:00

abstract：:The mouse hind footpad inoculation model has served as a standard laboratory system for the study of the neuropathogenesis of herpes simplex virus type 1 (HSV-1) infection. The temporal and spatial distribution of viral antigen, known as the transneuronal spread phenotype, has not previously been described; nor is it ...

journal_title：Journal of virology

authors： Engel JP,Madigan TC,Peterson GM

更新日期：1997-03-01 00:00:00

abstract：:Rigorous investigation of many functions encoded by cytomegaloviruses (CMVs) requires analysis in the context of virus-host interactions. To facilitate the construction of rhesus CMV (RhCMV) mutants for in vivo studies, a bacterial artificial chromosome (BAC) containing an enhanced green fluorescent protein (EGFP) cas...

journal_title：Journal of virology

authors： Chang WL,Barry PA

更新日期：2003-05-01 00:00:00

abstract：:In coliphage 186, 22 essential genes were defined by complementation studies with amber mutants. Eighteen genes were associated with phage morphogenesis: 11 with phage tail formation, and 7 with phage head formation. The remaining four genes are discussed in the accompanying paper (S. M. Hocking and J. B. Egan, J. Vir...

journal_title：Journal of virology

authors： Hocking SM,Egan JB

更新日期：1982-12-01 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus (HIV) seizes control of cellular cullin-RING E3 ubiquitin ligases (CRLs) to promote viral replication. HIV-1 Vpr and HIV-2/simian immunodeficiency virus (SIV) Vpr and Vpx engage the cullin4 (CUL4)-containing ubiquitin ligase complex (CRL4) to cause polyubiquitination and proteaso...

journal_title：Journal of virology

authors： Sharifi HJ,Furuya AK,Jellinger RM,Nekorchuk MD,de Noronha CM

更新日期：2014-06-01 00:00:00

abstract：:In an effort to develop a useful AIDS vaccine or vaccine component, we have generated a combinatorial library of chimeric viruses in which the sequence IGPGRAFYTTKN from the V3 loop of the MN strain of human immunodeficiency virus type 1 (HIV-1) is displayed in many conformations on the surface of human rhinovirus 14 ...

journal_title：Journal of virology

authors： Smith AD,Geisler SC,Chen AA,Resnick DA,Roy BM,Lewi PJ,Arnold E,Arnold GF

更新日期：1998-01-01 00:00:00

abstract：:Herpes simplex virus type 1 packages its DNA genome into a precursor capsid, referred to as the procapsid. Of the three capsid-associated DNA-packaging proteins, UL17, UL25, and UL6, only UL17 and UL6 appear to be components of the procapsid, with UL25 being added subsequently. To determine whether the association of ...

journal_title：Journal of virology

authors： Thurlow JK,Murphy M,Stow ND,Preston VG

更新日期：2006-03-01 00:00:00

abstract：:Posttranscriptional gene silencing (PTGS), a homology-dependent RNA degradation system, has a role in defending against virus infection in plants, but plant viruses encode a suppressor to combat PTGS. Using transgenic tobacco in which the expression of green fluorescent protein (GFP) is posttranscriptionally silenced,...

journal_title：Journal of virology

authors： Kubota K,Tsuda S,Tamai A,Meshi T

更新日期：2003-10-01 00:00:00

abstract：:Human bocavirus (HBoV) is a newly discovered parvovirus associated with acute respiratory tract illness (ARTI) and gastrointestinal illness. No previous reports indicated the presence of HBoV infection in Jiangsu Province, China. Here we report three complete genomic sequences of HBoV strains from children with gastro...

journal_title：Journal of virology

authors： Wang X,Zhang X,Tian H,Ling F,Yu M,Sun G,Yang S,Shen Q,Wang Y,Shao S,Zhang W

更新日期：2012-12-01 00:00:00

abstract：:Muscle is an attractive target for gene delivery because of its mass and because vectors can be delivered in a noninvasive fashion. Adeno-associated virus (AAV) has been shown to be effective for muscle-targeted gene transfer. Recent progress in characterization of AAV serotype 1 (AAV1) and AAV6 demonstrated that thes...

journal_title：Journal of virology

authors： Hauck B,Xiao W

更新日期：2003-02-01 00:00:00

abstract：:The ability of the gamma(1)34.5 protein to suppress the PKR response plays a crucial role in herpes simplex virus pathogenesis. In this process, the gamma(1)34.5 protein associates with protein phosphatase 1 to form a large complex that dephosphorylates eIF-2alpha and thereby prevents translation shutoff mediated by P...

journal_title：Journal of virology

authors： Jing X,Cerveny M,Yang K,He B

更新日期：2004-07-01 00:00:00

abstract：:The complete DNA sequence of bovine adenovirus type 3 is reported here. The size of the genome is 34,446 bp in length with a G+C content of 54%. All the genes of the early and late regions are present in the expected locations of the genome. However, the late-region genes are organized into seven families, instead of ...

journal_title：Journal of virology

authors： Reddy PS,Idamakanti N,Zakhartchouk AN,Baxi MK,Lee JB,Pyne C,Babiuk LA,Tikoo SK

更新日期：1998-02-01 00:00:00

abstract：:Although the herpes simplex virus type 1 (HSV-1) tegument is comprised of a large number of viral and cellular proteins, how and where in the cell these proteins are recruited into the virus structure is poorly understood. We have shown previously that the immediate-early gene product ICP0 is packaged by a mechanism d...

journal_title：Journal of virology

authors： Maringer K,Elliott G

更新日期：2010-05-01 00:00:00

abstract：:The core promoter mutants of hepatitis B virus (HBV) emerge as the dominant viral population at the late HBeAg and the anti-HBe stages of HBV infection, with the A1762T/G1764A substitutions as the hotspot mutations. The double core promoter mutations were found by many investigators to moderately enhance viral genome ...

journal_title：Journal of virology

authors： Parekh S,Zoulim F,Ahn SH,Tsai A,Li J,Kawai S,Khan N,Trépo C,Wands J,Tong S

更新日期：2003-06-01 00:00:00