Abstract:
:The Epstein-Barr virus BZLF1 gene product ZEBRA is a DNA-binding protein that is partially homologous to c-Fos, binds specifically to AP-1 sites, and can induce the lytic cycle in latently infected B lymphocytes. Induction of the viral lytic cycle can also be achieved by treatment with the phorbol ester 12-O-tetrade-canoylphorbol-13-acetate, a reagent which activates gene expression in part through AP-1 (Jun/Fos). In this article the interrelationship between ZEBRA and AP-1 is extended by the demonstration that ZEBRA can induce c-Fos expression through AP-1 and "AP-1-like" sites present in the c-fos promoter. Induction of c-Fos may be necessary for the expression of other viral lytic genes and perhaps cellular genes whose products are required for viral replication.
journal_name
J Viroljournal_title
Journal of virologyauthors
Flemington E,Speck SHdoi
10.1128/JVI.64.9.4549-4552.1990subject
Has Abstractpub_date
1990-09-01 00:00:00pages
4549-52issue
9eissn
0022-538Xissn
1098-5514journal_volume
64pub_type
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doi:10.1128/JVI.01619-09
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journal_title:Journal of virology
pub_type: 杂志文章
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doi:10.1128/JVI.64.2.936-940.1990
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abstract::Epstein-Barr virus (EBV) is a ubiquitous human pathogen associated with Burkitt's lymphoma and nasopharyngeal carcinoma. Although the EBV genome harbors more than a hundred genes, a full transcription map with EBV polyadenylation profiles remains unknown. To elucidate the 3' ends of all EBV transcripts genome-wide, we...
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pub_type: 杂志文章
doi:10.1128/JVI.53.1.221-227.1985
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.68.11.7546-7548.1994
更新日期:1994-11-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1128/JVI.65.2.1013-1018.1991
更新日期:1991-02-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.4.2347-2354.1994
更新日期:1994-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.03771-13
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.72.7.5886-5896.1998
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pub_type: 杂志文章
doi:10.1128/JVI.72.2.1691-1698.1998
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pub_type: 杂志文章
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更新日期:2016-09-29 00:00:00
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更新日期:2004-08-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01946-07
更新日期:2008-03-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01740-08
更新日期:2009-04-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.24.13399-13408.2004
更新日期:2004-12-01 00:00:00
abstract::Nonstructural protein 1 (NS1) of yellow fever virus (YF) is a glycoprotein localized to extracytoplasmic compartments within infected cells. We have previously shown that NS1 can be supplied in trans and is required for viral RNA replication, a process thought to occur in membrane-bound cytoplasmic complexes. Here we ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.6.4611-4621.1999
更新日期:1999-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.5.2056-2062.1989
更新日期:1989-05-01 00:00:00