Effects of S-adenosylhomocysteine and analogs on Epstein-Barr virus-induced transformation, expression of the Epstein-Barr virus capsid antigen, and methylation of Epstein-Barr virus DNA.

Abstract:

:S-Adenosylhomocysteine was found to have no effect on Epstein-Barr virus-induced transformation of B-lymphocytes and to stimulate viral capsid antigen expression only slightly in the FF41-1 cell line. In contrast, the S-adenosylhomocysteine analogs sinefungin and S-isobutyladenosine inhibited Epstein-Barr virus transformation and induced a significant increase in the numbers of cells expressing the viral capsid antigen. An inverse relationship between levels of viral DNA methylation and gene expression was demonstrated.

journal_name

J Virol

journal_title

Journal of virology

authors

Long WK,Fronko GE,Lindemeyer RG,Wu B,Henderson EE

doi

10.1128/JVI.61.1.221-224.1987

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

221-4

issue

1

eissn

0022-538X

issn

1098-5514

journal_volume

61

pub_type

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