A distinct class of internal ribosomal entry site in members of the Kobuvirus and proposed Salivirus and Paraturdivirus genera of the Picornaviridae.

abstract：:The development of immunization strategies to protect against ocular infection with herpes simplex virus 1 (HSV-1) must address the issue of the effects of the strategy on the establishment of latency in the trigeminal ganglia (TG). It is the reactivation of this latent virus that can cause recurrent disease and corne...

journal_title：Journal of virology

authors： Matundan H,Mott KR,Ghiasi H

更新日期：2014-07-01 00:00:00

abstract：:The herpes simplex virus (HSV) heterodimer gE/gI and another membrane protein, US9, which has neuron-specific effects, promote the anterograde transport of virus particles in neuronal axons. Deletion of both HSV gE and US9 blocks the assembly of enveloped particles in the neuronal cytoplasm, which explains why HSV vir...

journal_title：Journal of virology

authors： DuRaine G,Wisner TW,Johnson DC

更新日期：2020-11-09 00:00:00

abstract：:The Epstein-Barr virus (EBV) immediate-early protein BZLF1 mediates the switch between the latent and lytic forms of EBV infection and has been previously shown to induce a G(1)/S block in cell cycle progression in some cell types. To examine the effect of BZLF1 on cellular gene expression, we performed microarray ana...

journal_title：Journal of virology

authors： Mauser A,Holley-Guthrie E,Zanation A,Yarborough W,Kaufmann W,Klingelhutz A,Seaman WT,Kenney S

更新日期：2002-12-01 00:00:00

abstract：:Due to increasing concerns about human infection by various H7 influenza viruses, including recent H7N9 viruses, we evaluated the genetic relationships and cross-protective efficacies of three different Eurasian H7 avian influenza viruses. Phylogenic and molecular analyses revealed that recent Eurasian H7 viruses can ...

journal_title：Journal of virology

authors： Kwon HI,Kim YI,Park SJ,Song MS,Kim EH,Kim SM,Si YJ,Lee IW,Song BM,Lee YJ,Yun SJ,Kim WJ,Choi YK

更新日期：2017-05-12 00:00:00

abstract：:Noroviruses are the causative agents of the majority of viral gastroenteritis outbreaks in humans. During the past 15 years, noroviruses of genotype GGII.4 have caused four epidemic seasons of viral gastroenteritis, during which four novel variants (termed epidemic variants) emerged and displaced the resident viruses....

journal_title：Journal of virology

authors： Siebenga JJ,Vennema H,Renckens B,de Bruin E,van der Veer B,Siezen RJ,Koopmans M

更新日期：2007-09-01 00:00:00

abstract：:Current knowledge of human immunodeficiency virus type 1 envelope (Env) glycoprotein structure and function is based on studies of clade B viruses. We present evidence of sequence and structural differences in viral glycoprotein gp120 between clades B and C. In clade C, the C3 region alpha2-helix exhibits high sequenc...

journal_title：Journal of virology

authors： Gnanakaran S,Lang D,Daniels M,Bhattacharya T,Derdeyn CA,Korber B

更新日期：2007-05-01 00:00:00

abstract：:The E7 oncoprotein of human papillomavirus 16 (HPV16) transforms basal and suprabasal cervical epithelial cells and is a tumor-specific antigen in cervical carcinoma, to which immunotherapeutic strategies aimed at cytotoxic T-lymphocyte (CTL) induction are currently directed. By quantifying major histocompatibility co...

journal_title：Journal of virology

authors： Tindle RW,Herd K,Doan T,Bryson G,Leggatt GR,Lambert P,Frazer IH,Street M

更新日期：2001-07-01 00:00:00

abstract：:Two forms of herpes simplex virus glycoprotein gD were recombined into Autographa californica nuclear polyhedrosis virus (baculovirus) and expressed in infected Spodoptera frugiperda (Sf9) cells. Each protein was truncated at residue 306 of mature gD. One form, gD-1(306t), contains the coding sequence of Patton strain...

journal_title：Journal of virology

authors： Sisk WP,Bradley JD,Leipold RJ,Stoltzfus AM,Ponce de Leon M,Hilf M,Peng C,Cohen GH,Eisenberg RJ

更新日期：1994-02-01 00:00:00

abstract：:Defective interfering (DI) RNAs of Tomato bushy stunt virus (TBSV), a plus-sense RNA virus, comprise four conserved noncontiguous regions (I through IV) derived from the viral genome. Region III, a 70-nucleotide-long sequence corresponding to a genomic segment located 378 nucleotides upstream of the 3' terminus of the...

journal_title：Journal of virology

authors： Ray D,White KA

更新日期：2003-01-01 00:00:00

abstract：:The recently developed subgenomic hepatitis C virus (HCV) replicons were limited by the fact that the sequence encoding the structural proteins was missing. Therefore, important information about a possible influence of these proteins on replication and pathogenesis and about the mechanism of virus formation could not...

journal_title：Journal of virology

authors： Pietschmann T,Lohmann V,Kaul A,Krieger N,Rinck G,Rutter G,Strand D,Bartenschlager R

更新日期：2002-04-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) LANA is an 1,162-amino-acid protein that tethers terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence in dividing cells. C-terminal LANA self-associates to bind TR DNA. LANA contains independent N- and C-terminal chromosome binding regions. N-ter...

journal_title：Journal of virology

authors： Kelley-Clarke B,De Leon-Vazquez E,Slain K,Barbera AJ,Kaye KM

更新日期：2009-05-01 00:00:00

abstract：:Neutralizing antibodies may have critical importance in immunity against human immunodeficiency virus type 1 (HIV-1) infection. However, the amount of protective antibody needed at mucosal surfaces has not been fully established. Here, we evaluated systemic and mucosal pharmacokinetics (PK) and pharmacodynamics (PD) o...

journal_title：Journal of virology

authors： Klein K,Veazey RS,Warrier R,Hraber P,Doyle-Meyers LA,Buffa V,Liao HX,Haynes BF,Shaw GM,Shattock RJ

更新日期：2013-11-01 00:00:00

abstract：:In this work we show evidence of mother-to-offspring transmission in a transgenic mouse line expressing bovine PrP (boTg) experimentally infected by intracerebral administration of bovine spongiform encephalopathy (BSE) prions. PrP(res) was detected in brains of newborns from infected mothers only when mating was allo...

journal_title：Journal of virology

authors： Castilla J,Brun A,Díaz-San Segundo F,Salguero FJ,Gutiérrez-Adán A,Pintado B,Ramírez MA,del Riego L,Torres JM

更新日期：2005-07-01 00:00:00

abstract：:A virus structurally similar to viruses associated with maedi, progressive pneumonia, and visna of sheep has been isolated from buffy coat cells of cattle with chronic lymphocytosis. Electron microscope studies revealed three variants of the virion: (i) an intracytoplasmic form 98 to 116 nm in diameter when occurring ...

journal_title：Journal of virology

authors： Boothe AD,Van der Maaten AJ

更新日期：1974-01-01 00:00:00

abstract：:In 2014 and 2015, the United States experienced an unprecedented outbreak of Eurasian clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus. Initial cases affected mainly wild birds and mixed backyard poultry species, while later outbreaks affected mostly commercial chickens and turkeys. The pathogenesis, tr...

journal_title：Journal of virology

authors： Bertran K,Lee DH,Pantin-Jackwood MJ,Spackman E,Balzli C,Suarez DL,Swayne DE

更新日期：2017-10-13 00:00:00

abstract：:HB-3, a temperate bacteriophage of Streptococcus pneumoniae, synthesizes its own murein hydrolase activity when multiplying on cultures of pneumococcus. The enzyme (HBL) was purified and biochemically characterized as an N-acetylmuramoyl-L-alanine amidase of 36,000 daltons, and a 2.1-kilobase DraI fragment containing ...

journal_title：Journal of virology

authors： Romero A,Lopez R,Garcia P

更新日期：1990-01-01 00:00:00

abstract：:Ocular herpes simplex keratitis (HSK) is a consequence of viral reactivations from trigeminal ganglia (TG) and occurs almost exclusively in the same eye in humans. In our murine oro-ocular (OO) model, herpes simplex virus 1 (HSV-1) inoculation in one side of the lip propagates virus to infect the ipsilateral TG. Repli...

journal_title：Journal of virology

authors： Poccardi N,Rousseau A,Haigh O,Takissian J,Naas T,Deback C,Trouillaud L,Issa M,Roubille S,Juillard F,Efstathiou S,Lomonte P,Labetoulle M

更新日期：2019-11-26 00:00:00

abstract：:The Vpr protein, encoded by the human immunodeficiency virus type 1 (HIV-1) genome, is one of the nonstructural proteins packaged in large amounts into viral particles. We have previously reported that Vpr associates with the DNA repair enzyme uracil DNA glycosylase (UDG). In this study, we extended these observations...

journal_title：Journal of virology

authors： Willetts KE,Rey F,Agostini I,Navarro JM,Baudat Y,Vigne R,Sire J

更新日期：1999-02-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S c...

journal_title：Journal of virology

authors： Lee HR,Mitra J,Lee S,Gao SJ,Oh TK,Kim MH,Ha T,Jung JU

更新日期：2015-10-21 00:00:00

abstract：:The limited efficiency of in vivo gene transfer by replication-deficient retroviral vectors remains an obstacle to achieving effective gene therapy for solid tumors. One approach to circumvent this problem is the use of replication-competent retroviral vectors. However, the application of such vectors is at a comparat...

journal_title：Journal of virology

authors： Paar M,Schwab S,Rosenfellner D,Salmons B,Günzburg WH,Renner M,Portsmouth D

更新日期：2007-07-01 00:00:00

abstract：UNLABELLED:Cell culture (cc)-derived hepatitis B virus (HBV) can infect differentiated HepaRG cells, but efficient infection requires addition of polyethylene glycol (PEG) during inoculation. Identification of sodium taurocholate cotransporting polypeptide (NTCP) as an HBV receptor enabled ccHBV infection of NTCP recon...

journal_title：Journal of virology

authors： Li J,Zong L,Sureau C,Barker L,Wands JR,Tong S

更新日期：2016-08-26 00:00:00

abstract：:Luteoviruses avoid degradation in the hemolymph of their aphid vector by interacting with a GroEL homolog from the aphid's primary endosymbiotic bacterium (Buchnera sp.). Mutational analysis of GroEL from the primary endosymbiont of Myzus persicae (MpB GroEL) revealed that the amino acids mediating binding of Potato l...

journal_title：Journal of virology

authors： Hogenhout SA,van der Wilk F,Verbeek M,Goldbach RW,van den Heuvel JF

更新日期：2000-05-01 00:00:00

abstract：:Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to esta...

journal_title：Journal of virology

authors： Nishizawa T,Okamoto H,Tsuda F,Aikawa T,Sugai Y,Konishi K,Akahane Y,Ukita M,Tanaka T,Miyakawa Y,Mayumi M

更新日期：1999-11-01 00:00:00

abstract：:Dengue virus (DENV) is a major global pathogen that causes significant morbidity and mortality in tropical and subtropical areas worldwide. An improved understanding of the regions within the DENV genome and its encoded proteins that are required for the virus replication cycle will expedite the development of urgentl...

journal_title：Journal of virology

authors： Eyre NS,Johnson SM,Eltahla AA,Aloi M,Aloia AL,McDevitt CA,Bull RA,Beard MR

更新日期：2017-11-14 00:00:00

abstract：:We have measured in 22 asymptomatic human immunodeficiency virus type 1-infected patients (10 rapid progressors and 12 slow progressors) the proviral load of CD4(+) T cells homogeneously superinfected by the same dose of a non-syncytium-inducing virus in the presence or in the absence of autologous CD8(+) T cells. We ...

journal_title：Journal of virology

authors： Salerno-Gonçalves R,Lu W,Andrieu JM

更新日期：2000-07-01 00:00:00

abstract：:In order to analyze the function of VPg amplification in aphthoviruses, we have undertaken the first mutational analysis of the repetitive VPg-coding region using an improved foot-and-mouth disease virus (FMDV) cDNA clone from which infective viral RNA was synthesized. A set of VPg mutants was constructed by site-dire...

journal_title：Journal of virology

authors： Falk MM,Sobrino F,Beck E

更新日期：1992-04-01 00:00:00

abstract：:Primate lentiviruses use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection. Simian immunodeficiency virus (SIV) productively infects human cells expressing CD4 and the human allele of the chemokine coreceptor CCR-5 as efficiently as it infects macaque cells expressing human CD4, suggest...

journal_title：Journal of virology

authors： Chackerian B,Long EM,Luciw PA,Overbaugh J

更新日期：1997-05-01 00:00:00

abstract：:We report here the isolation by molecular cloning and the analysis by heteroduplex and restriction enzyme mapping of seven distinct DNA fragments containing hepatitis B virus (HBV) sequences from genomic DNA of the PLC/PRF/5 human liver carcinoma cell line (the Alexander cell). No intact full-length HBV genomes were p...

journal_title：Journal of virology

authors： Shaul Y,Ziemer M,Garcia PD,Crawford R,Hsu H,Valenzuela P,Rutter WJ

更新日期：1984-09-01 00:00:00

abstract：:NS4B is one of the nonstructural proteins of classical swine fever virus (CSFV), the etiological agent of a severe, highly lethal disease of swine. Protein domain analysis of the predicted amino acid sequence of the NS4B protein of highly pathogenic CSFV strain Brescia (BICv) identified a putative Toll/interleukin-1 r...

journal_title：Journal of virology

authors： Fernandez-Sainz I,Gladue DP,Holinka LG,O'Donnell V,Gudmundsdottir I,Prarat MV,Patch JR,Golde WT,Lu Z,Zhu J,Carrillo C,Risatti GR,Borca MV

更新日期：2010-02-01 00:00:00

abstract：:In 2010 and 2011, several devastating Newcastle disease (ND) outbreaks occurred in China, affecting broilers, layers, and breeders. The CK-JSX1-201005 virus was isolated from broiler breeder flocks vaccinated with the classical ND virus (NDV) vaccine program, but laying rate decreased from 80% to 30 to 40% in the clin...

journal_title：Journal of virology

authors： Chen F,Liu J,Liu D,Yan Z,Ji J,Qin J,Li H,Ma J,Bi Y,Xie Q

更新日期：2012-11-01 00:00:00