Replication and IRES-dependent translation are both affected by core coding sequences in subgenomic GB virus B replicons.

abstract：:The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein la...

journal_title：Journal of virology

authors： Tran EE,Simmons JA,Bartesaghi A,Shoemaker CJ,Nelson E,White JM,Subramaniam S

更新日期：2014-09-01 00:00:00

abstract：:Expression of human papillomavirus late genes encoding L1 and L2 capsid proteins is restricted to terminally differentiated epithelial cells. We have previously identified and characterized an AU-rich, cis-acting negative regulatory element in the 3' untranslated region of human papillomavirus type 1 late mRNAs. This ...

journal_title：Journal of virology

authors： Zhao C,Tan W,Sokolowski M,Schwartz S

更新日期：1996-06-01 00:00:00

abstract：:Senecavirus A (SVA) is a picornavirus that causes acute vesicular disease (VD), that is clinically indistinguishable from foot-and-mouth disease (FMD), in pigs. Notably, SVA RNA has been detected in lymphoid tissues of infected animals several weeks following resolution of the clinical disease, suggesting that the vir...

journal_title：Journal of virology

authors： Maggioli MF,Fernandes MHV,Joshi LR,Sharma B,Tweet MM,Noll JCG,Bauermann FV,Diel DG

更新日期：2019-10-15 00:00:00

abstract：:Upon inoculation into AKR mice, mink cell focus-forming murine leukemia virus (MCF MLV) accelerates thymic lymphoma formation. During the preleukemic phase of disease, we observed the induction of apoptosis in thymic lymphocytes. A similar induction of apoptosis was observed for cultured mink epithelial cells after MC...

journal_title：Journal of virology

authors： Nanua S,Yoshimura FK

更新日期：2004-05-01 00:00:00

abstract：:The stimulation of host macromolecular synthesis and induction into the cell cycle of serum-deprived G0-G1-arrested mouse embryo fibroblasts were examined after infection of resting cells with wild-type simian virus 40 or with viral mutants affecting T antigen (tsA58) or small t antigen (dl884). At various times after...

journal_title：Journal of virology

authors： Hiscott JB,Defendi V

更新日期：1981-02-01 00:00:00

abstract：:We applied deep sequencing technology to small RNA fractions from cells lytically infected with murine gammaherpesvirus 68 (gammaHV68) in order to define in detail small RNAs generated from a cluster of tRNA-related polycistronic structures located at the left end of the viral genome. We detected 10 new candidate micr...

journal_title：Journal of virology

authors： Reese TA,Xia J,Johnson LS,Zhou X,Zhang W,Virgin HW

更新日期：2010-10-01 00:00:00

abstract：UNLABELLED:Aminoquinolines and piperazines, linked or not, have been used successfully to treat malaria, and some molecules of this family also exhibit antiviral properties. Here we tested several derivatives of 4-aminoquinolines and piperazines for their activity against hepatitis C virus (HCV). We screened 11 molecul...

journal_title：Journal of virology

authors： Vausselin T,Séron K,Lavie M,Mesalam AA,Lemasson M,Belouzard S,Fénéant L,Danneels A,Rouillé Y,Cocquerel L,Foquet L,Rosenberg AR,Wychowski C,Meuleman P,Melnyk P,Dubuisson J

更新日期：2016-09-12 00:00:00

abstract：:Foamy viruses (FVs) generate their Pol protein precursor molecule independently of the Gag protein from a spliced mRNA. This mode of expression raises the question of the mechanism of Pol protein incorporation into the viral particle (capsid). We previously showed that the packaging of (pre)genomic RNA is essential fo...

journal_title：Journal of virology

authors： Peters K,Wiktorowicz T,Heinkelein M,Rethwilm A

更新日期：2005-06-01 00:00:00

abstract：:Expression of the cellular heat shock protein 70 gene (hsp70) is transiently induced by human cytomegalovirus (HCMV) infection of permissive human diploid fibroblasts. Induction of the cellular heat shock response during critical times of infection had previously been reported to alter the growth of HCMV in vitro. Thu...

journal_title：Journal of virology

authors： Santomenna LD,Colberg-Poley AM

更新日期：1990-05-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) causes significant morbidity and mortality in humans worldwide. HSV-1 enters epithelial cells via an endocytosis mechanism that is low-pH dependent. However, the precise intracellular pathway has not been identified, including the compartment where fusion occurs. In this study, we utiliz...

journal_title：Journal of virology

authors： Tebaldi G,Pritchard SM,Nicola AV

更新日期：2020-11-23 00:00:00

abstract：:The yeast two-hybrid system was used to catalog all detectable interactions among the P2 nonstructural cleavage products of poliovirus type 1 (Mahoney). Evidence has been obtained for specific associations among 2A(pro), 2BC, 2C, and 2B. Specifically, 2A(pro) can interact with itself and 2BC and its cleavage products ...

journal_title：Journal of virology

authors： Cuconati A,Xiang W,Lahser F,Pfister T,Wimmer E

更新日期：1998-02-01 00:00:00

abstract：:Treatment of [3H]glucosamine-labeled Friend mink cell focus-forming virus (FrMCF) gp70 with excess peptide:N-glycanase F (PNGase F) resulted in removal of the expected seven N-linked oligosaccharide chains; however, approximately 10% of the glucosamine label was retained in the resulting 49,000-Mr (49K) product. For [...

journal_title：Journal of virology

authors： Pinter A,Honnen WJ

更新日期：1988-03-01 00:00:00

abstract：:Polyoma virus complementary RNA, synthesized in vitro by using highly purified Escherichia coli RNA polymerase and nondefective form I polyoma DNA, was translated in a wheat germ cell-free system. Polypeptides were synthesized that comigrated on sodium dodecyl sulfate-polyacrylamide gels with the polyoma capsid protei...

journal_title：Journal of virology

authors： Mangel WF,Hewick RM,Bayley ST,Wheeler T,Harvey R,Waterfield MD,Smith AE

更新日期：1978-02-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) is a large (150-kb) double-stranded DNA virus that forms latent infections in neuronal cells of the human peripheral nervous system. Previous work determined that the HSV-1 genome is found in an ordered nucleosomal structure during latent infection. However, during lytic infection, ...

journal_title：Journal of virology

authors： Kent JR,Zeng PY,Atanasiu D,Gardner J,Fraser NW,Berger SL

更新日期：2004-09-01 00:00:00

abstract：:We have identified a cytomegalovirus virion protein capable of modulating the rapid induction of an interferon-like response in cells that follows virus binding and penetration. Functional genomics revealed a role for the major cytomegalovirus structural protein, pp65 (ppUL83), in counteracting this response. The unde...

journal_title：Journal of virology

authors： Abate DA,Watanabe S,Mocarski ES

更新日期：2004-10-01 00:00:00

abstract：:Treatment of patients with lamivudine (3TC) results in loss of detectable levels of hepatitis B virus (HBV) DNA from serum; however, the relapse rate, with regard to both reappearance of virus in the bloodstream and hepatic inflammation, is high when therapy is terminated. Although the rebound observed in patients has...

journal_title：Journal of virology

authors： Abdelhamed AM,Kelley CM,Miller TG,Furman PA,Isom HC

更新日期：2002-08-01 00:00:00

abstract：:The capsid mRNA transcripts of human bocavirus 1 (HBoV1) can be generated by alternative splicing from the mRNA precursor transcribed from the P5 promoter. However, the alternative translation regulation mechanism of capsid mRNA transcripts is largely unknown. Here we report that the polycistronic capsid mRNA transcri...

journal_title：Journal of virology

authors： Liu X,Hao S,Chen Z,Xu H,Wang H,Huang M,Guan W

更新日期：2018-10-12 00:00:00

abstract：:The genome of the Neodiprion sertifer nucleopolyhedrovirus (NeseNPV), which infects the European pine sawfly, N. sertifer (Hymenoptera: Diprionidae), was sequenced and analyzed. The genome was 86,462 bp in size. The C+G content of 34% was lower than that of the majority of baculoviruses. A total of 90 methionine-initi...

journal_title：Journal of virology

authors： Garcia-Maruniak A,Maruniak JE,Zanotto PM,Doumbouya AE,Liu JC,Merritt TM,Lanoie JS

更新日期：2004-07-01 00:00:00

abstract：:The experimental infection of newborn calves with bovine norovirus was used as a homologous large animal model to study the pathogenesis of norovirus infection and to determine target cells for viral replication. Six newborn calves were inoculated orally with Jena virus (JV), a bovine norovirus GIII.1 strain, and six ...

journal_title：Journal of virology

authors： Otto PH,Clarke IN,Lambden PR,Salim O,Reetz J,Liebler-Tenorio EM

更新日期：2011-11-01 00:00:00

abstract：UNLABELLED:Identification and characterization of CD8(+) T cells effectively controlling HIV-1 variants are necessary for the development of AIDS vaccines and for studies of AIDS pathogenesis, although such CD8(+) T cells have been only partially identified. In this study, we sought to identify CD8(+) T cells controlli...

journal_title：Journal of virology

authors： Murakoshi H,Akahoshi T,Koyanagi M,Chikata T,Naruto T,Maruyama R,Tamura Y,Ishizuka N,Gatanaga H,Oka S,Takiguchi M

更新日期：2015-05-01 00:00:00

abstract：:We report the use of a HeLa whole cell extract (WCE) runoff transcription system for the study of cis- and trans-acting elements, participating in the regulation of transcription initiation from the P38 promoter of the parvovirus minute virus of mice (MVM). Our initial studies with HeLa WCE indicated that transcriptio...

journal_title：Journal of virology

authors： Krauskopf A,Resnekov O,Aloni Y

更新日期：1990-01-01 00:00:00

abstract：:In Epstein-Barr virus (EBV)-carrying nonproducer Raji cells, the induction of the viral replicative cycle by chemical treatment is limited to only the early stage and viral DNA synthesis is totally inhibited. We previously showed the absence of two messenger RNAs that are encoded by the BamHI-A fragment of the EBV gen...

journal_title：Journal of virology

authors： Decaussin G,Leclerc V,Ooka T

更新日期：1995-11-01 00:00:00

abstract：:In-frame stop codons were introduced into the coding region of human immunodeficiency virus type 1 (HIV-1) transmembrane protein (gp41). Truncation of 147 amino acids from the carboxyl terminus of gp41 (TM709) significantly decreased the stability and cell surface expression of the viral Env proteins, while truncation...

journal_title：Journal of virology

authors： Yu X,Yuan X,McLane MF,Lee TH,Essex M

更新日期：1993-01-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) protein is a transcriptional regulator of viral and cellular genes that is essential for EBV-mediated immortalization of B lymphocytes in vitro. EBNA-3C can inhibit transcription through an association with the cellular DNA-binding protein Jkappa, a function sh...

journal_title：Journal of virology

authors： Zhao B,Sample CE

更新日期：2000-06-01 00:00:00

abstract：UNLABELLED:Enteroviruses (EVs) are a genetically and antigenically diverse group of viruses infecting humans. A mostly distinct set of EV variants have additionally been documented to infect wild apes and several, primarily captive, Old World monkey (OWM) species. To investigate the prevalence and genetic characteristi...

journal_title：Journal of virology

authors： Van Nguyen D,Harvala H,Ngole EM,Delaporte E,Woolhouse ME,Peeters M,Simmonds P

更新日期：2014-06-01 00:00:00

abstract：:Infection of cells with herpes simplex virus type 1 (HSV-1) results in a rapid alteration of phosphorylation on the large subunit of cellular RNA polymerase II (RNAP II), most likely on its C-terminal domain (S. A. Rice, M. C. Long, V. Lam, C. A. Spencer, J. Virol. 68:988-1001, 1994). This phosphorylation modification...

journal_title：Journal of virology

authors： Rice SA,Long MC,Lam V,Schaffer PA,Spencer CA

更新日期：1995-09-01 00:00:00

abstract：:Dendritic cells (DC) are believed to play an important role in the initiation of innate and adaptive immune responses to infection, including respiratory tract infections, where respiratory DC (RDC) perform this role. In this report, we examined the susceptibilities of isolated murine RDC to influenza virus infection ...

journal_title：Journal of virology

authors： Hao X,Kim TS,Braciale TJ

更新日期：2008-05-01 00:00:00

abstract：:Reoviruses are encapsidated double-stranded RNA viruses that cause systemic disease in mice after peroral (p.o.) inoculation and primary replication in the intestine. In this study, we define components of the immune system involved in the clearing of reovirus from the proximal small intestine. The intestines of immun...

journal_title：Journal of virology

authors： Barkon ML,Haller BL,Virgin HW 4th

更新日期：1996-02-01 00:00:00

abstract：:Monocytes/macrophages (MO/Mphi) are the major target cells for both dengue virus (DV) and bacterial lipopolysaccharide (LPS), and the aim of this study was to define their interactions. We had found that LPS markedly suppressed DV infection of primary human MO/Mphi when it was added to cultures prior to or together wi...

journal_title：Journal of virology

authors： Chen YC,Wang SY,King CC

更新日期：1999-04-01 00:00:00

abstract：:An unusual set of 3' coterminal, spliced mRNAs transcribed through the BamHI A fragment have been previously identified in nasopharyngeal carcinoma (NPC) tissues. These RNAs have also been detected at low levels in Burkitt's lymphoma (BL) cell lines and Epstein-Barr virus (EBV)-transformed lymphocytes. Sequence analys...

journal_title：Journal of virology

authors： Fries KL,Sculley TB,Webster-Cyriaque J,Rajadurai P,Sadler RH,Raab-Traub N

更新日期：1997-04-01 00:00:00