Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression.

abstract：:The v-rel oncogene encoded by reticuloendotheliosis virus strain T is the acutely transforming member of the Rel/NF-kappaB family of transcription factors. In v-Rel-transformed cells, v-Rel exists as homodimers or heterodimers with the endogenous Rel/NF-kappaB proteins c-Rel, NF-kappaB1, NF-kappaB2, and RelA. To exami...

journal_title：Journal of virology

authors： Liss AS,Bose HR Jr

更新日期：2002-05-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) envelope protein is required for virus spread. This study further characterizes the role of the envelope protein in HTLV-1 immortalization. Viruses with single amino acid substitutions within the SU protein at residue 75, 81, 95, 101, 105, or 195 or with a C-terminal cyt...

journal_title：Journal of virology

authors： Tsukahara T,Wielgosz MM,Ratner L

更新日期：2001-10-01 00:00:00

abstract：:The mutational alterations in polyoma virus mutants ts-a and ts-25E which cause their large T-antigens to be thermolabile have been identified. In ts-a, a G leads to A transition at nucleotide 2193 causes the replacement of Ala (GCT) by Thr (ACT). In ts-25E, a G leads to T transversion at nucleotide 2883 causes the re...

journal_title：Journal of virology

authors： Thomas T,Vollmer P,Folk WR

更新日期：1981-03-01 00:00:00

abstract：:Therapeutic vaccination has the potential to boost immune responses and enhance viral control during chronic infections. However, many therapeutic vaccination approaches have fallen short of expectations, and effective boosting of antiviral T-cell responses is not always observed. To examine these issues, we studied t...

journal_title：Journal of virology

authors： Wherry EJ,Blattman JN,Ahmed R

更新日期：2005-07-01 00:00:00

abstract：:Initial studies determined whether intraperitoneal (i.p.) injection of BALB/c mice with 0.1, 1.0, and 10 mg of adriamycin (a cardiotoxic anthracycline antibiotic) for times ranging between 1 and 9 weeks prior to i.p. injection of 10(5) PFU of coxsackievirus B3 (CVB3) would alter the severity of virus-induced myocardit...

journal_title：Journal of virology

authors： Huber SA,Moraska A,Choate M

更新日期：1992-11-01 00:00:00

abstract：:A mutation (asparagine 815 to serine 815) was introduced into the herpes simplex virus type 1 (HSV-1) DNA polymerase (pol). The HSV-1 pol enzyme in lysates of Saccharomyces cerevisiae cells expressing the mutant protein showed increased resistance to acyclovir triphosphate and increased sensitivity to phosphonoacetate...

journal_title：Journal of virology

authors： Matthews JT,Carroll RD,Stevens JT,Haffey ML

更新日期：1989-11-01 00:00:00

abstract：:We have investigated the mechanism of duck hepatitis B virus (DHBV) entry into susceptible primary duck hepatocytes (PDHs), using mutants of carboxypeptidase D (gp180), a transmembrane protein shown to act as the primary cellular receptor for avian hepatitis B virus uptake. The variant proteins were abundantly produce...

journal_title：Journal of virology

authors： Breiner KM,Schaller H

更新日期：2000-03-01 00:00:00

abstract：:The binding of cyclophilin A (CypA) to the human immunodeficiency virus type 1 (HIV-1) capsid protein (CA protein) is required soon after virus entry into natural target cells. In Jurkat T lymphocytes, disrupting CypA-CA interaction either by cyclosporine (Cs) treatment or by alteration (e.g., P90A) of the CA inhibits...

journal_title：Journal of virology

authors： Li Y,Kar AK,Sodroski J

更新日期：2009-11-01 00:00:00

abstract：:The expression of a human immunodeficiency virus (HIV) type 1 provirus (F12-HIV) cloned from a nonproducer, chronically infected CD4 down-regulated Hut-78 cell clone (F12) does not lead to the formation of viral particles and, upon transfection in HeLa CD4+ cells, confers resistance to HIV superinfection without affec...

journal_title：Journal of virology

authors： Federico M,Nappi F,Ferrari G,Chelucci C,Mavilio F,Verani P

更新日期：1995-11-01 00:00:00

abstract：:We have developed a means to identify genes associated with particular aspects of virulence. By beginning with an avirulent deletion mutant of rabbitpox virus and systematically reintroducing overlapping segments of the deleted region, we have identified two regions of the viral genome associated with increased virule...

journal_title：Journal of virology

authors： Bloom DC,Edwards KM,Hager C,Moyer RW

更新日期：1991-03-01 00:00:00

abstract：:Measles is a highly contagious human disease caused by the measles virus (MeV). In this study, by proteomic analysis, we identified peroxiredoxin 1 (Prdx1) as a host factor that binds to the C-terminal region of the nucleoprotein (N; N(TAIL)) of MeV. Glutathione S-transferase (GST) pulldown experiments showed that the...

journal_title：Journal of virology

authors： Watanabe A,Yoneda M,Ikeda F,Sugai A,Sato H,Kai C

更新日期：2011-03-01 00:00:00

abstract：:When human adenovirus type 2 or 12 infects cells, either productively or non-productively, three classes of viral deoxyribonucleic acid (DNA) are found within the cells: (i) viral DNA which cosediments with DNA extracted from infectious adenovirions at 31.3S for adenovirus type 2 and at 29.0S for adenovirus type 12, (...

journal_title：Journal of virology

authors： Burlingham BT,Doerfler W

更新日期：1971-06-01 00:00:00

abstract：:Airborne viruses are expected to be ubiquitous in the atmosphere but they still remain poorly understood. This study investigated the temporal and spatial dynamics of airborne viruses and their genotypic characteristics in air samples collected from three distinct land use types (a residential district [RD], a forest ...

journal_title：Journal of virology

authors： Whon TW,Kim MS,Roh SW,Shin NR,Lee HW,Bae JW

更新日期：2012-08-01 00:00:00

abstract：:The HIV-1 Rev response element (RRE) is a 351-base element in unspliced and partially spliced viral RNA; binding of the RRE by the viral Rev protein induces nuclear export of RRE-containing RNAs, as required for virus replication. It contains one long, imperfect double helix (domain I), one branched domain (domain II)...

journal_title：Journal of virology

authors： O'Carroll IP,Thappeta Y,Fan L,Ramirez-Valdez EA,Smith S,Wang YX,Rein A

更新日期：2017-10-13 00:00:00

abstract：:The isolation and characterization of an adenovirus mutant, Ad5dl802r1, containing two independent deletions in the 72-kilodalton (kDa) DNA-binding protein (DBP) gene is described. The two deletions remove amino acids 23 through 105 of DBP, resulting in the production of a 50-kDa product. Expression of this truncated ...

journal_title：Journal of virology

authors： Cleghon V,Voelkerding K,Morin N,Delsert C,Klessig DF

更新日期：1989-05-01 00:00:00

abstract：:We show here that the white spot syndrome virus (WSSV) immediate-early protein IE1 interacts with the Penaeus monodon TATA box-binding protein (PmTBP) and that this protein-protein interaction occurs in the absence of any other viral or cellular proteins or nucleic acids, both in vitro and in vivo. Mapping studies usi...

journal_title：Journal of virology

authors： Liu WJ,Chang YS,Huang WT,Chen IT,Wang KC,Kou GH,Lo CF

更新日期：2011-07-01 00:00:00

abstract：:NF-κB-interacting long noncoding RNA (NKILA) was recently identified as a negative regulator of NF-κB signaling and plays an important role in the development of various cancers. It is well known that NF-κB-mediated activation of human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-driven gene expres...

journal_title：Journal of virology

authors： Wang H,Liu Y,Huan C,Yang J,Li Z,Zheng B,Wang Y,Zhang W

更新日期：2020-08-17 00:00:00

abstract：:In resting CD4(+) T lymphocytes harboring human immunodeficiency virus type 1 (HIV-1), replication-competent virus persists in patients responding to highly active antiretroviral therapy (HAART). This small latent reservoir represents between 10(3) and 10(7) cells per patient. However, the efficiency of HIV-1 DNA-posi...

journal_title：Journal of virology

authors： Fondere JM,Petitjean G,Huguet MF,Salhi SL,Baillat V,Macura-Biegun A,Becquart P,Reynes J,Vendrell JP

更新日期：2004-10-01 00:00:00

abstract：:HBI is a recombinant avian retrovirus with novel pathogenic properties that was derived from the myc-containing virus MC29. In contrast to MC29, which causes endotheliomas in chickens, HBI induces lymphoid tumors. The results of molecular cloning and nucleotide sequencing of HBI reported here show that the virus conta...

journal_title：Journal of virology

authors： Smith DR,Vennstrom B,Hayman MJ,Enrietto PJ

更新日期：1985-12-01 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) experience a marked loss of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the depletion of these cells are not yet understood. In this study, we observed that CD4+ T lymphocytes from HIV type 1 (HIV-1)-infected and uninfec...

journal_title：Journal of virology

authors： Heinkelein M,Sopper S,Jassoy C

更新日期：1995-11-01 00:00:00

abstract：:To study fundamental aspects of RNA recombination, an in vivo RNA recombination system was established. This system allowed the efficient generation of recombinant cytopathogenic pestiviruses after transfection of synthetic, nonreplicatable, subgenomic transcripts in cells infected with a replicating noncytopathogenic...

journal_title：Journal of virology

authors： Gallei A,Pankraz A,Thiel HJ,Becher P

更新日期：2004-06-01 00:00:00

abstract：:Analysis of the complete sequence of a human immunodeficiency virus (HIV) isolate (Ant70) obtained from a Cameroonian patient indicates that this virus is the most divergent strain within the HIV-1 family hitherto described. Comparison of the Pol protein, usually highly conserved within the HIV-1 family, shows only ab...

journal_title：Journal of virology

authors： Vanden Haesevelde M,Decourt JL,De Leys RJ,Vanderborght B,van der Groen G,van Heuverswijn H,Saman E

更新日期：1994-03-01 00:00:00

abstract：:Tegument is a unique structure of herpesvirus, which surrounds the capsid and interacts with the envelope. Morphogenesis of gammaherpesvirus is poorly understood due to lack of efficient lytic replication for Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, which are etiologically as...

journal_title：Journal of virology

authors： Guo H,Wang L,Peng L,Zhou ZH,Deng H

更新日期：2009-10-01 00:00:00

abstract：:Coronavirus subgenomic mRNA possesses a 5'-end leader sequence which is derived from the 5' end of genomic RNA and is linked to the mRNA body sequence. This study examined whether coronavirus transcription involves a discontinuous transcription step; the possibility that a leader sequence from mouse hepatitis virus (M...

journal_title：Journal of virology

authors： Jeong YS,Makino S

更新日期：1994-04-01 00:00:00

abstract：:The monoclonal antibody PAb280 binds to small t antigen but not to large T antigen. Its binding site within the unique region of small t antigen was localized by studying its reaction with simian virus 40 mutants, other papovaviruses, and bacterial expression vectors coding for fragments of small t antigen. The antibo...

journal_title：Journal of virology

authors： Montano X,Lane DP

更新日期：1989-07-01 00:00:00

abstract：:Vaccine-elicited humoral immune responses comprise an array of antibody forms and specificities, with only a fraction contributing to protective host immunity. Elucidation of antibody effector functions responsible for protective immunity against human immunodeficiency virus type 1 (HIV-1) acquisition is a major goal ...

journal_title：Journal of virology

authors： Wills S,Hwang KK,Liu P,Dennison SM,Tay MZ,Shen X,Pollara J,Lucas JT,Parks R,Rerks-Ngarm S,Pitisuttithum P,Nitayapan S,Kaewkungwal J,Thomas R,Kim JH,Michael NL,Robb ML,McRaven M,Montefiori DC,Hope TJ,Liao HX,Mood

更新日期：2018-03-14 00:00:00

abstract：:Phosphorylation of the expressed NS5A protein of hepatitis C virus (HCV), a member of the Hepacivirus genus of the family Flaviviridae, has been demonstrated in mammalian cells and in a cell-free assay by an associated kinase activity. In this report, phosphorylation is also shown for the NS5A and NS5 proteins, respec...

journal_title：Journal of virology

authors： Reed KE,Gorbalenya AE,Rice CM

更新日期：1998-07-01 00:00:00

abstract：:Co-infection of neonatal BALB/c mice with Friend virus (FV) complex (containing defective spleen focus-forming virus [SFFV] and endogenous N-tropic leukemia-inducing helper virus [LLV-F]) and B-tropic Tennant leukemia virus (TenLV) resulted in the inhibition of LLV-F by the Fv-1(b) gene and recovery of a TenLV pseudot...

journal_title：Journal of virology

authors： Eckner RJ

更新日期：1973-09-01 00:00:00

abstract：UNLABELLED:TRIM5α proteins are a potent barrier to the cross-species transmission of retroviruses. TRIM5α proteins exhibit an ability to self-associate at many levels, ultimately leading to the formation of protein assemblies with hexagonal symmetry in vitro and cytoplasmic assemblies when expressed in cells. However, ...

journal_title：Journal of virology

authors： Sastri J,Johnsen L,Smolin N,Imam S,Mukherjee S,Lukic Z,Brandariz-Nuñez A,Robia SL,Diaz-Griffero F,Wiethoff C,Campbell EM

更新日期：2014-08-01 00:00:00

abstract：:The nodavirus flock house virus (FHV) has a bipartite, positive-sense, RNA genome that encodes the catalytic subunit of the RNA replicase and the viral capsid protein precursor on separate genomic segments (RNA1 and RNA2, respectively). RNA1 can replicate autonomously when transfected into permissive cells, allowing s...

journal_title：Journal of virology

authors： Johnson KL,Ball LA

更新日期：1999-10-01 00:00:00